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Identification and characterization of sexual dimorphism‑linked gene expression profile in hepatocellular carcinoma

  • Authors:
    • Yuchao Wu
    • Naijuan Yao
    • Yali Feng
    • Zhen Tian
    • Yuan Yang
    • Yingren Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 937-952
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    Published online on: June 28, 2019
       https://doi.org/10.3892/or.2019.7217
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Abstract

Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence in males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation with regard to sex factors affecting disease progression. In the present study, functional signatures of differentially expressed genes (DEGs) were screened in female and male tumors via bioinformatics analysis. The following gene chip expression profiles were downloaded from the Gene Expression Omnibus: GSE19665, GSE23342 and GSE9843. They comprised cancerous and non‑cancerous tissue from patients with HCC and included critical sex features. Further evaluation of selected DEGs in the two sexual groups was performed via hierarchical clustering analysis. Venn diagram and functional protein‑protein interaction (PPI) network analyses were performed. Survival analysis of patients with differences in gene expression levels was subsequently performed using the Kaplan‑Meier Plotter database. Certain identified DEGs were common in female and male tumor samples, whereas others exhibited a sexually‑biased expression profile. Gene Ontology revealed that the cell cycle module 'biological process' was enriched in tumors derived from both sexes, whereas the metabolic pathways and drug metabolism modules were only significantly enriched in cancer tissues from male subjects. A number of hub DEGs in the cell cycle and p53 signaling pathways were involved in significant protein‑protein interaction (PPI) modules, including CDK1 and CCNB1. These DEGs were upregulated in tumors derived from female subjects compared with those derived from male subjects, and could be used as markers of poor prognosis in male patients. Other genes, such as CYP3A4 and SERPINA4, were identified in metabolic pathways, and were downregulated in male compared with female subjects. These genes were associated with a decreased survival rate. The data demonstrated that sex differences in physiology may regulate the levels of gene expression and/or activity, including gene function associated with oncogenesis and the outcomes of liver cancer. Additional surveys are required to explore in detail the molecular mechanisms underlying the differences in gene expression between the two sexes during the development of liver cancer.
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1 

Lagranha CJ, Silva TLA, Silva SCA, Braz GRF, da Silva AI, Fernandes MP and Sellitti DF: Protective effects of estrogen against cardiovascular disease mediated via oxidative stress in the brain. Life Sci. 192:190–198. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Li R, Cui J and Shen Y: Brain sex matters: Estrogen in cognition and Alzheimer's disease. Mol Cell Endocrinol. 389:13–21. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Dorak MT and Karpuzoglu E: Gender differences in cancer susceptibility: An inadequately addressed issue. Front Genet. 3:2682012. View Article : Google Scholar : PubMed/NCBI

5 

Institute of Medicine (US) Committee on Understanding the Biology of Sex and Gender Differences, . Exploring the Biological Contributions to Human Health: Does Sex Matter? Wizemann TM and Pardue ML: National Academies Press (US); Washington, DC: 2001,

6 

Li Z, Tuteja G, Schug J and Kaestner KH: Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer. Cell. 148:72–83. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Molife R, Lorigan P and MacNeil S: Gender and survival in malignant tumours. Cancer Treat Rev. 27:201–209. 2001. View Article : Google Scholar : PubMed/NCBI

8 

El-Serag HB: Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 142:1264–1273.e1. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Ruggieri A, Barbati C and Malorni W: Cellular and molecular mechanisms involved in hepatocellular carcinoma gender disparity. Int J Cancer. 127:499–504. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Yuan Y, Liu L, Chen H, Wang Y, Xu Y, Mao H, Li J, Mills GB, Shu Y, Li L and Liang H: Comprehensive characterization of molecular differences in cancer between male and female patients. Cancer Cell. 29:711–722. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Villa E, Baldini GM, Pasquinelli C, Melegari M, Cariani E, Di Chirico G and Manenti F: Risk factors for hepatocellular carcinoma in Italy. Male sex, hepatitis B virus, non-A non-B infection, and alcohol. Cancer. 62:611–615. 1988. View Article : Google Scholar : PubMed/NCBI

12 

Lee CM, Lu SN, Changchien CS, Yeh CT, Hsu TT, Tang JH, Wang JH, Lin DY, Chen CL and Chen WJ: Age, gender, and local geographic variations of viral etiology of hepatocellular carcinoma in a hyperendemic area for hepatitis B virus infection. Cancer. 86:1143–1150. 1999. View Article : Google Scholar : PubMed/NCBI

13 

El-Serag HB: Hepatocellular carcinoma and hepatitis C in the United States. Hepatology 36 (5 Suppl 1). S74–S83. 2002.

