Open Access

sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells

  • Authors:
    • Shaoxuan Wu
    • Xudong Zhang
    • Meng Dong
    • Zhenzhen Yang
    • Mingzhi Zhang
    • Qingjiang Chen
  • View Affiliations

  • Published online on: August 10, 2020     https://doi.org/10.3892/or.2020.7722
  • Pages: 1467-1478
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Extranodal natural killer (NK)/T cell lymphoma, nasal type (ENKL) is a rare type of non‑Hodgkin's lymphoma that is associated with limited effective treatment options and unfavorable survival rate, which is partly the result of multidrug resistance (MDR). The presence of side population (SP) cells‑SNK‑6/ADM‑SP (SSP) cells has been previously used to explore mechanisms of drug resistance. ATP‑binding cassette subfamily G member 2 (ABCG2) is a gene involved in MDR and is closely associated with SPs. However, the function of ABCG2 in SSP cells is unclear. The present study verified the high expression of ABCG2 in SSP cells. The IC50 values of doxorubicin, cytarabine, cisplatin, gemcitabine and l‑asparaginase were tested to evaluate drug sensitivity in SSP cells with different levels of ABCG2 expression. ABCG2 was identified as a gene promoting in MDR. ABCG2 upregulated cell proliferation, increased clonogenicity, increased invasive ability and decreased apoptosis, in vivo and in vitro, when cells were treated with gemcitabine. To conclude, ABCG2 enhanced MDR and increased the typical biological characteristics associated with cancer cells in SP cells. With further investigation of the ABCG2 gene could have the potential to reverse MDR in ENKL.
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October-2020
Volume 44 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wu S, Zhang X, Dong M, Yang Z, Zhang M and Chen Q: sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells. Oncol Rep 44: 1467-1478, 2020
APA
Wu, S., Zhang, X., Dong, M., Yang, Z., Zhang, M., & Chen, Q. (2020). sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells. Oncology Reports, 44, 1467-1478. https://doi.org/10.3892/or.2020.7722
MLA
Wu, S., Zhang, X., Dong, M., Yang, Z., Zhang, M., Chen, Q."sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells". Oncology Reports 44.4 (2020): 1467-1478.
Chicago
Wu, S., Zhang, X., Dong, M., Yang, Z., Zhang, M., Chen, Q."sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells". Oncology Reports 44, no. 4 (2020): 1467-1478. https://doi.org/10.3892/or.2020.7722