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Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma

  • Authors:
    • Ling Li
    • Kang Huang
    • Zhongshan Lu
    • Huijia Zhao
    • Hao Li
    • Qifa Ye
    • Guizhu Peng
  • View Affiliations / Copyright

    Affiliations: Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2185-2197
    |
    Published online on: September 25, 2020
       https://doi.org/10.3892/or.2020.7779
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Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer‑related morbidity and mortality globally. Despite the remarkable improvements in comprehensive HCC treatment, the underlying mechanistic details of HCC remain elusive. We screened HCC patients for differentially expressed genes (DEGs) using the Gene Expression Omnibus (GSE113850) and The Cancer Genome Atlas (TCGA) datasets. LINC01554 expression in 40 paired samples was determined by quantitative reverse transcription polymerase chain reaction (RT‑qPCR), and its clinical significance was assessed. LINC01554 was found to have a gain‑of‑function role in HCC in vitro. Additionally, the bioinformatics analysis of the genes co‑expressed with LINC01554 was performed using the Co‑LncRNA website, and potential molecular mechanisms were investigated using the Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes resources and validated by in vitro experiments. A total of 229 DEGs were identified from the GSE113850 dataset. Among the identified DEGs, three long non‑coding RNAs (lncRNAs) (DIO3OS, LINC01554, and LINC01093) with |logFC| ≥2 and P<0.05 were screened. A total of 148 lncRNAs with |logFC| ≥1 and P<0.05 were identified from TCGA dataset. Low LINC01554 expression levels were significantly correlated with overall survival, pathological stage, hepatitis B infection, tumour size, portal vein tumour thrombus, and TNM stage. Using gain‑of‑function assays, we further showed that LINC01554 inhibited the proliferation, migration, and invasion of the HCCLM9 and SK‑Hep1 cells and promoted G0/G1 arrest, but it did not significantly affect apoptosis. Western blotting revealed that LINC01554 overexpression resulted in increased ZO‑1 and E‑cadherin expression levels, but decreased N‑cadherin and vimentin expression levels. Moreover, LINC01554 overexpression inhibited Akt, p‑Akt, β‑catenin, and p‑Gsk3β expression. Our results showed that LINC01554 repressed HCC cell invasiveness and epithelial‑to‑mesenchymal transition partly by inhibiting Wnt and PI3K‑Akt signalling in vitro. Taken together, our findings provide new insights into the molecular mechanisms underlying HCC tumourigenesis and implicate LINC01554 as a potential target for HCC therapy.
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View References

1 

De Martel C, Maucort-Boulch D, Plummer M and Franceschi S: World-wide relative contribution of hepatitis B and C viruses in hepatocellular carcinoma. Hepatology. 62:1190–1200. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Aravalli RN, Steer CJ and Cressman EN: Molecular mechanism of hepatocellular carcinoma. Hepatology. 48:2047–2063. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I and Inazawa J: miR-124 and miR-203 are epigenetically silenced tumour-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis. 31:766–776. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Quinn JJ and Chang HY: Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 17:47–62. 2016. View Article : Google Scholar : PubMed/NCBI

6 

St Laurent G, Wahlestedt C and Kapranov P: The landscape of long noncoding RNA classification. Trends Genet. 31:239–251. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Maruyama R and Suzuki H: Long noncoding RNA involvement in cancer. BMB Rep. 45:604–611. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Ryaboshapkina M and Hammar M: Human hepatic gene expression signature of non-alcoholic fatty liver disease progression, a meta-analysis. Sci Rep. 7:123612017. View Article : Google Scholar : PubMed/NCBI

9 

Fan Q and Liu B: Identification of a RNA-Seq based 8-long non-coding RNA signature predicting survival in esophageal cancer. Med Sci Monit. 22:5163–5172. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Klingenberg M, Groß M, Goyal A, Polycarpou-Schwarz M, Miersch T, Ernst A, Leupold J, Patil N, Warnken U, Allgayer H, et al: The long noncoding RNA cancer susceptibility 9 and RNA binding protein heterogeneous nuclear ribonucleoprotein L form a complex and coregulate genes linked to AKT signaling. Hepatology. 68:1817–1832. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Lim LJ, Wong SYS, Huang F, Lim S, Chong SS, Ooi LL, Kon OL and Lee CG: Roles and regulation of long noncoding RNAs in hepatocellular carcinoma. Cancer Res. 79:5131–5139. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Cui K, Jin S, Du Y, Yu J, Feng H, Fan Q and Ma W: Long noncoding RNA DIO3OS interacts with miR-122 to promote proliferation and invasion of pancreatic cancer cells through upregulating ALDOA. Cancer Cell Int. 19:2022019. View Article : Google Scholar : PubMed/NCBI

