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Article Open Access

Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells

  • Authors:
    • Juan Wang
    • Zhi‑Qian Zhang
    • Fang‑Qiong Li
    • Jia‑Ning Chen
    • Xiaoting Gong
    • Bei‑Bei Cao
    • Wei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, P.R. China, College of Medical Technology, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Clinical Laboratory, Hangzhou Linan District People's Hospital, Hangzhou, Zhejiang 311300, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1863-1874
    |
    Published online on: March 30, 2020
       https://doi.org/10.3892/or.2020.7569
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Abstract

Lung cancer has one of the highest mortalities of any cancer worldwide. Triptolide (TP) is a promising tumor suppressor extracted from the Chinese herb Tripterygium wilfordii. Our previous proteomics analysis revealed that TP significantly interfered with the ribosome biogenesis pathway; however, the underlying molecular mechanism remains poorly understood. The aim of the present study was to determine the molecular mechanism of TP's anticancer effect by investigating the association between ribosomal stress and p53 activation. It was found that TP induces nucleolar disintegration together with RNA polymerase I (Pol I) and upstream binding factor (UBF) translocation. TP interrupted ribosomal (r)RNA synthesis through inhibition of RNA Pol I and UBF transcriptional activation. TP treatment increased the binding of ribosomal protein L23 (RPL23) to mouse double minute 2 protein (MDM2), resulting in p53 being released from MDM2 and stabilized. Activation of p53 induced apoptosis and cell cycle arrest by enhancing the activation of p53 upregulated modulator of apoptosis, caspase 9 and caspase 3, and suppressing BCL2. In vivo experiments showed that TP significantly reduced xenograft tumor size and increased mouse body weight. Immunohistochemical assays confirmed that TP significantly increased the p53 level and induced nucleolus disintegration, during which nucleolin distribution moved from the nucleolus to the nucleoplasm, and RPL23 clustered at the edge of the cell membrane. Therefore, it was proposed that TP induces ribosomal stress, which leads to nucleolus disintegration, and inhibition of rRNA transcription and synthesis, resulting in increased binding of RPL23 with MDM2. Consequently, p53 is activated, which induces apoptosis and cell cycle arrest.
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1 

Osmani L, Askin F, Gabrielson E and Li QK: Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy. Semin Cancer Biol. 52:103–109. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Jain NA and Otterson GA: Immunotherapy in inoperable stage III non-small cell lung cancer: A review. Drugs Context. 8:2125782019. View Article : Google Scholar : PubMed/NCBI

3 

Zhang D, Jin Q, Jiang C, Gao M, Ni Y and Zhang J: Imaging cell death: Focus on early evaluation of tumor response to therapy. Bioconjug Chem. Mar 23–2020.(Epub ahead of print). View Article : Google Scholar

4 

Li-Weber M: Targeting apoptosis pathways in cancer by Chinese medicine. Cancer Lett. 332:304–312. 2013. View Article : Google Scholar : PubMed/NCBI

5 

de Almeida EM, Ferreira HJ, Alves DR and Da Silva WMB: Therapeutic potential of medicinal plants indicated by the Brazilian public health system in treating the collateral effects induced by chemotherapy, radiotherapy, and chemoradiotherapy: A systematic review. Complement Ther Med. 49:1022932020. View Article : Google Scholar : PubMed/NCBI

6 

Luo D, Zuo Z, Zhao H, Tan Y and Xiao C: Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice. Front Med. 13:556–563. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Noel P, Von Hoff DD, Saluja AK, Velagapudi M, Borazanci E and Han H: Triptolide and its derivatives as cancer therapies. Trends Pharmacol Sci. 40:327–341. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Chen SR, Dai Y, Zhao J, Lin L and Wang Y and Wang Y: A mechanistic overview of triptolide and celastrol, natural products from tripterygium wilfordii Hook F. Front Pharmacol. 9:1042018. View Article : Google Scholar : PubMed/NCBI

