|
1
|
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta
R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS,
et al: Ferroptosis: An iron-dependent form of nonapoptotic cell
death. Cell. 149:1060–1072. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Friedmann Angeli JP, Schneider M, Proneth
B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch
A, Eggenhofer E, et al: Inactivation of the ferroptosis regulator
Gpx4 triggers acute renal failure in mice. Nat Cell Biol.
16:1180–1191. 2014. View
Article : Google Scholar : PubMed/NCBI
|
|
3
|
Bersuker K, Hendricks JM, Li Z, Magtanong
L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, et al:
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit
ferroptosis. Nature. 575:688–692. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Doll S, Proneth B, Tyurina YY, Panzilius
E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A,
et al: ACSL4 dictates ferroptosis sensitivity by shaping cellular
lipid composition. Nat Chem Biol. 13:91–98. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Jiang L, Kon N, Li T, Wang SJ, Su T,
Hibshoosh H, Baer R and Gu W: Ferroptosis as a p53-mediated
activity during tumour suppression. Nature. 520:57–62. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Gao M, Monian P, Quadri N, Ramasamy R and
Jiang X: Glutaminolysis and transferrin regulate ferroptosis. Mol
Cell. 59:298–308. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Hassannia B, Vandenabeele P and Vanden
Berghe T: Targeting ferroptosis to iron out cancer. Cancer Cell.
35:830–849. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Stockwell BR, Friedmann Angeli JP, Bayir
H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK,
Kagan VE, et al: Ferroptosis: A regulated cell death nexus linking
metabolism, redox biology, and disease. Cell. 171:273–285. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Wu J, Minikes AM, Gao M, Bian H, Li Y,
Stockwell BR, Chen ZN and Jiang X: Intercellular interaction
dictates cancer cell ferroptosis via NF2-YAP signalling. Nature.
572:402–406. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Lee J, You JH, Kim MS and Roh JL:
Epigenetic reprogramming of epithelial-mesenchymal transition
promotes ferroptosis of head and neck cancer. Redox Biol.
37:1016972020. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Melosky B, Juergens R, McLeod D, Leighl N,
Brade A, Card PB and Chu Q: Immune checkpoint-inhibitors and
chemoradiation in stage III unresectable non-small cell lung
cancer. Lung Cancer. 134:259–267. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Pinto R, Petriella D, Lacalamita R,
Montrone M, Catino A, Pizzutilo P, Botticella MA, Zito FA, Del Bene
G, Zonno A, et al: KRAS-Driven lung adenocarcinoma and B Cell
infiltration: Novel insights for immunotherapy. Cancers (Basel).
11:11452019. View Article : Google Scholar
|
|
13
|
Mitton B, Chae HD, Hsu K, Dutta R,
Aldana-Masangkay G, Ferrari R, Davis K, Tiu BC, Kaul A, Lacayo N,
et al: Small molecule inhibition of cAMP response element binding
protein in human acute myeloid leukemia cells. Leukemia.
30:2302–2311. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Chae HD, Mitton B, Lacayo NJ and Sakamoto
KM: Replication factor C3 is a CREB target gene that regulates cell
cycle progression through the modulation of chromatin loading of
PCNA. Leukemia. 29:1379–1389. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Wang J, Ma L, Weng W, Qiao Y, Zhang Y, He
J, Wang H, Xiao W, Li L, Chu Q, et al: Mutual interaction between
YAP and CREB promotes tumorigenesis in liver cancer. Hepatology.
58:1011–1020. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Wang J, Tang X, Weng W, Qiao Y, Lin J, Liu
W, Liu R, Ma L, Yu W, Yu Y, et al: The membrane protein melanoma
cell adhesion molecule (MCAM) is a novel tumor marker that
stimulates tumorigenesis in hepatocellular carcinoma. Oncogene.
34:5781–5795. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Zhang X, Xu Y, Qian Z, Zheng W, Wu Q, Chen
Y, Zhu G, Liu Y, Bian Z, Xu W, et al: circRNA_104075 stimulates
YAP-dependent tumorigenesis through the regulation of HNF4a and may
serve as a diagnostic marker in hepatocellular carcinoma. Cell
Death Dis. 9:10912018. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Zhang X, Sun F, Qiao Y, Zheng W, Liu Y,
Chen Y, Wu Q, Liu X, Zhu G, Chen Y, et al: TFCP2 is required for
YAP-Dependent transcription to stimulate liver malignancy. Cell
Rep. 21:1227–1239. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Chandrashekar DS, Bashel B, Balasubramanya
SA, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BV and Varambally
S: UALCAN: A portal for facilitating tumor subgroup gene expression
and survival analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Fornes O, Castro-Mondragon JA, Khan A, van
der Lee R, Zhang X, Richmond PA, Modi BP, Correard S, Gheorghe M,
Baranašić D, et al: JASPAR 2020: Update of the open-access database
of transcription factor binding profiles. Nucleic Acids Res.
