Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
October-2020 Volume 44 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2020 Volume 44 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells

  • Authors:
    • Shaoxuan Wu
    • Xudong Zhang
    • Meng Dong
    • Zhenzhen Yang
    • Mingzhi Zhang
    • Qingjiang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1467-1478
    |
    Published online on: August 10, 2020
       https://doi.org/10.3892/or.2020.7722
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Extranodal natural killer (NK)/T cell lymphoma, nasal type (ENKL) is a rare type of non‑Hodgkin's lymphoma that is associated with limited effective treatment options and unfavorable survival rate, which is partly the result of multidrug resistance (MDR). The presence of side population (SP) cells‑SNK‑6/ADM‑SP (SSP) cells has been previously used to explore mechanisms of drug resistance. ATP‑binding cassette subfamily G member 2 (ABCG2) is a gene involved in MDR and is closely associated with SPs. However, the function of ABCG2 in SSP cells is unclear. The present study verified the high expression of ABCG2 in SSP cells. The IC50 values of doxorubicin, cytarabine, cisplatin, gemcitabine and l‑asparaginase were tested to evaluate drug sensitivity in SSP cells with different levels of ABCG2 expression. ABCG2 was identified as a gene promoting in MDR. ABCG2 upregulated cell proliferation, increased clonogenicity, increased invasive ability and decreased apoptosis, in vivo and in vitro, when cells were treated with gemcitabine. To conclude, ABCG2 enhanced MDR and increased the typical biological characteristics associated with cancer cells in SP cells. With further investigation of the ABCG2 gene could have the potential to reverse MDR in ENKL.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Jaccard A and Hermine O: A major turning point in NK/T-cell lymphoma? Blood. 129:2342–2343. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Tse E and Kwong YL: Nasal NK/T-cell lymphoma: RT, CT, or both. Blood. 126:1400–1401. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Haverkos BM, Pan Z, Gru AA, Freud AG, Rabinovitch R, Xu-Welliver M, Otto B, Barrionuevo C, Baiocchi RA, Rochford R and Porcu P: Extranodal NK/T cell lymphoma, nasal type (ENKTL-NT): An update on epidemiology, clinical presentation, and natural history in north American and european cases. Curr Hematol Malig Rep. 11:514–527. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Johnson WT and Mishra A: The EZ-riding NK/T-cell lymphoma. Blood. 134:1999–2000. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Somasundaram N, Lim JQ, Ong CK and Lim ST: Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL). J Hematol Oncol. 12:282019. View Article : Google Scholar : PubMed/NCBI

6 

Kucuk C, Jiang B, Hu X, Zhang W, Chan JKC, Xiao W, Lack N, Alkan C, Williams JC, Avery KN, et al: Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells. Nat Commun. 6:60252015. View Article : Google Scholar : PubMed/NCBI

7 

Chen YW, Guo T, Shen L, Wong KY, Tao Q, Choi WWL, Au-Yeung RKH, Chan YP, Wong MLY, Tang JCO, et al: Receptor-type tyrosine-protein phosphatase κ directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma. Blood. 125:1589–1600. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Kwong YL, Chan TSY, Tan D, Kim SJ, Poon LM, Mow B, Khong PL, Loong F, Au-Yeung R, Iqbal J, et al: PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing l-asparaginase. Blood. 129:2437–2442. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Wang Y and Teng JS: Increased multi-drug resistance and reduced apoptosis in osteosarcoma side population cells are crucial factors for tumor recurrence. Exp Ther Med. 12:81–86. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Kim MC, D'Costa S, Suter S and Kim Y: Evaluation of a side population of canine lymphoma cells using Hoechst 33342 dye. J Vet Sci. 14:481–486. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Moti N, Malcolm T, Hamoudi R, Mian S, Garland G, Hook CE, Burke GAA, Wasik MA, Merkel O, Kenner L, et al: Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin. Oncogene. 34:1843–1852. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Teshima K, Nara M, Watanabe A, Ito M, Ikeda S, Hatano Y, Oshima K, Seto M, Sawada K and Tagawa H: Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti- apoptotic potential in the side population of refractory mantle cell lymphoma. Oncogene. 33:2191–2203. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Yamazaki J, Mizukami T, Takizawa K, Kuramitsu M, Momose H, Masumi A, Ami Y, Hasegawa H, Hall WW, Tsujimoto H, et al: Identification of cancer stem cells in a tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma. Blood. 114:2709–2720. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Zabierowski SE and Herlyn M: Learning the ABCs of melanoma-initiating cells. Cancer Cell. 13:185–187. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Zhang X, Fu X, Dong M, Yang Z, Wu S, Ma M, Li Z, Wang X, Li L, Li X, et al: Conserved cell populations in doxorubicin- resistant human nasal natural killer/T cell lymphoma cell line: Super multidrug resistanT cells? Cancer Cell Int. 18:1502018. View Article : Google Scholar : PubMed/NCBI

