Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
May-2020 Volume 43 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2020 Volume 43 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Clinical significance of circulating tumor cells in patients with locally advanced head and neck squamous cell carcinoma

  • Authors:
    • Kun Liu
    • Nanxiang Chen
    • Jian Wei
    • Lin Ma
    • Shiming Yang
    • Xinxin Zhang
  • View Affiliations / Copyright

    Affiliations: College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, P.R. China; National Clinical Research Center for Otolaryngologic Diseases; State Key Lab of Hearing Science, Ministry of Education; Beijing Key Lab of Hearing Impairment for Prevention and Treatment, Department of Radiotherapy, Chinese PLA General Hospital, Beijing 100853, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1525-1535
    |
    Published online on: March 9, 2020
       https://doi.org/10.3892/or.2020.7536
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate the clinical relevance of circulating tumor cells (CTCs) in patients with locally advanced head and neck squamous cell carcinoma (LA‑HNSCC), particularly in patients with nasopharyngeal and hypopharyngeal squamous cell carcinoma. CTCs were isolated using negative immunomagnetic bead enrichment and were identified by fluorescence in situ hybridization. Youden's index and the receiver operating characteristic (ROC) curve were used to select the optimal CTC baseline value. χ2 test or Fisher's test were used to determine the association between CTC counts and clinical parameters, curative effects and prognosis. The Kaplan‑Meier estimator was used to analyze overall survival (OS) and progression‑free survival (PFS). In the present study, 356 peripheral blood samples (178 pretreatment samples and 178 post‑treatment samples) from 178 patients were examined. The results revealed that the pretreatment CTC detection rate was 73.8%. The minimum, maximum and median CTC counts were 1, 22 and 2/3.2 ml, respectively. The number of polyploid CTCs was associated with distant metastasis (P=0.026). In addition, patients with undetectable CTCs, and decreasing or negative CTCs post‑treatment tended to have a good prognosis (P<0.05). For nasopharyngeal squamous cell carcinoma, the PFS of patients with increased CTCs and CTCs ≥2/3.2 ml after treatment was significantly lower (P<0.05). For hypopharyngeal squamous cell carcinoma, it was suggested that CTCs with a cutoff value of 3 may be used to evaluate PFS and OS before and after treatment. In conclusion, CTCs may be used to monitor disease progression and the response to chemoradiotherapy for patients with LA‑HNSCC. Furthermore, CTCs are a better predictor of the prognosis of hypopharyngeal squamous cell carcinoma than that of nasopharyngeal squamous cell carcinoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Jatana KR, Balasubramanian P, Lang JC, Yang L, Jatana CA, White E, Agrawal A, Ozer E, Schuller DE, Teknos TN and Chalmers JJ: Significance of circulating tumor cells in patients with squamous cell carcinoma of the head and neck: Initial results. Arch Otolaryngol Head Neck Surg. 136:1274–1279. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Fanelli MF, Oliveira TB, Braun AC, Corassa M, Abdallah EA, Nicolau UR, da Silva Alves V, Garcia D, Calsavara VF, Kowalski LP and Chinen LTD: Evaluation of incidence, significance, and prognostic role of circulating tumor microemboli and transforming growth factor-β receptor I in head and neck cancer. Head Neck. 39:2283–2292. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Denaro N, Merlano MC and Russi EG: Follow-up in head and neck cancer: Do more does it mean do better? A systematic review and our proposal based on our experience. Clin Exp Otorhinolaryngol. 9:287–297. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Economopoulou P, Kotsantis I, Kyrodimos E, Lianidou ES and Psyrri A: Liquid biopsy: An emerging prognostic and predictive tool in head and neck squamous cell carcinoma (HNSCC). Focus on circulating tumor cells (CTCs). Oral Oncol. 74:83–89. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Tognela A, Spring KJ, Becker T, Caixeiro NJ, Bray VJ, Yip PY, Chua W, Lim SH and de Souza P: Predictive and prognostic value of circulating tumor cell detection in lung cancer: A clinician's perspective. Crit Rev Oncol Hematol. 93:90–102. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Mateo J, Gerlinger M, Rodrigues DN and de Bono JS: The promise of circulating tumor cell analysis in cancer management. Genome Biol. 15:4482014. View Article : Google Scholar : PubMed/NCBI

