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Article

A novel highly frequent single‑nucleotide polymorphism site of cadherin 23 in clear cell renal cell carcinoma with sarcomatoid differentiation based on whole exome sequencing

  • Authors:
    • Wenjuan Yu
    • Xiaohui Wang
    • Yuewei Wang
    • Yanxia Jiang
    • Wei Zhang
    • Hailei Shi
    • Yujun Li
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Department of Vascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Department of Pathology, 971 Navy Hospital of Chinese People's Liberation Army, Qingdao, Shandong 266071, P.R. China
  • Pages: 735-746
    |
    Published online on: May 19, 2020
       https://doi.org/10.3892/or.2020.7613
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Abstract

Clear cell renal cell carcinoma (CCRCC) with sarcomatoid differentiation (CCRCCS) displays invasive behavior, poor prognosis, and poor therapeutic response. The present study was aimed to gain new insights into the molecular mechanisms of sarcomatoid transformation, and identify new prognostic and therapeutic targets for CCRCCS. Whole exome sequencing was performed on matched carcinomatous and sarcomatoid elements from five specimens with CCRCCS. A non‑synonymous single‑nucleotide polymorphism (SNP) of cadherin 23 (CDH23) was further studied through Sanger sequencing in expanded 40 specimens with CCRCCS and 50 specimens with CCRCC. Carcinomatous and sarcomatoid elements shared most somatic single‑nucleotide variants (SSNVs) as revealed through whole exome sequencing. Sarcomatoid element had higher overall SSNVs than carcinomatous element. A highly frequent mutation of CDH23 (rs3802711) was observed in CCRCCS that resulted in an alteration in the highly conserved calcium‑binding site in the three‑dimensional (3D) structure mediating the functions of cadherins. In the expanded 90 specimens, CDH23 SNP (rs3802711) was a highly frequent mutation in CCRCCS than that in all CCRCC samples and even high grade CCRCC. Cox multivariate analysis indicated that CDH23 (rs3802711) genotype was an independent prognostic factor affecting the overall survival of the cohort. CDH23 gene and protein were negatively or weakly expressed in most CCRCCS specimens with CDH23 mutation. The present study revealed, for the first time, that the CDH23 (rs3802711) was a highly genetic risk factor for CCRCCS. It was associated with the decreased expression of CDH23 protein, resulting in the absence of cadherin function of CDH23, indicating that the CDH23 mutation may be involved in the sarcomatoid transformation in CCRCCS. Collectively, a novel and specific SNP of CDH23 was identified in CCRCCS and a new candidate cadherin involved in EMT was revealed. Furthermore, a new prognostic evaluation factor and potential therapeutic target for CCRCCS was identified.
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View References

1 

Nguyen DP, Vilaseca A, Vertosick EA, Corradi RB, Touijer KA, Benfante NE, Sjoberg DD and Russo P: Histologic subtype impacts cancer-specific survival in patients with sarcomatoid-variant renal cell carcinoma treated surgically. World J Urol. 34:539–544. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Farrow GM, Harrison EG Jr, Utz DC and ReMine WH: Sarcomas and sarcomatoid and mixed malignant tumors of the kidney in adults. Cancer. 22:556–563. 1968. View Article : Google Scholar : PubMed/NCBI

