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Transcriptome sequencing analysis of mono‑ADP‑ribosylation in colorectal cancer cells

  • Authors:
    • Ning‑Ning Zhang
    • Ting Lin
    • Ming Xiao
    • Qing‑Shu Li
    • Xian Li
    • Lian Yang
    • Chuan‑Ling Wang
    • Ya‑Lan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1413-1428
    |
    Published online on: February 24, 2020
       https://doi.org/10.3892/or.2020.7516
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Abstract

Colorectal cancer (CRC) is a global health concern. The role of epigenetics in tumors has garnered increasing interest. ADP ribosylation is an epigenetic modification that is associated with a variety of biological functions and diseases, and its association with tumor development and progression has been hypothesized. However, due to the limitations of available techniques and methods, ADP ribosylation of specific sites is difficult to determine. In previous studies, it was shown that arginine‑117 of histone 3 (H3R117) in Lovo cells can be modified by mono‑ADP‑ribosylation. This site was mutated and Lovo cells overexpressing this mutant construct were established. In the present study, the expression of differentially expressed genes (DEGs) between untransfected Lovo cells and H3R117A Lovo cells was analyzed. A total of 58,174 DEGs were identified, of which 2,324 were significantly differentially expressed (q‑value <0.05; fold change >2). Functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment was used to analyze the functions and possible roles of the DEGs. The DEGs were enriched in pathways associated with metabolic process, catalytic activity, organelle and chromatin structure, and dynamics. Through this comprehensive and systematic analysis, the role of mono‑ADP‑ribosylation in CRC was examined, providing a foundation for future studies.
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View References

1 

Araghi M, Soerjomataram I, Jenkins M, Brierley J, Morris E, Bray F and Arnold M: Global trends in colorectal cancer mortality: Projections to the year 2035. Int J Cancer. 144:2992–3000. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Schreuders EH, Ruco A, Rabeneck L, Schoen RE, Sung JJ, Young GP and Kuipers EJ: Colorectal cancer screening: A global overview of existing programmes. Gut. 64:1637–1649. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Li XX, Peng JJ, Liang L, Huang LY, Li DW, Shi DB, Zheng HT and Cai SJ: RNA-seq identifies determinants of oxaliplatin sensitivity in colorectal cancer cell lines. Int J Clin Exp Pathol. 7:3763–3770. 2014.PubMed/NCBI

4 

Cohen MS and Chang P: Insights into the biogenesis, function, and regulation of ADP-ribosylation. Nat Chem Biol. 14:236–243. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Luscher B, Butepage M, Eckei L, Krieg S, Verheugd P and Shilton BH: ADP-ribosylation, a multifaceted posttranslational modification involved in the control of cell physiology in health and disease. Chem Rev. 118:1092–1136. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Jain PG and Patel BD: Medicinal chemistry approaches of poly ADP-Ribose polymerase 1 (PARP1) inhibitors as anticancer agents-A recent update. Eur J Med Chem. 165:198–215. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Kunze FA and Hottiger MO: Regulating immunity via ADP-ribosylation: Therapeutic implications and beyond. Trends Immunol. 40:159–173. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Hendriks IA, Larsen SC and Nielsen ML: An advanced strategy for comprehensive profiling of ADP-ribosylation sites using mass spectrometry-based proteomics. Mol Cell Proteomics. 18:1010–1026. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Sakthianandeswaren A, Parsons MJ, Mouradov D, MacKinnon RN, Catimel B, Liu S, Palmieri M, Love C, Jorissen RN, Li S, et al: MACROD2 haploinsufficiency impairs catalytic activity of PARP1 and promotes chromosome instability and growth of intestinal tumors. Cancer Discov. 8:988–1005. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Rajaram M, Zhang J, Wang T, Li J, Kuscu C, Qi H, Kato M, Grubor V, Weil RJ, Helland A, et al: Two distinct categories of focal deletions in cancer genomes. PLoS One. 8:e662642013. View Article : Google Scholar : PubMed/NCBI

