1
|
Arnold M, Sierra MS, Laversanne M,
Soerjomataram I, Jemal A and Bray F: Global patterns and trends in
colorectal cancer incidence and mortality. Gut. 66:683–691. 2017.
View Article : Google Scholar : PubMed/NCBI
|
2
|
Bray F, Ferlay J, Soerjomataram I, Siegel
RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN
estimates of incidence and mortality worldwide for 36 cancers in
185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI
|
3
|
Dekker E, Tanis PJ, Vleugels JLA, Kasi PM
and Wallace MB: Colorectal cancer. Lancet. 394:1467–1480. 2019.
View Article : Google Scholar : PubMed/NCBI
|
4
|
Prasetyanti PR, van Hooff SR, van
Herwaarden T, de Vries N, Kalloe K, Rodermond H, van Leersum R, de
Jong JH, Franitza M, Nürnberg P, et al: Capturing colorectal cancer
inter-tumor heterogeneity in patient-derived xenograft (PDX)
models. Int J Cancer. 144:366–371. 2019. View Article : Google Scholar : PubMed/NCBI
|
5
|
Mahasneh A, Al-Shaheri F and Jamal E:
Molecular biomarkers for an early diagnosis, effective treatment
and prognosis of colorectal cancer: Current updates. Exp Mol
Pathol. 102:475–483. 2017. View Article : Google Scholar : PubMed/NCBI
|
6
|
Sepulveda AR, Hamilton SR, Allegra CJ,
Grody W, Cushman-Vokoun AM, Funkhouser WK, Kopetz SE, Lieu C,
Lindor NM, Minsky BD, et al: Molecular biomarkers for the
evaluation of colorectal cancer: Guideline from the American
society for clinical pathology, college of American Pathologists,
Association for Molecular Pathology, and the American Society of
Clinical Oncology. J Clin Oncol. 35:1453–1486. 2017. View Article : Google Scholar : PubMed/NCBI
|
7
|
Wang S, Sun C, Li J, Zhang E, Ma Z, Xu W,
Li H, Qiu M, Xu Y, Xia W, et al: Roles of RNA methylation by means
of N6-methyladenosine (m6A) in human cancers.
Cancer Lett. 408:112–120. 2017. View Article : Google Scholar : PubMed/NCBI
|
8
|
Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han
D, Fu Y, Parisien M, Dai Q, Jia G, et al:
N6-methyladenosine-dependent regulation of messenger RNA stability.
Nature. 505:117–120. 2014. View Article : Google Scholar : PubMed/NCBI
|
9
|
Zheng G, Dahl JA, Niu Y, Fedorcsak P,
Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, et al: ALKBH5
is a mammalian RNA demethylase that impacts RNA metabolism and
mouse fertility. Mol Cell. 49:18–29. 2013. View Article : Google Scholar : PubMed/NCBI
|
10
|
Zhao X, Yang Y, Sun BF, Shi Y, Yang X,
Xiao W, Hao YJ, Ping XL, Chen YS, Wang WJ, et al: FTO-dependent
demethylation of N6-methyladenosine regulates mRNA splicing and is
required for adipogenesis. Cell Res. 24:1403–1419. 2014. View Article : Google Scholar : PubMed/NCBI
|
11
|
Fustin JM, Doi M, Yamaguchi Y, Hida H,
Nishimura S, Yoshida M, Isagawa T, Morioka MS, Kakeya H, Manabe I,
et al: RNA-methylation-dependent RNA processing controls the speed
of the circadian clock. Cell. 155:793–806. 2013. View Article : Google Scholar : PubMed/NCBI
|
12
|
Wang Y, Li Y, Toth JI, Petroski MD, Zhang
Z and Zhao JC: N6-methyladenosine modification destabilizes
developmental regulators in embryonic stem cells. Nat Cell Biol.
