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Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells

  • Authors:
    • Lei Xiang
    • Bin He
    • Qiang Liu
    • Dongdong Hu
    • Wenjing Liao
    • Ruochan Li
    • Xinyi Peng
    • Qian Wang
    • Gang Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Medical Biology, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China, Department of Pathogen Biology, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China
    Copyright: © Xiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1997-2008
    |
    Published online on: September 14, 2020
       https://doi.org/10.3892/or.2020.7765
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Abstract

Curcumin is the main component of the Chinese herbal plant turmeric, which has been demonstrated to possess antitumor and other pharmacological properties. The aim of the present study was to investigate the effects of curcumin on the viability, migration and apoptosis of human colorectal carcinoma HCT‑116 cells, and to explore the underlying molecular mechanisms. In addition, it was investigated whether the antitumor effect of curcumin on HCT‑116 cells could match that of the chemotherapeutic drug 5‑fluorouracil (5‑FU). HCT‑116 cells were treated with curcumin (10, 20 and 30 µM) and 5‑FU (500 µM), and cell viability and proliferation were detected by Cell Counting Kit‑8 and colony formation assays, respectively. The migration and invasion of treated cells were determined using Transwell and carboxyfluorescein succinimidyl amino ester fluorescent labeling assays. Cell cycle distribution and apoptosis rates were detected by flow cytometry. Furthermore, cell morphology changes associated with apoptosis were observed by fluorescence microscopy with acridine orange/ethidium bromide dual staining. To investigate the possible underlying molecular mechanisms, the gene and protein levels of Fas, Fas‑associated via death domain (FADD), caspase‑8, caspase‑3, matrix metalloproteinase (MMP)‑9, nuclear factor (NF)‑κB, E‑cadherin and claudin‑3 were detected using quantitative PCR analysis, zymography and western blotting. The results revealed that curcumin markedly inhibited the viability and proliferation of HCT‑116 cells in a dose‑ and time‑dependent manner. The migration, aggregation and invasion of HCT‑116 cells into the lungs of mice were decreased by curcumin treatment in a dose‑dependent manner. S‑phase arrest and gradually increased apoptotic rates of HCT‑116 cells were observed with increasing curcumin concentrations. Additionally, the mRNA and protein levels of apoptosis‑associated proteins (Fas, FADD, caspase‑8 and caspase‑3) and E‑cadherin in HCT‑116 cells were upregulated following treatment with curcumin in a dose‑dependent manner. By contrast, the expression of migration‑associated proteins, including MMP‑9, NF‑κB and claudin‑3, was downregulated with increasing curcumin concentrations. These data suggested that the inhibitory effect of curcumin on HCT‑116 cells may match that of 5‑FU. Therefore, curcumin induced cell apoptosis and inhibited tumor cell metastasis by regulating the NF‑κB signaling pathway, and its therapeutic effect may be comparable to that of 5‑FU.
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View References

1 

Duan Y, Fang Z, Shi Z and Zhang L: Knockdown of lncRNA CCEPR suppresses colorectal cancer progression. Exp Ther Med. 18:3534–3542. 2019.PubMed/NCBI

2 

Yu F, Zhou C, Zeng H, Liu Y and Li S: BMI1 activates WNT signaling in colon cancer by negatively regulating the WNT antagonist IDAX. Biochem Biophys Res Commun. 496:468–474. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Krijger ID, Mekenkamp LJ, Punt CJ and Nagtegaal LD: MicroRNAs in colorectal cancer metastasis. J Pathol. 224:438–447. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Bengmark S and Hafström L: The natural history of primary and secondary malignant tumors of the liver. I. The prognosis for patients with hepatic metastases from colonic and rectal carcinoma by laparotomy. Cancer. 23:198–202. 1969. View Article : Google Scholar : PubMed/NCBI

