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June-2020 Volume 43 Issue 6

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Review

Oral therapies in digestive oncology (Review)

  • Authors:
    • Caroline Prieux‑Klotz
    • Solene Dermine
    • Lola‑Jade Palmieri
    • Julie Lavole
    • Stanislas Chaussade
    • Catherine Brezault
    • Romain Coriat
  • View Affiliations / Copyright

    Affiliations: Department of Hepatology and Gastroenterology, Percy Military Hospital, 92140 Clamart, France, Department of Gastroenterology, Cochin Teaching Hospital, 75014 Paris, France
  • Pages: 1719-1728
    |
    Published online on: March 20, 2020
       https://doi.org/10.3892/or.2020.7555
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Abstract

Targeted therapy and oral chemotherapy indications are increasing in the realm of digestive oncology. Oral intake of cancer agents is sometimes compulsory (no i.v. equivalent) or is preferred by the patient or the physician. Although oral chemotherapy facilitates the treatment of oncology patients, the treatment diversity, risk of pharmaceutical interactions and monitoring of side effects are potentially challenging and need to be fully acknowledged by the physician. We offer here a literature review of the indications, doses, side effects and monitoring of every oral therapy indicated in Digestive Oncology. We suggest a prescription algorithm including therapeutic education by the physician or a trained nurse, and pharmaceutical counseling.
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1 

Bassan F, Peter F, Houbre B, Brennstuhl MJ, Costantini M, Speyer E and Tarquinio C: Adherence to oral antineoplastic agents by cancer patients: Definition and literature review. Eur J Cancer Care (Engl). 23:22–35. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Schüller J, Cassidy J, Dumont E, Roos B, Durston S, Banken L, Utoh M, Mori K, Weidekamm E and Reigner B: Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients. Cancer Chemother Pharmacol. 45:291–297. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Loriot MA, Ciccolini J, Thomas F, Barin-Le-Guellec C, Royer B, Milano G, Picard N, Becquemont L, Verstuyft C, Narjoz C, et al: Dihydropyrimidine déhydrogenase (DPD) deficiency screening and securing of fluoropyrimidine-based chemotherapies: Update and recommendations of the French GPCO-Unicancer and RNPGx networks. Bull Cancer. 105:397–407. 2018.(In French). View Article : Google Scholar : PubMed/NCBI

4 

Gérard JP, Azria D, Gourgou-Bourgade S, Martel-Laffay I, Hennequin C, Etienne PL, Vendrely V, François E, de La Roche G, Bouché O, et al: Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: Results of the phase III trial ACCORD 12/0405-Prodige 2. J Clin Oncol. 28:1638–1644. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Primrose JN, Fox RP, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, et al: Capecitabine compared with observation in resected biliary tract cancer (BILCAP): A randomised, controlled, multicentre, phase 3 study. Lancet Oncol. 20:663–673. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Twelves C, Wong A, Nowacki MP, Abt M, Burris H III, Carrato A, Cassidy J, Cervantes A, Fagerberg J, Georgoulias V, et al: Capecitabine as adjuvant treatment for stage III colon cancer. N Engl J Med. 352:2696–2704. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Grothey A, Sobrero A, Meyerhardt JA, Yoshino T, Paul J, Taieb J, Souglakos I, Kerr R, Labianca R, Shields AF, et al: Prospective pooled analysis of six phase III trials investigating duration of adjuvant (adjuv) oxaliplatin-based therapy (3 vs. 6 months) for patients (pts) with stage III colon cancer (CC): Updated results of IDEA (International Duration Evaluation of Adjuvant Chemotherapy). Ann Oncol. 28 (Suppl 5):v605–v649. 2017. View Article : Google Scholar

8 

Neoptolemos JP, Palmer DH, Ghaneh P, Psarelli EE, Valle JW, Halloran CM, Faluyi O, O'Reilly DA, Cunningham D, Wadsley J, et al: Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): A multicentre, open-label, randomised, phase 3 trial. Lancet. 389:1011–1024. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Cunningham D, Starling N, Rao S, Iveson T, Nicolson M, Coxon F, Middleton G, Daniel F, Oates J and Norman AR; Upper Gastrointestinal Clinical Studies Group of the National Cancer Research Institute of the United Kingdom, : Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med. 358:36–46. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Simkens LH, van Tinteren H, May A, ten Tije AJ, Creemers GJ, Loosveld OJ, de Jongh FE, Erdkamp FL, Erjavec Z, van der Torren AM, et al: Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer (CAIRO3): A phase 3 randomised controlled trial of the Dutch colorectal cancer group. Lancet. 385:1843–1852. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Strosberg JR, Fine RL, Choi J, Nasir A, Coppola D, Chen DT, Helm J and Kvols L: First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. Cancer. 117:268–275. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Ikenishi M, Ueda M, Kuroda A, Tsukazaki H, Nakao M, Takeuchi M, Konishi Y, Matsuda T, Figoni W, Ohtori T, et al: A study on drug interaction between warfarin and capecitabine with special reference to the co-administered term or the discontinuation term of capecitabine. Gan To Kagaku Ryoho. 42:833–839. 2015.PubMed/NCBI