16:191–198. 2014. View Article : Google Scholar : PubMed/NCBI
|
13
|
Zhang S, Zhao BS, Zhou A, Lin K, Zheng S,
Lu Z, Chen Y, Sulman EP, Xie K, Bögler O, et al: m6A
demethylase ALKBH5 maintains tumorigenicity of glioblastoma
stem-like cells by sustaining FOXM1 expression and cell
proliferation program. Cancer Cell. 31:591–606.e6. 2017. View Article : Google Scholar : PubMed/NCBI
|
14
|
Li Z, Weng H, Su R, Weng X, Zuo Z, Li C,
Huang H, Nachtergaele S, Dong L, Hu C, et al: FTO plays an
oncogenic role in acute myeloid leukemia as a
N6-methyladenosine RNA demethylase. Cancer Cell.
31:127–141. 2017. View Article : Google Scholar : PubMed/NCBI
|
15
|
Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun
G, Lu Z, Huang Y, Yang CG, et al: m6A RNA methylation
regulates the self-renewal and tumorigenesis of glioblastoma stem
cells. Cell Rep. 18:2622–2634. 2017. View Article : Google Scholar : PubMed/NCBI
|
16
|
Lin S, Choe J, Du P, Triboulet R and
Gregory RI: The m(6)A methyltransferase METTL3 promotes translation
in human cancer cells. Mol Cell. 62:335–345. 2016. View Article : Google Scholar : PubMed/NCBI
|
17
|
Wang Q, Chen C, Ding Q, Zhao Y, Wang Z,
Chen J, Jiang Z, Zhang Y, Xu G, Zhang J, et al: METTL3-mediated
m6A modification of HDGF mRNA promotes gastric cancer
progression and has prognostic significance. Gut. 69:1193–1205.
2020. View Article : Google Scholar : PubMed/NCBI
|
18
|
Yue B, Song C, Yang L, Cui R, Cheng X,
Zhang Z and Zhao G: METTL3-mediated N6-methyladenosine modification
is critical for epithelial-mesenchymal transition and metastasis of
gastric cancer. Mol Cancer. 18:1422019. View Article : Google Scholar : PubMed/NCBI
|
19
|
Taketo K, Konno M, Asai A, Koseki J,
Toratani M, Satoh T, Doki Y, Mori M, Ishii H and Ogawa K: The
epitranscriptome m6A writer METTL3 promotes chemo- and
radioresistance in pancreatic cancer cells. Int J Oncol.
52:621–629. 2018.PubMed/NCBI
|
20
|
Wu M, Song D, Li H, Yang Y, Ma X, Deng S,
Ren C and Shu X: Negative regulators of STAT3 signaling pathway in
cancers. Cancer Manag Res. 11:4957–4969. 2019. View Article : Google Scholar : PubMed/NCBI
|
21
|
Jiang M, Zhang WW, Liu P, Yu W, Liu T and
Yu J: Dysregulation of SOCS-mediated negative feedback of cytokine
signaling in carcinogenesis and its significance in cancer
treatment. Front Immunol. 8:702017. View Article : Google Scholar : PubMed/NCBI
|
22
|
Sutherland KD, Lindeman GJ, Choong DY,
Wittlin S, Brentzell L, Phillips W, Campbell IG and Visvader JE:
Differential hypermethylation of SOCS genes in ovarian and breast
carcinomas. Oncogene. 23:7726–7733. 2004. View Article : Google Scholar : PubMed/NCBI
|
23
|
Slattery ML, Lundgreen A, Hines LM,
Torres-Mejia G, Wolff RK, Stern MC and John EM: Genetic variation
in the JAK/STAT/SOCS signaling pathway influences breast
cancer-specific mortality through interaction with cigarette
smoking and use of aspirin/NSAIDs: The Breast Cancer Health
Disparities Study. Breast Cancer Res Treat. 147:145–158. 2014.
