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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February-2019 Volume 41 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review)

Mingzhe Li, Xin Bu, Bolei Cai, Ping Liang, Kai Li, Xuan Qu, Liangliang Shen
Pages: 727-741
Published online on: 23 November 2018

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Article Open Access

NADH dehydrogenase complex I is overexpressed in incipient metastatic murine colon cancer cells

Joana Marquez, Irina Kratchmarova, Vyacheslav Akimov, Fernando Unda, Gaskon Ibarretxe, Ariane Schaub Clerigué, Nerea Osinalde, Iker Badiola
Pages: 742-752
Published online on: 27 November 2018

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Article Open Access

TROP2 promotes the proliferation and metastasis of glioblastoma cells by activating the JAK2/STAT3 signaling pathway

Jianbing Hou, Ailing Lv, Qing Deng, Guanghui Zhang, Xiaosong Hu, Hongjuan Cui
Pages: 753-764
Published online on: 09 November 2018

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Article Open Access

Reactive oxygen species induced by icaritin promote DNA strand breaks and apoptosis in human cervical cancer cells

Xin Chen, Liyan Song, Yuefang Hou, Fan Li
Pages: 765-778
Published online on: 12 November 2018

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Article Open Access

CDK5 suppresses the metastasis of gastric cancer cells by interacting with and regulating PP2A

Jun Lu, Jian‑Xian Lin, Peng‑Yang Zhang, Yu‑Qin Sun, Ping Li, Jian‑Wei Xie, Jia‑Bin Wang, Qi‑Yue Chen, Long‑Long Cao, Yao Lin, Chang‑Ming Huang, Chao‑Hui Zheng
Pages: 779-788
Published online on: 09 November 2018

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Article Open Access

lincRNA‑p21 inhibits the progression of non‑small cell lung cancer via targeting miR‑17‑5p

Xiang Ao, Ming Jiang, Jie Zhou, Hongling Liang, Haoming Xia, Gang Chen
Pages: 789-800
Published online on: 30 November 2018

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Article Open Access

Overexpression of MUC1 predicts poor prognosis in patients with breast cancer

Xuan Jing, Hongping Liang, Chonghua Hao, Xiaojuan Yang, Xiangrong Cui
Pages: 801-810
Published online on: 27 November 2018

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Article Open Access

Carvedilol suppresses malignant proliferation of mammary epithelial cells through inhibition of the ROS‑mediated PI3K/AKT signaling pathway

Zhongbing Ma, Xingli Liu, Qiang Zhang, Zhigang Yu, Dezong Gao
Pages: 811-818
Published online on: 19 November 2018

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Article Open Access

MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7

Junfeng Zhang, Shiyu Mao, Longsheng Wang, Wentao Zhang, Ziwei Zhang, Yadong Guo, Yuan Wu, Faxian Yi, Xudong Yao
Pages: 819-828
Published online on: 21 November 2018

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Article Open Access

Inhibition of autophagy enhances adenosine‑induced apoptosis in human hepatoblastoma HepG2 cells

Xiao‑Tao Zhou, Ze‑Jin Pu, Li‑Xuan Liu, Guo‑Ping Li, Jia‑Lin Feng, Hua‑Chen Zhu, Ling‑Fei Wu
Pages: 829-838
Published online on: 30 November 2018

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Article Open Access

Genetic, epigenetic and transcriptional comparison of esophagus tumor‑associated and adjacent normal myofibroblasts

Ildikó Huliák, László Bodai, Mátyás Czepán, Dávid Kovács, Anikó Szabó, László Tiszlavicz, György Lázár, Zoltán Rakonczay Jr, Péter Hegyi, Imre Miklós Boros, Mónika Kiricsi
Pages: 839-852
Published online on: 06 December 2018

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Article Open Access

Hypoxia‑induced galectin‑3 enhances RhoA function to activate the motility of tumor cells in non‑small cell lung cancer

Yoko Kataoka, Yasuhiko Ohshio, Koji Teramoto, Tomoyuki Igarashi, Tohru Asai, Jun Hanaoka
Pages: 853-862
Published online on: 07 December 2018

