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Article Open Access

Long non‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis

Retraction in: /10.3892/or.2021.8129
  • Authors:
    • Jihong Wen
    • Shumei Han
    • Man Cui
    • Yanli Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
    Copyright: © Wen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1375-1384
    |
    Published online on: July 17, 2020
       https://doi.org/10.3892/or.2020.7694
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Abstract

The long non‑coding RNA (lncRNA) MCM3AP antisense 1 (MCM3AP‑AS1) has previously been shown to be a key regulator of multiple types of cancer; however whether it is important in the context of ovarian cancer (OC) is uncertain. The present study determined that MCM3AP‑AS1 expression in samples from patients with OC was significantly increased, and was associated with tumor stage, presence of lymph node metastases and poorer overall survival. The role of this lncRNA was investigated in vitro, and it was observed that knockdown of MCM3AP‑AS1 impaired OC cell proliferation, migration and colony formation. Similarly, it disrupted tumor growth in vivo. The present study further determined that MCM3AP‑AS1 was able to directly interact with microRNA (miRNA or miR)‑143‑3p as a competing endogenous (ce)RNA for this miRNA, thereby regulating the expression of transforming growth factor‑β‑activated kinase 1 (TAK1), a known target of miR‑143‑3p in OC. Consistent with this, inhibition of miR‑143‑3p was sufficient to partially reverse the effects of MCM3AP‑AS1‑knockdown, which inhibited the proliferation, migration and invasion of OC cells. Together, these results indicate that MCM3AP‑AS1 serves as an oncogenic lncRNA in OC by binding to miR‑143‑3p and thereby promoting TAK1 expression, and suggest that this lncRNA may be a possible target for therapy in OC.
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1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Dembo AJ, Davy M, Stenwig AE, Berle EJ, Bush RS and Kjorstad K: Prognostic factors in patients with stage I epithelial ovarian cancer. Obstet Gynecol. 75:263–273. 1990.PubMed/NCBI

3 

Permuth-Wey J and Sellers TA: Epidemiology of ovarian cancer. Methods Mol Biol. 472:413–437. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Kornienko AE, Guenzl PM, Barlow DP and Pauler FM: Gene regulation by the act of long non-coding RNA transcription. BMC Biol. 11:592013. View Article : Google Scholar : PubMed/NCBI

5 

Geisler S and Coller J: RNA in unexpected places: Long non-coding RNA functions in diverse cellular contexts. Nat Rev Mol Cell Biol. 14:699–712. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Ponting CP, Oliver PL and Reik W: Evolution and functions of long noncoding RNAs. Cell. 136:629–641. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Zhan L, Li J and Wei B: Long non-coding RNAs in ovarian cancer. J Exp Clin Cancer Res. 37:1202018. View Article : Google Scholar : PubMed/NCBI

8 

Zhong Y, Gao D, He S, Shuai C and Peng S: Dysregulated expression of long noncoding RNAs in ovarian cancer. Int J Gynecol Cancer. 26:1564–1570. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Li X, Yu M and Yang C: YY1-mediated overexpression of long noncoding RNA MCM3AP-AS1 accelerates angiogenesis and progression in lung cancer by targeting miR-340-5p/KPNA4 axis. J Cell Biochem. 121:2258–2267. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Zhang H, Luo C and Zhang G: LncRNA MCM3AP-AS1 regulates epidermal growth factor receptor and autophagy to promote hepatocellular carcinoma metastasis by interacting with miR-455. DNA Cell Biol. 38:857–864. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Wang Y, Yang L, Chen T, Liu X, Guo Y, Zhu Q, Tong X, Yang W, Xu Q, Huang D and Tu K: A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis. Mol Cancer. 18:282019. View Article : Google Scholar : PubMed/NCBI

12 

Liang M, Jia J, Chen L, Wei B, Guan Q, Ding Z, Yu J, Pang R and He G: LncRNA MCM3AP-AS1 promotes proliferation and invasion through regulating miR-211-5p/SPARC axis in papillary thyroid cancer. Endocrine. 65:318–326. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Yang C, Zheng J, Xue Y, Yu H, Liu X, Ma J, Liu L, Wang P, Li Z, Cai H and Liu Y: The effect of MCM3AP-AS1/miR-211/KLF5/AGGF1 axis regulating glioblastoma aangiogenesis. Front Mol Neurosci. 10:4372018. View Article : Google Scholar : PubMed/NCBI

14 

Wang R, Ma Z, Feng L, Yang Y, Tan C, Shi Q, Lian M, He S, Ma H and Fang J: LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumorigenesis by promoting cell-cycle progression. Mol Cancer. 17:1622018. View Article : Google Scholar : PubMed/NCBI

15 

Shi H, Shen H, Xu J, Zhao S, Yao S and Jiang N: MiR-143-3p suppresses the progression of ovarian cancer. Am J Transl Res. 10:866–874. 2018.PubMed/NCBI

