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Tanshinone IIA enhances the inhibitory effect of imatinib on proliferation and motility of acute leukemia cell line TIB‑152 in vivo and in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway

Retraction in: /10.3892/or.2024.8725
  • Authors:
    • Zhi Teng
    • Shijuan Xu
    • Qin Lei
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, 215 Hospital of Shanxi Nuclear Industry, Xianyang, Shanxi 712000, P.R. China
    Copyright: © Teng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 503-515
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    Published online on: December 31, 2019
       https://doi.org/10.3892/or.2019.7453
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Abstract

Acute lymphoblastic leukemia (ALL) is a malignant hematological disease. Tanshinone IIA (Tan IIA) has antitumor activity in vitro and in vivo. The aim of the present study was to investigate the effects of Tan IIA in combination with imatinib (IM) on the proliferation, apoptosis, migration and invasion of acute T lymphocytic leukemia TIB‑152 cells in vivo and in vitro, and analyze the potential underlying mechanism. Tan IIA and IM, alone and in combination, significantly inhibited proliferation, migration and invasion of TIB‑152 cells, and promoted apoptosis; the effect of co‑treatment with Tan IIA plus IM was enhanced. IGF‑1 promoted the proliferation, migration and invasion of TIB‑152 cells and inhibited apoptosis, while Tan IIA treatment significantly reversed these effects. In vivo experiments demonstrated that treatment with Tan IIA and IM, alone or in combination, significantly inhibited tumor growth in TIB‑152 xenograft mice; the growth inhibition of Tan IIA plus IM was the strongest observed. Western blot analysis revealed that the combination of Tan IIA and IM resulted in significantly lower levels of p‑PI3K, p‑AKT and p‑mTOR in cells and tissues compared with the IM and Tan alone treatment groups. In addition, the combination of Tan IIA and IM significantly decreased the levels of Ki67, cleaved caspase‑3, VEGF and MMP‑9 in cells and tissues, and the level of caspase‑3 was significantly increased. Taken together, the results revealed that Tan IIA enhanced the inhibitory effect of imatinib on TIB‑152 cell proliferation, migration and invasion, and induced apoptosis, which may be associated with inhibition of the PI3K/AKT/mTOR signaling pathway.
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1 

Yang T, Yao S, Zhang X and Guo Y: Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemia Jurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways. Drug Des Devel Ther. 10:1389–1397. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Mullighan CG, Phillips LA, Su X, Ma J, Miller CB, Shurtleff SA and Downing JR: Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia. Science. 322:1377–1380. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Yilmaz M, Kantarjian H and Jabbour E: Treatment of acute lymphoblastic leukemia in older adults: Now and the future. Clin Adv Hematol Oncol. 15:266–274. 2017.PubMed/NCBI

4 

Fujimaki K, Hattori Y and Nakajima H: 10-year complete remission in a philadelphia chromosome-positive acute lymphoblastic leukemia patient using imatinib without high-intensity chemotherapy or allogeneic stem cell transplantation. Int J Hematol. 107:709–711. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Zhang SH, An FY, Xu JX, Kong LJ, He HL, Chai YH and Zhao WL: Clinical features and prognostic factors of children with acute lymphoblastic leukemia in high-risk group. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 25:365–370. 2017.(In Chinese). PubMed/NCBI

6 

Anand P, Sundaram C, Jhurani S, Kunnumakkara AB and Aggarwal BB: Curcumin and cancer: An ‘old-age’ disease with an ‘age-old’ solution. Cancer Lett. 267:133–164. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Ireson CR, Jones DJ, Orr S, Coughtrie MW, Boocock DJ, Williams ML, Farmer PB, Steward WF and Gescher AJ: Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol Biomarkers Prev. 11:105–111. 2002.PubMed/NCBI

8 

Tabernero J, Kunzmann V, Scheithauer W, Reni M, Shiansong Li J, Ferrara S and Djazouli K: Nab-paclitaxel plus gemcitabine for metastatic pancreatic cancer: A subgroup analysis of the Western European cohort of the MPACT trial. Onco Targets Ther. 10:591–596. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Zhang RW, Liu ZG, Xie Y, Wang LX, Li MC and Sun X: In vitro inhibition of invasion and metastasis in colon cancer cells by TanIIA. Genet Mol Res. 15:2016. View Article : Google Scholar :

10 

Zu Y, Wang J, Ping W and Sun W: Tan IIA inhibits H1299 cell viability through the MDM4-IAP3 signaling pathway. Mol Med Rep. 17:2384–2392. 2018.PubMed/NCBI

11 

Munagala R, Aqil F, Jeyabalan J, Vadhanam M and Gupta R: Increased anti-tumor activity by novel systemic delivery and molecular targets of tanshinone II A. Cancer Res. 70:56902011.