7 

Li F, Liu J, Song D, Zhang Q, Ding N and He X: Circulating tumor cells in the blood of poorly differentiated nasal squamous cell carcinoma patients: Correlation with treatment response. Acta Otolaryngol. 136:1164–1167. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Fu X, Shen C, Wang H, Chen F, Li G and Wen Z: Joint quantitative measurement of hTERT mRNA in both peripheral blood and circulating tumor cells of patients with nasopharyngeal carcinoma and its clinical significance. BMC Cancer. 17:4792017. View Article : Google Scholar : PubMed/NCBI

9 

Lu SH, Tsai WS, Chang YH, Chou TY, Pang ST, Lin PH, Tsai CM and Chang YC: Identifying cancer origin using circulating tumor cells. Cancer Biol Ther. 17:430–438. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Zhang HD and Yu ZK: Enrichment and detection of circulating tumor cells and its application in head and neck squamous cell carcinoma. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 52:147–151. 2017.(In Chinese). PubMed/NCBI

11 

Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, Bartlett BR, Wang H, Luber B, Alani RM, et al: Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med. 6:224ra242014. View Article : Google Scholar : PubMed/NCBI

12 

Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, Reuben JM, Doyle GV, Allard WJ, Terstappen LW and Hayes DF: Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med. 351:781–791. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Ramirez JM, Fehm T, Orsini M, Cayrefourcq L, Maudelonde T, Pantel K and Alix Panabières C: Prognostic relevance of viable circulating tumor cells detected by EPISPOT in metastatic breast cancer patients. Clin Chem. 60:214–221. 2014. View Article : Google Scholar : PubMed/NCBI

14 

de Bono JS, Scher HI, Montgomery RB, Parker C, Miller MC, Tissing H, Doyle GV, Terstappen LW, Pienta KJ and Raghavan D: Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res. 14:6302–6309. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Cohen SJ, Punt CJ, Iannotti N, Saidman BH, Sabbath KD, Gabrail NY, Picus J, Morse M, Mitchell E, Miller MC, et al: Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol. 26:3213–3221. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Reeh M, Effenberger KE, Koenig AM, Riethdorf S, Eichstädt D, Vettorazzi E, Uzunoglu FG, Vashist YK, Izbicki JR, Pantel K and Bockhorn M: Circulating tumor cells as a biomarker for preoperative prognostic staging in patients with esophageal cancer. Ann Surg. 261:1124–1130. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Racila E, Euhus D, Weiss AJ, Rao C, McConnell J, Terstappen LW and Uhr JW: Detection and characterization of carcinoma cells in the blood. Proc Natl Acad Sci USA. 95:4589–4594. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Hiltermann TJN, Pore MM, Van Den Berg A, Timens W, Boezen HM, Liesker JJ, Schouwink JH, Wijnands WJ, Kerner GS, Kruyt FA, et al: Circulating tumor cells in small-cell lung cancer: A predictive and prognostic factor. Ann Oncol. 23:2937–2942. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Krebs MG, Sloane R, Priest L, Lancashire L, Hou JM, Greystoke A, Ward TH, Ferraldeschi R, Hughes A, Clack G, et al: Evaluation and prognostic significance of cir-culating tumor cells in patients with non-small-cell lung cancer. J Clin Oncol. 29:1556–1563. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Matsusaka S, Chin K, Oqura M, Suenaga M, Shinozaki E, Mishima Y, Terui Y, Mizunuma N and Hatake K: Circulating tumor cells as a surrogate marker for determining response to chemotherapy in patients with advanced gastric cancer. Cancer Sci. 101:1067–1071. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Rao C, Bui T, Connelly M, Doyle G, Karydis I, Middleton MR, Clack G, Malone M, Coumans FA and Terstappen LW: Circulating melanoma cells and survival in metastatic melanoma. Int J Oncol. 38:755–760. 2011.PubMed/NCBI