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Article Open Access

MicroRNA‑98/PTEN/AKT pathway inhibits cell proliferation and malignant progression of hypopharyngeal carcinoma by MTDH

Qiwei Wang, Lijun Tan, Jiangtao Liu, Jiannan Zhao, Xiaojie Zhou, Tianjiao Yu
Pages: 863-874
Published online on: 06 December 2018

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Article Open Access

Overexpressed PLAGL2 transcriptionally activates Wnt6 and promotes cancer development in colorectal cancer

Nanpeng Li, Daojiang Li, Yuheng Du, Chen Su, Chunxing Yang, Changwei Lin, Xiaorong Li, Gui Hu
Pages: 875-884
Published online on: 07 December 2018

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Article Open Access

Potential efficacy and prognosis of silencing the CRLF2‑mediated AKT/mTOR pathway in pediatric acute B‑cell lymphoblastic leukemia

Min Jiang, Xueqin Zou, Lingyun Lu
Pages: 885-894
Published online on: 07 December 2018

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Article Open Access

Pathway analysis of a genome‑wide association study on a long non‑coding RNA expression profile in oral squamous cell carcinoma

Yong‑Le Qiu, Yuan‑Hang Liu, Jian‑Dong Ban, Wen‑Jing Wang, Mei Han, Peng Kong, Bing‑Hui Li
Pages: 895-907
Published online on: 15 November 2018

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Article Open Access

Ten genes associated with MGMT promoter methylation predict the prognosis of patients with glioma

Yang Zhang, Junwei Zhu
Pages: 908-916
Published online on: 04 December 2018

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Article Open Access

Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial‑mesenchymal transition Expression of Concern in /10.3892/or.2025.8971

Dan‑Hua Lu, Jiang Yang, Li‑Kun Gao, Jie Min, Jian‑Ming Tang, Ming Hu, Yang Li, Su‑Ting Li, Jing Chen, Li Hong
Pages: 917-927
Published online on: 27 November 2018

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Article Open Access

Mechanical, nanomorphological and biological reconstruction of early‑stage apoptosis in HeLa cells induced by cytochalasin B

Xuelian Su, Ling Zhang, Hong Kang, Baoping Zhang, Guangjie Bao, Jizeng Wang
Pages: 928-938
Published online on: 07 December 2018

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Article Open Access

Expression levels and co‑targets of miRNA‑126‑3p and miRNA‑126‑5p in lung adenocarcinoma tissues: Αn exploration with RT‑qPCR, microarray and bioinformatic analyses

Peng Chen, Yong‑Yao Gu, Fu‑Chao Ma, Rong‑Quan He, Zu‑Yun Li, Gao‑Qiang Zhai, Xia Lin, Xiao‑Hua Hu, Lin‑Jiang Pan, Gang Chen
Pages: 939-953
Published online on: 04 December 2018

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Article

Oncolytic potential of an E4-deficient adenovirus that can recognize the stabilization of AU-rich element containing mRNA in cancer cells

Aya Yanagawa-Matsuda, Yohei Mikawa, Umma Habiba, Tetsuya Kitamura, Motoaki Yasuda, Mohammad Towfik-Alam, Yoshimasa Kitagawa, Kazuyuki Minowa, Masanobu Shindoh, Fumihiro Higashino
Pages: 954-960
Published online on: 12 November 2018

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Article

Functional analysis of protein disulfide isomerase P5 in glioblastoma cells as a novel anticancer target

Tomohisa Horibe, Aya Torisawa, Yoshie Masuda, Koji Kawakami
Pages: 961-972
Published online on: 15 November 2018

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Article

Inhibition of cell proliferation and migration in non‑small cell lung cancer cells through the suppression of LYPLA1

Anaz Mohammed, Caixin Zhang, Shuwen Zhang , Qin Shen, Jieying Li, Zhiyuan Tang, Hua Liu
Pages: 973-980
Published online on: 09 November 2018

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Article

Evironmental pollutant perfluorodecanoic acid upregulates cIAP2 to suppress gastric cell senescence