16 

Wang JY, Lu AQ and Chen LJ: LncRNAs in ovarian cancer. Clin Chim Acta. 490:17–27. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Nikpayam E, Tasharrofi B, Sarrafzadeh S and Ghafouri-Fard S: The role of long non-coding RNAs in ovarian cancer. Iran Biomed J. 21:3–15. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Chan JJ and Tay Y: Noncoding RNA:RNA regulatory networks in cancer. Int J Mol Sci. 19:E13102018. View Article : Google Scholar : PubMed/NCBI

19 

Qi X, Zhang DH, Wu N, Xiao JH, Wang X and Ma W: ceRNA in cancer: Possible functions and clinical implications. J Med Genet. 52:710–718. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Ulitsky I: Interactions between short and long noncoding RNAs. FEBS Lett. 592:2874–2883. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Xie F, Li C, Zhang X, Peng W and Wen T: MiR-143-3p suppresses tumorigenesis in pancreatic ductal adenocarcinoma by targeting KRAS. Biomed Pharmacother. 119:1094242019. View Article : Google Scholar : PubMed/NCBI

22 

Qian Y, Teng Y, Li Y, Lin X, Guan M, Li Y, Cao X and Gao Y: MiR-143-3p suppresses the progression of nasal squamous cell carcinoma by targeting Bcl-2 and IGF1R. Biochem Biophys Res Commun. 518:492–499. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Li D, Hu J, Song H, Xu H, Wu C, Zhao B, Xie D, Wu T, Zhao J and Fang L: miR-143-3p targeting LIM domain kinase 1 suppresses the progression of triple-negative breast cancer cells. Am J Transl Res. 9:2276–2285. 2017.PubMed/NCBI

24 

Zhang H and Li W: Dysregulation of micro-143-3p and BALBP1 contributes to the pathogenesis of the development of ovarian carcinoma. Oncol Rep. 36:3605–3610. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Aashaq S, Batool A and Andrabi KI: TAK1 mediates convergence of cellular signals for death and survival. Apoptosis. 24:3–20. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Neumann D: Is TAK1 a direct upstream kinase of AMPK? Int J Mol Sci. 19:E24122018. View Article : Google Scholar : PubMed/NCBI

27 

Mukhopadhyay H and Lee NY: Multifaceted roles of TAK1 signaling in cancer. Oncogene. 39:1402–1413. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Kilty I and Jones LH: TAK1 selective inhibition: State of the art and future opportunities. Future Med Chem. 7:23–33. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Cai PC, Shi L, Liu VW, Tang HW, Liu IJ, Leung TH, Chan KK, Yam JW, Yao KM, Ngan HY and Chem DW: Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κB signaling. Oncotarget. 5:7549–7562. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Ataie-Kachoie P, Badar S, Morris DL and Pourgholami MH: Minocycline targets the NF-κB nexus through suppression of TGF-β1-TAK1-IκB signaling in ovarian cancer. Mol Cancer Res. 11:1279–1291. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wen J, Han S, Cui M and Wang Y: Long non‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis Retraction in /10.3892/or.2021.8129. Oncol Rep 44: 1375-1384, 2020.
APA
Wen, J., Han, S., Cui, M., & Wang, Y. (2020). Long non‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis Retraction in /10.3892/or.2021.8129. Oncology Reports, 44, 1375-1384. https://doi.org/10.3892/or.2020.7694
MLA
Wen, J., Han, S., Cui, M., Wang, Y."Long non‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis Retraction in /10.3892/or.2021.8129". Oncology Reports 44.4 (2020): 1375-1384.
Chicago
Wen, J., Han, S., Cui, M., Wang, Y."Long non‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis Retraction in /10.3892/or.2021.8129". Oncology Reports 44, no. 4 (2020): 1375-1384. https://doi.org/10.3892/or.2020.7694
Copy and paste a formatted citation
x
Spandidos Publications style
Wen J, Han S, Cui M and Wang Y: Long non‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis Retraction in /10.3892/or.2021.8129. Oncol Rep 44: 1375-1384, 2020.
APA
Wen, J., Han, S., Cui, M., & Wang, Y. (2020). Long non‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis Retraction in /10.3892/or.2021.8129. Oncology Reports, 44, 1375-1384. https://doi.org/10.3892/or.2020.7694
MLA
Wen, J., Han, S., Cui, M., Wang, Y."Long non‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis Retraction in /10.3892/or.2021.8129". Oncology Reports 44.4 (2020): 1375-1384.
Chicago
Wen, J., Han, S., Cui, M., Wang, Y."Long non‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis Retraction in /10.3892/or.2021.8129". Oncology Reports 44, no. 4 (2020): 1375-1384. https://doi.org/10.3892/or.2020.7694
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