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Article Open Access

Splice variants of lysosome‑associated membrane proteins 2A and 2B are involved in sunitinib resistance in human renal cell carcinoma cells

  • Authors:
    • Ryoma Nishikawa
    • Mitsuhiko Osaki
    • Ryo Sasaki
    • Mizuho Ishikawa
    • Tetsuya Yumioka
    • Noriya Yamaguchi
    • Hideto Iwamoto
    • Masashi Honda
    • Tomohiro Kabuta
    • Atsushi Takenaka
    • Futoshi Okada
  • View Affiliations / Copyright

    Affiliations: Division of Urology, Faculty of Medicine, Tottori University, Yonago, Tottori 683‑8503, Japan, Division of Experimental Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori 683‑8503, Japan, Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187‑8502, Japan
    Copyright: © Nishikawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1810-1820
    |
    Published online on: September 4, 2020
       https://doi.org/10.3892/or.2020.7752
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Abstract

Sunitinib, a tyrosine kinase inhibitor, is among the first‑line treatments for metastatic or advanced stage renal cell carcinoma (RCC). However, patients with RCC develop resistance to sunitinib. We have previously demonstrated that lysosome‑associated membrane protein 2 (LAMP‑2), which has three splice variants with different functions (LAMP‑2A, LAMP‑2B, and LAMP‑2C), is involved in RCC. In the present study, we examined which splice variants of LAMP‑2 contributed to sunitinib resistance in RCC cells. In vitro analysis using ACHN, human RCC cell line, revealed that the IC50 of sunitinib was significantly increased by overexpression of LAMP‑2A and LAMP‑2B, but not LAMP‑2C (P<0.01). Kaplan‑Meier survival analysis using clinical samples revealed an association between shorter survival and high expression of LAMP‑2A and LAMP‑2B, but not LAMP‑2C, in patients with RCC treated with sunitinib (P=0.01). Furthermore, high expression of LAMP‑2A and LAMP‑2B in RCC revealed a weak to moderate inverse correlation with the tumor shrinkage rate and progression‑free survival, respectively. Thus, high expression of LAMP‑2A and LAMP‑2B contributed to the acquisition of sunitinib resistance, indicating that the expression of these two variants can predict the efficacy of sunitinib treatment in patients with RCC.
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View References

1 

Capitanio U and Montorsi F: Renal cancer. Lancet. 387:894–906. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Eggener SE, Yossepowitch O, Pettus JA, Snyder ME, Motzer RJ and Russo P: Renal cell carcinoma recurrence after nephrectomy for localized disease: Predicting survival from time of recurrence. J Clin Oncol. 24:3101–3106. 2006. View Article : Google Scholar : PubMed/NCBI

3 

National Comprehensive Cancer Network, . Guidelines are available at. https://www.nccn.org/professionals/physician_gls/default.aspx

4 

Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, Negrier S, Szczylik C, Pili R, Bjarnason GA, et al: Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol. 27:3584–3590. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Motzer RJ, Michaelson MD, Redman BG, Hudes GR, Wilding G, Figlin RA, Ginsberg MS, Kim ST, Baum CM, DePrimo SE, et al: Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol. 24:16–24. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Motzer RJ, Rini BI, Bukowski RM, Curti BD, George DJ, Hudes GR, Redman BG, Margolin KA, Merchan JR, Wilding G, et al: Sunitinib in patients with metastatic renal cell carcinoma. JAMA. 295:2516–2524. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Barrios CH, Hernandez-Barajas D, Brown MP, Lee SH, Fein L, Liu JH, Hariharan S, Martell BA, Yuan J, Bello A, et al: Phase II trial of continuous once-daily dosing of sunitinib as first-line treatment in patients with metastatic renal cell carcinoma. Cancer. 118:1252–1259. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Motzer RJ, Hutson TE, Olsen MR, Hudes GR, Burke JM, Edenfield WJ, Wilding G, Agarwal N, Thompson JA, Cella D, et al: Randomized phase II trial of sunitinib on an intermittent versus continuous dosing schedule as first-line therapy for advanced renal cell carcinoma. J Clin Oncol. 30:1371–1377. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Gore ME, Szczylik C, Porta C, Bracarda S, Bjarnason GA, Oudard S, Hariharan S, Lee SH, Haanen J, Castellano D, et al: Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: An expanded-access trial. Lancet Oncol. 10:757–763. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Gore ME, Szczylik C, Porta C, Bracarda S, Bjarnason GA, Oudard S, Lee SH, Haanen J, Castellano D, Vrdoljak E, et al: Final results from the large sunitinib global expanded-access trial in metastatic renal cell carcinoma. Br J Cancer. 113:12–19. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Motzer RJ, Hutson TE, Cella D, Reeves J, Hawkins R, Guo J, Nathan P, Staehler M, de Souza P, Merchan JR, et al: Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med. 369:722–731. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Morais C: Sunitinib resistance in renal cell carcinoma. J Kidney Cancer VHL. 1:1–11. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Yamaguchi N, Osaki M, Onuma K, Yumioka T, Iwamoto H, Sejima T, Kugoh H, Takenaka A and Okada F: Identification of MicroRNAs involved in resistance to sunitinib in renal cell carcinoma cells. Anticancer Res. 37:2985–2992. 2017.PubMed/NCBI