11 

Zhang Y, Wang J, Ding M and Yu Y: Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteome. Nat Methods. 10:981–984. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Bonfiglio JJ, Fontana P, Zhang Q, Colby T, Gibbs-Seymour I, Atanassov I, Bartlett E, Zaja R, Ahel I and Matic I: Serine ADP-ribosylation depends on HPF1. Mol Cell. 65:932–940 e6. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Paone G, Wada A, Stevens LA, Matin A, Hirayama T, Levine RL and Moss J: ADP ribosylation of human neutrophil peptide-1 regulates its biological properties. Proc Natl Acad Sci USA. 99:8231–8235. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Ling F, Tang Y, Li M, Li QS, Li X, Yang L, Zhao W, Jin CC, Zeng Z, Liu C, et al: Mono-ADP-ribosylation of histone 3 at arginine-117 promotes proliferation through its interaction with P300. Oncotarget. 8:72773–72787. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Jing C, Ma R, Cao H, Wang Z, Liu S, Chen D, Wu Y, Zhang J and Wu J: Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis. Cancer Med. 8:1641–1651. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Vacchelli E, Ma Y, Baracco EE, Sistigu A, Enot DP, Pietrocola F, Yang H, Adjemian S, Chaba K, Semeraro M, et al: Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1. Science. 350:972–978. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Lin KT, Shann YJ, Chau GY, Hsu CN and Huang CY: Identification of latent biomarkers in hepatocellular carcinoma by ultra-deep whole-transcriptome sequencing. Oncogene. 33:4786–4794. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Kalathas D, Theocharis DA, Bounias D, Kyriakopoulou D, Papageorgakopoulou N, Stavropoulos MS and Vynios DH: Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer. Mol Med Rep. 4:363–368. 2011.PubMed/NCBI

19 

Kalathas D, Theocharis DA, Bounias D, Kyriakopoulou D, Papageorgakopoulou N, Stavropoulos MS and Vynios DH: Alterations of glycosaminoglycan disaccharide content and composition in colorectal cancer: Structural and expressional studies. Oncol Rep. 22:369–375. 2009.PubMed/NCBI

20 

Jayson GC, Lyon M, Paraskeva C, Turnbull JE, Deakin JA and Gallagher JT: Heparan sulfate undergoes specific structural changes during the progression from human colon adenoma to carcinoma in vitro. J Biol Chem. 273:51–57. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Zeng L, Qian J, Luo X, Zhou A, Zhang Z and Fang Q: CHSY1 promoted proliferation and suppressed apoptosis in colorectal cancer through regulation of the NFκB and/or caspase-3/7 signaling pathway. Oncol Lett. 16:6140–6146. 2018.PubMed/NCBI

22 

Hoshiba T: An extracellular matrix (ECM) model at high malignant colorectal tumor increases chondroitin sulfate chains to promote epithelial-mesenchymal transition and chemoresistance acquisition. Exp Cell Res. 370:571–578. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Bolger AM, Lohse M and Usadel B: Trimmomatic: A flexible trimmer for Illumina sequence data. Bioinformatics. 30:2114–2120. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Pertea M, Pertea GM, Antonescu CM, Chang TC, Mendell JT and Salzberg SL: StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nat Biotechnol. 33:290–295. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Okonechnikov K, Conesa A and García-Alcalde F: Qualimap 2: Advanced multi-sample quality control for high-throughput sequencing data. Bioinformatics. 32:292–294. 2016.PubMed/NCBI

27 

Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45(D1): D353–D361. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Mizumoto S, Yamada S and Sugahara K: Molecular interactions between chondroitin-dermatan sulfate and growth factors/receptors/matrix proteins. Curr Opin Struct Biol. 34:35–42. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Yoon YS, Kim JW, Kang KW, Kim YS, Choi KH and Joe CO: Poly(ADP-ribosyl)ation of histone H1 correlates with internucleosomal DNA fragmentation during apoptosis. J Biol Chem. 271:9129–9134. 1996. View Article : Google Scholar : PubMed/NCBI

30 

Voigt P, Tee WW and Reinberg D: A double take on bivalent promoters. Genes Dev. 27:1318–1338. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Gupte R, Liu Z and Kraus WL: PARPs and ADP-ribosylation: Recent advances linking molecular functions to biological outcomes. Genes Dev. 31:101–126. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Hottiger MO: Nuclear ADP-ribosylation and its role in chromatin plasticity, cell differentiation, and epigenetics. Annu Rev Biochem. 84:227–263. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Xu YM, Du JY and Lau AT: Posttranslational modifications of human histone H3: An update. Proteomics. 14:2047–2060. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Rakhimova A, Ura S, Hsu DW, Wang HY, Pears CJ and Lakin ND: Site-specific ADP-ribosylation of histone H2B in response to DNA double strand breaks. Sci Rep. 7:437502017. View Article : Google Scholar : PubMed/NCBI