16 

Mo W and Zhang JT: Human ABCG2: Structure, function, and its role in multidrug resistance. Int J Biochem Mol Biol. 3:1–27. 2012.PubMed/NCBI

17 

Mao Q and Unadkat JD: Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport-an update. AAPS J. 17:65–82. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Noguchi K, Katayama K and Sugimoto Y: Human ABC transporter ABCG2/BCRP expression in chemoresistance: Basic and clinical perspectives for molecular cancer therapeutics. Pharmgenomics Pers Med. 7:53–64. 2014.PubMed/NCBI

19 

Nagata H, Konno A, Kimura N, Zhang Y, Kimura M, Demachi A, Sekine T, Yamamoto K and Shimizu N: Characterization of novel natural killer (NK)-cell and gammadelta T-cell lines established from primary lesions of nasal T/NK-cell lymphomas associated with the epstein-barr virus. Blood. 97:708–713. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Li Z, Zhang X, Xue W, Zhang Y, Li C, Song Y, Mei M, Lu L, Wang Y, Zhou Z, et al: Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma. Nat Commun. 10:42092019. View Article : Google Scholar : PubMed/NCBI

21 

Manska S, Octaviano R and Rossetto CC: 5-Ethynyl- 2′-deoxycytidine and 5-ethynyl-2′-deoxyuridine are differentially incorporated in cells infected with HSV-1, HCMV, and KSHV viruses. J Biol Chem. 295:5871–5890. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Ghosh S and Mukherjee S: Testicular germ cell apoptosis and sperm defects in mice upon long-term high fat diet feeding. J Cell Physiol. 233:6896–6909. 2018. View Article : Google Scholar : PubMed/NCBI

24 

To KKW, Poon DC, Wei Y, Wang F, Lin G and Fu L: Pelitinib (EKB-569) targets the up-regulation of ABCB1 and ABCG2 induced by hyperthermia to eradicate lung cancer. Br J Pharmacol. 172:4089–4106. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Ji N, Yang Y, Cai CY, Lei ZN, Wang JQ, Gupta P, Shukla S, Ambudkar SV, Kong D and Chen ZS: Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells. Cancer Lett. 440-441:82–93. 2019. View Article : Google Scholar : PubMed/NCBI

26 

To KKW, Poon DC, Wei Y, Wang F, Lin G and Fu LW: Vatalanib sensitizes ABCB1 and ABCG2-overexpressing multidrug resistant colon cancer cells to chemotherapy under hypoxia. Biochem Pharmacol. 97:27–37. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Campbell GR, To RK and Spector SA: TREM-1 protects HIV-1-infected macrophages from apoptosis through maintenance of mitochondrial function. mBio. 10:e02638–19. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Riedell PA and Smith SM: Double hit and double expressors in lymphoma: Definition and treatment. Cancer. 124:4622–4632. 2018. View Article : Google Scholar : PubMed/NCBI

29 

de Mel S, Hue SSS, Jeyasekharan AD, Chng WJ and Ng SB: Molecular pathogenic pathways in extranodal NK/T cell lymphoma. J Hematol Oncol. 12:332019. View Article : Google Scholar : PubMed/NCBI

30 

Hu J, Li J, Yue X, Wang J, Liu J, Sun L and Kong D: Expression of the cancer stem cell markers ABCG2 and OCT-4 in right-sided colon cancer predicts recurrence and poor outcomes. Oncotarget. 8:28463–28470. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Farhana L, Nangia-Makker P, Arbit E, Shango K, Sarkar S, Mahmud H, Hadden T, Yu Y and Majumdar APN: Bile acid: A potential inducer of colon cancer stem cells. Stem Cell Res Ther. 7:1812016. View Article : Google Scholar : PubMed/NCBI

32 

Di Desidero T, Orlandi P, Fioravanti A, Alì G, Cremolini C, Loupakis F, Gentile D, Banchi M, Cucchiara F, Antoniotti C, et al: Chemotherapeutic and antiangiogenic drugs beyond tumor progression in colon cancer: Evaluation of the effects of switched schedules and related pharmacodynamics. Biochem Pharmacol. 164:94–105. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Hsu HH, Chen MC, Baskaran R, Lin YM, Day CH, Lin YJ, Tu CC, Padma VV, Kuo WW and Huang CY: Oxaliplatin resistance in colorectal cancer cells is mediated via activation of ABCG2 to alleviate ER stress induced apoptosis. J Cell Physiol. 233:5458–5467. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Zhao L, Ren Y, Tang H, Wang W, He Q, Sun J, Zhou X and Wang A: Deregulation of the miR-222-ABCG2 regulatory module in tongue squamous cell carcinoma contributes to chemoresistance and enhanced migratory/invasive potential. Oncotarget. 6:44538–44550. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Peña-Solórzano D, Stark SA, König B, Sierra CA and Ochoa-Puentes C: ABCG2/BCRP: Specific and nonspecific modulators. Med Res Rev. 37:987–1050. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, Murata M, Nishida K, Miyamura S, Ishima Y, et al: Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism. Kidney Int. 91:658–670. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Wang XK, He JH, Xu JH, Ye S, Wang F, Zhang H, Huang ZC, To KKW and Fu LW: Afatinib enhances the efficacy of conventional chemotherapeutic agents by eradicating cancer stem-like cells. Cancer Res. 74:4431–4445. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Wang XK, To KK, Huang LY, Xu JH, Yang K, Wang F, Huang ZC, Ye S and Fu LW: Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo. Oncotarget. 5:11971–11985. 2014. View Article : Google Scholar : PubMed/NCBI