Zhun Zhang, Ning Song, Yanping Peng, Ziyan Fan, Mingyong Han, Min Zhao, Tianyi Dong, Shili Liu
Pages: 981-988
Published online on: 09 November 2018

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Article

Glutathione S‑transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer

Mingyue Zou, Xiaolei Hu, Bangtian Xu, Tingting Tong, Yixian Jing, Lei Xi, Wei Zhou, Jinpeng Lu, Xin Wang, Xiaolan Yang, Fei Liao
Pages: 989-998
Published online on: 09 November 2018

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Article

Mitochondrial‑DNA‑associated TLR9 signalling is a potential serological biomarker for non‑small cell lung cancer

Yu‑Heng Lai, Hao‑Yun Liu, Chun‑Yao Huang, Yat‑Pang Chau, Semon Wu
Pages: 999-1006
Published online on: 09 November 2018

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Article

Tumor suppressor PLZF regulated by lncRNA ANRIL suppresses proliferation and epithelial mesenchymal transformation of gastric cancer cells Corrigendum in /10.3892/or.2023.8624

Jun‑Bin Wang, Yan Jin, Peng Wu, Yang Liu, Wen‑Jing Zhao, Jin‑Fei Chen, Wei De, Fen Yang
Pages: 1007-1018
Published online on: 12 November 2018

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Article

Comparative proteomic analysis identifies exosomal Eps8 protein as a potential metastatic biomarker for pancreatic cancer

Keiichi Ohshima, Keiichi Hatakeyama, Kaori Kanto, Tomomi Ide, Yuko Watanabe, Sachi Moromizato, Kanako Wakabayashi‑Nakao, Naoki Sakura, Ken Yamaguchi, Tohru Mochizuki
Pages: 1019-1034
Published online on: 15 November 2018

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Article

Molecular mechanism of LKB1 in the invasion and metastasis of colorectal cancer

Yangyang Chen, Yifei Liu, Yanhong Zhou, Hongxia You
Pages: 1035-1044
Published online on: 21 November 2018

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Article

Association between interleukin‑33 and ovarian cancer

Xiaoqing Liu, Dwayne M. Hansen, Noah J. Timko, Ziwen Zhu, Andrew Ames, Chenglu Qin, Michael B. Nicholl, Qian Bai, Xuhui Chen, Mark R. Wakefield, Gage West, Yujiang Fang
Pages: 1045-1050
Published online on: 07 December 2018

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Article

Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB‑2‑HIF‑1α axis

Jiguang Ma, Mengwen Xue, Simei Zhang, Liang Cheng, Weikun Qian, Wanxing Duan, Xin Shen
Pages: 1051-1058
Published online on: 28 November 2018

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Article

Dual blockade of EGFR tyrosine kinase using osimertinib and afatinib eradicates EGFR‑mutant Ba/F3 cells

Kimio Yonesaka, Yoshihisa Kobayashi, Hidetoshi Hayashi, Yasutaka Chiba, Tetsuya Mitsudomi, Kazuhiko Nakagawa
Pages: 1059-1066
Published online on: 22 November 2018

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Article

Docetaxel promotes cell apoptosis and decreases SOX2 expression in CD133‑expressing hepatocellular carcinoma stem cells by suppressing the PI3K/AKT signaling pathway

Xuesong Zhang, Jianfeng Shao, Xinyan Li, Lihua Cui, Zhengbing Tan
Pages: 1067-1074
Published online on: 27 November 2018

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Article

TP53 upregulates α‑smooth muscle actin expression in tamoxifen‑resistant breast cancer cells

Sangmin Kim, Daeun You, Yisun Jeong, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee
Pages: 1075-1082
Published online on: 06 December 2018

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Article

Long non‑coding RNA DANCR promotes HMGA2‑mediated invasion in lung adenocarcinoma cells

Ningning Zhang, Wei Jiang
Pages: 1083-1090
Published online on: 30 November 2018

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Article

Overexpression of ID1 promotes tumor progression in penile squamous cell carcinoma

Xiheng Hu, Mingfeng Chen, Yangle Li, Yin Wang, Sailan Wen, Fu Jun
Pages: 1091-1100
Published online on: 06 December 2018