12 

Shan QQ, Gong YP, Guo Y, Lin J, Zhou RQ and Yang X: Anti-tumor effect of tanshinone IIA, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines. Sichuan Da Xue Xue Bao Yi Xue Ban. 43:362–366. 2012.(In Chinese). PubMed/NCBI

13 

Yun SM, Jeong SJ, Kim JH, Jung JH, Lee HJ, Sohn EJ, Lee MH and Kim SH: Activation of c-Jun N-terminal kinase mediates tanshinone IIA-induced apoptosis in KBM-5 chronic myeloid leukemia cells. Biol Pharm Bull. 36:208–214. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Liu C, Li J, Wang L, Wu F, Huang L, Xu Y, Ye J, Xiao B, Meng F, Chen S and Yang M: Analysis of tanshinone IIA induced cellular apoptosis in leukemia cells by genome-wide expression profiling. BMC Complement Altern Med. 12:52012. View Article : Google Scholar : PubMed/NCBI

15 

Li L, Zhang ZH and Zhao WD: Apoptosis of MR2 cells induced by tanshinone II A combined with arsenic trioxide. Sichuan Da Xue Xue Bao Yi Xue Ban. 40:812–816. 2009.(In Chinese). PubMed/NCBI

16 

Keppler-Noreuil KM, Parker VE, Darling TN and Martinez-Agosto JA: Somatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strategies. Am J Med Genet C Semin Med Genet. 172:402–421. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Goda S, Kaneshita Y, Inoue H, Domae E, Ikeo T, Iida J and Domae N: Enamel matrix derivative protein stimulated wound healing via phosphoinositide 3-kinase. J Periodontol. 80:1631–1637. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Molgaard S, Ulrichsen M, Olsen D and Glerup S: Detection of phosphorylated Akt and MAPK in cell culture assays. MethodsX. 3:386–398. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Zhang Y, Kwok-Shing Ng P, Kucherlapati M, Chen F, Liu Y, Tsang YH, de Velasco G, Jeong KJ, Akbani R, Hadjipanayis A, et al: A pan-cancer proteogenomic atlas of PI3K/AKT/mTOR pathway alterations. Cancer Cell. 31:820–832.e3. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Costa RLB, Han HS and Gradishar WJ: Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: A review. Breast Cancer Res Treat. 169:397–406. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Park S, Chapuis N, Tamburini J, Bardet V, Cornillet-Lefebvre P, Willems L, Green A, Mayeux P, Lacombe C and Bouscary D: Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia. Haematologica. 95:819–828. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Robles-Escajeda E, Das U, Ortega NM, Parra K, Francia G, Dimmock JR, Varela-Ramirez A and Aguilera RJ: A novel curcumin-like dienone induces apoptosis in triple-negative breast cancer cells. Cell Oncol (Dordr). 39:265–277. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Jiang P, Chen M, Lu J, Chen C and Jiao BH: Effect of tanshinone IIA on MMP-2 and iNOS expression and free radical release in hippocampus of rat Alzheimer's disease model. Acad J Second Mil Med Univ. 30:380–384. 2010. View Article : Google Scholar

24 

Petrelli F, Viale G, Cabiddu M and Barni S: Prognostic value of different cut-off levels of Ki-67 in breast cancer: A systematic review and meta-analysis of 64,196 patients. Breast Cancer Res Treat. 153:477–491. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Mirzayans R, Andrais B, Kumar P and Murray D: The growing complexity of cancer cell response to DNA-damaging agents: Caspase 3 mediates cell death or survival? Int J Mol Sci. 17:E7082016. View Article : Google Scholar : PubMed/NCBI

26 

Castro MG, Campos LE, Rodriguez YI and Alvarez SE: In vitro methods to study the modulation of migration and invasion by sphingosine-1-phosphate. Methods Mol Biol. 1697:117–131. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Evans IM, Kennedy SA, Paliashvili K, Santra T, Yamaji M, Lovering RC, Britton G, Frankel P, Kolch W and Zachary IC: Vascular endothelial growth factor (VEGF) promotes assembly of the p130Cas interactome to drive endothelial chemotactic signaling and angiogenesis. Mol Cell Proteomics. 16:168–180. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Gregory CD: Apoptosis in cancer pathogenesis and anti-cancer therapy. New Perspectives and Opportunities. Springer International Publishing; Cham: pp. p2472016

29 

Su CC and Chiu TL: Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. Oncol Rep. 36:1173–1179. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Zhang S, Liu Q, Luo H, Chen P, Wu X, Yang M, Kong W and Guo W: UFLC-MS/MS analysis of four tanshinone components in Salvia miltiorrhizae after ultrasound-assisted extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 1017-1018:204–210. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Buenafe OE, Orellana-Paucar A, Maes J, Huang H, Ying X, De Borggraeve W, Crawford AD, Luyten W, Esguerra CV and de Witte P: Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models. ACS Chem Neurosci. 4:1479–1487. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Gong Y, Li Y, Abdolmaleky HM, Li L and Zhou JR: Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of aurora A expression and function. PLoS One. 7:e336562012. View Article : Google Scholar : PubMed/NCBI