14 

Iyer JK, Kalra M, Kaul A, Payton ME and Kaul R: Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis. World J Gastroenterol. 23:6802–6816. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Hassan MM, Botrus G, Abdel-Wahab R, Wolff RA, Li D, Tweardy D, Phan AT, Hawk E, Javle M, Lee JS, et al: Estrogen replacement reduces risk and increases survival times of women with hepatocellular carcinoma. Clin Gastroenterol Hepatol. 15:1791–1799. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM and Karin M: Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 317:121–124. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Zhao Y and Li Z: Interplay of estrogen receptors and FOXA factors in the liver cancer. Mol Cell Endocrinol. 418:334–339. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Zheng B, Zhu YJ, Wang HY and Chen L: Gender disparity in hepatocellular carcinoma (HCC): Multiple underlying mechanisms. Sci China Life Sci. 60:575–584. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Ma J, Malladi S and Beck AH: Systematic analysis of sex-linked molecular alterations and therapies in cancer. Sci Rep. 6:191192016. View Article : Google Scholar : PubMed/NCBI

20 

Angarica VE and Del Sol A: Bioinformatics tools for genome-wide epigenetic research. Adv Exp Med Biol. 978:489–512. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Edgar R, Domrachev M and Lash AE: Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30:207–210. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Deng YB, Nagae G, Midorikawa Y, Yagi K, Tsutsumi S, Yamamoto S, Hasegawa K, Kokudo N, Aburatani H and Kaneda A: Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma. Cancer Sci. 101:1501–1510. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, et al: A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Cell Metab. 12:483–495. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Chiang DY, Villanueva A, Hoshida Y, Peix J, Newell P, Minguez B, LeBlanc AC, Donovan DJ, Thung SN, Solé M, et al: Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res. 68:6779–6788. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 4:249–264. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

27 

Diboun I, Wernisch L, Orengo CA and Koltzenburg M: Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma. BMC Genomics. 7:2522006. View Article : Google Scholar : PubMed/NCBI

28 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc Ser B (Methodological). 57:289–300. 1995.

29 

Perry M: Heatmaps: Flexible heatmaps for functional genomics and sequence features. R package version 1.0.0. https://rdrr.io/bioc/heatmaps/

30 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

31 

The Gene Ontology Consortium, . The Gene Ontology Resource: 20 years and still GOing strong. Nucleic Acids Res. 47:D330–d338. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45:D353–D361. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Kanehisa M, Sato Y, Furumichi M, Morishima K and Tanabe M: New approach for understanding genome variations in KEGG. Nucleic Acids Res. 47:D590–D595. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Wickham H.: ggplot2: Elegant graphics for data analysis. Springer-Verlag; New York, NY: 2016

36 

Snel B, Lehmann G, Bork P and Huynen MA: STRING: A web-server to retrieve and display the repeatedly occurring neighbourhood of a gene. Nucleic Acids Res. 28:3442–3444. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

39 

Menyhart O, Nagy A and Gyorffy B: Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma. R Soc Open Sci. 5:1810062018. View Article : Google Scholar : PubMed/NCBI

40 

Delongchamp RR, Velasco C, Dial S and Harris AJ: Genome-wide estimation of gender differences in the gene expression of human livers: Statistical design and analysis. BMC Bioinformatics. 6 (Suppl 2):S132005. View Article : Google Scholar : PubMed/NCBI

41 

Mayne BT, Bianco-Miotto T, Buckberry S, Breen J, Clifton V, Shoubridge C and Roberts CT: Large scale gene expression meta-analysis reveals tissue-specific, sex-biased gene expression in humans. Front Genet. 7:1832016. View Article : Google Scholar : PubMed/NCBI