48:D87–D92. 2020.PubMed/NCBI
|
|
22
|
Szklarczyk D, Gable AL, Lyon D, Junge A,
Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork
P, et al: STRING v11: Protein-protein association networks with
increased coverage, supporting functional discovery in genome-wide
experimental datasets. Nucleic Acids Res. 47:D607–D613. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
UniProt Consortium: UniProt: A worldwide
hub of protein knowledge. Nucleic Acids Res. 47:D506–D515. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Yu W, Li L, Zheng F, Yang W, Zhao S, Tian
C, Yin W, Chen Y, Guo W, Zou L and Deng W: β-Catenin Cooperates
with CREB binding protein to promote the growth of tumor cells.
Cell Physiol Biochem. 44:467–478. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Jin X, Di X, Wang R, Ma H, Tian C, Zhao M,
Cong S, Liu J, Li R and Wang K: RBM10 inhibits cell proliferation
of lung adenocarcinoma via RAP1/AKT/CREB signalling pathway. J Cell
Mol Med. 23:3897–3904. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Lei HM, Zhang KR, Wang CH, Wang Y, Zhuang
GL, Lu LM, Zhang J, Shen Y, Chen HZ and Zhu L: Aldehyde
dehydrogenase 1A1 confers erlotinib resistance via facilitating the
reactive oxygen species-reactive carbonyl species metabolic pathway
in lung adenocarcinomas. Theranostics. 9:7122–7139. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Hayano M, Yang WS, Corn CK, Pagano NC and
Stockwell BR: Loss of cysteinyl-tRNA synthetase (CARS) induces the
transsulfuration pathway and inhibits ferroptosis induced by
cystine deprivation. Cell Death Differ. 23:270–278. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R
and Tang D: Activation of the p62-Keap1-NRF2 pathway protects
against ferroptosis in hepatocellular carcinoma cells. Hepatology.
63:173–184. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Sun X, Ou Z, Xie M, Kang R, Fan Y, Niu X,
Wang H, Cao L and Tang D: HSPB1 as a novel regulator of ferroptotic
cancer cell death. Oncogene. 34:5617–5625. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Ou Y, Wang SJ, Li D, Chu B and Gu W:
Activation of SAT1 engages polyamine metabolism with p53-mediated
ferroptotic responses. Proc Natl Acad Sci USA. 113:E6806–E6812.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Tessarz P and Kouzarides T: Histone core
modifications regulating nucleosome structure and dynamics. Nat Rev
Mol Cell Biol. 15:703–708. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Kinnaird A, Zhao S, Wellen KE and
Michelakis ED: Metabolic control of epigenetics in cancer. Nat Rev
Cancer. 16:694–707. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Ebrahimi A, Sevinc K, Gurhan Sevinc G,
Cribbs AP, Philpott M, Uyulur F, Morova T, Dunford JE, Göklemez S,
Arı Ş, et al: Bromodomain inhibition of the coactivators CBP/EP300
facilitate cellular reprogramming. Nat Chem Biol. 15:519–528. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Hoeffler JP, Meyer TE, Yun Y, Jameson JL
and Habener JF: Cyclic AMP-responsive DNA-binding protein:
Structure based on a cloned placental cDNA. Science. 242:1430–1433.
1988. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Chen Z, Li JL, Lin S, Cao C, Gimbrone NT,
Yang R, Fu DA, Carper MB, Haura EB, Schabath MB, et al:
cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer
and mediates tumor growth. J Clin Invest. 126:2267–2279. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Rodon L, Svensson RU, Wiater E, Chun MG,
Tsai WW, Eichner LJ, Shaw RJ and Montminy M: The CREB coactivator
CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung
cancer. Sci Adv. 5:eaaw64552019. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Daskalaki MG, Tsatsanis C and Kampranis
SC: Histone methylation and acetylation in macrophages as a
mechanism for regulation of inflammatory responses. J Cell Physiol.
