Autophagy regulation by microRNAs in chemotherapy resistance (Review)

  • Authors:
    • Tianqiao Huang
    • Zhen Xu
    • Lin Cao
    • Yuanyuan Lian
    • Yichuan Huang
  • View Affiliations

  • Published online on: June 22, 2020     https://doi.org/10.3892/or.2020.7655
  • Pages: 791-797
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Abstract

Chemotherapy, as an adjuvant therapy, utilizes drugs to treat cancer, and resistance to therapeutic drugs limits the efficacy of chemotherapy treatments. Several mechanisms have been proposed to improve the effect of tumor chemotherapy in order to overcome drug resistance. Among these, autophagy mediated by microRNAs (miRNAs) is one of the primary mechanisms. A large number of molecules targeted by miRNAs are involved in each step of the autophagic pathway. Recent advancement in chemotherapy research has revealed that miRNAs involved in the autophagy process target some of these molecules, thereby influencing the therapeutic effect of chemotherapy drugs. Thus, miRNAs appear to be potential tools or targets with which to suppress tumor growth and should be studied in further details for their clinical application against drug resistance.
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September-2020
Volume 44 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Huang T, Xu Z, Cao L, Lian Y and Huang Y: Autophagy regulation by microRNAs in chemotherapy resistance (Review). Oncol Rep 44: 791-797, 2020
APA
Huang, T., Xu, Z., Cao, L., Lian, Y., & Huang, Y. (2020). Autophagy regulation by microRNAs in chemotherapy resistance (Review). Oncology Reports, 44, 791-797. https://doi.org/10.3892/or.2020.7655
MLA
Huang, T., Xu, Z., Cao, L., Lian, Y., Huang, Y."Autophagy regulation by microRNAs in chemotherapy resistance (Review)". Oncology Reports 44.3 (2020): 791-797.
Chicago
Huang, T., Xu, Z., Cao, L., Lian, Y., Huang, Y."Autophagy regulation by microRNAs in chemotherapy resistance (Review)". Oncology Reports 44, no. 3 (2020): 791-797. https://doi.org/10.3892/or.2020.7655