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Review

Cellular senescence in ionizing radiation (Review)

  • Authors:
    • Zhengting Chen
    • Ke Cao
    • Yaoxiong Xia
    • Yunfen Li
    • Yu Hou
    • Li Wang
    • Lan Li
    • Li Chang
    • Wenhui Li
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital, Kunming, Yunnan 650118, P.R. China
  • Pages: 883-894
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    Published online on: June 24, 2019
       https://doi.org/10.3892/or.2019.7209
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Abstract

Radiotherapy (RT) is one of most common treatments for cancer. However, overcoming the failure and side effects of RT as well as radioresistance, recurrence and metastasis remains challenging in cancer treatment. Cellular senescence (CS) is permanent arrested state of cell division induced by various factors, including exposure to ionizing radiation (IR). CS induced by IR contributes to tumour cell control and often even causes side effects in normal cells. Improvement of the therapeutic RT ratio is dependent on more cancer cell death and less normal cell damage. In addition, the biological behaviour of tumour cells after IR has also been linked to CS. This review summarizes our understanding of CS in IR, which may be beneficial for providing new insight for improving the therapeutic outcomes of RT.
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Copy and paste a formatted citation
Spandidos Publications style
Chen Z, Cao K, Xia Y, Li Y, Hou Y, Wang L, Li L, Chang L and Li W: Cellular senescence in ionizing radiation (Review). Oncol Rep 42: 883-894, 2019.
APA
Chen, Z., Cao, K., Xia, Y., Li, Y., Hou, Y., Wang, L. ... Li, W. (2019). Cellular senescence in ionizing radiation (Review). Oncology Reports, 42, 883-894. https://doi.org/10.3892/or.2019.7209
MLA
Chen, Z., Cao, K., Xia, Y., Li, Y., Hou, Y., Wang, L., Li, L., Chang, L., Li, W."Cellular senescence in ionizing radiation (Review)". Oncology Reports 42.3 (2019): 883-894.
Chicago
Chen, Z., Cao, K., Xia, Y., Li, Y., Hou, Y., Wang, L., Li, L., Chang, L., Li, W."Cellular senescence in ionizing radiation (Review)". Oncology Reports 42, no. 3 (2019): 883-894. https://doi.org/10.3892/or.2019.7209
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Z, Cao K, Xia Y, Li Y, Hou Y, Wang L, Li L, Chang L and Li W: Cellular senescence in ionizing radiation (Review). Oncol Rep 42: 883-894, 2019.
APA
Chen, Z., Cao, K., Xia, Y., Li, Y., Hou, Y., Wang, L. ... Li, W. (2019). Cellular senescence in ionizing radiation (Review). Oncology Reports, 42, 883-894. https://doi.org/10.3892/or.2019.7209
MLA
Chen, Z., Cao, K., Xia, Y., Li, Y., Hou, Y., Wang, L., Li, L., Chang, L., Li, W."Cellular senescence in ionizing radiation (Review)". Oncology Reports 42.3 (2019): 883-894.
Chicago
Chen, Z., Cao, K., Xia, Y., Li, Y., Hou, Y., Wang, L., Li, L., Chang, L., Li, W."Cellular senescence in ionizing radiation (Review)". Oncology Reports 42, no. 3 (2019): 883-894. https://doi.org/10.3892/or.2019.7209
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