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Article

YWHAZ promotes ovarian cancer metastasis by modulating glycolysis

Jie Shi, Jun Ye, He Fei, Shu‑Hen Jiang, Zhi‑Yong Wu, Ya‑Ping Chen, Li‑Wen Zhang, Xiao‑Mei Yang
Pages: 1101-1112
Published online on: 07 December 2018

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Article

Long non‑coding RNA MALAT1 correlates with cell viability and mobility by targeting miR‑22‑3p in renal cell carcinoma via the PI3K/Akt pathway

Zhong Li, Zhiqiang Ma, Xiangdong Xu
Pages: 1113-1121
Published online on: 06 November 2018

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Article

HOXA5 inhibits the proliferation and induces the apoptosis of cervical cancer cells via regulation of protein kinase B and p27

Zefei Wang, Chunzhi Yu, Hong Wang
Pages: 1122-1130
Published online on: 20 November 2018

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Article

miR‑138‑5p modulates the expression of excision repair cross‑complementing proteins ERCC1 and ERCC4, and regulates the sensitivity of gastric cancer cells to cisplatin

Jie Ning, Yang Jiao, Xiaoque Xie, Xuefei Deng, Yiyin Zhang, Yuexin Yang, Chenchen Zhao, Hua Wang, Kangsheng Gu
Pages: 1131-1139
Published online on: 06 December 2018

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Article Open Access

Involvement of the glutamine RF‑amide peptide and its cognate receptor GPR103 in prostate cancer

Mohamed Ab. Kawan, Ioannis Kyrou, Manjunath Ramanjaneya, Kevin Williams, Jeyarooban Jeyaneethi, Harpal S. Randeva, Emmanouil Karteris
Pages: 1140-1150
Published online on: 27 November 2018

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Article

Epigenetic knockdown of Notch1 inhibits hepatitis B virus X protein‑induced hepatocarcinogenesis of L02/HBx cells

Yan Peng, Dejiang Zhou, Yusheng Ye, Chang Kai, Zhongyong Jiang, Ziyi Zhu, Xiaoling Wu, Jie Xiong
Pages: 1151-1159
Published online on: 15 November 2018

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Article

ERK5‑regulated RERG expression promotes cancer progression in prostatic carcinoma

Ying Xiong, Hui Huang, Shaoping Chen, Haitao Dai, Luying Zhang
Pages: 1160-1168
Published online on: 05 November 2018

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Article

TROAP regulates prostate cancer progression via the WNT3/survivin signalling pathways

Jianqing Ye, Chuanmin Chu, Ming Chen, Zhan Shi, Sishun Gan, Fajun Qu, Xiuwu Pan, Qiwei Yang, Yijun Tian, Lei Wang, Wei Yang, Xingang Cui
Pages: 1169-1179
Published online on: 09 November 2018

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Article

Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway

Hui Xu, Xingai Jiao, Yilei Wu, Shuo Li, Lili Cao, Liang Dong
Pages: 1180-1188
Published online on: 09 November 2018

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Article

IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes

Bartlomiej E. Krazinski, Anna E. Kowalczyk, Agnieszka Sliwinska‑Jewsiewicka, Jedrzej Grzegrzolka, Janusz Godlewski, Przemyslaw Kwiatkowski, Piotr Dziegiel, Zbigniew Kmiec, Jolanta Kiewisz
Pages: 1189-1197
Published online on: 19 November 2018

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Article

Levistolide A synergistically enhances doxorubicin‑induced apoptosis of k562/dox cells by decreasing MDR1 expression through the ubiquitin pathway

Yuanyuan Ding, Weibo Niu, Tao Zhang, Jue Wang, Jiao Cao, He Chen, Ruiqi Wang, Hongli An
Pages: 1198-1208
Published online on: 27 November 2018

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Article

Identification of long non‑coding RNA expression patterns useful for molecular‑based classification of type I endometrial cancers

Maria Ravo, Angela Cordella, Pasquale Saggese, Antonio Rinaldi, Maria Antonietta Castaldi, Giovanni Nassa, Giorgio Giurato, Fulvio Zullo, Alessandro Weisz, Roberta Tarallo, Francesca Rizzo, Maurizio Guida
Pages: 1209-1217
Published online on: 21 November 2018

