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Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model

  • Authors:
    • Nobuyuki Ishikura
    • Keigo Yorozu
    • Mitsue Kurasawa
    • Mieko Yanagisawa
    • Masamichi Sugimoto
    • Kaname Yamamoto
  • View Affiliations / Copyright

    Affiliations: Product Research Department, Chugai Pharmaceutical Co., Ltd., Kamakura 247-8530, Japan
    Copyright: © Ishikura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1057-1065
    |
    Published online on: June 26, 2019
       https://doi.org/10.3892/or.2019.7211
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Abstract

Although bevacizumab maintenance following bevacizumab in combination with chemotherapy has demonstrated significant prolongation of progression-free survival in clinical studies in patients with ovarian cancer, the majority of the cancer cases in the study were of the serous histotype; therefore, data regarding clear cell carcinoma is limited. Furthermore, the efficacy of bevacizumab beyond progression has not yet been demonstrated in ovarian cancer. A xenograft model using the human ovarian clear cell carcinoma cell line RMG-I was used to investigate the antitumor effects and the mechanisms of bevacizumab in maintenance treatment and bevacizumab when administered beyond disease progression. In the RMG-I model, bevacizumab maintenance following bevacizumab in combination with paclitaxel exhibited increased tumor suppression, compared with its absence, and inhibited the increase of microvessel density (MVD) in tumors. Following disease progression during bevacizumab maintenance, continued bevacizumab treatment in combination with PEGylated liposomal doxorubicin as a secondary chemotherapeutic agent had increased efficacy, compared with PEGylated liposomal doxorubicin alone, and resulted in lower MVD accompanied with lower levels of insulin-like growth factor binding protein-3, which is reported to have angiogenic activity. Continuous suppression of angiogenesis by bevacizumab may contribute to the superior efficacy of bevacizumab maintenance and bevacizumab beyond progression in ovarian cancer.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Chan JK, Teoh D, Hu JM, Shin JY, Osann K and Kapp DS: Do clear cell ovarian carcinomas have poorer prognosis compared to other epithelial cell types? A study of 1411 clear cell ovarian cancers. Gynecol Oncol. 109:370–376. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Sugiyama T, Kamura T, Kigawa J, Terakawa N, Kikuchi Y, Kita T, Suzuki M, Sato I and Taguchi K: Clinical characteristics of clear cell carcinoma of the ovary: A distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy. Cancer. 88:2584–2589. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Itamochi H, Kigawa J and Terakawa N: Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma. Cancer Sci. 99:653–658. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Mackay HJ, Brady MF, Oza AM, Reuss A, Pujade-Lauraine E, Swart AM, Siddiqui N, Colombo N, Bookman MA, Pfisterer J and Du Bois A; Gynecologic Cancer InterGroup, : Prognostic relevance of uncommon ovarian histology in women with stage III/IV epithelial ovarian cancer. Int J Gynecol Cancer. 20:945–952. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Piccart MJ, Bertelsen K, James K, Cassidy J, Mangioni C, Simonsen E, Stuart G, Kaye S, Vergote I, Blom R, et al: Randomized intergroup trial of cisplatin-paclitaxel versus cisplatin-cyclophosphamide in women with advanced epithelial ovarian cancer: Three-year results. J Natl Cancer Inst. 92:699–708. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Vasey PA, Jayson GC, Gordon A, Gabra H, Coleman R, Atkinson R, Parkin D, Paul J, Hay A and Kaye SB; Scottish Gynaecological Cancer Trials Group, : Phase III randomized trial of docetaxel-carboplatin versus paclitaxel-carboplatin as first-line chemotherapy for ovarian carcinoma. J Natl Cancer Inst. 96:1682–1691. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Köbel M, Kalloger SE, Huntsman DG, Santos JL, Swenerton KD, Seidman JD and Gilks CB; Cheryl Brown Ovarian Cancer Outcomes Unit of the British Columbia Cancer Agency, Vancouver BC, : Differences in tumor type in low-stage versus high-stage ovarian carcinomas. Int J Gynecol Pathol. 29:203–211. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Burger RA, Brady MF, Bookman MA, Fleming GF, Monk BJ, Huang H, Mannel RS, Homesley HD, Fowler J, Greer BE, et al Gynecologic Oncology Group, : Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med. 365:2473–2483. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Morgan RJ Jr, Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Behbakht K, Chen LM, Copeland L, Crispens MA, De Rosa M, Dorigo O, et al: Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 14:1134–1163. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Masi G, Salvatore L, Boni L, Loupakis F, Cremolini C, Fornaro L, Schirripa M, Cupini S, Barbara C, Safina V, et al BEBYP Study Investigators, : Continuation or reintroduction of bevacizumab beyond progression to first-line therapy in metastatic colorectal cancer: Final results of the randomized BEBYP trial. Ann Oncol. 26:724–730. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Presta LG, Chen H, O'Connor SJ, Chisholm V, Meng YG, Krummen L, Winkler M and Ferrara N: Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 57:4593–4599. 1997.PubMed/NCBI

13 

Braghiroli MI, Sabbaga J and Hoff PM: Bevacizumab: Overview of the literature. Expert Rev Anticancer Ther. 12:567–580. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Crossin KL and Carney DH: Evidence that microtubule depolymerization early in the cell cycle is sufficient to initiate DNA synthesis. Cell. 23:61–71. 1981. View Article : Google Scholar : PubMed/NCBI