15 

He J, Zuo Q, Hu B, Jin H, Wang C, Cheng Z, Deng X, Yang C, Ruan H, Yu C, et al: A noval, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA. Cancer Lett. 450:98–109. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Zhang YL, Li L, Jia YX, Zhang BZ, Li JC, Zhu YH, Li MQ, He JZ, Zeng TT, Ban XJ, et al: LIN01554-mediated glucose metabolism reprogramming suppresses tumourigenicity in hepatocellular carcinoma via downregulating PKM2 expression and inhibiting Akt/mTOR signaling pathway. Theranostics. 9:796–810. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Labernadie A, Kato T, Brugues A, Serra-Picamal X, Derzsi S, Arwert E, Weston A, Gonzalez-Tarrago V, Elosegui-Artola A, Albertazzi L, et al: A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion. Nat Cell Biol. 19:224–237. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Saitoh M: Involvement of partial EMT in cancer progression. J Biochem. 164:257–264. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Cheng N, Li Y and Han ZG: Argonaute2 promotes tumour metastasis by way of up-regulating focal adhesion kinase expression in hepatocellular carcinoma. Hepatology. 57:1906–1918. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Liu YA, Liang BY, Guan Y, You J, Zhu L, Chen XP and Huang ZY: Loss of N-cadherin is associated with loss of E-cadherin expression and poor outcomes of liver resection in hepatocellular carcinoma. J Surg Res. 194:167–176. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Cho ES, Kang HE, Kim NH and Yook JI: Therapeutic implications of cancer epithelial-mesenchymal transition (EMT). Arch Pharm Res. 42:14–24. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Yu S, Yang D, Ye Y, Liu P, Chen Z, Lei T, Pu J, Liu L and Wang Z: Long noncoding RNA actin filament-associated protein 1 antisense RNA 1 promotes malignant phenotype through binging with lysine-specific demethylase 1 and repressing HMG box-containing protein 1 in non-small-cell lung cancer. Cancer Sci. 110:2211–2225. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Tang YH, He GL, Huang SZ, Zhong KB, Liao H, Cai L, Gao Y, Peng ZW and Fu SJ: The long noncoding RNA AK002107 negatively modulates miR-140-5p and targets TGFBR1 to induce epithelial-mesenchymal transition in hepatocellular carcinoma. Mol Oncol. 13:1296–1310. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Zhang J, Le TD, Liu L and Li J: Inferring and analysing module-specific lncRNA-mRNA causal regulatory networks in human cancer. Brief Bioinform. 20:1403–1419. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Chen J, Rajasekaran M, Xia H, Zhang X, Kong SN, Sekar K, Seshachalam VP, Deivasigamani A, Goh BKP, Ooi LL, et al: The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinomain association with the Wnt/β-catenin signalling pathway. Gut. 65:1522–1534. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Zhang J, Cai H, Sun L, Zhan P, Chen M, Zhang F, Ran Y and Wan J: LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients. J Exp Clin Cancer Res. 37:2252018. View Article : Google Scholar : PubMed/NCBI

27 

Heuberger J and Birchmeier W: Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. Cold Spring Harb Perspect Biol. 2:a0029152010. View Article : Google Scholar : PubMed/NCBI

28 

Zhang Z, Zhou C, Chang Y, Zhang Z, Hu Y, Zhang F, Lu Y, Zheng L, Zhang W and Li X and Li X: Long non-coding RNA CASC11 interacts with hnRNA-K and activates the WNT/β-catenin pathway to promote growth and metastasis in colorectal cancer. Cancer Lett. 376:62–73. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Chen L, Guo P, He Y, Chen Z, Chen L, Luo Y, Qi L, Liu Y, Wu Q, Cui Y, et al: HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signaling pathway. Cell Death Dis. 9:5132018. View Article : Google Scholar : PubMed/NCBI