35 

Li M, Tang Y, Li Q, Xiao M, Yang Y and Wang Y: Mono-ADP-ribosylation of H3R117 traps 5mC hydroxylase TET1 to impair demethylation of tumor suppressor gene TFPI2. Oncogene. 38:3488–3503. 2019.
Castle JC, Loewer M, Boegel S, de Graaf J, Bender C, Tadmor AD, Boisguerin V, Bukur T, Sorn P, Paret C, et al: Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma. BMC Genomics 15: 190, 2014. View Article : Google Scholar : PubMed/NCBI

36 

Simonian M, Mosallaei M, Khosravi S and Salehi R: rs12904 polymorphism in the 3′-untranslated region of ephrin A1 ligand and the risk of sporadic colorectal cancer in the Iranian population. J Cancer Res Ther. 15:15–19. 2019.PubMed/NCBI

37 

Penney ME, Parfrey PS, Savas S and Yilmaz YE: A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer. BMC Cancer. 19:1332019. View Article : Google Scholar : PubMed/NCBI

38 

Sveen A, Kilpinen S, Ruusulehto A, Lothe RA and Skotheim RI: Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes. Oncogene. 35:2413–2427. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Liu J, Li H, Shen S, Sun L, Yuan Y and Xing C: Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer. J Cancer. 9:1754–1764. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Resar L, Chia L and Xian L: Lessons from the Crypt: HMGA1-Amping up Wnt for stem cells and tumor progression. Cancer Res. 78:1890–1897. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Lee AJ, Endesfelder D, Rowan AJ, Walther A, Birkbak NJ, Futreal PA, Downward J, Szallasi Z, Tomlinson IP, Howell M, et al: Chromosomal instability confers intrinsic multidrug resistance. Cancer Res. 71:1858–1870. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Ahmed D, Eide PW, Eilertsen IA, Danielsen SA, Eknæs M, Hektoen M, Lind GE and Lothe RA: Epigenetic and genetic features of 24 colon cancer cell lines. Oncogenesis. 2:e712013. View Article : Google Scholar : PubMed/NCBI

43 

van den Broek E, Dijkstra MJ, Krijgsman O, Sie D, Haan JC, Traets JJ, van de Wiel MA, Nagtegaal ID, Punt CJ, Carvalho B, et al: High prevalence and clinical relevance of genes affected by chromosomal breaks in colorectal cancer. PLoS One. 10:e01381412015. View Article : Google Scholar : PubMed/NCBI

44 

Martinez-Zamudio R and Ha HC: Histone ADP-ribosylation facilitates gene transcription by directly remodeling nucleosomes. Mol Cell Biol. 32:2490–2502. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Abplanalp J and Hottiger MO: Cell fate regulation by chromatin ADP-ribosylation. Semin Cell Dev Biol. 63:114–122. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Clouaire T and Legube G: A snapshot on the Cis chromatin response to DNA double-strand breaks. Trends Genet. 35:330–345. 2019. View Article : Google Scholar : PubMed/NCBI

47 

Wintergerst L, Selmansberger M, Maihoefer C, Schüttrumpf L, Walch A, Wilke C, Pitea A, Woischke C, Baumeister P, Kirchner T, et al: A prognostic mRNA expression signature of four 16q24.3 genes in radio(chemo)therapy-treated head and neck squamous cell carcinoma (HNSCC). Mol Oncol. 12:2085–2101. 2018. View Article : Google Scholar : PubMed/NCBI

48 

Zhen Z: Effects of Histone H3 Arginine-specific Mono-ADP-ribosylation on proliferation and apoptosis of human colon cancer cell and its possible mechanism. Chongqing Med Univ; 2016