14 

Yumioka T, Osaki M, Sasaki R, Yamaguchi N, Onuma K, Iwamoto H, Morizane S, Honda M, Takenaka A and Okada F: Lysosome-associated membrane protein 2 (LAMP-2) expression induced by miR-194-5p downregulation contributes to sunitinib resistance in human renal cell carcinoma cells. Oncol Lett. 15:893–900. 2018.PubMed/NCBI

15 

Eskelinen EL, Cuervo AM, Taylor MR, Nishino I, Blum JS, Dice JF, Sandoval IV, Lippincott-Schwartz J, August JT and Saftig P: Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2. Traffic. 6:1058–1061. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Punt S, Houwing-Duistermaat JJ, Schulkens IA, Thijssen VL, Osse EM, de Kroon CD, Griffioen AW, Fleuren GJ, Gorter A and Jordanova ES: Correlations between immune response and vascularization qRT-PCR gene expression clusters in squamous cervical cancer. Mol Cancer. 14:712015. View Article : Google Scholar : PubMed/NCBI

19 

Gotink KJ, Broxterman HJ, Labots M, de Haas RR, Dekker H, Honeywell RJ, Rudek MA, Beerepoot LV, Musters RJ, Jansen G, et al: Lysosomal sequestration of sunitinib: A novel mechanism of drug resistance. Clin Cancer Res. 17:7337–7346. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Pérez L, McLetchie S, Gardiner GJ, Deffit SN, Zhou D and Blum JS: LAMP-2C Inhibits MHC Class II presentation of cytoplasmic antigens by disrupting chaperone-mediated autophagy. J Immunol. 196:2457–2465. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Dice JF: Chaperone-mediated autophagy. Autophagy. 3:295–299. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Endo Y, Furuta A and Nishino I: Danon disease: A phenotypic expression of LAMP-2 deficiency. Acta Neuropathol. 129:391–398. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Goldsmith J, Levine B and Debnath J: Autophagy and cancer metabolism. Methods Enzymol. 542:25–57. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Ng G and Huang J: The significance of autophagy in cancer. Mol Carcinog. 43:183–187. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Notte A, Leclere L and Michiels C: Autophagy as a mediator of chemotherapy-induced cell death in cancer. Biochem Pharmacol. 82:427–434. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Liu J, Fan L, Wang H and Sun G: Autophagy, a double-edged sword in anti-angiogenesis therapy. Med Oncol. 33:102016. View Article : Google Scholar : PubMed/NCBI

27 

Giuliano S, Cormerais Y, Dufies M, Grépin R, Colosetti P, Belaid A, Parola J, Martin A, Lacas-Gervais S, Mazure NM, et al: Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux. Autophagy. 11:1891–1904. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Adelaiyr R, Ciamporcero E, Miles KM, Sotomayor P, Bard J, Tsompana M, Conroy D, Shen L, Ramakrishnan S, Ku SY, et al: Sunitinib dose escalation overcomes transient resistance in clear cell renal cell carcinoma and is associated with epigenetic modifications. Mol Cancer Ther. 14:513–522. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Sasaki K, Tsuno NH, Sunami E, Tsurita G, Kawai K, Okaji Y, Nishikawa T, Shuno Y, Hongo K, Hiyoshi M, et al: Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC Cancer. 10:3702010. View Article : Google Scholar : PubMed/NCBI

30 

Li ML, Xu YZ, Lu WJ, Li YH, Tan SS, Lin HJ, Wu TM, Li Y, Wang SY and Zhao YL: Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis. Oncol Lett. 15:2839–2846. 2018.PubMed/NCBI