13 

Chu MP, Hecht JR, Slamon D, Wainberg ZA, Bang YJ, Hoff PM, Sobrero A, Qin S, Afenjar K, Houe V, et al: Association of proton pump inhibitors and capecitabine efficacy in advanced gastroesophageal cancer: Secondary analysis of the TRIO-013/LOGiC randomized clinical trial. JAMA Oncol. 3:767–773. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Baan J, Bos MMEM, Gonesh-Kisoensingh SU, Meynaar IA, Alsma J, Meijer E and GVulto A: Capecitabine-induced toxicity: An outcome study into drug safety. J Integr Oncol. 3:1132014. View Article : Google Scholar

15 

Cassidy J, Clarke S, Díaz-Rubio E, Scheithauer W, Figer A, Wong R, Koski S, Lichinitser M, Yang TS, Rivera F, et al: Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer. J Clin Oncol. 26:2006–2012. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Hofheinz RD, Wenz F, Post S, Matzdorff A, Laechelt S, Hartmann JT, Müller L, Link H, Moehler M, Kettner E, et al: Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: A randomised, multicentre, non-inferiority, phase 3 trial. Lancet Oncol. 13:579–588. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Mayer RJ, Van Cutsem E, Falcone A, Yoshino T, Garcia-Carbonero R, Mizunuma N, Yamazaki K, Shimada Y, Tabernero J, Komatsu Y, et al: Randomized trial of TAS-102 for refractory metastatic colorectal cancer. N Engl J Med. 372:1909–1919. 2015. View Article : Google Scholar : PubMed/NCBI

18 

New drug extends lives of brain cancer patients. FDA Consum. 39:32005.

19 

Kunz PL, Catalano PJ, Nimeiri H, Fisher GA, Longacre TA, Suarez CJ, Yao JC, Kulke MH, Hendifar AE, Shanks JC, et al: A randomized study of temozolomide or temozolomide and capecitabine in patients with advanced pancreatic neuroendocrine tumors: A trial of the ECOG-ACRIN Cancer Research Group (E2211). J Clin Oncol. 36 (15 Suppl):S40042018. View Article : Google Scholar

20 

Marx J: Cancer. Encouraging results for second-generation antiangiogenesis drugs. Science. 308:1248–1249. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, et al: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 359:378–390. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, et al: Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: A randomised phase 3 non-inferiority trial. Lancet. 391:1163–1173. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Tada T, Kumada T, Hiraoka A, Michitaka K, Atsukawa M, Hirooka M, Tsuji K, Ishikawa T, Takaguchi K, Kariyama K, et al: Safety and efficacy of lenvatinib in elderly patients with unresectable hepatocellular carcinoma: A multicenter analysis with propensity score matching. Hepatol Res. 50:75–83. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Ettrich TJ and Seufferlein T: Regorafenib. Recent Results Cancer Res. 211:45–56. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Grothey A, Van Cutsem E, Sobrero A, Siena S, Falcone A, Ychou M, Humblet Y, Bouché O, Mineur L, Barone C, et al: Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 381:303–312. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Bekaii-Saab TS, Ou FS, Ahn DH, Boland PM, Ciombor KK, Heying EN, Dockter TJ, Jacobs NL, Pasche BC, Cleary JM, et al: Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): A randomised, multicentre, open-label, phase 2 study. Lancet Oncol. 20:1070–1082. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Bruix J, Qin S, Merle P, Granito A, Huang YH, Bodoky G, Pracht M, Yokosuka O, Rosmorduc O, Breder V, et al: Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): A randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 389:56–66. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Demetri GD, Reichardt P, Kang YK, Blay JY, Rutkowski P, Gelderblom H, Hohenberger P, Leahy M, von Mehren M, Joensuu H, et al: Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): An international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 381:295–302. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Grüllich C: Cabozantinib: A MET, RET, and VEGFR2 tyrosine kinase inhibitor. Recent Results Cancer Res. 201:207–214. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Abou-Alfa GK, Meyer T, Cheng AL, El-Khoueiry AB, Rimassa L, Ryoo BY, Cicin I, Merle P, Chen Y, Park JW, et al: Cabozantinib in patients with advanced and progressing hepatocellular carcinoma. N Engl J Med. 379:54–63. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Blumenthal GM, Cortazar P, Zhang JJ, Tang S, Sridhara R, Murgo A, Justice R and Pazdur R: FDA approval summary: Sunitinib for the treatment of progressive well-differentiated locally advanced or metastatic pancreatic neuroendocrine tumors. Oncologist. 17:1108–1113. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Raymond E, Dahan L, Raoul JL, Bang YJ, Borbath I, Lombard-Bohas C, Valle J, Metrakos P, Smith D, Vinik A, et al: Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med. 364:501–513. 2011. View Article : Google Scholar : PubMed/NCBI