9 

Yan P and Sun X: Triptolide: A new star for treating human malignancies. J Cancer Res Ther. 14:S271–S275. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Meng G, Wang W, Chai K, Yang S, Li F and Jiang K: Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways. Int J Oncol. 46:1007–1017. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Li F, Zhao D, Yang S, Wang J, Liu Q, Jin X and Wang W: ITRAQ-based proteomics analysis of triptolide on human A549 lung adenocarcinoma cells. Cell Physiol Biochem. 45:917–934. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Goodfellow SJ and Zomerdijk JC: Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes. Subcell Biochem. 61:211–236. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Wang M and Pestov DG: Quantitative northern blot analysis of mammalian rRNA processing. Methods Mol Biol. 1455:147–157. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Russell J and Zomerdijk JC: The RNA polymerase I transcription machinery. Biochem Soc Symp. 73:203–216. 2006. View Article : Google Scholar

15 

O'Sullivan AC, Sullivan GJ and McStay B: UBF binding in vivo is not restricted to regulatory sequences within the vertebrate ribosomal DNA repeat. Mol Cell Biol. 22:657–668. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Wang HT, Chen TY, Weng CW, Yang CH and Tang MS: Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells. Oncotarget. 7:80450–80464. 2016.PubMed/NCBI

17 

Vispé S, DeVries L, Créancier L, Besse J, Bréand S, Hobson DJ, Svejstrup JQ, Annereau JP, Cussac D, Dumontet C, et al: Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA. Mol Cancer Ther. 8:2780–2790. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Boulon S, Westman BJ, Hutten S, Boisvert FM and Lamond AI: The nucleolus under stress. Mol Cell. 40:216–227. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Mitrea DM, Cika JA, Guy CS, Ban D, Banerjee PR, Stanley CB, Nourse A, Deniz AA and Kriwacki RW: Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA. Elife. 5:e135712016. View Article : Google Scholar : PubMed/NCBI

21 

Burger K, Mühl B, Harasim T, Rohrmoser M, Malamoussi A, Orban M, Kellner M, Gruber-Eber A, Kremmer E, Hölzel M and Eick D: Chemotherapeutic drugs inhibit ribosome biogenesis at various levels. J Biol Chem. 285:12416–12425. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Turi Z, Lacey M, Mistrik M and Moudry P: Impaired ribosome biogenesis: Mechanisms and relevance to cancer and aging. Aging (Albany NY). 11:2512–2540. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Dai MS, Zeng SX, Jin Y, Sun XX, David L and Lu H: Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol. 24:7654–7668. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Chen J: The cell-cycle arrest and apoptotic functions of p53 in tumor initiation and progression. Cold Spring Harb Perspect Med. 6:a0261042016. View Article : Google Scholar : PubMed/NCBI

25 

Deregowska A, Adamczyk J, Kwiatkowska A, Gurgul A, Skoneczny M, Skoneczna A, Szmatola T, Jasielczuk I, Magda M, Rawska E, et al: Shifts in rDNA levels act as a genome buffer promoting chromosome homeostasis. Cell Cycle. 14:3475–3487. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Wang W, Luo J, Xiang F, Liu X, Jiang M, Liao L and Hu J: Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells. PLoS One. 9:e1101012014. View Article : Google Scholar : PubMed/NCBI

27 

Phi JH, Sun CH, Lee SH, Lee S, Park I, Choi SA, Park SH, Lee JY, Wang KC, Kim SK, et al: NPM1 as a potential therapeutic target for atypical teratoid/rhabdoid tumors. BMC Cancer. 19:8482019. View Article : Google Scholar : PubMed/NCBI

28 

Okur MN, Lee JH, Osmani W, Kimura R, Demarest TG, Croteau DL and Bohr VA: Cockayne syndrome group A and B proteins function in rRNA transcription through nucleolin regulation. Nucleic Acids Res. 48:2473–2485. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Murano K, Okuwaki M, Hisaoka M and Nagata K: Transcription regulation of the rRNA gene by a multifunctional nucleolar protein, B23/nucleophosmin, through its histone chaperone activity. Mol Cell Biol. 28:3114–3126. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Engel C, Gubbey T, Neyer S, Sainsbury S, Oberthuer C, Baejen C, Bernecky C and Cramer P: Structural basis of RNA polymerase I transcription initiation. Cell. 169:120–131.e22. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Lin YM, Chu PH and Ouyang P: Ectopically expressed pNO40 suppresses ribosomal RNA synthesis by inhibiting UBF-dependent transcription activation. Biochem Biophys Res Commun. 516:381–387. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Sugiyama T, Li S, Kato M, Ikeuchi K, Ichimura A, Matsuo Y and Inada T: Sequential ubiquitination of ribosomal protein uS3 triggers the degradation of non-functional 18S rRNA. Cell Rep. 26:3400–3415.e7. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Zhang Y and Lu H: Signaling to p53: Ribosomal proteins find their way. Cancer Cell. 16:369–377. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Li XQ, Yu Q, Chen FS, Tan WF, Zhang ZL and Ma H: Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway. J Neuroinflammation. 15:2502018. View Article : Google Scholar : PubMed/NCBI

