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Article Open Access

RP11‑156L14.1 regulates SSR1 expression by competitively binding to miR‑548ao‑3p in hypopharyngeal squamous cell carcinoma

  • Authors:
    • Jing Yan
    • Zheng‑Hui Wang
    • Yan Yan
    • Hua‑Nan Luo
    • Xiao‑Yong Ren
    • Na Li
    • Guo‑Xi Zheng
    • Jin Hou
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology Head and Neck Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2080-2092
    |
    Published online on: September 10, 2020
       https://doi.org/10.3892/or.2020.7762
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Abstract

Emerging studies have demonstrated that long non‑coding RNAs (lncRNAs) play essential roles in tumorigenesis. However, the role and function of lncRNAs in hypopharyngeal squamous cell carcinoma (HSCC) have not been completely elucidated. The present study explored the function of a novel lncRNA, RP11‑156L14.1, in HSCC. RP11‑156L14.1 was revealed to be highly expressed in HSCC tissues and cell lines. Knockdown of RP11‑156L14.1 inhibited proliferation, migration, and invasion in HSCC cells. Furthermore, RP11‑156L14.1 regulated epithelial‑mesenchymal transition (EMT) by controlling EMT‑related protein expression. Mechanistically, RP11‑156L14.1 exerted its function as a competing endogenous RNA (ceRNA) and directly interacted with miR‑548ao‑3p. The present study also demonstrated that miR‑548ao‑3p regulated signal sequence receptor subunit 1 (SSR1) expression by targeting SSR1 3'‑UTR. Moreover, the xenograft HSCC tumor model revealed that knockdown of RP11‑156L14.1 markedly suppressed HSCC tumor growth in vivo. In summary, these findings indicated that the lncRNA RP11‑156L14.1 functions as an oncogene in HSCC by competing with miR‑548ao‑3p in regulating SSR1 expression. The RP11‑156L14.1/miR‑548ao‑3p/SSR1 axis could be utilized as a potential novel biomarker and therapeutic target for HSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Yan J, Wang ZH, Yan Y, Luo HN, Ren XY, Li N, Zheng GX and Hou J: RP11‑156L14.1 regulates SSR1 expression by competitively binding to miR‑548ao‑3p in hypopharyngeal squamous cell carcinoma. Oncol Rep 44: 2080-2092, 2020.
APA
Yan, J., Wang, Z., Yan, Y., Luo, H., Ren, X., Li, N. ... Hou, J. (2020). RP11‑156L14.1 regulates SSR1 expression by competitively binding to miR‑548ao‑3p in hypopharyngeal squamous cell carcinoma. Oncology Reports, 44, 2080-2092. https://doi.org/10.3892/or.2020.7762
MLA
Yan, J., Wang, Z., Yan, Y., Luo, H., Ren, X., Li, N., Zheng, G., Hou, J."RP11‑156L14.1 regulates SSR1 expression by competitively binding to miR‑548ao‑3p in hypopharyngeal squamous cell carcinoma". Oncology Reports 44.5 (2020): 2080-2092.
Chicago
Yan, J., Wang, Z., Yan, Y., Luo, H., Ren, X., Li, N., Zheng, G., Hou, J."RP11‑156L14.1 regulates SSR1 expression by competitively binding to miR‑548ao‑3p in hypopharyngeal squamous cell carcinoma". Oncology Reports 44, no. 5 (2020): 2080-2092. https://doi.org/10.3892/or.2020.7762
Copy and paste a formatted citation
x
Spandidos Publications style
Yan J, Wang ZH, Yan Y, Luo HN, Ren XY, Li N, Zheng GX and Hou J: RP11‑156L14.1 regulates SSR1 expression by competitively binding to miR‑548ao‑3p in hypopharyngeal squamous cell carcinoma. Oncol Rep 44: 2080-2092, 2020.
APA
Yan, J., Wang, Z., Yan, Y., Luo, H., Ren, X., Li, N. ... Hou, J. (2020). RP11‑156L14.1 regulates SSR1 expression by competitively binding to miR‑548ao‑3p in hypopharyngeal squamous cell carcinoma. Oncology Reports, 44, 2080-2092. https://doi.org/10.3892/or.2020.7762
MLA
Yan, J., Wang, Z., Yan, Y., Luo, H., Ren, X., Li, N., Zheng, G., Hou, J."RP11‑156L14.1 regulates SSR1 expression by competitively binding to miR‑548ao‑3p in hypopharyngeal squamous cell carcinoma". Oncology Reports 44.5 (2020): 2080-2092.
Chicago
Yan, J., Wang, Z., Yan, Y., Luo, H., Ren, X., Li, N., Zheng, G., Hou, J."RP11‑156L14.1 regulates SSR1 expression by competitively binding to miR‑548ao‑3p in hypopharyngeal squamous cell carcinoma". Oncology Reports 44, no. 5 (2020): 2080-2092. https://doi.org/10.3892/or.2020.7762
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