View Article : Google Scholar : PubMed/NCBI
|
24
|
Das R, Gregory PA, Fernandes RC, Denis I,
Wang Q, Townley SL, Zhao SG, Hanson AR, Pickering MA, Armstrong HK,
et al: MicroRNA-194 promotes prostate cancer metastasis by
inhibiting SOCS2. Cancer Res. 77:1021–1034. 2017. View Article : Google Scholar : PubMed/NCBI
|
25
|
Vitali C, Bassani C, Chiodoni C, Fellini
E, Guarnotta C, Miotti S, Sangaletti S, Fuligni F, De Cecco L,
Piccaluga PP, et al: SOCS2 controls proliferation and stemness of
hematopoietic cells under stress conditions and its deregulation
marks unfavorable acute leukemias. Cancer Res. 75:2387–2399. 2015.
View Article : Google Scholar : PubMed/NCBI
|
26
|
de Sousa e Melo F, Kurtova AV, Harnoss JM,
Kljavin N, Hoeck JD, Hung J, Anderson JE, Storm EE, Modrusan Z,
Koeppen H, et al: A distinct role for Lgr5+ stem cells
in primary and metastatic colon cancer. Nature. 543:676–680. 2017.
View Article : Google Scholar : PubMed/NCBI
|
27
|
Shimokawa M, Ohta Y, Nishikori S, Matano
M, Takano A, Fujii M, Date S, Sugimoto S, Kanai T and Sato T:
Visualization and targeting of LGR5+ human colon cancer
stem cells. Nature. 545:187–192. 2017. View Article : Google Scholar : PubMed/NCBI
|
28
|
Stanisavljević L, Myklebust MP, Leh S and
Dahl O: LGR5 and CD133 as prognostic and predictive markers for
fluoropyrimidine-based adjuvant chemotherapy in colorectal cancer.
Acta Oncol. 55:1425–1433. 2016. View Article : Google Scholar : PubMed/NCBI
|
29
|
Shannon P, Markiel A, Ozier O, Baliga NS,
Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A
software environment for integrated models of biomolecular
interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI
|
30
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
31
|
Li HB, Tong J, Zhu S, Batista PJ, Duffy
EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, et al:
m6A mRNA methylation controls T cell homeostasis by
targeting the IL-7/STAT5/SOCS pathways. Nature. 548:338–342. 2017.
View Article : Google Scholar : PubMed/NCBI
|
32
|
Karoopongse E, Yeung C, Byon J,
Ramakrishnan A, Holman ZJ, Jiang PY, Yu Q, Deeg HJ and Marcondes
AM: The KDM2B-let-7b-EZH2 axis in myelodysplastic syndromes as a
target for combined epigenetic therapy. PLoS One. 9:e1078172014.
View Article : Google Scholar : PubMed/NCBI
|
33
|
Jing N, Huang T, Guo H, Yang J, Li M, Chen
Z and Zhang Y: LncRNA CASC15 promotes colon cancer cell
proliferation and metastasis by regulating the
miR4310/LGR5/Wnt/β-catenin signaling pathway. Mol Med Rep.
18:2269–2276. 2018.PubMed/NCBI
|
34
|
Gopalan V, Ebrahimi F, Islam F, Vider J,
Qallandar OB, Pillai S, Lu CT and Lam AK: Tumour suppressor
properties of miR-15a and its regulatory effects on BCL2 and SOX2
proteins in colorectal carcinomas. Exp Cell Res. 370:245–253. 2018.
View Article : Google Scholar : PubMed/NCBI
|
35
|
Alcantara-Flores E, Brechu-Franco AE,
Garcia-Lopez P, Rocha-Zavaleta L, Lopez-Marure R and
Martinez-Vazquez M: Argentatin B inhibits proliferation of prostate
and colon cancer cells by inducing cell senescence. Molecules.
20:21125–21137. 2015. View Article : Google Scholar : PubMed/NCBI
|
36
|
Gong S, Xu D, Zhu J, Zou F and Peng R:
Efficacy of the MEK inhibitor cobimetinib and its potential
application to colorectal cancer cells. Cell Physiol Biochem.
