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Article Open Access

Cadmium chloride enhances cisplatin sensitivity in osteosarcoma cells by reducing FOXM1 expression

  • Authors:
    • Konghe Hu
    • Wenquan Xie
    • Songjia Ni
    • Shumin Yan
    • Gaoqiang Tian
    • Weizhong Qi
    • Yang Duan
  • View Affiliations / Copyright

    Affiliations: Department of Spine Surgery, The Affiliated Yuebei People's Hospital of Shantou University Medical College, Shaoguan, Guangdong 512025, P.R. China, Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 650-660
    |
    Published online on: June 4, 2020
       https://doi.org/10.3892/or.2020.7632
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Abstract

Osteosarcoma is a highly malignant disease and is associated with a poor patient prognosis and a high mortality rate. Disease prognosis significantly correlates with chemotherapeutic responses. Cadmium is a heavy metal with specific effects on bone, but its benefits for osteosarcoma treatment have not been characterized. In the present study, cadmium chloride was used to treat MG63 osteosarcoma cells, and their gene expression profiles were assessed by GeneChip technology. We found that forkhead box protein M1 (FOXM1) was downregulated by cadmium chloride, and lentiviral‑mediated silencing of FOXM1 confirmed a role for this factor in the cisplatin resistance of MG63 cells. In nude mice, cadmium chloride enhanced the sensitivity of osteosarcoma to cisplatin, an effect mediated by FOXM1. Collectively, these data indicate that cadmium chloride can alter the sensitivity of osteosarcoma cells to cisplatin through FOXM1, highlighting it as a potential therapeutic target and prognostic factor for osteosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Hu K, Xie W, Ni S, Yan S, Tian G, Qi W and Duan Y: Cadmium chloride enhances cisplatin sensitivity in osteosarcoma cells by reducing FOXM1 expression. Oncol Rep 44: 650-660, 2020.
APA
Hu, K., Xie, W., Ni, S., Yan, S., Tian, G., Qi, W., & Duan, Y. (2020). Cadmium chloride enhances cisplatin sensitivity in osteosarcoma cells by reducing FOXM1 expression. Oncology Reports, 44, 650-660. https://doi.org/10.3892/or.2020.7632
MLA
Hu, K., Xie, W., Ni, S., Yan, S., Tian, G., Qi, W., Duan, Y."Cadmium chloride enhances cisplatin sensitivity in osteosarcoma cells by reducing FOXM1 expression". Oncology Reports 44.2 (2020): 650-660.
Chicago
Hu, K., Xie, W., Ni, S., Yan, S., Tian, G., Qi, W., Duan, Y."Cadmium chloride enhances cisplatin sensitivity in osteosarcoma cells by reducing FOXM1 expression". Oncology Reports 44, no. 2 (2020): 650-660. https://doi.org/10.3892/or.2020.7632
Copy and paste a formatted citation
x
Spandidos Publications style
Hu K, Xie W, Ni S, Yan S, Tian G, Qi W and Duan Y: Cadmium chloride enhances cisplatin sensitivity in osteosarcoma cells by reducing FOXM1 expression. Oncol Rep 44: 650-660, 2020.
APA
Hu, K., Xie, W., Ni, S., Yan, S., Tian, G., Qi, W., & Duan, Y. (2020). Cadmium chloride enhances cisplatin sensitivity in osteosarcoma cells by reducing FOXM1 expression. Oncology Reports, 44, 650-660. https://doi.org/10.3892/or.2020.7632
MLA
Hu, K., Xie, W., Ni, S., Yan, S., Tian, G., Qi, W., Duan, Y."Cadmium chloride enhances cisplatin sensitivity in osteosarcoma cells by reducing FOXM1 expression". Oncology Reports 44.2 (2020): 650-660.
Chicago
Hu, K., Xie, W., Ni, S., Yan, S., Tian, G., Qi, W., Duan, Y."Cadmium chloride enhances cisplatin sensitivity in osteosarcoma cells by reducing FOXM1 expression". Oncology Reports 44, no. 2 (2020): 650-660. https://doi.org/10.3892/or.2020.7632
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