5 

Nordman IC, Iyer S, Joshua AM and Clarke SJ: Advances in the adjuvant treatment of colorectal cancer. ANZ J Surg. 76:373–380. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Apostolou P, Toloudi M, Kalliara I, Kipourou V, Tourna I and Papasotiriou I: Gene expression changes in colorectal cancer during metronomic chemotherapy and high-concentration drug administration. J Cancer Ther. 6:679–689. 2015. View Article : Google Scholar

7 

Alfarouk KO: Tumor metabolism, cancer cell transporters, and microenvironmental resistance. J Enzyme Inhib Med Chem. 31:859–866. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Gupta SC, Patchva S and Aggarwal BB: Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 15:195–218. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Kuttan R, Bhanumathy P, Nirmala K and George MC: Potential anticancer activity of turmeric (Curcuma longa). Cancer Lett. 29:197–202. 1985. View Article : Google Scholar : PubMed/NCBI

10 

Dai XZ, Yin HT, Sun LF, Hu X, Zhou C, Zhou Y, Zhang W, Huang XE and Li XC: Potential therapeutic efficacy of curcumin in liver cancer. Asian Pac J Cancer Prev. 14:3855–3859. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Merlin JLP: Biochemical characterization of caspase-12 in apoptosis and a way for its purification using fusion proteins. J Chosun Nat Sci. 7:103–112. 2014. View Article : Google Scholar

12 

Dasmahaparea G, Almenara JA and Grant S: Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2. Mol Pharmacol. 69:2882006. View Article : Google Scholar : PubMed/NCBI

13 

Szarynska M, Olejniczak A, Wierzbicki P, Kobiela J, Laski D, Sledzinski Z, Adrych K, Guzek M and Kmiec Z: FasR and FasL in colorectal cancer. Int J Oncol. 51:975–986. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Sánchez-Tilló E, de Barrios O, Siles L, Cuatrecasas M, Castells A and Postigo A: β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness. Proc Natl Acad Sci USA. 108:19204–19209. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Karabulut M, Alis H, Bas K, Karabulut S, Afsar CU, Oguz H, Gunaldi M, Akarsu C, Kones O and Aykan NF: Clinical significance of serum claudin-1 and claudin-7 levels in patients with colorectal cancer. Mol Clin Oncol. 3:1255–1267. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Benedicto A, Romayor I and Arteta B: Role of liver ICAM-1 in metastasis. Oncol Lett. 14:3883–3892. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Qazi AK, Hussain A, Aga MA, Ali S, Taneja SC, Sharma PR, Saxena AK, Mondhe DM and Hamid A: Cell specific apoptosis by RLX is mediated by NFκB in human colon carcinoma HCT-116 cells. BMC Cell Biol. 15:362014. View Article : Google Scholar : PubMed/NCBI

18 

Gogly B, Groult N, Hornebeck W, Godeaua G and Pellata B: Collagen zymography as a sensitive and specific technique for the determination of subpicogram levels of interstitial collagenase. Anal Biochem. 255:211–216. 1998. View Article : Google Scholar : PubMed/NCBI

19 

Hoefel D, Grooby WL, Monis PT, Andrews S and Saint CP: A comparative study of carboxyfluorescein diacetate and carboxyfluorescein diacetate succinimidyl ester as indicators of bacterial activity. J Microbiol Methods. 52:379–388. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Chidambaram M, Manavalan R and Kathiresan K: Nanotherapeutics to overcome conventional cancer chemotherapy limitations. J Pharm Pharm Sci. 14:67–77. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Ren M, Ye L, Hao X, Ren Z, Ren S, Xu K and Li J: Polysaccharides from Tricholoma matsutake and Lentinus edodes enhance 5-fluorouracil-mediated H22 cell growth inhibition. J Tradit Chin Med. 34:309–316. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Suttle AB, Ball HA, Molimard M, Hutson TE, Carpenter C, Rajagopalan D, Lin Y, Swann S, Amado R and Pandite L: Relationships between pazopanib exposure and clinical safety and efficacy in patients with advanced renal cell carcinoma. Br J Cancer. 111:1909–1916. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Quispe-Soto1 ET and Calaf GM: Effect of curcumin and paclitaxel on breast carcinogenesis. Int J Oncol. 49:2569–2577. 2016. View Article : Google Scholar : PubMed/NCBI