35 

Garufi A, Pistritto G, Baldari S, Toietta G, Cirone M and D'Orazi G: p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions. J Exp Clin Cancer Res. 36:1262017. View Article : Google Scholar : PubMed/NCBI

36 

Chen D, Ni HM, Wang L, Ma X, Yu J, Ding WX and Zhang L: p53 up-regulated modulator of apoptosis induction mediates acetaminophen-induced necrosis and liver injury in mice. Hepatology. 69:2164–2179. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, et al: Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway. Nat Cell Biol. 20:789–799. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, et al: Ribosomal protein RPL22eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex. Cell Cycle. 18:759–770. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Heissenberger C, Liendl L, Nagelreiter F, Gonskikh Y, Yang G, Stelzer EM, Krammer TL, Micutkova L, Vogt S, Kreil DP, et al: Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth. Nucleic Acids Res. 47:11807–11825. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, Deng H, Luo J, Ke Y and Du X: NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep. 17:349–366. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Xing Y, Liu Y, Liu T, Meng Q, Lu H, Liu W, Hu J, Li C, Cao M, Yan S, et al: TNFAIP8 promotes the proliferation and cisplatin chemoresistance of non-small cell lung cancer through MDM2p53 pathway. Cell Commun Signal. 16:432018. View Article : Google Scholar : PubMed/NCBI

42 

Zhou Q, Hou Z, Zuo S, Zhou X, Feng Y, Sun Y and Yuan X: LUCAT1 promotes colorectal cancer tumorigenesis by targeting the ribosomal protein L40-MDM2-p53 pathway through binding with UBA52. Cancer Sci. 110:1194–1207. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Lempiäinen H and Shore D: Growth control and ribosome biogenesis. Curr Opin Cell Biol. 21:855–863. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Zhang ZQ, Li FQ, Chen JN, Gong X, Cao BB and Wang W: Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells. Oncol Rep 43: 1863-1874, 2020.
APA
Wang, J., Zhang, Z., Li, F., Chen, J., Gong, X., Cao, B., & Wang, W. (2020). Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells. Oncology Reports, 43, 1863-1874. https://doi.org/10.3892/or.2020.7569
MLA
Wang, J., Zhang, Z., Li, F., Chen, J., Gong, X., Cao, B., Wang, W."Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells". Oncology Reports 43.6 (2020): 1863-1874.
Chicago
Wang, J., Zhang, Z., Li, F., Chen, J., Gong, X., Cao, B., Wang, W."Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells". Oncology Reports 43, no. 6 (2020): 1863-1874. https://doi.org/10.3892/or.2020.7569
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Zhang ZQ, Li FQ, Chen JN, Gong X, Cao BB and Wang W: Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells. Oncol Rep 43: 1863-1874, 2020.
APA
Wang, J., Zhang, Z., Li, F., Chen, J., Gong, X., Cao, B., & Wang, W. (2020). Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells. Oncology Reports, 43, 1863-1874. https://doi.org/10.3892/or.2020.7569
MLA
Wang, J., Zhang, Z., Li, F., Chen, J., Gong, X., Cao, B., Wang, W."Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells". Oncology Reports 43.6 (2020): 1863-1874.
Chicago
Wang, J., Zhang, Z., Li, F., Chen, J., Gong, X., Cao, B., Wang, W."Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells". Oncology Reports 43, no. 6 (2020): 1863-1874. https://doi.org/10.3892/or.2020.7569
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