42 

Weng Y, DiRusso CC, Reilly AA, Black PN and Ding X: Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype. J Biol Chem. 280:31686–31698. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Cai Z and Liu Q: Cell cycle regulation in treatment of breast cancer. Adv Exp Med Biol. 1026:251–270. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Otto T and Sicinski P: Cell cycle proteins as promising targets in cancer therapy. Nat Rev Cancer. 17:93–115. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Brandmaier A, Hou SQ and Shen WH: Cell cycle control by PTEN. J Mol Biol. 429:2265–2277. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Berger C, Qian Y and Chen X: The p53-estrogen receptor loop in cancer. Curr Mol Med. 13:1229–1240. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Feng H, Cheng AS, Tsang DP, Li MS, Go MY, Cheung YS, Zhao GJ, Ng SS, Lin MC, Yu J, et al: Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives β-catenin/T cell factor-dependent hepatocarcinogenesis. J Clin Invest. 121:3159–3175. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Brown NR, Korolchuk S, Martin MP, Stanley WA, Moukhametzianov R, Noble MEM and Endicott JA: CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Nat Commun. 6:67692015. View Article : Google Scholar : PubMed/NCBI

49 

Liu P, Kao TP and Huang H: CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor. Oncogene. 27:4733–4744. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Ding K, Li W, Zou Z, Zou X and Wang C: CCNB1 is a prognostic biomarker for ER+ breast cancer. Med Hypotheses. 83:359–364. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Bednarek K, Kiwerska K, Szaumkessel M, Bodnar M, Kostrzewska-Poczekaj M, Marszalek A, Janiszewska J, Bartochowska A, Jackowska J, Wierzbicka M, et al: Recurrent CDK1 overexpression in laryngeal squamous cell carcinoma. Tumour Biol. 37:11115–11126. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Spaziani A, Alisi A, Sanna D and Balsano C: Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1. J Biol Chem. 281:10983–10989. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Park TJ, Kim JY, Oh SP, Kang SY, Kim BW, Wang HJ, Song KY, Kim HC and Lim IK: TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop. Hepatology. 47:1533–1543. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Brown JW, Prieto LM, Perez-Stable C, Montoya M, Cappell S and Fishman LM: Estrogen and progesterone lower cyclin B1 AND D1 expression, block cell cycle in G2/M, and trigger apoptosis in human adrenal carcinoma cell cultures. Horm Metab Res. 40:306–310. 2008. View Article : Google Scholar : PubMed/NCBI

55 

Tanaka E: Gender-related differences in pharmacokinetics and their clinical significance. J Clin Pharm Ther. 24:339–346. 1999. View Article : Google Scholar : PubMed/NCBI

56 

Ueno K and Sato H: Sex-related differences in pharmacokinetics and pharmacodynamics of anti-hypertensive drugs. Hypertens Res. 35:245–250. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Abu-Remaileh M and Aqeilan RI: The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism. Exp Biol Med (Maywood). 240:345–350. 2015. View Article : Google Scholar : PubMed/NCBI

58 

Roszczenko P, Radomska KA, Wywial E, Collet JF and Jagusztyn-Krynicka EK: A novel insight into the oxidoreductase activity of Helicobacter pylori HP0231 protein. PLoS One. 7:e465632012. View Article : Google Scholar : PubMed/NCBI

59 

Ashida R, Okamura Y, Ohshima K, Kakuda Y, Uesaka K, Sugiura T, Ito T, Yamamoto Y, Sugino T, Urakami K, et al: CYP3A4 gene is a novel biomarker for predicting a poor prognosis in hepatocellular carcinoma. Cancer Genomics Proteomics. 14:445–453. 2017.PubMed/NCBI

60 

Rodriguez-Antona C and Ingelman-Sundberg M: Cytochrome P450 pharmacogenetics and cancer. Oncogene. 25:1679–1691. 2006. View Article : Google Scholar : PubMed/NCBI

