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Downregulation of exosomal miR‑1273a increases cisplatin resistance of non‑small cell lung cancer by upregulating the expression of syndecan binding protein

  • Authors:
    • Xiaolong Zhao
    • Mengxia Li
    • Xiaoyan Dai
    • Yuyin Yang
    • Yang Peng
    • Chengxiong Xu
    • Nan Dai
    • Dong Wang
  • View Affiliations / Copyright

    Affiliations: Cancer Center, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2165-2173
    |
    Published online on: September 4, 2020
       https://doi.org/10.3892/or.2020.7753
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Abstract

Resistance to platinum‑based drugs, such as cisplatin (CDDP), has been one of the major factors adversely affecting the clinical prognosis of patients with advanced non‑small cell lung cancer (NSCLC). While it has been demonstrated that dysregulation of microRNAs (miRNAs) may contribute to cisplatin resistance in NSCLC, the underlying mechanisms remain largely unclear. In the present study, the effect of exosomal miR‑1273a on cisplatin sensitivity of NSCLC was investigated. Microarray analysis was conducted to analyze the miRNA expression profiles in exosomes isolated from A549 cells treated with or without CDDP, and miR‑1273a was found to be the most prominently downregulated miRNA in CDDP‑treated exosomes. Overexpression of miR‑1273a significantly increased the cytotoxicity of CDDP and induced apoptosis in A549 cells. Syndecan binding protein (SDCBP) was predicted to be a direct target of miR‑1273a by bioinformatics and was found to be downregulated by miR‑1273a in A549 cells. Furthermore, decreased plasma exosomal miR‑1273a and increased plasma SDCBP levels were found to be associated with worse therapeutic outcomes of patients with advanced NSCLC receiving platinum‑based chemotherapy. These findings suggest that miR‑1273a is closely associated with the development of cisplatin resistance and may serve as a potential prognostic biomarker and therapeutic target for NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Li M, Dai X, Yang Y, Peng Y, Xu C, Dai N and Wang D: Downregulation of exosomal miR‑1273a increases cisplatin resistance of non‑small cell lung cancer by upregulating the expression of syndecan binding protein. Oncol Rep 44: 2165-2173, 2020.
APA
Zhao, X., Li, M., Dai, X., Yang, Y., Peng, Y., Xu, C. ... Wang, D. (2020). Downregulation of exosomal miR‑1273a increases cisplatin resistance of non‑small cell lung cancer by upregulating the expression of syndecan binding protein. Oncology Reports, 44, 2165-2173. https://doi.org/10.3892/or.2020.7753
MLA
Zhao, X., Li, M., Dai, X., Yang, Y., Peng, Y., Xu, C., Dai, N., Wang, D."Downregulation of exosomal miR‑1273a increases cisplatin resistance of non‑small cell lung cancer by upregulating the expression of syndecan binding protein". Oncology Reports 44.5 (2020): 2165-2173.
Chicago
Zhao, X., Li, M., Dai, X., Yang, Y., Peng, Y., Xu, C., Dai, N., Wang, D."Downregulation of exosomal miR‑1273a increases cisplatin resistance of non‑small cell lung cancer by upregulating the expression of syndecan binding protein". Oncology Reports 44, no. 5 (2020): 2165-2173. https://doi.org/10.3892/or.2020.7753
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Li M, Dai X, Yang Y, Peng Y, Xu C, Dai N and Wang D: Downregulation of exosomal miR‑1273a increases cisplatin resistance of non‑small cell lung cancer by upregulating the expression of syndecan binding protein. Oncol Rep 44: 2165-2173, 2020.
APA
Zhao, X., Li, M., Dai, X., Yang, Y., Peng, Y., Xu, C. ... Wang, D. (2020). Downregulation of exosomal miR‑1273a increases cisplatin resistance of non‑small cell lung cancer by upregulating the expression of syndecan binding protein. Oncology Reports, 44, 2165-2173. https://doi.org/10.3892/or.2020.7753
MLA
Zhao, X., Li, M., Dai, X., Yang, Y., Peng, Y., Xu, C., Dai, N., Wang, D."Downregulation of exosomal miR‑1273a increases cisplatin resistance of non‑small cell lung cancer by upregulating the expression of syndecan binding protein". Oncology Reports 44.5 (2020): 2165-2173.
Chicago
Zhao, X., Li, M., Dai, X., Yang, Y., Peng, Y., Xu, C., Dai, N., Wang, D."Downregulation of exosomal miR‑1273a increases cisplatin resistance of non‑small cell lung cancer by upregulating the expression of syndecan binding protein". Oncology Reports 44, no. 5 (2020): 2165-2173. https://doi.org/10.3892/or.2020.7753
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