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Article

A systematic analysis reveals gene expression alteration of serum deprivation response (SDPR) gene is significantly associated with the survival of patients with cancer

  • Authors:
    • Yingshuang Wang
    • Zhen Song
    • Ping Leng
    • Yun Liu
  • View Affiliations / Copyright

    Affiliations: College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, P.R. China, Peking University Medical and Health Analytical Center, Peking University Health Science Center, Beijing 100191, P.R. China
  • Pages: 1161-1172
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    Published online on: June 26, 2019
       https://doi.org/10.3892/or.2019.7212
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Abstract

Serum deprivation response (SDPR) gene has been recently characterized as a gene signature marker or serving a tumor suppressor role in specific types of cancer. However, gene expression alterations of SDPR in various types of cancer and their relevance to clinical outcomes remain unclear. In the present study, SDPR expression was profiled using the Oncomine database, and SDPR downregulation was indicated in most types of cancer. In agreement with previously reported breast cancer cases, downregulation of SDPR was indicated to be significantly associated with poor survival in patients with lung cancer, glioma and sarcoma. To clarify why SDPR expression was altered in these types of cancer, both DNA methylation patterns and potential transcriptional factors of SDPR were analyzed. Altered DNA methylation levels of SDPR were found in 17/18 cancer types using MethHC. To the best of our knowledge, the present study for the first time, identified the CpG site (cg10082589) as one of the best survival methylation markers for lung adenocarcinoma, and the CpG site (cg07488576) for sarcoma using Methsurv. In addition, GATA binding protein 2 was identified as a potential transcription factor for SDPR, by integrating and analyzing both the co‑expressed genes and the potential transcription factor binding sites of SDPR. In the present study, the systematic analysis of SDPR provided insight for the underlying molecular mechanisms in cancer progression, revealing novel perspectives for the clinical prognostic evaluation of lung adenocarcinoma and sarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Song Z, Leng P and Liu Y: A systematic analysis reveals gene expression alteration of serum deprivation response (SDPR) gene is significantly associated with the survival of patients with cancer. Oncol Rep 42: 1161-1172, 2019.
APA
Wang, Y., Song, Z., Leng, P., & Liu, Y. (2019). A systematic analysis reveals gene expression alteration of serum deprivation response (SDPR) gene is significantly associated with the survival of patients with cancer. Oncology Reports, 42, 1161-1172. https://doi.org/10.3892/or.2019.7212
MLA
Wang, Y., Song, Z., Leng, P., Liu, Y."A systematic analysis reveals gene expression alteration of serum deprivation response (SDPR) gene is significantly associated with the survival of patients with cancer". Oncology Reports 42.3 (2019): 1161-1172.
Chicago
Wang, Y., Song, Z., Leng, P., Liu, Y."A systematic analysis reveals gene expression alteration of serum deprivation response (SDPR) gene is significantly associated with the survival of patients with cancer". Oncology Reports 42, no. 3 (2019): 1161-1172. https://doi.org/10.3892/or.2019.7212
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Song Z, Leng P and Liu Y: A systematic analysis reveals gene expression alteration of serum deprivation response (SDPR) gene is significantly associated with the survival of patients with cancer. Oncol Rep 42: 1161-1172, 2019.
APA
Wang, Y., Song, Z., Leng, P., & Liu, Y. (2019). A systematic analysis reveals gene expression alteration of serum deprivation response (SDPR) gene is significantly associated with the survival of patients with cancer. Oncology Reports, 42, 1161-1172. https://doi.org/10.3892/or.2019.7212
MLA
Wang, Y., Song, Z., Leng, P., Liu, Y."A systematic analysis reveals gene expression alteration of serum deprivation response (SDPR) gene is significantly associated with the survival of patients with cancer". Oncology Reports 42.3 (2019): 1161-1172.
Chicago
Wang, Y., Song, Z., Leng, P., Liu, Y."A systematic analysis reveals gene expression alteration of serum deprivation response (SDPR) gene is significantly associated with the survival of patients with cancer". Oncology Reports 42, no. 3 (2019): 1161-1172. https://doi.org/10.3892/or.2019.7212
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