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Article

miRNA‑885‑3p inhibits docetaxel chemoresistance in lung adenocarcinoma by downregulating Aurora A

Jiongrui Cao, Jian Geng, Xiaoyuan Chu, Rui Wang, Guichun Huang, Longbang Chen
Pages: 1218-1230
Published online on: 09 November 2018

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Article

MicroRNA‑223 promotes hepatocellular carcinoma cell resistance to sorafenib by targeting FBW7

Xiaofeng Tang, Weigang Yang, Zheyue Shu, Xiaodong Shen, Weichen Zhang, Chao Cen, Linping Cao, Min Zhang, Shusen Zheng, Jun Yu
Pages: 1231-1237
Published online on: 06 December 2018

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Article

Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration

Agata Mlynska, Greta Salciuniene, Karolina Zilionyte, Sima Garberyte, Marius Strioga, Birute Intaite, Ausrine Barakauskiene, Gianrocco Lazzari, Neringa Dobrovolskiene, Jan Aleksander Krasko, Vita Pasukoniene
Pages: 1238-1252
Published online on: 27 November 2018

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Article

Oncogenic Ras/squamous cell carcinoma antigen signaling pathway activation promotes invasiveness and lymph node metastases in papillary thyroid carcinoma

Dingyuan Luo, Ying Liu, Shaojian Lin, Langping Tan, Zehu Du, Miaoyun Long, Yue Zhu, Xinzhi Peng, Weixing Zong, Gerardo G. Mackenzie, Honghao Li, Nengtai Ouyang
Pages: 1253-1263
Published online on: 28 November 2018

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Article

Glutathione peroxidase 4 maintains a stemness phenotype, oxidative homeostasis and regulates biological processes in Panc‑1 cancer stem‑like cells

Guiqin Peng, Zongwei Tang, Yongjia Xiang, Wanyi Chen
Pages: 1264-1274
Published online on: 06 December 2018

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Article

Silencing of the transcriptional factor ZEB1 alters the steroidogenic pathway, and increases the concentration of testosterone and DHT in DU145 cells

D. Herrera, O. Orellana‑Serradell, P. Villar, M. J. Torres, R. Paciucci, E. A. Castellón, H. R. Contreras
Pages: 1275-1283
Published online on: 26 November 2018

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Article

SETDB1 induces epithelial‑mesenchymal transition in breast carcinoma by directly binding with Snail promoter

Wenlin Yang, Ying Su, Chenjian Hou, Linlin Chen, Danmei Zhou, Kehan Ren, Zhaoping Zhou, Renya Zhang, Xiuping Liu
Pages: 1284-1292
Published online on: 19 November 2018

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Article

Leukocyte‑associated immunoglobulin‑like receptor 1 promotes tumorigenesis in RCC

Kentaro Jingushi, Motohide Uemura, Kosuke Nakano, Yujiro Hayashi, Cong Wang, Yu Ishizuya, Yoshiyuki Yamamoto, Takuji Hayashi, Toshiro Kinouchi, Kyosuke Matsuzaki, Taigo Kato, Atsunari Kawashima, Takeshi Ujike, Akira Nagahara, Kazutoshi Fujita, Koji Ueda, Kazutake Tsujikawa, Norio Nonomura
Pages: 1293-1303
Published online on: 20 November 2018

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Article

BAI1‑associated protein 2‑like 2 is a potential biomarker in lung cancer

Lei Xu, Hua Du, Qiang Zhang, Chao Wang, Li Yan, Guoying Tian, Xiuhua Fu
Pages: 1304-1312
Published online on: 26 November 2018

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Article

Expression of cyclin B1, D1 and K in non‑small cell lung cancer H1299 cells following treatment with sulforaphane

Agnieszka Żuryń, Adrian Krajewski, Anna Klimaszewska‑Wiśniewska, Alina Grzanka, Dariusz Grzanka
Pages: 1313-1323
Published online on: 07 December 2018

