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Article Open Access

BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor

Corrigendum in: /10.3892/or.2022.8352
  • Authors:
    • Jing Yu
    • Ling Chen
    • Zhenhua Bao
    • Ying Liu
    • Guohong Liu
    • Fengling Li
    • Lianqin Li
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, P.R. China, Department of Obstetrics and Gynecology, First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang 832001, P.R. China, Department of Oncology, People's Hospital of Haiyang, Haiyang, Shandong 265100, P.R. China, Department of Physical Examination, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, P.R. China, Department of Obstetrics and Gynecology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1630-1640
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    Published online on: March 10, 2020
       https://doi.org/10.3892/or.2020.7539
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Abstract

Endometrial adenocarcinoma is one of the most common types of gynecological malignancies and its incidence and mortality rates are increasing. Due to tumor recurrence and metastasis, the overall five‑year survival rate of patients with endometrial adenocarcinoma is shortened. The aim of the present was to investigate the role of the polycomb group protein B‑lymphoma Mo‑MLV insertion region 1 (BMI‑1) in the invasion, metastasis and the epithelial‑mesenchymal transition (EMT) of endometrial adenocarcinoma cells, as well its effects on the prognosis of patients with endometrial adenocarcinoma. Immunohistochemistry was used to examine the expression profile of BMI‑1 in normal and endometrial adenocarcinoma tissues. Western blotting was used to examine the expression levels of BMI‑1 and EMT markers. Kaplan‑Meier plots and a Cox proportional hazards model were used to assess the overall survival. MTT cell viability assays were used to detect the proliferation of endometrial cancer cells. Transwell assays were used to examine cell migration and invasion. Small interfering RNA was used to downregulate BMI‑1 expression levels, to study its effect on EMT. Immunohistochemical and clinicopathological analyses showed that BMI‑1 expression was increased in endometrial adenocarcinoma tissue compared with the normal endometrial tissue (P<0.05). The increased expression levels of BMI‑1 were closely associated with stage, myometrial invasion and lymph node metastasis (P<0.05). Kaplan‑Meier plots and a Cox proportional hazards model showed that increased BMI‑1 expression was associated with a less favorable prognosis [P=0.040, hazards ratio (HR)=1.596] and was associated with late‑stage adenocarcinoma (P=0.006, HR=1.670). Myometrial invasion (P=0.006, HR=1.509) and lymph node metastasis (P=0.004, HR=1.703) were determined to predict a less favorable prognosis. Downregulation of BMI‑1 reduced migration and invasion in endometrial cancer cells in vivo. It was also found that downregulation of BMI‑1 increased the expression levels of the epithelial markers E‑cadherin and keratin, and decreased the expression levels of the mesenchymal markers N‑cadherin, vimentin and the downstream transcription factor, Slug. In conclusion, BMI‑1 expression was correlated with tumor invasion and metastasis, contributing to deep myometrial invasion and lymph node metastasis, and was a poor prognostic factor for endometrial adenocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Yu J, Chen L, Bao Z, Liu Y, Liu G, Li F and Li L: BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor Corrigendum in /10.3892/or.2022.8352. Oncol Rep 43: 1630-1640, 2020.
APA
Yu, J., Chen, L., Bao, Z., Liu, Y., Liu, G., Li, F., & Li, L. (2020). BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor Corrigendum in /10.3892/or.2022.8352. Oncology Reports, 43, 1630-1640. https://doi.org/10.3892/or.2020.7539
MLA
Yu, J., Chen, L., Bao, Z., Liu, Y., Liu, G., Li, F., Li, L."BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor Corrigendum in /10.3892/or.2022.8352". Oncology Reports 43.5 (2020): 1630-1640.
Chicago
Yu, J., Chen, L., Bao, Z., Liu, Y., Liu, G., Li, F., Li, L."BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor Corrigendum in /10.3892/or.2022.8352". Oncology Reports 43, no. 5 (2020): 1630-1640. https://doi.org/10.3892/or.2020.7539
Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Chen L, Bao Z, Liu Y, Liu G, Li F and Li L: BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor Corrigendum in /10.3892/or.2022.8352. Oncol Rep 43: 1630-1640, 2020.
APA
Yu, J., Chen, L., Bao, Z., Liu, Y., Liu, G., Li, F., & Li, L. (2020). BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor Corrigendum in /10.3892/or.2022.8352. Oncology Reports, 43, 1630-1640. https://doi.org/10.3892/or.2020.7539
MLA
Yu, J., Chen, L., Bao, Z., Liu, Y., Liu, G., Li, F., Li, L."BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor Corrigendum in /10.3892/or.2022.8352". Oncology Reports 43.5 (2020): 1630-1640.
Chicago
Yu, J., Chen, L., Bao, Z., Liu, Y., Liu, G., Li, F., Li, L."BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor Corrigendum in /10.3892/or.2022.8352". Oncology Reports 43, no. 5 (2020): 1630-1640. https://doi.org/10.3892/or.2020.7539
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