3 

Moch H, Cubilla AL, Humphrey PA, Reuter VE and Ulbright TM: The 2016 WHO Classification of tumours of the urinary system and male genital organs-part a: Renal, penile, and testicular tumours. Eur Urol. 70:93–105. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Trudeau V, Larcher A, Sun M, Boehm K, Dell'Oglio P, Sosa J, Tian Z, Fossati N, Briganti A, Shariat SF and Karakiewicz P: Comparison of oncologic outcomes between sarcomatoid and clear cell renal cell carcinoma. World J Urol. 34:1429–1436. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Morra L, Rechsteiner M, Casagrande S, Duc Luu V, Santimaria R, Diener PA, Sulser T, Kristiansen G, Schraml P, Moch H and Soltermann A: Relevance of periostin splice variants in renal cell carcinoma. Am J Pathol. 179:1513–1521. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Bi M, Zhao S, Said JW, Merino MJ, Adeniran AJ, Xie Z, Nawaf CB, Choi J, Belldegrun AS, Pantuck AJ, et al: Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma. Proc Natl Acad Sci USA. 113:2170–2175. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Shuch B, Bratslavsky G, Linehan WM and Srinivasan R: Sarcomatoid renal cell carcinoma: A comprehensive review of the biology and current treatment strategies. Oncologist. 17:46–54. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Jones TD, Eble JN, Wang M, Maclennan GT, Jain S and Cheng L: Clonal divergence and genetic heterogeneity in clear cell renal cell carcinomas with sarcomatoid transformation. Cancer. 104:1195–1203. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Shuch B, Said J, LaRochelle JC, Zhou Y, Li G, Klatte T, Pouliot F, Kabbinavar FF, Belldegrun AS and Pantuck AJ: Histologic evaluation of metastases in renal cell carcinoma with sarcomatoid transformation and its implications for systemic therapy. Cancer. 116:616–624. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Conant JL, Peng Z, Evans MF, Naud S and Cooper K: Sarcomatoid renal cell carcinoma is an example of epithelial-mesenchymal transition. J Clin Pathol. 64:1088–1092. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Siemens J, Lillo C, Dumont RA, Reynolds A, Williams DS, Gillespie PG and Müller U: Cadherin 23 is a component of the tip link in hair-cell stereocilia. Nature. 428:950–955. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Mizutari K, Mutai H, Namba K, Miyanaga Y, Nakano A, Arimoto Y, Masuda S, Morimoto N, Sakamoto H, Kaga K and Matsunaga T: High prevalence of CDH23 mutations in patients with congenital high-frequency sporadic or recessively inherited hearing loss. Orphanet J Rare Dis. 10:602015. View Article : Google Scholar : PubMed/NCBI

13 

Schultz JM, Bhatti R, Madeo AC, Turriff A, Muskett JA, Zalewski CK, King KA, Ahmed ZM, Riazuddin S, Ahmad N, et al: Allelic hierarchy of CDH23 mutations causing non-syndromic deafness DFNB12 or Usher syndrome USH1D in compound heterozygotes. J Med Genet. 48:767–775. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Taniuchi K, Nakagawa H, Hosokawa M, Nakamura T, Eguchi H, Ohigashi H, Ishikawa O, Katagiri T and Nakamura Y: Overexpressed P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases. Cancer Res. 65:3092–3099. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Li H and Durbin R: Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 25:1754–1760. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Li H and Durbin R: Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics. 26:589–595. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Cibulskis K, Lawrence MS, Carter SL, Sivachenko A, Jaffe D, Sougnez C, Gabriel S, Meyerson M, Lander ES and Getz G: Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol. 31:213–219. 2013. View Article : Google Scholar : PubMed/NCBI

18 

McKenna A, Hanna M, Banks E, Sivachenko A, Cibulskis K, Kernytsky A, Garimella K, Altshuler D, Gabriel S, Daly M and DePristo MA: The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20:1297–1303. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Yang H and Wang K: Genomic variant annotation and prioritization with ANNOVAR and wANNOVAR. Nat Protoc. 10:1556–1566. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Chang X and Wang K: wANNOVAR: Annotating genetic variants for personal genomes via the web. J Med Genet. 49:433–436. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Adzhubei I, Jordan DM and Sunyaev SR: Predicting functional effect of human missense mutations using polyphen-2. Curr Protoc Hum Genet. 7:Unit7.20. 2013.PubMed/NCBI

22 

Waterhouse A, Bertoni M, Bienert S, Studer G, Tauriello G, Gumienny R, Heer FT, de Beer TAP, Rempfer C, Bordoli L, et al: SWISS-MODEL: Homology modelling of protein structures and complexes. Nucleic Acids Res. 46:(W1):W296–W303. 2018. View Article : Google Scholar

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2 (Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Ito T, Pei J, Dulaimi E, Menges C, Abbosh PH, Smaldone MC, Chen DY, Greenberg RE, Kutikov A, Viterbo R, et al: Genomic copy number alterations in renal cell carcinoma with sarcomatoid features. J Urol. 195:852–858. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Malouf GG, Ali SM, Wang K, Balasubramanian S, Ross JS, Miller VA, Stephens PJ, Khayat D, Pal SK, Su X, et al: Genomic characterization of renal cell carcinoma with sarcomatoid dedifferentiation pinpoints recurrent genomic alterations. Eur Urol. 70:348–357. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Sircar K, Yoo SY, Majewski T, Wani K, Patel LR, Voicu H, Torres-Garcia W, Verhaak RG, Tannir N, Karam JA, et al: Biphasic elements of sarcomatoid clear cell renal cell carcinomas are molecularly similar to each other, but distinct from, non-sarcomatoid renal carcinomas. J Biphasic Pathol Clin Res. 1:212–224. 2015. View Article : Google Scholar

27 

Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, et al: A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 9:e10005822011. View Article : Google Scholar : PubMed/NCBI