61 

Sun HM, Mi YS, Yu FD, Han Y, Liu XS, Lu S, Zhang Y, Zhao SL, Ye L, Liu TT, et al: SERPINA4 is a novel independent prognostic indicator and a potential therapeutic target for colorectal cancer. Am J Cancer Res. 6:1636–1649. 2016.PubMed/NCBI

62 

Frühbeck G, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Valentí V, Moncada R, Becerril S, Unamuno X, Silva C, Salvador J and Catalán V: Novel protective role of kallistatin in obesity by limiting adipose tissue low grade inflammation and oxidative stress. Metabolism. 87:123–135. 2018. View Article : Google Scholar : PubMed/NCBI

63 

Nallagangula KS, Shashidhar KN, Lakshmaiah V and Muninarayana C: Cirrhosis of liver: Interference of serpins in quantification of SERPINA4-a preliminary study. Pract Lab Med. 9:53–57. 2017. View Article : Google Scholar : PubMed/NCBI

64 

Calan M, Guler A, Unal Kocabas G, Alarslan P, Bicer M, Imamoglu C, Yuksel A, Bozkaya G and Bilgir O: Association of kallistatin with carotid intima-media thickness in women with polycystic ovary syndrome. Minerva Endocrinol. 43:236–245. 2018.PubMed/NCBI

65 

Mauvais-Jarvis F, Arnold AP and Reue K: A guide for the design of pre-clinical studies on sex differences in metabolism. Cell Metab. 25:1216–1230. 2017. View Article : Google Scholar : PubMed/NCBI

66 

Kim HI, Lim H and Moon A: Sex differences in cancer: Epidemiology, genetics and therapy. Biomol Ther. 26:335–342. 2018. View Article : Google Scholar

67 

Zhang Y, Klein K, Sugathan A, Nassery N, Dombkowski A, Zanger UM and Waxman DJ: Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease. PLoS One. 6:e235062011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu Y, Yao N, Feng Y, Tian Z, Yang Y and Zhao Y: Identification and characterization of sexual dimorphism‑linked gene expression profile in hepatocellular carcinoma. Oncol Rep 42: 937-952, 2019.
APA
Wu, Y., Yao, N., Feng, Y., Tian, Z., Yang, Y., & Zhao, Y. (2019). Identification and characterization of sexual dimorphism‑linked gene expression profile in hepatocellular carcinoma. Oncology Reports, 42, 937-952. https://doi.org/10.3892/or.2019.7217
MLA
Wu, Y., Yao, N., Feng, Y., Tian, Z., Yang, Y., Zhao, Y."Identification and characterization of sexual dimorphism‑linked gene expression profile in hepatocellular carcinoma". Oncology Reports 42.3 (2019): 937-952.
Chicago
Wu, Y., Yao, N., Feng, Y., Tian, Z., Yang, Y., Zhao, Y."Identification and characterization of sexual dimorphism‑linked gene expression profile in hepatocellular carcinoma". Oncology Reports 42, no. 3 (2019): 937-952. https://doi.org/10.3892/or.2019.7217
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Spandidos Publications style
Wu Y, Yao N, Feng Y, Tian Z, Yang Y and Zhao Y: Identification and characterization of sexual dimorphism‑linked gene expression profile in hepatocellular carcinoma. Oncol Rep 42: 937-952, 2019.
APA
Wu, Y., Yao, N., Feng, Y., Tian, Z., Yang, Y., & Zhao, Y. (2019). Identification and characterization of sexual dimorphism‑linked gene expression profile in hepatocellular carcinoma. Oncology Reports, 42, 937-952. https://doi.org/10.3892/or.2019.7217
MLA
Wu, Y., Yao, N., Feng, Y., Tian, Z., Yang, Y., Zhao, Y."Identification and characterization of sexual dimorphism‑linked gene expression profile in hepatocellular carcinoma". Oncology Reports 42.3 (2019): 937-952.
Chicago
Wu, Y., Yao, N., Feng, Y., Tian, Z., Yang, Y., Zhao, Y."Identification and characterization of sexual dimorphism‑linked gene expression profile in hepatocellular carcinoma". Oncology Reports 42, no. 3 (2019): 937-952. https://doi.org/10.3892/or.2019.7217
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