47:680–693. 2018. View Article : Google Scholar : PubMed/NCBI
|
37
|
Chen M, Wei L, Law CT, Tsang FH, Shen J,
Cheng CL, Tsang LH, Ho DW, Chiu DK, Lee JM, et al: RNA
N6-methyladenosine methyltransferase-like 3 promotes liver cancer
progression through YTHDF2-dependent posttranscriptional silencing
of SOCS2. Hepatology. 67:2254–2270. 2018. View Article : Google Scholar : PubMed/NCBI
|
38
|
Zhao X, Zhang W and Ji W: miR-196b is a
prognostic factor of human laryngeal squamous cell carcinoma and
promotes tumor progression by targeting SOCS2. Biochem Biophys Res
Commun. 501:584–592. 2018. View Article : Google Scholar : PubMed/NCBI
|
39
|
Zhou Y, Zhang Z, Wang N, Chen J, Zhang X,
Guo M, John ZL and Wang Q: Suppressor of cytokine signalling-2
limits IGF1R-mediated regulation of epithelial-mesenchymal
transition in lung adenocarcinoma. Cell Death Dis. 9:4292018.
View Article : Google Scholar : PubMed/NCBI
|
40
|
Chhabra Y, Wong HY, Nikolajsen LF,
Steinocher H, Papadopulos A, Tunny KA, Meunier FA, Smith AG,
Kragelund BB, Brooks AJ, et al: A growth hormone receptor SNP
promotes lung cancer by impairment of SOCS2-mediated degradation.
Oncogene. 37:489–501. 2018. View Article : Google Scholar : PubMed/NCBI
|
41
|
Hatano Y, Fukuda S, Hisamatsu K, Hirata A,
Hara A and Tomita H: Multifaceted Interpretation of Colon Cancer
Stem Cells. Int J Mol Sci. 18:14462017. View Article : Google Scholar
|
42
|
Chen X, Wei B, Han X, Zheng Z, Huang J,
Liu J, Huang Y and Wei H: LGR5 is required for the maintenance of
spheroid-derived colon cancer stem cells. Int J Mol Med. 34:35–42.
2014. View Article : Google Scholar : PubMed/NCBI
|
43
|
Skrzypczak M, Goryca K, Rubel T, Paziewska
A, Mikula M, Jarosz D, Pachlewski J, Oledzki J and Ostrowski J:
Modeling oncogenic signaling in colon tumors by multidirectional
analyses of microarray data directed for maximization of analytical
reliability. PLoS One. 5:e130912010. View Article : Google Scholar : PubMed/NCBI
|
44
|
Graudens E, Boulanger V, Mollard C,
Mariage-Samson R, Barlet X, Gremy G, Couillault C, Lajemi M,
Piatier-Tonneau D, Zaborski P, et al: Deciphering cellular states
of innate tumor drug responses. Genome Biol. 7:R192006. View Article : Google Scholar : PubMed/NCBI
|
45
|
Sabates-Bellver J, Van der Flier LG, de
Palo M, Cattaneo E, Maake C, Rehrauer H, Laczko E, Kurowski MA,
Bujnicki JM, Menigatti M, et al: Transcriptome profile of human
colorectal adenomas. Mol Cancer Res. 5:1263–1275. 2007. View Article : Google Scholar : PubMed/NCBI
|
46
|
Kaiser S, Park YK, Franklin JL, Halberg
RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga AG, et
al: Transcriptional recapitulation and subversion of embryonic
colon development by mouse colon tumor models and human colon
cancer. Genome Biol. 8:R1312007. View Article : Google Scholar : PubMed/NCBI
|
47
|
Hong Y, Downey T, Eu KW, Koh PK and Cheah
PY: A ‘metastasis-prone’ signature for early-stage mismatch-repair
proficient sporadic colorectal cancer patients and its implications
for possible therapeutics. Clin Exp Metastasis. 27:83–90. 2010.