33 

George S, Blay JY, Casali PG, Le Cesne A, Stephenson P, Deprimo SE, Harmon CS, Law CN, Morgan JA, Ray-Coquard I, et al: Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure. Eur J Cancer. 45:1959–1968. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Choi BS: Risks associated with sunitinib use and monitoring to improve patient outcomes. Korean J Intern Med. 29:23–26. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Pavel ME, Hainsworth JD, Baudin E, Peeters M, Hörsch D, Winkler RE, Klimovsky J, Lebwohl D, Jehl V, Wolin EM, et al: Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): A randomised, placebo-controlled, phase 3 study. Lancet. 378:2005–2012. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Yao JC, Fazio N, Singh S, Buzzoni R, Carnaghi C, Wolin E, Tomasek J, Raderer M, Lahner H, Voi M, et al: Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): A randomised, placebo-controlled, phase 3 study. Lancet. 387:968–977. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Yao JC, Shah MH, Ito T, Bohas CL, Wolin EM, Van Cutsem E, Hobday TJ, Okusaka T, Capdevila J, de Vries EG, et al: Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med. 364:514–523. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Lombard-Bohas C, Cariou B, Vergès B, Coriat R, N'guyen T, François E, Hammel P, Niccoli P and Hentic O: Management of metabolic disorders induced by everolimus in patients with differentiated neuroendocrine tumors: Expert proposals. Bull Cancer. 101:175–183. 2014.(In French). View Article : Google Scholar : PubMed/NCBI

39 

Klümpen HJ, Beijnen JH, Gurney H and Schellens JH: Inhibitors of mTOR. Oncologist. 15:1262–1269. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Mesa RA: Imatinib and tyrosine kinase inhibition, in the management of BCR-ABL negative myeloproliferative disorders. Biologics. 1:129–138. 2007.PubMed/NCBI

41 

Dematteo RP, Ballman KV, Antonescu CR, Maki RG, Pisters PW, Demetri GD, Blackstein ME, Blanke CD, von Mehren M, Brennan MF, et al: Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: A randomised, double-blind, placebo-controlled trial. Lancet. 373:1097–1104. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Corless CL, Ballman KV, Antonescu CR, Kolesnikova V, Maki RG, Pisters PW, Blackstein ME, Blanke CD, Demetri GD, Heinrich MC, et al: Pathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: The ACOSOG Z9001 trial. J Clin Oncol. 32:1563–1570. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Joensuu H, Eriksson M, Sundby Hall K, Hartmann JT, Pink D, Schütte J, Ramadori G, Hohenberger P, Duyster J, Al-Batran SE, et al: One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: A randomized trial. JAMA. 307:1265–1272. 2012. View Article : Google Scholar : PubMed/NCBI

44 

ESMO/European Sarcoma Network Working Group, : Gastrointestinal stromal tumours: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 25 (Suppl 3):iii21–iii26. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Blanke CD, Rankin C, Demetri GD, Ryan CW, von Mehren M, Benjamin RS, Raymond AK, Bramwell VH, Baker LH, Maki RG, et al: Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. J Clin Oncol. 26:626–632. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Zalcberg JR, Verweij J, Casali PG, Le Cesne A, Reichardt P, Blay JY, Schlemmer M, Van Glabbeke M, Brown M and Judson IR; EORTC Soft Tissue and Bone Sarcoma Group and the Italian Sarcoma Group and Australasian Gastrointestinal Trials Group, : Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg. Eur J Cancer. 41:1751–1757. 2005. View Article : Google Scholar : PubMed/NCBI