33 

Su CC: Tanshinone IIA potentiates the efficacy of 5-FU in Colo205 colon cancer cells in vivo through downregulation of P-gp and LC3-II. Exp Ther Med. 3:555–559. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Chang TW, Lin CY, Tzeng YJ and Lur HS: Synergistic combinations of tanshinone IIA and trans-resveratrol toward cisplatin-comparable cytotoxicity in HepG2 human hepatocellular carcinoma cells. Anticancer Res. 34:5473–5480. 2014.PubMed/NCBI

35 

Lv C, Zeng HW, Wang JX, Yuan X, Zhang C, Fang T, Yang PM, Wu T, Zhou YD, Nagle DG and Zhang WD: The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG. Cell Death Dis. 9:1652018. View Article : Google Scholar : PubMed/NCBI

36 

Hochhaus A and La Rosée P: Imatinib therapy in chronic myelogenous leukemia: Strategies to avoid and overcome resistance. Leukemia. 18:1321–1331. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Jabbour E, Cortes J and Kantarjian H: Treatment selection after imatinib resistance in chronic myeloid leukemia. Target Oncol. 4:3–10. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Pu X, Storr SJ, Zhang Y, Rakha EA, Green AR, Ellis IO and Martin SG: Caspase-3 and caspase-8 expression in breast cancer: Caspase-3 is associated with survival. Apoptosis. 22:357–368. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Liu JJ, Zhang Y, Lin DJ and Xiao RZ: Tanshinone IIA inhibits leukemia THP-1 cell growth by induction of apoptosis. Oncol Rep. 21:1075–1781. 2009.PubMed/NCBI

40 

Zhang Y, Wei RX, Zhu XB, Cai L, Jin W and Hu H: Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. Anticancer Drugs. 23:212–219. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Rizwan A, Cheng M, Krishnamachary B, Jiang L, Bhujwalla Z and Kristine G: Cancer cell adhesion and degradome interact to metastasize. Cancer Res. 74:31642014.

42 

Shi YL, Xu T, Li LP and Chen XP: Over-expression of VEGF and MMP-9 in Residual Tumor Cells of Hepatocellular Carcinoma after Embolization with Lipidol. J Huazhong Univ Sci Technolog Med Sci. 33:90–95. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Yang L, Dong ZR, Wen SP, Pan L, Zhang XJ, Luo JM and Xu SR: Relationship between VEGF and MMP-2, MMP-9 in 82 patients with acute myeloid leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 14:15–20. 2006.(In Chinese). PubMed/NCBI

44 

Lonetti A, Cappellini A, Bertaina A, Locatelli F, Pession A, Buontempo F, Evangelisti C, Evangelisti C, Orsini E, Zambonin L, et al: Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway. J Hematol Oncol. 9:1142016. View Article : Google Scholar : PubMed/NCBI

45 

Lin M: Experimental study of atorvastatin regulation of HL-60 leukemia cell apoptosis through PI3K/AKT/mTOR. J Hainan Med Univ. 22:9–12. 2016.

46 

Tabe Y, Tafuri A, Sekihara K, Yang H and Konopleva M: Inhibition of mTOR kinase as a therapeutic target for acute myeloid leukemia. Expert Opin Ther Targets. 21:705–714. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Jiang S, Wang Q, Feng M, Li J, Guan Z, An D, Dong M, Peng Y, Kuerban K and Ye L: C2-ceramide enhances sorafenib-induced caspase-dependent apoptosis via PI3K/AKT/mTOR and Erk signaling pathways in HCC cells. Appl Microbiol Biotechnol. 101:1535–1546. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Reddy EP, Divakar SA, Reddy MVR, Cosenza SC, Baker SJ, Akula B and Parekh S: Abstract 4519: Targeting of cyclin D/Rb/E2F and PI3K/AKT/MTOR pathways with ON 123300 as a therapeutic strategy for mantle cell lymphoma. Cancer Res. 74:45192014.