31 

Wiedmer T, Blank A, Pantasis S, Normand L, Bill R, Krebs P, Tschan MP, Marinoni I and Perren A: Autophagy inhibition improves sunitinib efficacy in pancreatic neuroendocrine tumors via a lysosome-dependent mechanism. Mol Cancer Ther. 16:2502–2515. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Fujiwara Y, Furuta A, Kikuchi H, Aizawa S, Hatanaka Y, Konya C, Uchida K, Yosihmura A, Tamai Y, Wada K and Kabuta T: Discovery of a novel type of autophagy targeting RNA. Autophagy. 9:403–409. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Fujiwara Y, Kikuchi H, Aizawa S, Furuta A, Hatanaka Y, Konya C, Uchida K, Wada K and Kabuta T: Direct uptake and degradation of DNA by lysosomes. Autophagy. 9:1167–1171. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nishikawa R, Osaki M, Sasaki R, Ishikawa M, Yumioka T, Yamaguchi N, Iwamoto H, Honda M, Kabuta T, Takenaka A, Takenaka A, et al: Splice variants of lysosome‑associated membrane proteins 2A and 2B are involved in sunitinib resistance in human renal cell carcinoma cells. Oncol Rep 44: 1810-1820, 2020.
APA
Nishikawa, R., Osaki, M., Sasaki, R., Ishikawa, M., Yumioka, T., Yamaguchi, N. ... Okada, F. (2020). Splice variants of lysosome‑associated membrane proteins 2A and 2B are involved in sunitinib resistance in human renal cell carcinoma cells. Oncology Reports, 44, 1810-1820. https://doi.org/10.3892/or.2020.7752
MLA
Nishikawa, R., Osaki, M., Sasaki, R., Ishikawa, M., Yumioka, T., Yamaguchi, N., Iwamoto, H., Honda, M., Kabuta, T., Takenaka, A., Okada, F."Splice variants of lysosome‑associated membrane proteins 2A and 2B are involved in sunitinib resistance in human renal cell carcinoma cells". Oncology Reports 44.5 (2020): 1810-1820.
Chicago
Nishikawa, R., Osaki, M., Sasaki, R., Ishikawa, M., Yumioka, T., Yamaguchi, N., Iwamoto, H., Honda, M., Kabuta, T., Takenaka, A., Okada, F."Splice variants of lysosome‑associated membrane proteins 2A and 2B are involved in sunitinib resistance in human renal cell carcinoma cells". Oncology Reports 44, no. 5 (2020): 1810-1820. https://doi.org/10.3892/or.2020.7752
Copy and paste a formatted citation
x
Spandidos Publications style
Nishikawa R, Osaki M, Sasaki R, Ishikawa M, Yumioka T, Yamaguchi N, Iwamoto H, Honda M, Kabuta T, Takenaka A, Takenaka A, et al: Splice variants of lysosome‑associated membrane proteins 2A and 2B are involved in sunitinib resistance in human renal cell carcinoma cells. Oncol Rep 44: 1810-1820, 2020.
APA
Nishikawa, R., Osaki, M., Sasaki, R., Ishikawa, M., Yumioka, T., Yamaguchi, N. ... Okada, F. (2020). Splice variants of lysosome‑associated membrane proteins 2A and 2B are involved in sunitinib resistance in human renal cell carcinoma cells. Oncology Reports, 44, 1810-1820. https://doi.org/10.3892/or.2020.7752
MLA
Nishikawa, R., Osaki, M., Sasaki, R., Ishikawa, M., Yumioka, T., Yamaguchi, N., Iwamoto, H., Honda, M., Kabuta, T., Takenaka, A., Okada, F."Splice variants of lysosome‑associated membrane proteins 2A and 2B are involved in sunitinib resistance in human renal cell carcinoma cells". Oncology Reports 44.5 (2020): 1810-1820.
Chicago
Nishikawa, R., Osaki, M., Sasaki, R., Ishikawa, M., Yumioka, T., Yamaguchi, N., Iwamoto, H., Honda, M., Kabuta, T., Takenaka, A., Okada, F."Splice variants of lysosome‑associated membrane proteins 2A and 2B are involved in sunitinib resistance in human renal cell carcinoma cells". Oncology Reports 44, no. 5 (2020): 1810-1820. https://doi.org/10.3892/or.2020.7752
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