15 

Gabizon AA: Pegylated liposomal doxorubicin: Metamorphosis of an old drug into a new form of chemotherapy. Cancer Invest. 19:424–436. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Pérez-López ME, Curiel T, Gómez JG and Jorge M: Role of pegylated liposomal doxorubicin (Caelyx) in the treatment of relapsing ovarian cancer. Anticancer Drugs. 18:611–617. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Fogh J, Wright WC and Loveless JD: Absence of HeLa cell contamination in 169 cell lines derived from human tumors. J Natl Cancer Inst. 58:209–214. 1977. View Article : Google Scholar : PubMed/NCBI

18 

Nozawa S, Tsukazaki K, Sakayori M, Jeng CH and Iizuka R: Establishment of a human ovarian clear cell carcinoma cell line (RMG-I) and its single cell cloning - with special reference to the stem cell of the tumor. Hum Cell. 1:426–435. 1988.PubMed/NCBI

19 

Holm S: A simple sequentially rejective multiple test procedure. Scand J Stat. 6:65–70. 1979.

20 

Belotti D, Vergani V, Drudis T, Borsotti P, Pitelli MR, Viale G, Giavazzi R and Taraboletti G: The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin Cancer Res. 2:1843–1849. 1996.PubMed/NCBI

21 

Naumova E, Ubezio P, Garofalo A, Borsotti P, Cassis L, Riccardi E, Scanziani E, Eccles SA, Bani MR and Giavazzi R: The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis. Clin Cancer Res. 12:1839–1849. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Iwai T, Sugimoto M, Harada S, Yorozu K, Kurasawa M and Yamamoto K: Continuous administration of bevacizumab plus capecitabine, even after acquired resistance to bevacizumab, restored anti-angiogenic and antitumor effect in a human colorectal cancer xenograft model. Oncol Rep. 36:626–632. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Granata R, Trovato L, Lupia E, Sala G, Settanni F, Camussi G, Ghidoni R and Ghigo E: Insulin-like growth factor binding protein-3 induces angiogenesis through IGF-I- and SphK1-dependent mechanisms. J Thromb Haemost. 5:835–845. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Slomiany MG and Rosenzweig SA: Autocrine effects of IGF-I-induced VEGF and IGFBP-3 secretion in retinal pigment epithelial cell line ARPE-19. Am J Physiol Cell Physiol. 287:C746–C753. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Slomiany MG and Rosenzweig SA: IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1 alpha expression and activity in retinal pigment epithelial cell line D407. Invest Ophthalmol Vis Sci. 45:2838–2847. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Duyndam MC, van Berkel MP, Dorsman JC, Rockx DA, Pinedo HM and Boven E: Cisplatin and doxorubicin repress vascular endothelial growth factor expression and differentially down-regulate hypoxia-inducible factor I activity in human ovarian cancer cells. Biochem Pharmacol. 74:191–201. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Yanagisawa M, Yorozu K, Kurasawa M, Nakano K, Furugaki K, Yamashita Y, Mori K and Fujimoto-Ouchi K: Bevacizumab improves the delivery and efficacy of paclitaxel. Anticancer Drugs. 21:687–694. 2010.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ishikura N, Yorozu K, Kurasawa M, Yanagisawa M, Sugimoto M and Yamamoto K: Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model. Oncol Rep 42: 1057-1065, 2019.
APA
Ishikura, N., Yorozu, K., Kurasawa, M., Yanagisawa, M., Sugimoto, M., & Yamamoto, K. (2019). Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model. Oncology Reports, 42, 1057-1065. https://doi.org/10.3892/or.2019.7211
MLA
Ishikura, N., Yorozu, K., Kurasawa, M., Yanagisawa, M., Sugimoto, M., Yamamoto, K."Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model". Oncology Reports 42.3 (2019): 1057-1065.
Chicago
Ishikura, N., Yorozu, K., Kurasawa, M., Yanagisawa, M., Sugimoto, M., Yamamoto, K."Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model". Oncology Reports 42, no. 3 (2019): 1057-1065. https://doi.org/10.3892/or.2019.7211
Copy and paste a formatted citation
x
Spandidos Publications style
Ishikura N, Yorozu K, Kurasawa M, Yanagisawa M, Sugimoto M and Yamamoto K: Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model. Oncol Rep 42: 1057-1065, 2019.
APA
Ishikura, N., Yorozu, K., Kurasawa, M., Yanagisawa, M., Sugimoto, M., & Yamamoto, K. (2019). Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model. Oncology Reports, 42, 1057-1065. https://doi.org/10.3892/or.2019.7211
MLA
Ishikura, N., Yorozu, K., Kurasawa, M., Yanagisawa, M., Sugimoto, M., Yamamoto, K."Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model". Oncology Reports 42.3 (2019): 1057-1065.
Chicago
Ishikura, N., Yorozu, K., Kurasawa, M., Yanagisawa, M., Sugimoto, M., Yamamoto, K."Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model". Oncology Reports 42, no. 3 (2019): 1057-1065. https://doi.org/10.3892/or.2019.7211
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