233:6495–6507. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Thanh Nha Uyen L, Amano Y, Al-Kzayer LFY,
Kubota N, Kobayashi J, Nakazawa Y, Koike K and Sakashita K: PCDH17
functions as a common tumor suppressor gene in acute leukemia and
its transcriptional downregulation is mediated primarily by
aberrant histone acetylation, not DNA methylation. Int J Hematol.
111:451–462. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Tong Q, Weaver MR, Kosmacek EA, O'Connor
BP, Harmacek L, Venkataraman S and Oberley-Deegan RE: MnTE-2-PyP
reduces prostate cancer growth and metastasis by suppressing p300
activity and p300/HIF-1/CREB binding to the promoter region of the
PAI-1 gene. Free Radic Biol Med. 94:185–194. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Tung WH, Hsieh HL, Lee IT and Yang CM:
Enterovirus 71 modulates a COX-2/PGE2/cAMP-dependent viral
replication in human neuroblastoma cells: Role of the
c-Src/EGFR/p42/p44 MAPK/CREB signaling pathway. J Cell Biochem.
112:559–570. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Boer U, Eglins J, Krause D, Schnell S,
Schofl C and Knepel W: Enhancement by lithium of cAMP-induced
CRE/CREB-directed gene transcription conferred by TORC on the CREB
basic leucine zipper domain. Biochem J. 408:69–77. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Braganca J, Eloranta JJ, Bamforth SD,
Ibbitt JC, Hurst HC and Bhattacharya S: Physical and functional
interactions among AP-2 transcription factors, p300/CREB-binding
protein, and CITED2. J Biol Chem. 278:16021–16029. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Liu X, Wang L, Zhao K, Thompson PR, Hwang
Y, Marmorstein R and Cole PA: The structural basis of protein
acetylation by the p300/CBP transcriptional coactivator. Nature.
451:846–850. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Friedmann Angeli JP, Krysko DV and Conrad
M: Ferroptosis at the crossroads of cancer-acquired drug resistance
and immune evasion. Nat Rev Cancer. 19:405–414. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Lee J, You JH, Shin D and Roh JL:
Inhibition of Glutaredoxin 5 predisposes cisplatin-resistant head
and neck cancer cells to ferroptosis. Theranostics. 10:7775–7786.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Chio IIC and Tuveson DA: ROS in cancer:
The burning question. Trends Mol Med. 23:411–429. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Ma L, Chen T, Zhang X, Miao Y, Tian X, Yu
K, Xu X, Niu Y, Guo S, Zhang C, et al: The m6A reader
YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing
SLC7A11-dependent antioxidant function. Redox Biol. 38:1018012020.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Galan-Cobo A, Sitthideatphaiboon P, Qu X,
Poteete A, Pisegna MA, Tong P, Chen PH, Boroughs LK, Rodriguez MLM,
Zhang W, et al: LKB1 and KEAP1/NRF2 pathways cooperatively promote
metabolic reprogramming with enhanced glutamine dependence in
KRAS-Mutant lung adenocarcinoma. Cancer Res. 79:3251–3267. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Song X, Zhu S, Chen P, Hou W, Wen Q, Liu
J, Xie Y, Liu J, Klionsky DJ, Kroemer G, et al: AMPK-Mediated BECN1
phosphorylation promotes ferroptosis by directly blocking system
Xc- Activity. Curr Biol. 28:2388–2399.e5. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Gaschler MM, Andia AA, Liu H, Csuka JM,
Hurlocker B, Vaiana CA, Heindel DW, Zuckerman DS, Bos PH, Reznik E,
et al: FINO2 initiates ferroptosis through GPX4 inactivation and
iron oxidation. Nat Chem Biol. 14:507–515. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Houessinon A, Francois C, Sauzay C,
Louandre C, Mongelard G, Godin C, Bodeau S, Takahashi S, Saidak Z,
Gutierrez L, et al: Metallothionein-1 as a biomarker of altered
redox metabolism in hepatocellular carcinoma cells exposed to
sorafenib. Mol Cancer. 15:382016. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Sehm T, Rauh M, Wiendieck K, Buchfelder M,
Eyupoglu IY and Savaskan NE: Temozolomide toxicity operates in a
xCT/SLC7a11 dependent manner and is fostered by ferroptosis.
Oncotarget. 7:74630–74647. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Yang WS, SriRamaratnam R, Welsch ME,
Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji
AF, Clish CB, et al: Regulation of ferroptotic cancer cell death by
GPX4. Cell. 156:317–331. 2014. View Article : Google Scholar : PubMed/NCBI
|