View Article : Google Scholar : PubMed/NCBI
|
48
|
Gaedcke J, Grade M, Jung K, Camps J, Jo P,
Emons G, Gehoff A, Sax U, Schirmer M, Becker H, et al: Mutated KRAS
results in overexpression of DUSP4, a MAP-kinase phosphatase, and
SMYD3, a histone methyltransferase, in rectal carcinomas. Genes
Chromosomes Cancer. 49:1024–1034. 2010. View Article : Google Scholar : PubMed/NCBI
|
49
|
Alon U, Barkai N, Notterman DA, Gish K,
Ybarra S, Mack D and Levine AJ: Broad patterns of gene expression
revealed by clustering analysis of tumor and normal colon tissues
probed by oligonucleotide arrays. Proc Natl Acad Sci USA.
96:6745–6750. 1999. View Article : Google Scholar : PubMed/NCBI
|
50
|
Notterman DA, Alon U, Sierk AJ and Levine
AJ: Transcriptional gene expression profiles of colorectal adenoma,
adenocarcinoma, and normal tissue examined by oligonucleotide
arrays. Cancer Res. 61:3124–3130. 2001.PubMed/NCBI
|
51
|
Ki DH, Jeung HC, Park CH, Kang SH, Lee GY,
Lee WS, Kim NK, Chung HC and Rha SY: Whole genome analysis for
liver metastasis gene signatures in colorectal cancer. Int J
Cancer. 121:2005–2012. 2007. View Article : Google Scholar : PubMed/NCBI
|
52
|
Gaspar C, Cardoso J, Franken P, Molenaar
L, Morreau H, Moslein G, Sampson J, Boer JM, de Menezes RX and
Fodde R: Cross-species comparison of human and mouse intestinal
polyps reveals conserved mechanisms in adenomatous polyposis coli
(APC)-driven tumorigenesis. Am J Pathol. 172:1363–1380. 2008.
View Article : Google Scholar : PubMed/NCBI
|
53
|
Dominissini D, Moshitch-Moshkovitz S,
Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K,
Jacob-Hirsch J, Amariglio N, Kupiec M, et al: Topology of the human
and mouse m6A RNA methylomes revealed by m6A-seq. Nature.
485:201–206. 2012. View Article : Google Scholar : PubMed/NCBI
|
54
|
Yang D, Qiao J, Wang G, Lan Y, Li G, Guo
X, Xi J, Ye D, Zhu S, Chen W, et al: N6-methyladenosine
modification of lincRNA 1281 is critically required for mESC
differentiation potential. Nucleic Acids Res. 46:3906–3920. 2018.
View Article : Google Scholar : PubMed/NCBI
|
55
|
Bertero A, Brown S, Madrigal P, Osnato A,
Ortmann D, Yiangou L, Kadiwala J, Hubner NC, de Los MI, Sadee C, et
al: The SMAD2/3 interactome reveals that TGFβ controls
m6A mRNA methylation in pluripotency. Nature.
555:256–259. 2018. View Article : Google Scholar : PubMed/NCBI
|
56
|
Deng X, Su R, Weng H, Huang H, Li Z and
Chen J: RNA N(6)-methyladenosine modification in cancers: Current
status and perspectives. Cell Res. 28:507–517. 2018. View Article : Google Scholar : PubMed/NCBI
|
57
|
Vu LP, Pickering BF, Cheng Y, Zaccara S,
Nguyen D, Minuesa G, Chou T, Chow A, Saletore Y, MacKay M, et al:
The N6-methyladenosine (m6A)-forming enzyme
METTL3 controls myeloid differentiation of normal hematopoietic and
leukemia cells. Nat Med. 23:1369–1376. 2017. View Article : Google Scholar : PubMed/NCBI
|
58
|
Visvanathan A, Patil V, Arora A, Hegde AS,
Arivazhagan A, Santosh V and Somasundaram K: Essential role of
METTL3-mediated m6A modification in glioma stem-like
cells maintenance and radioresistance. Oncogene. 37:522–533. 2018.