24 

He B, Wei W, Liu J, Xu YD and Zhao G: Synergistic anticancer effect of curcumin and chemotherapy regimen FP in human gastric cancer MGC-803 cells. Oncol Lett. 14:3387–3394. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Vinod BS, Antony J, Nair HH, Puliyappadamba VT, Saikia M, Narayanan SS, Bevin A and Anto RJ: Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil. Cell Death Dis. 4:e5052013. View Article : Google Scholar : PubMed/NCBI

26 

Aggarwal ML, Chacko KM and Kuruvilla BT: Systematic and comprehensive investigation of the toxicity of curcuminoid-essential oil complex: A bioavailable turmeric formulation. Mol Med Rep. 13:592–604. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Panahi Y, Saadat A, Beiraghdar F, Hosseini Nouzari SM, Jalalian HR and Sahebkar A: Antioxidant effects of bioavailability-enhanced curcuminoids in patients with solid tumors: A randomized double-blind placebo-controlled trial. J Funct Foods. 6:615–622. 2014. View Article : Google Scholar

28 

Kunwar A, Barik A, Mishra B, Rathinasamy K, Pandey R and Priyadarsini KI: Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells. Biochim Biophys Acta. 1780:673–679. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Sivanantham B, Sethuraman S and Krishnan UM: Combinatorial effects of curcumin with an anti-neoplastic agent on head and neck squamous cell carcinoma through the regulation of EGFR-ERK1/2 and apoptotic signaling pathways. ACS Comb. 18:22–35. 2016. View Article : Google Scholar

30 

Arumuggam N, Bhowmick NA and Rupasinghe HP: A review: Phytochemicals targeting JAK/STAT signaling and IDO expression in cancer. Phytother Res. 29:805–817. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Kumar G, Mittal S, Sak K and Tuli HS: Molecular mechanisms underlying chemopreventive potential of curcumin: Current challenges and future perspectives. Life Sci. 148:313–328. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Shakibaei M, Mobasheri A, Lueders C, Busch F, Shayan P and Goel A: Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-κB and Src protein kinase signaling pathways. PLoS One. 8:e572182013. View Article : Google Scholar : PubMed/NCBI

33 

Li YB, Gao JL, Zhong ZF, Hoi PM, Lee SM and Wang YT: Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacol Rep. 65:700–709. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Sun W, Liu DB, Li WW, Zhang LL, Long GX, Wang JF, Mei Q and Hu GQ: Interleukin-6 promotes the migration and invasion of nasopharyngeal carcinoma cell lines and upregulates the expression of MMP-2 and MMP-9. Int J Oncol. 44:1551–1560. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Kang J, Kim E, Kim W, Seong KM, Youn H, Kim JW, Kim J and Youn B: Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines. J Biol Chem. 288:27343–27357. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Fu Z, Chen X, Guan S, Yan Y, Lin H and Hua ZC: Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway. Oncotarget. 6:19469–19482. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Aaron JS, John O and Dino P: Multiple Actions of curcumin including anticancer, anti-inflammatory, antimicrobial and enhancement via cyclodextrin. J Cancer Ther. 6:257–272. 2015. View Article : Google Scholar

38 

Siegel R, Desantis C, Virgo K, Stein K, Mariotto A, Smith T, Cooper D, Gansler T, Lerro C, Fedewa S, et al: Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 62:220–241. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Shehzad A, Khan S, Shehzad O and Lee YS: Curcumin therapeutic promises and bioavailability in colorectal cancer. Drugs Today (Barc). 46:523–532. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Harrison DE and Lerner CP: Most primitive hematopoietic stem cells are stimulated to cycle rapidly after treatment with 5-fluorouracil. Blood. 78:1237–1240. 1991. View Article : Google Scholar : PubMed/NCBI