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Article

Caspase‑dependent apoptotic death by gadolinium chloride (GdCl3) via reactive oxygen species production and MAPK signaling in rat C6 glioma cells

Yuh‑Feng Tsai, Yuh‑Fung Chen, Chen‑Yu Hsiao, Ching‑Wen  Huang, Chi‑Cheng Lu, Shih‑Chang Tsai, Jai‑Sing Yang
Pages: 1324-1332
Published online on: 07 December 2018

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Article

Erythropoietin promotes expression of survivin via STAT3 activation and reduces sensitivity to cisplatin in cervical cancer cells

María José Vázquez‑Mellado, Liliana Guadalupe Cortés‑Ballinas, Irma Carolina Blanco‑Flores, Cecilia Aguilar, Gerardo Vázquez‑Gómez, Leticia Rocha‑Zavaleta
Pages: 1333-1341
Published online on: 27 November 2018

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Article

miR‑124 targets retinoid X receptor α to reduce growth of TSC2‑deficient lymphangioleiomyomatosis

Jia Liu, Jun Yuan, Tianxiang Feng, Yinjuan Zhao, Qian Sun, Jun Chen, Jingyu Chen, Meiling Jin, Bin Xue
Pages: 1342-1350
Published online on: 07 December 2018

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Article

Sodium cantharidinate suppresses human osteosarcoma MG‑63 cell proliferation and induces cell cycle arrest by inhibition of PI3K/AKT activation

Da‑Liang Kong, Yang Liu, Jing‑Ying Wang, Gong Liu, Ming‑Lei Zhang
Pages: 1351-1358
Published online on: 06 December 2018

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Article

MAPT (Tau) expression is a biomarker for an increased rate of survival for low‑grade glioma

Saif Zaman, Boris I. Chobrutskiy, Dhiraj Sikaria, George Blanck
Pages: 1359-1366
Published online on: 28 November 2018

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Article

Tumor p16INK4 gene expression and prognosis in colorectal cancer

Hirotaka Kitamura, Hirofumi Takemura, Toshinari Minamoto
Pages: 1367-1376
Published online on: 26 November 2018

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Article

Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non‑small cell lung cancer cell lines

Ahmad Fudhaili, Nal Ae Yoon, Seokmin Kang, Jinhyun Ryu, Joo Yeon Jeong, Dong Hoon Lee, Sang Soo Kang
Pages: 1377-1386
Published online on: 30 November 2018

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Article

Wnt/β‑catenin inhibition reverses multidrug resistance in pediatric acute lymphoblastic leukemia

Jinqiu Fu, Libo Si, Yong Zhuang, Aijun Zhang, Nianzheng Sun, Dong Li, Bin Hao, Xiuli Ju
Pages: 1387-1394
Published online on: 04 December 2018

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Article

Downregulation of miR-95 in gastric cancer promotes EMT via regulation of Slug, thereby promoting migration and invasion

Wei Zhang, Jing Sun, Jinyan Chen, Caiyun Xu, Lixia Zhang
Pages: 1395-1403
Published online on: 06 December 2018

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Article

FOXN3 is downregulated in osteosarcoma and transcriptionally regulates SIRT6, and suppresses migration and invasion in osteosarcoma

Wentao Xue, Linjie Ma, Zhiqian Wang, Weidong Zhang, Xiugong Zhang
Pages: 1404-1414
Published online on: 21 November 2018

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Article

AT‑101 induces G1/G0 phase arrest via the β‑catenin/cyclin D1 signaling pathway in human esophageal cancer cells

Fuchang Que, Lixia Dai, Dan Zhou, Qinghuan Lin, Xiaoyun Zeng, Le Yu, Yilei Li, Shuwen Liu
Pages: 1415-1423
Published online on: 20 November 2018

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Correction Open Access

[Corrigendum] Netrin‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation

Kai Yin, Mengyuan Shang, Shengchun Dang, Linjun Wang, Yiwen Xia, Lei Cui, Xin Fan, Jianguo Qu, Jixiang Chen, Zekuan Xu
Pages: 1424-1424
Published online on: 09 November 2018

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Article Open Access

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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