View Article : Google Scholar : PubMed/NCBI
|
59
|
Cai X, Wang X, Cao C, Gao Y, Zhang S, Yang
Z, Liu Y, Zhang X, Zhang W and Ye L: HBXIP-elevated
methyltransferase METTL3 promotes the progression of breast cancer
via inhibiting tumor suppressor let-7g. Cancer Lett. 415:11–19.
2018. View Article : Google Scholar : PubMed/NCBI
|
60
|
Barbieri I, Tzelepis K, Pandolfini L, Shi
J, Millan-Zambrano G, Robson SC, Aspris D, Migliori V, Bannister
AJ, Han N, et al: Promoter-bound METTL3 maintains myeloid leukaemia
by m6A-dependent translation control. Nature.
552:126–131. 2017. View Article : Google Scholar : PubMed/NCBI
|
61
|
Dimitriou ID, Clemenza L, Scotter AJ, Chen
G, Guerra FM and Rottapel R: Putting out the fire: Coordinated
suppression of the innate and adaptive immune systems by SOCS1 and
SOCS3 proteins. Immunol Rev. 224:265–283. 2008. View Article : Google Scholar : PubMed/NCBI
|
62
|
Palmer DC and Restifo NP: Suppressors of
cytokine signaling (SOCS) in T cell differentiation, maturation,
and function. Trends Immunol. 30:592–602. 2009. View Article : Google Scholar : PubMed/NCBI
|
63
|
Letellier E and Haan S: SOCS2:
Physiological and pathological functions. Front Biosci (Elite Ed).
8:189–204. 2016.PubMed/NCBI
|
64
|
Newton VA, Ramocki NM, Scull BP, Simmons
JG, McNaughton K and Lund PK: Suppressor of cytokine signaling-2
gene disruption promotes Apc(Min/+) tumorigenesis and activator
protein-1 activation. Am J Pathol. 176:2320–2332. 2010. View Article : Google Scholar : PubMed/NCBI
|
65
|
Miller ME, Michaylira CZ, Simmons JG, Ney
DM, Dahly EM, Heath JK and Lund PK: Suppressor of cytokine
signaling-2: A growth hormone-inducible inhibitor of intestinal
epithelial cell proliferation. Gastroenterology. 127:570–581. 2004.
View Article : Google Scholar : PubMed/NCBI
|
66
|
Letellier E, Schmitz M, Baig K, Beaume N,
Schwartz C, Frasquilho S, Antunes L, Marcon N, Nazarov PV, Vallar
L, et al: Identification of SOCS2 and SOCS6 as biomarkers in human
colorectal cancer. Br J Cancer. 111:726–735. 2014. View Article : Google Scholar : PubMed/NCBI
|
67
|
Slattery ML, Lundgreen A, Kadlubar SA,
Bondurant KL and Wolff RK: JAK/STAT/SOCS-signaling pathway and
colon and rectal cancer. Mol Carcinog. 52:155–166. 2013. View Article : Google Scholar : PubMed/NCBI
|
68
|
Hanahan D and Weinberg RA: Hallmarks of
cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI
|
69
|
Barker N, van Es JH, Kuipers J, Kujala P,
van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H,
Peters PJ, et al: Identification of stem cells in small intestine
and colon by marker gene Lgr5. Nature. 449:1003–1007. 2007.
View Article : Google Scholar : PubMed/NCBI
|
70
|
Jiang Y, Li W, He X, Zhang H, Jiang F and
Chen Z: Lgr5 expression is a valuable prognostic factor for
colorectal cancer: Evidence from a meta-analysis. BMC Cancer.
16:122016. View Article : Google Scholar : PubMed/NCBI
|