30 

Ding D, Huang H, Jiang W, Yu W, Zhu H, Liu J, Saiyin H, Wu J, Huang H, Jiang S and Yu L: Reticulocalbin-2 enhances hepatocellular carcinoma proliferation via modulating the EGFR-ERK pathway. Oncogene. 36:6691–6700. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Wang G, Zhang ZJ, Jian WG, Liu PH, Xue W, Wang TD, Meng YY, Yuan C, Li HM, Yu YP, et al: Novel long noncoding RNA OTUD6B-AS1 indicates poor prognosis and inhibits clear cell renal cell carcinoma proliferation via the Wnt/β-catenin signaling pathway. Mol Cancer. 18:152019. View Article : Google Scholar : PubMed/NCBI

32 

Meng J, Zhang XT, Liu XL, Fan L, Li C, Sun Y, Liang XH, Wang JB, Mei QB, Zhang F and Zhang T: WSTF promotes proliferation and invasion of lung cancer cells by inducing EMT via PI3K/Akt and IL-6/STAT3 signaling pathways. Cell Signal. 28:1673–1682. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Wang W, Pan Q, Fuhler GM, Smits R and Peppelenbosch MP: Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma. J Gastroenterol. 52:419–431. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Wang R, Yu Z, Chen F, Xu H, Shen S, Chen W, Chen L, Su Q, Zhang L, Bi J, et al: miR-300 regulates the epithelial-mesenchymal transition and invasion of hepatocellular carcinoma by targeting the FAK/PI3K/AKT signaling pathway. Biomed Pharmacother. 103:1632–1642. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Wang H, Wu Q, Liu Z, Luo X, Fan Y, Liu Y, Zhang Y, Hua S, Fu Q, Zhao M, et al: Downregulation of FAP suppresses cell proliferation and metastasis through PTEN/PI3K/AKT and Ras-ERK signaling in oral squamous cell carcinoma. Cell Death Dis. 5:e11552014. View Article : Google Scholar : PubMed/NCBI

36 

Chen Z, Zhou ZY, He CC, Zhang JL, Wang J and Xiao ZY: Down-regulation of LncRNA NR027113 inhibits cells proliferration and metastasis via PTEN/PI3K/Akt signaling pathway in hepatocellular carcinoma. Eur Rev Med Pharmacol Sci. 22:7222–7232. 2018.PubMed/NCBI

37 

Chaturvedi VK, Singh A, Dudey SK, Hetta HF, John J and Singh MP: Molecular mechanistic insight of hepatitis B virus mediated hepatocellular carcinoma. Microb Pathog. 128:184–194. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li L, Huang K, Lu Z, Zhao H, Li H, Ye Q and Peng G: Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma. Oncol Rep 44: 2185-2197, 2020.
APA
Li, L., Huang, K., Lu, Z., Zhao, H., Li, H., Ye, Q., & Peng, G. (2020). Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma. Oncology Reports, 44, 2185-2197. https://doi.org/10.3892/or.2020.7779
MLA
Li, L., Huang, K., Lu, Z., Zhao, H., Li, H., Ye, Q., Peng, G."Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma". Oncology Reports 44.5 (2020): 2185-2197.
Chicago
Li, L., Huang, K., Lu, Z., Zhao, H., Li, H., Ye, Q., Peng, G."Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma". Oncology Reports 44, no. 5 (2020): 2185-2197. https://doi.org/10.3892/or.2020.7779
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Huang K, Lu Z, Zhao H, Li H, Ye Q and Peng G: Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma. Oncol Rep 44: 2185-2197, 2020.
APA
Li, L., Huang, K., Lu, Z., Zhao, H., Li, H., Ye, Q., & Peng, G. (2020). Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma. Oncology Reports, 44, 2185-2197. https://doi.org/10.3892/or.2020.7779
MLA
Li, L., Huang, K., Lu, Z., Zhao, H., Li, H., Ye, Q., Peng, G."Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma". Oncology Reports 44.5 (2020): 2185-2197.
Chicago
Li, L., Huang, K., Lu, Z., Zhao, H., Li, H., Ye, Q., Peng, G."Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma". Oncology Reports 44, no. 5 (2020): 2185-2197. https://doi.org/10.3892/or.2020.7779
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