49 

Mende M, Bednarek C, Wawryszyn M, Sauter P, Biskup MB, Schepers U and Bräse S: Chemical synthesis of glycosaminoglycans. Chem Rev. 116:8193–8255. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Liao WC, Yen HR, Liao CK, Tseng TJ, Lan CT and Liu CH: DSE regulates the malignant characters of hepatocellular carcinoma cells by modulating CCL5/CCR1 axis. Am J Cancer Res. 9:347–362. 2019.PubMed/NCBI

51 

Pudelko A, Wisowski G, Olczyk K and Kozma EM: The dual role of the glycosaminoglycan chondroitin-6-sulfate in the development, progression and metastasis of cancer. FEBS J. 286:1815–1837. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Kopec M, Imiela A and Abramczyk H: Monitoring glycosylation metabolism in brain and breast cancer by Raman imaging. Sci Rep. 9:1662019. View Article : Google Scholar : PubMed/NCBI

53 

Nikitovic D, Chatzinikolaou G, Tsiaoussis J, Tsatsakis A, Karamanos NK and Tzanakakis GN: Insights into targeting colon cancer cell fate at the level of proteoglycans/glycosaminoglycans. Curr Med Chem. 19:4247–4258. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Qi J, Yu Y, Akilli Öztürk Ö, Holland JD, Besser D, Fritzmann J, Wulf-Goldenberg A, Eckert K, Fichtner I and Birchmeier W: New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals. Gut. 65:1690–1701. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Ji CH and Kwon YT: Crosstalk and interplay between the ubiquitin-proteasome system and autophagy. Mol Cells. 40:441–449. 2017.PubMed/NCBI

56 

Zhou W and Slingerland JM: Links between oestrogen receptor activation and proteolysis: Relevance to hormone-regulated cancer therapy. Nat Rev Cancer. 14:26–38. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Zhi J, Sun J, Wang Z and Ding W: Support vector machine classifier for prediction of the metastasis of colorectal cancer. Int J Mol Med. 41:1419–1426. 2018.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang NN, Lin T, Xiao M, Li QS, Li X, Yang L, Wang CL and Wang YL: Transcriptome sequencing analysis of mono‑ADP‑ribosylation in colorectal cancer cells. Oncol Rep 43: 1413-1428, 2020.
APA
Zhang, N., Lin, T., Xiao, M., Li, Q., Li, X., Yang, L. ... Wang, Y. (2020). Transcriptome sequencing analysis of mono‑ADP‑ribosylation in colorectal cancer cells. Oncology Reports, 43, 1413-1428. https://doi.org/10.3892/or.2020.7516
MLA
Zhang, N., Lin, T., Xiao, M., Li, Q., Li, X., Yang, L., Wang, C., Wang, Y."Transcriptome sequencing analysis of mono‑ADP‑ribosylation in colorectal cancer cells". Oncology Reports 43.5 (2020): 1413-1428.
Chicago
Zhang, N., Lin, T., Xiao, M., Li, Q., Li, X., Yang, L., Wang, C., Wang, Y."Transcriptome sequencing analysis of mono‑ADP‑ribosylation in colorectal cancer cells". Oncology Reports 43, no. 5 (2020): 1413-1428. https://doi.org/10.3892/or.2020.7516
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang NN, Lin T, Xiao M, Li QS, Li X, Yang L, Wang CL and Wang YL: Transcriptome sequencing analysis of mono‑ADP‑ribosylation in colorectal cancer cells. Oncol Rep 43: 1413-1428, 2020.
APA
Zhang, N., Lin, T., Xiao, M., Li, Q., Li, X., Yang, L. ... Wang, Y. (2020). Transcriptome sequencing analysis of mono‑ADP‑ribosylation in colorectal cancer cells. Oncology Reports, 43, 1413-1428. https://doi.org/10.3892/or.2020.7516
MLA
Zhang, N., Lin, T., Xiao, M., Li, Q., Li, X., Yang, L., Wang, C., Wang, Y."Transcriptome sequencing analysis of mono‑ADP‑ribosylation in colorectal cancer cells". Oncology Reports 43.5 (2020): 1413-1428.
Chicago
Zhang, N., Lin, T., Xiao, M., Li, Q., Li, X., Yang, L., Wang, C., Wang, Y."Transcriptome sequencing analysis of mono‑ADP‑ribosylation in colorectal cancer cells". Oncology Reports 43, no. 5 (2020): 1413-1428. https://doi.org/10.3892/or.2020.7516
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