47 

Riese C, Weiß B, Borges U Jr, Beylich A, Dengler R, Hermes-Moll K, Welslau M and Baumann W: Effectiveness of a standardized patient education program on therapy-related side effects and unplanned therapy interruptions in oral cancer therapy: A cluster-randomized controlled trial. Support Care Cancer. 25:3475–3483. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Favier-Archinard C, Leguelinel-Blache G, Cousin C, Gillet C, Bourquard P, Dubois F, Passemard N, Tora S, Rey A, Heraut B, et al: Élaboration d'un guide standardisé d'informations d'optimisation de l'adhésion médicamenteuse à dispenser lors d'une consultation pharmaceutique au patient atteint de myélome multiple: Validation finale. Bull Cancer. 105:1157–1172. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Moriwaki T, Fukuoka S, Taniguchi H, Takashima A, Kumekawa Y, Kajiwara T, Yamazaki K, Esaki T, Makiyama C, Denda T, et al: Propensity score analysis of regorafenib versus trifluridine/tipiracil in patients with metastatic colorectal cancer refractory to standard chemotherapy (REGOTAS): A Japanese society for cancer of the colon and rectum multicenter observational study. Oncologist. 23:7–15. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Patel AK, Barghout V, Yenikomshian MA, Germain G, Jacques P, Laliberté F and Duh MS: Real-world adherence in patients with metastatic colorectal cancer treated with trifluridine plus tipiracil or regorafenib. Oncologist. 25:e75–e84. 2020. View Article : Google Scholar : PubMed/NCBI

51 

Roila F, Molassiotis A, Herrstedt J, Aapro M, Gralla RJ, Bruera E, Clark-Snow RA, Dupuis LL, Einhorn LH, Feyer P, et al: 2016 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting and of nausea and vomiting in advanced cancer patients. Ann Oncol. 27 (Suppl 5):v119–v33. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Gebbia V, Carreca I, Testa A, Valenza R, Curto G, Cannata G, Borsellino N, Latteri MA, Cipolla C, Florena M, et al: Subcutaneous octreotide versus oral loperamide in the treatment of diarrhea following chemotherapy. Anticancer Drugs. 4:443–445. 1993. View Article : Google Scholar : PubMed/NCBI

53 

Bryce J and Boers-Doets CB: Non-rash dermatologic adverse events related to targeted therapies. Semin Oncol Nurs. 30:155–168. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Lalla RV, Sonis ST and Peterson DE: Management of oral mucositis in patients who have cancer. Dent Clin North Am. 5261–77. (viii)2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Prieux‑Klotz C, Dermine S, Palmieri LJ, Lavole J, Chaussade S, Brezault C and Coriat R: Oral therapies in digestive oncology (Review). Oncol Rep 43: 1719-1728, 2020.
APA
Prieux‑Klotz, C., Dermine, S., Palmieri, L., Lavole, J., Chaussade, S., Brezault, C., & Coriat, R. (2020). Oral therapies in digestive oncology (Review). Oncology Reports, 43, 1719-1728. https://doi.org/10.3892/or.2020.7555
MLA
Prieux‑Klotz, C., Dermine, S., Palmieri, L., Lavole, J., Chaussade, S., Brezault, C., Coriat, R."Oral therapies in digestive oncology (Review)". Oncology Reports 43.6 (2020): 1719-1728.
Chicago
Prieux‑Klotz, C., Dermine, S., Palmieri, L., Lavole, J., Chaussade, S., Brezault, C., Coriat, R."Oral therapies in digestive oncology (Review)". Oncology Reports 43, no. 6 (2020): 1719-1728. https://doi.org/10.3892/or.2020.7555
Copy and paste a formatted citation
x
Spandidos Publications style
Prieux‑Klotz C, Dermine S, Palmieri LJ, Lavole J, Chaussade S, Brezault C and Coriat R: Oral therapies in digestive oncology (Review). Oncol Rep 43: 1719-1728, 2020.
APA
Prieux‑Klotz, C., Dermine, S., Palmieri, L., Lavole, J., Chaussade, S., Brezault, C., & Coriat, R. (2020). Oral therapies in digestive oncology (Review). Oncology Reports, 43, 1719-1728. https://doi.org/10.3892/or.2020.7555
MLA
Prieux‑Klotz, C., Dermine, S., Palmieri, L., Lavole, J., Chaussade, S., Brezault, C., Coriat, R."Oral therapies in digestive oncology (Review)". Oncology Reports 43.6 (2020): 1719-1728.
Chicago
Prieux‑Klotz, C., Dermine, S., Palmieri, L., Lavole, J., Chaussade, S., Brezault, C., Coriat, R."Oral therapies in digestive oncology (Review)". Oncology Reports 43, no. 6 (2020): 1719-1728. https://doi.org/10.3892/or.2020.7555
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