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Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling

  • Authors:
    • Minglei Zhang
    • Li Chen
    • Yang Liu
    • Minghui Chen
    • Shuang Zhang
    • Daliang Kong
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Oral Radiology, School and Hospital of Stomatology, Jilin University, Changchun, Jilin 130021, P.R. China, Department of Radiology, The Second Affiliated Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Department of Cardiovascular Medicine, The Second Affiliated Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Healthcare Department, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin 130021, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 469-476
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    Published online on: May 19, 2020
       https://doi.org/10.3892/or.2020.7614
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Abstract

Osteosarcoma (OS) has been demonstrated to be difficult to cure due to its potently malignant metastasis. Therefore, new therapeutic approaches blocking the metastatic potential of OS are urgently required to improve the outcomes for OS patients. In the present study, the anti‑metastatic capacity of sea cucumber (Cucumaria frondosa) fucoidan (Cf‑Fuc) was evaluated on osteosarcoma cells by cell adhesion assay, Transwell assay and U2OS cell migration assay. The underlying mechanism on the dynamic remodeling of the cytoskeleton was also explored. The present data indicated that Cf‑Fuc could block the U2OS osteosarcoma cell adhesion to fibronectin and significantly inhibit U2OS cell migration. Cf‑Fuc greatly impaired the migration capacity of U2OS cells, and the migrated distance and velocity of Cf‑Fuc‑treated cells were markedly reduced. Also, Cf‑Fuc could impair the dynamic remodeling of the cytoskeleton possibly by suppressing the phosphorylation of focal adhesion kinase and paxillin, as well as the activation of the Rac1/PAK1/LIMK1/cofilin signaling axis. Collectively, the present findings provide a novel therapeutic potential of C. frondosa fucoidan for osteosarcoma metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang M, Chen L, Liu Y, Chen M, Zhang S and Kong D: Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling. Oncol Rep 44: 469-476, 2020.
APA
Zhang, M., Chen, L., Liu, Y., Chen, M., Zhang, S., & Kong, D. (2020). Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling. Oncology Reports, 44, 469-476. https://doi.org/10.3892/or.2020.7614
MLA
Zhang, M., Chen, L., Liu, Y., Chen, M., Zhang, S., Kong, D."Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling". Oncology Reports 44.2 (2020): 469-476.
Chicago
Zhang, M., Chen, L., Liu, Y., Chen, M., Zhang, S., Kong, D."Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling". Oncology Reports 44, no. 2 (2020): 469-476. https://doi.org/10.3892/or.2020.7614
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang M, Chen L, Liu Y, Chen M, Zhang S and Kong D: Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling. Oncol Rep 44: 469-476, 2020.
APA
Zhang, M., Chen, L., Liu, Y., Chen, M., Zhang, S., & Kong, D. (2020). Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling. Oncology Reports, 44, 469-476. https://doi.org/10.3892/or.2020.7614
MLA
Zhang, M., Chen, L., Liu, Y., Chen, M., Zhang, S., Kong, D."Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling". Oncology Reports 44.2 (2020): 469-476.
Chicago
Zhang, M., Chen, L., Liu, Y., Chen, M., Zhang, S., Kong, D."Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling". Oncology Reports 44, no. 2 (2020): 469-476. https://doi.org/10.3892/or.2020.7614
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