22 

Gazzaniga P, Gradilone A, de Berardinis E, Busetto GM, Raimondi C, Gandini O, Nicolazzo C, Petracca A, Vincenzi B, Farcomeni A, et al: Prognostic value of circulating tumor cells in nonmuscle invasive bladder cancer: A cellsearch analysis. Ann Oncol. 23:2352–2356. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Poveda A, Kaye SB, McCormack R, Wang S, Parekh T, Ricci D, Lebedinsky CA, Tercero JC, Zintl P and Monk BJ: Circulating tumor cells predict progression free survival and overall survival in patients with relapsed/recurrent advanced ovarian cancer. Gynecol Oncol. 122:567–572. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Harris L, Firtsche H, Mennel R, Norton L, Ravdin P, Taube S, Somerfield MR, Hayes DF and Bast RC Jr; American Society of Clinical Oncology, : American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol. 25:5287–5312. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Edge SB and Compton CC: The American joint committee on cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Zhang L, Riethdorf S, Wu G, Wang T, Yang K, Peng G, Liu J and Pantel K: Meta-analysis of the prognostic value of circulating tumor cells in breast cancer. Clin Cancer Res. 18:5701–5710. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Buglione M, Grisanti S, Almici C, Mangoni M, Polli C, Consoli F, Verardi R, Costa L, Paiar F, Pasinetti N, et al: Circulating tumour cells in locally advanced head and neck cancer: Preliminary report about their possible role in predicting response to non-surgical treatment and survival. Eur J Cancer. 48:3019–3026. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Nichols AC, Lowes LE, Szeto CCT, Basmaji J, Dhaliwal S, Chapeskie C, Todorovic B, Read N, Venkatesan V, Hammond A, et al: Detection of circulating tumor cells in advanced head and neck cancer using the CellSearch system. Head Neck. 34:1440–1444. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Hristozova T, Konschak R, Budach V and Tinhofer I: A simple multicolor flow cytometry protocol for detection and molecular characterization of circulating tumor cells in epithelial cancers. Cytometry A. 81:489–495. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Tinhofer I, Hristozova T, Stromberger C, Keilhoiz U and Budach V: Monitoring of circulating tumor cells and their expression of EGFR/phospho-EGFR during combined radiotherapy regimens in locally advanced squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 83:e685–e690. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Bozec A, Ilie M, Dassonville O, Long E, Poissonnet G, Santini J, Chamorey E, Ettaiche M, Chauvière D, Peyrade F, et al: Significance of circulating tumor cell detection using the cellsearch system in patients with locally advanced head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol. 270:2745–2749. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Wollenberga B, Walza A, Kolbow K, Pauli C, Chaubal S and Andratschke M: Clinical relevance of circulating tumour cells in the bone marrow of patients with SCCHN. Onkologie. 27:358–362. 2004.PubMed/NCBI

33 

Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET and Carbone PP: Toxicity and response criteria of the Eastern cooperative oncology group. Am J Clin Oncol. 5:649–655. 1982. View Article : Google Scholar : PubMed/NCBI

34 

Zhang Z, Xiao Y, Zhao J, Chen M, Xu Y, Zhong W, Xing J and Wang M: Relationship between circulating tumour cell count and prognosis following chemotherapy in patients with advanced non-small-cell lung cancer. Respirology. 21:519–525. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Tanaka M, Takeuchi H, Osaki Y, Hiraiwa K, Nakamura R, Oyama T, Takahashi T, Wada N, Kawakubo H, Saikawa Y, et al: Prognostic significance of circulating tumor cells in patients with advanced esophageal cancer. Esophagus. 12:352–359. 2015. View Article : Google Scholar

36 

Cao Q, Gao X, Lin Y, Yue C, Wang Y, Quan F, Zhang Z, Liu X, Lu Y, Zhan Y, et al: Thymopentin ameliorates dextran sulfate sodium-induced colitis by triggering the production of IL-22 in both innate and adaptive lymphocytes. Theranostics. 9:7490–7505. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Wu X, Li X, Fu Q, Cao Q, Chen X, Wang M, Yu J, Long J, Yao J, Liu H, et al: AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program. J Exp Med. 214:1065–1079. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Zhang C, Wang L, Guan Y, Sun Y, Liu X, Zhu D and Guo Q: Progress of circulating tumor cells in cancer management. Technol Cancer Res Treat. 15:509–516. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Zhang X, Wei L, Li J, Zheng J, Zhang S and Zhou J: Epithelial-mesenchymal transition phenotype of circulating tumor cells is associated with distant metastasis in patients with NSCLC. Mol Med Rep. 19:601–608. 2019.PubMed/NCBI

40 

Castro J, Sanchez L, Nuñez MT, Lu M, Castro T, Sharifi HR and Ericsson C: Screening circulating tumor cells as a noninvasive cancer test in 3388 individuals from high-risk groups (ICELLATE2). Dis Markers. 2018:46531092018. View Article : Google Scholar : PubMed/NCBI