28 

Woo HM, Park HJ, Park MH, Kim BY, Shin JW, Yoo WG and Koo SK: Identification of CDH23 mutations in Korean families with hearing loss by whole-exome sequencing. BMC Med Genet. 15:462014. View Article : Google Scholar : PubMed/NCBI

29 

Kowalski TJ, Pawelczyk M, Rajkowska E, Dudarewicz A and Sliwinska-Kowalska M: Genetic variants of CDH23 associated with noise-induced hearing loss. Otol Neurotol. 35:358–365. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Zhang Q, Peng C, Song J, Zhang Y, Chen J, Song Z, Shou X, Ma Z, Peng H, Jian X, et al: Germline mutations in CDH23, encoding cadherin-related 23, are associated with both familial and sporadic pituitary adenomas. Am J Hum Genet. 100:817–823. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Karlsson MC, Gonzalez SF, Welin J and Fuxe J: Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system. Mol Oncol. 11:781–791. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Zaric J, Joseph JM, Tercier S, Sengstag T, Ponsonnet L, Delorenzi M and Rüegg C: Identification of MAGI1 as a tumor-suppressor protein induced by cyclooxygenase-2 inhibitors in colorectal cancer cells. Oncogene. 31:48–59. 2012. View Article : Google Scholar : PubMed/NCBI

33 

De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, et al: Alzheimer's disease: Early alterationsin brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci. 17:1156–63. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al: Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci. 17:1164–1170. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Vanniya SP, Srisailapathy CRS and Kunka Mohanram R: The tip link protein Cadherin-23: From hearing loss to cancer. Pharmacol Res. 130:25–35. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yu W, Wang X, Wang Y, Jiang Y, Zhang W, Shi H and Li Y: A novel highly frequent single‑nucleotide polymorphism site of cadherin 23 in clear cell renal cell carcinoma with sarcomatoid differentiation based on whole exome sequencing. Oncol Rep 44: 735-746, 2020.
APA
Yu, W., Wang, X., Wang, Y., Jiang, Y., Zhang, W., Shi, H., & Li, Y. (2020). A novel highly frequent single‑nucleotide polymorphism site of cadherin 23 in clear cell renal cell carcinoma with sarcomatoid differentiation based on whole exome sequencing. Oncology Reports, 44, 735-746. https://doi.org/10.3892/or.2020.7613
MLA
Yu, W., Wang, X., Wang, Y., Jiang, Y., Zhang, W., Shi, H., Li, Y."A novel highly frequent single‑nucleotide polymorphism site of cadherin 23 in clear cell renal cell carcinoma with sarcomatoid differentiation based on whole exome sequencing". Oncology Reports 44.2 (2020): 735-746.
Chicago
Yu, W., Wang, X., Wang, Y., Jiang, Y., Zhang, W., Shi, H., Li, Y."A novel highly frequent single‑nucleotide polymorphism site of cadherin 23 in clear cell renal cell carcinoma with sarcomatoid differentiation based on whole exome sequencing". Oncology Reports 44, no. 2 (2020): 735-746. https://doi.org/10.3892/or.2020.7613
Copy and paste a formatted citation
x
Spandidos Publications style
Yu W, Wang X, Wang Y, Jiang Y, Zhang W, Shi H and Li Y: A novel highly frequent single‑nucleotide polymorphism site of cadherin 23 in clear cell renal cell carcinoma with sarcomatoid differentiation based on whole exome sequencing. Oncol Rep 44: 735-746, 2020.
APA
Yu, W., Wang, X., Wang, Y., Jiang, Y., Zhang, W., Shi, H., & Li, Y. (2020). A novel highly frequent single‑nucleotide polymorphism site of cadherin 23 in clear cell renal cell carcinoma with sarcomatoid differentiation based on whole exome sequencing. Oncology Reports, 44, 735-746. https://doi.org/10.3892/or.2020.7613
MLA
Yu, W., Wang, X., Wang, Y., Jiang, Y., Zhang, W., Shi, H., Li, Y."A novel highly frequent single‑nucleotide polymorphism site of cadherin 23 in clear cell renal cell carcinoma with sarcomatoid differentiation based on whole exome sequencing". Oncology Reports 44.2 (2020): 735-746.
Chicago
Yu, W., Wang, X., Wang, Y., Jiang, Y., Zhang, W., Shi, H., Li, Y."A novel highly frequent single‑nucleotide polymorphism site of cadherin 23 in clear cell renal cell carcinoma with sarcomatoid differentiation based on whole exome sequencing". Oncology Reports 44, no. 2 (2020): 735-746. https://doi.org/10.3892/or.2020.7613
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