41 

Nicholson DW: Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ. 6:1028–1042. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Huang Q, Li F, Liu X, Li W, Shi W, Liu FF, O'Sullivan B, He Z, Peng Y, Tan AC, et al: Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med. 17:860–866. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Hyoudou K, Nishikawa M, Umeyama Y, Kobayashi Y, Yamashita F and Hashida M: Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: Quantitative analysis with firefly luciferase-expressing melanoma cells. Clin Cancer Res. 10:7685–7691. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Teicher BA: Tumor models in cancer research. Springer Science & Business Media; 2010

45 

Lorger M and Felding-Habermann B: Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis. Am J Pathol. 176:2958–2971. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Hayden MS and Sankar G: NF-κB, the first quarter-century: Remarkable progress and outstanding questions. Genes Dev. 26:203–234. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Meng Q, Zhi T, Chao Y, Nie E, Xu X, Shi Q, Hua L, Wang L, Zhan W, Wang Y, et al: Bex2 controls proliferation of human glioblastoma cells through NF-κB signaling pathway. J Mol Neurosci. 53:262–270. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Zheng Y, Miu Y, Yang X, Yang X and Zhu M: CCR7 mediates TGF-β1-induced human malignant glioma invasion, migration, and epithelial-mesenchymal transition by activating MMP2/9 through the nuclear factor kappaB signaling pathway. DNA Cell Biol. 36:853–861. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Wang H and Yang X: The expression patterns of tight junction protein claudin-1, −3, and −4 in human gastric neoplasms and adjacent non-neoplastic tissues. Int J Clin Exp Patho. 8:881–887. 2015.

50 

Oliveira SS and Morgado-Díaz JA: Claudins: Multifunctional players in epithelial tight junctions and their role in cancer. Cell Mol Life Sci. 64:17–28. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Guarino M, Rubino B and Ballabio G: The role of epithelial-mesenchymal transition in cancer pathology. Pathology. 39:305–318. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Downey C, Craig DH and Basson MD: Isoform-specific modulation of pressure-stimulated cancer cell proliferation and adhesion by α-actinin. Am J Surg. 202:520–523. 2011. View Article : Google Scholar : PubMed/NCBI

53 

Shant J, Cheng K, Marasa BS, Wang JY and Raufman JP: Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis. Exp Cell Res. 315:432–450. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiang L, He B, Liu Q, Hu D, Liao W, Li R, Peng X, Wang Q and Zhao G: Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells. Oncol Rep 44: 1997-2008, 2020.
APA
Xiang, L., He, B., Liu, Q., Hu, D., Liao, W., Li, R. ... Zhao, G. (2020). Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells. Oncology Reports, 44, 1997-2008. https://doi.org/10.3892/or.2020.7765
MLA
Xiang, L., He, B., Liu, Q., Hu, D., Liao, W., Li, R., Peng, X., Wang, Q., Zhao, G."Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells". Oncology Reports 44.5 (2020): 1997-2008.
Chicago
Xiang, L., He, B., Liu, Q., Hu, D., Liao, W., Li, R., Peng, X., Wang, Q., Zhao, G."Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells". Oncology Reports 44, no. 5 (2020): 1997-2008. https://doi.org/10.3892/or.2020.7765
Copy and paste a formatted citation
x
Spandidos Publications style
Xiang L, He B, Liu Q, Hu D, Liao W, Li R, Peng X, Wang Q and Zhao G: Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells. Oncol Rep 44: 1997-2008, 2020.
APA
Xiang, L., He, B., Liu, Q., Hu, D., Liao, W., Li, R. ... Zhao, G. (2020). Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells. Oncology Reports, 44, 1997-2008. https://doi.org/10.3892/or.2020.7765
MLA
Xiang, L., He, B., Liu, Q., Hu, D., Liao, W., Li, R., Peng, X., Wang, Q., Zhao, G."Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells". Oncology Reports 44.5 (2020): 1997-2008.
Chicago
Xiang, L., He, B., Liu, Q., Hu, D., Liao, W., Li, R., Peng, X., Wang, Q., Zhao, G."Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells". Oncology Reports 44, no. 5 (2020): 1997-2008. https://doi.org/10.3892/or.2020.7765
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