39 

van Hoppe S, Sparidans RW, Wagenaar E, Beijnen JH and Schinkel AH: Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-gp/ABCB1) transport afatinib and restrict its oral availability and brain accumulation. Pharmacol Res. 120:43–50. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Hu J, Zhang X, Wang F, Wang X, Yang K, Xu M, To KKW, Li Q and Fu L: Effect of ceritinib (LDK378) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo. Oncotarget. 6:44643–44659. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Zhang W, Ding W, Chen Y, Feng M, Ouyang Y, Yu Y and He Z: Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells. Acta Biochim Biophys Sin (Shanghai). 43:647–653. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Gong W, Wang Z, Wan Y, Shi L and Zhou Y: Downregulation of ABCG2 protein inhibits migration and invasion in U251 glioma stem cells. Neuroreport. 25:625–632. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Nie S, Huang Y, Shi M, Qian X, Li H, Peng C, Kong B, Zou X and Shen S: Protective role of ABCG2 against oxidative stress in colorectal cancer and its potential underlying mechanism. Oncology Rep. 40:2137–2146. 2018.

44 

Wang H, Wang X, Hu R, Yang W, Liao A, Zhao C, Zhang J and Liu Z: Methylation of SFRP5 is related to multidrug resistance in leukemia cells. Cancer Gene Ther. 21:83–89. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Huang GL, Song W, Zhou P, Fu QR, Lin C, Chen QX and Shen DY: Oncogenic retinoic acid receptor γ knockdown reverses multi-drug resistance of human colorectal cancer via Wnt/β-catenin pathway. Cell Cycle. 16:685–692. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Luo K, Gu X, Liu J, Zeng G, Peng L, Huang H, Jiang M, Yang P, Li M, Yang Y, et al: Inhibition of disheveled-2 resensitizes cisplatin-resistant lung cancer cells through down-regulating Wnt/β -catenin signaling. Exp Cell Res. 347:105–113. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Zhou H, Lin C, Zhang Y, Zhang X, Zhang C, Zhang P, Xie X and Ren Z: miR-506 enhances the sensitivity of human colorectal cancer cells to oxaliplatin by suppressing MDR1/P-gp expression. Cell Prolif. 50:e123412017. View Article : Google Scholar

48 

Shen DY, Zhang W, Zeng X and Liu CQ: Inhibition of Wnt/β -catenin signaling downregulates P-glycoprotein and reverses multi-drug resistance of cholangiocarcinoma. Cancer Sci. 104:1303–1308. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Zhang H, Jing X, Wu X, Hu J, Zhang X, Wang X, Su P, Li W and Zhou G: Suppression of multidrug resistance by rosiglitazone treatment in human ovarian cancer cells through downregulation of FZD1 and MDR1 genes. Anticancer Drugs. 26:706–715. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu S, Zhang X, Dong M, Yang Z, Zhang M and Chen Q: sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells. Oncol Rep 44: 1467-1478, 2020.
APA
Wu, S., Zhang, X., Dong, M., Yang, Z., Zhang, M., & Chen, Q. (2020). sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells. Oncology Reports, 44, 1467-1478. https://doi.org/10.3892/or.2020.7722
MLA
Wu, S., Zhang, X., Dong, M., Yang, Z., Zhang, M., Chen, Q."sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells". Oncology Reports 44.4 (2020): 1467-1478.
Chicago
Wu, S., Zhang, X., Dong, M., Yang, Z., Zhang, M., Chen, Q."sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells". Oncology Reports 44, no. 4 (2020): 1467-1478. https://doi.org/10.3892/or.2020.7722
Copy and paste a formatted citation
x
Spandidos Publications style
Wu S, Zhang X, Dong M, Yang Z, Zhang M and Chen Q: sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells. Oncol Rep 44: 1467-1478, 2020.
APA
Wu, S., Zhang, X., Dong, M., Yang, Z., Zhang, M., & Chen, Q. (2020). sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells. Oncology Reports, 44, 1467-1478. https://doi.org/10.3892/or.2020.7722
MLA
Wu, S., Zhang, X., Dong, M., Yang, Z., Zhang, M., Chen, Q."sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells". Oncology Reports 44.4 (2020): 1467-1478.
Chicago
Wu, S., Zhang, X., Dong, M., Yang, Z., Zhang, M., Chen, Q."sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells". Oncology Reports 44, no. 4 (2020): 1467-1478. https://doi.org/10.3892/or.2020.7722
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team