41 

Bidard FC, Peeters DJ, Fehm T, Nolé F, Gisbert-Criado R, Mavroudis D, Grisanti S, Generali D, Garcia-Saenz JA, Stebbing J, et al: Clinical validity of circulating tumour cells in patients with metastatic breast cancer: A pooled analysis of individual patient data. Lancet Oncol. 15:406–414. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Li L, Liu Y, Zhang S, Wang T, Bian L, Wu S, Song S, Liu B and Jiang Z: Detection of circulating tumor cells and its clinical value for different stages and various subtypes of breast cancer. Zhonghua Yi Xue Za Zhi. 94:2812–2815. 2014.(In Chinese). PubMed/NCBI

43 

Bu XM, Xu FF, Ma J and Jiang B: The expression of circulating tumor cells in peripheral blood of patients with non-small cell lungcancer and its detection. J Biol Regul Homeost Agents. 32:843–849. 2018.PubMed/NCBI

44 

Gorges TM, Tinhofer I, Drosch M, Röse L, Zollner TM, Krahn T and von Ahsen O: Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition. BMC Cancer. 12:1782012. View Article : Google Scholar : PubMed/NCBI

45 

Yin SL, Liu FK, Cai DM, et al: Effect of perioperative administration of thymopentin on cellular immunity and cytokine level following cardiopulmonary bypass. Xinfei Xueguanbing Zazhi. 30:116–118, 121. 2011.(In Chinese).

46 

Tinhofer I and Staudte S: Circulating tumor cells as biomarkers in head and neck cancer: Recent advances and future outlook. Expert Rev Mol Diagn. 18:897–906. 2018. View Article : Google Scholar : PubMed/NCBI

47 

McMullen KP, Chalmers JJ, Lang JC, Kumar P and Jatana KR: Circulating tumor cells in head and neck cancer: A review. World J Otorhinolaryngol Head Neck Surg. 2:109–116. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu K, Chen N, Wei J, Ma L, Yang S and Zhang X: Clinical significance of circulating tumor cells in patients with locally advanced head and neck squamous cell carcinoma. Oncol Rep 43: 1525-1535, 2020.
APA
Liu, K., Chen, N., Wei, J., Ma, L., Yang, S., & Zhang, X. (2020). Clinical significance of circulating tumor cells in patients with locally advanced head and neck squamous cell carcinoma. Oncology Reports, 43, 1525-1535. https://doi.org/10.3892/or.2020.7536
MLA
Liu, K., Chen, N., Wei, J., Ma, L., Yang, S., Zhang, X."Clinical significance of circulating tumor cells in patients with locally advanced head and neck squamous cell carcinoma". Oncology Reports 43.5 (2020): 1525-1535.
Chicago
Liu, K., Chen, N., Wei, J., Ma, L., Yang, S., Zhang, X."Clinical significance of circulating tumor cells in patients with locally advanced head and neck squamous cell carcinoma". Oncology Reports 43, no. 5 (2020): 1525-1535. https://doi.org/10.3892/or.2020.7536
Copy and paste a formatted citation
x
Spandidos Publications style
Liu K, Chen N, Wei J, Ma L, Yang S and Zhang X: Clinical significance of circulating tumor cells in patients with locally advanced head and neck squamous cell carcinoma. Oncol Rep 43: 1525-1535, 2020.
APA
Liu, K., Chen, N., Wei, J., Ma, L., Yang, S., & Zhang, X. (2020). Clinical significance of circulating tumor cells in patients with locally advanced head and neck squamous cell carcinoma. Oncology Reports, 43, 1525-1535. https://doi.org/10.3892/or.2020.7536
MLA
Liu, K., Chen, N., Wei, J., Ma, L., Yang, S., Zhang, X."Clinical significance of circulating tumor cells in patients with locally advanced head and neck squamous cell carcinoma". Oncology Reports 43.5 (2020): 1525-1535.
Chicago
Liu, K., Chen, N., Wei, J., Ma, L., Yang, S., Zhang, X."Clinical significance of circulating tumor cells in patients with locally advanced head and neck squamous cell carcinoma". Oncology Reports 43, no. 5 (2020): 1525-1535. https://doi.org/10.3892/or.2020.7536
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team