49 

Di J, Gao K, Qu D, Yang J and Zheng J: Rap2B promotes angiogenesis via PI3K/AKT/VEGF signaling pathway in human renal cell carcinoma. Tumour Biol. 39:10104283177016532017. View Article : Google Scholar : PubMed/NCBI

50 

Zhou H, Wu J, Wang T, Zhang X and Liu D: CXCL10/CXCR3 axis promotes the invasion of gastric cancer via PI3K/AKT pathway-dependent MMPs production. Biomed Pharmacother. 82:479–488. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Ding L, Wang S, Wang W, Lv P, Zhao D, Chen F, Meng T, Dong L and Qi L: Tanshinone IIA affects autophagy and apoptosis of glioma cells by inhibiting phosphatidylinositol 3-Kinase/Akt/Mammalian target of rapamycin signaling pathway. Pharmacology. 99:188–195. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Jin UH, Suh SJ, Chang HW, Son JK, Lee SH, Son KH, Chang YC and Kim CH: Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J Cell Biochem. 104:15–26. 2008. View Article : Google Scholar : PubMed/NCBI

53 

Munagala R, Aqil F, Jeyabalan J and Gupta RC: Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer. Cancer Lett. 356:536–546. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Zhou LH, Hu Q, Sui H, Ci SJ, Wang Y, Liu X, Liu NN, Yin PH, Qin JM and Li Q: Tanshinone II-a inhibits angiogenesis through down regulation of COX-2 in human colorectal cancer. Asian Pac J Cancer Prev. 13:4453–4458. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Ruiz-Medina BE, Lerma D, Hwang M, Ross JA, Skouta R, Aguilera RJ, Kirken RA, Varela-Ramirez A and Robles-Escajeda E: Green barley mitigates cytotoxicity in human lymphocytes undergoing aggressive oxidative stress, via activation of both the Lyn/PI3K/Akt and MAPK/ERK pathways. Sci Rep. 9:60052018. View Article : Google Scholar

56 

Xu Y, Li N, Xiang R and Sun P: Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence. Trends Biochem Sci. 39:268–276. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Watson AL, Anderson LK, Greeley AD, Keng VW, Rahrmann EP, Halfond AL, Powell NM, Collins MH, Rizvi T, Moertel CL, et al: Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity. Oncotarget. 5:1502–1514. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Saini KS, Loi S, de Azambuja E, Metzger-Filho O, Saini ML, Ignatiadis M, Dancey JE and Piccart-Gebhart MJ: Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer. Cancer Treat Rev. 39:935–946. 2013. View Article : Google Scholar : PubMed/NCBI

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Teng Z, Xu S and Lei Q: Tanshinone IIA enhances the inhibitory effect of imatinib on proliferation and motility of acute leukemia cell line TIB‑152 in vivo and in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway Retraction in /10.3892/or.2024.8725. Oncol Rep 43: 503-515, 2020.
APA
Teng, Z., Xu, S., & Lei, Q. (2020). Tanshinone IIA enhances the inhibitory effect of imatinib on proliferation and motility of acute leukemia cell line TIB‑152 in vivo and in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway Retraction in /10.3892/or.2024.8725. Oncology Reports, 43, 503-515. https://doi.org/10.3892/or.2019.7453
MLA
Teng, Z., Xu, S., Lei, Q."Tanshinone IIA enhances the inhibitory effect of imatinib on proliferation and motility of acute leukemia cell line TIB‑152 in vivo and in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway Retraction in /10.3892/or.2024.8725". Oncology Reports 43.2 (2020): 503-515.
Chicago
Teng, Z., Xu, S., Lei, Q."Tanshinone IIA enhances the inhibitory effect of imatinib on proliferation and motility of acute leukemia cell line TIB‑152 in vivo and in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway Retraction in /10.3892/or.2024.8725". Oncology Reports 43, no. 2 (2020): 503-515. https://doi.org/10.3892/or.2019.7453
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Spandidos Publications style
Teng Z, Xu S and Lei Q: Tanshinone IIA enhances the inhibitory effect of imatinib on proliferation and motility of acute leukemia cell line TIB‑152 in vivo and in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway Retraction in /10.3892/or.2024.8725. Oncol Rep 43: 503-515, 2020.
APA
Teng, Z., Xu, S., & Lei, Q. (2020). Tanshinone IIA enhances the inhibitory effect of imatinib on proliferation and motility of acute leukemia cell line TIB‑152 in vivo and in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway Retraction in /10.3892/or.2024.8725. Oncology Reports, 43, 503-515. https://doi.org/10.3892/or.2019.7453
MLA
Teng, Z., Xu, S., Lei, Q."Tanshinone IIA enhances the inhibitory effect of imatinib on proliferation and motility of acute leukemia cell line TIB‑152 in vivo and in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway Retraction in /10.3892/or.2024.8725". Oncology Reports 43.2 (2020): 503-515.
Chicago
Teng, Z., Xu, S., Lei, Q."Tanshinone IIA enhances the inhibitory effect of imatinib on proliferation and motility of acute leukemia cell line TIB‑152 in vivo and in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway Retraction in /10.3892/or.2024.8725". Oncology Reports 43, no. 2 (2020): 503-515. https://doi.org/10.3892/or.2019.7453
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