Open Access

Bioinformatics analysis of the network of histone H3 lysine 9 trimethylation in acute myeloid leukaemia

  • Authors:
    • Aishu Dong
    • Wenbin Yang
    • He Huang
    • Xiaohai Zhou
    • Zhewei He
    • Rongxing Yao
    • Wenjian Guo
  • View Affiliations

  • Published online on: May 28, 2020     https://doi.org/10.3892/or.2020.7627
  • Pages: 543-554
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Changes in histone H3 lysine 9 trimethylation (H3K9me3) may be related to the development of drug‑resistant acute myeloid leukaemia (AML); insights into the network of H3K9me3 may improve patient prognosis. Patient data were derived from the Gene Expression Omnibus (GEO) database and data from AML cells treated with chidamide, a novel benzamide chemical class of histone deacetylase inhibitor (HDACi), in vitro were derived from ChIP‑seq. Patients and AML cell data were analysed using GEO2R, GOseq, KOBAS, the STRING database and Cytoscape 3.5.1. We identified several genes related to the upregulation or downregulation of H3K9me3 in AML patients; some of these genes were related to apoptosis, autophagy, and the pathway of cell longevity. AML cells treated with chidamide in vitro showed the same gene changes. The protein interactions in the network did not have significantly more interactions than expected, suggesting the need for more research to identify these interactions. One compelling result from the protein interaction study was that sirtuin 1 (SIRT1) may have an indirect interaction with lysine‑specific demethylase 4A (KDM4A). These results help explain alterations of H3K9me3 in AML that may direct further studies aimed at improving patient prognosis. These results may also provide a basis for chidamide as a treatment strategy for AML patients in the future.

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August-2020
Volume 44 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Dong, A., Yang, W., Huang, H., Zhou, X., He, Z., Yao, R., & Guo, W. (2020). Bioinformatics analysis of the network of histone H3 lysine 9 trimethylation in acute myeloid leukaemia. Oncology Reports, 44, 543-554. https://doi.org/10.3892/or.2020.7627
MLA
Dong, A., Yang, W., Huang, H., Zhou, X., He, Z., Yao, R., Guo, W."Bioinformatics analysis of the network of histone H3 lysine 9 trimethylation in acute myeloid leukaemia". Oncology Reports 44.2 (2020): 543-554.
Chicago
Dong, A., Yang, W., Huang, H., Zhou, X., He, Z., Yao, R., Guo, W."Bioinformatics analysis of the network of histone H3 lysine 9 trimethylation in acute myeloid leukaemia". Oncology Reports 44, no. 2 (2020): 543-554. https://doi.org/10.3892/or.2020.7627