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Review

The clinical significance of PD‑L1 in colorectal cancer (Review)

  • Authors:
    • Vasileia Ntomi
    • Periklis Foukas
    • Dimitrios Papaconstantinou
    • Ioanna Antonopoulou
    • Andreas Pikoulis
    • Ioannis Panagiotides
    • Emmanouil Pikoulis
    • Konstantinos Syrigos
  • View Affiliations / Copyright

    Affiliations: Third Department of Surgery, Attikon University Hospital, 12462 Athens, Greece, Second Department of Pathology, Attikon University Hospital, 12462 Athens, Greece, Third Department of Medicine, Sotiria General Hospital, National and Kapodistrian University of Athens Medical School, 12462 Athens, Greece
  • Article Number: 92
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    Published online on: April 7, 2021
       https://doi.org/10.3892/or.2021.8043
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Abstract

Colorectal cancer (CRC) is one of the most frequently encountered neoplasms and has a high rate of morbidity and mortality. Recent findings showing that tumor immune evasion is an important mechanism underlying propagation of a cancer have changed the landscape of medical oncology through identification of Programmed‑Death receptor 1 and its ligand (PD‑1 and PD‑L1) as novel targets for oncological immune therapies. PD‑1 is primarily expressed on peritumoral lymphocytes and when activated, it suppresses its immune functions. Conversely, PD‑L1 is primarily expressed on the tumor infiltrating front with the purpose of deregulating physiological cytotoxic immune responses. Numerous studies have linked PD‑L1 overexpression to specific adverse clinicopathological features, such as poor differentiation, lymphovascular invasion and worse overall survival in CRC patients. Nevertheless, there is no concrete evidence showing which patients may exhibit the maximal beneficial effects of PD‑1/PD‑L1 blockade therapy, and how these novel molecular targets may be optimally integrated into therapeutic regimens for management of CRC patients with resectable and generalized disease.
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Copy and paste a formatted citation
Spandidos Publications style
Ntomi V, Foukas P, Papaconstantinou D, Antonopoulou I, Pikoulis A, Panagiotides I, Pikoulis E and Syrigos K: The clinical significance of PD‑L1 in colorectal cancer (Review). Oncol Rep 45: 92, 2021.
APA
Ntomi, V., Foukas, P., Papaconstantinou, D., Antonopoulou, I., Pikoulis, A., Panagiotides, I. ... Syrigos, K. (2021). The clinical significance of PD‑L1 in colorectal cancer (Review). Oncology Reports, 45, 92. https://doi.org/10.3892/or.2021.8043
MLA
Ntomi, V., Foukas, P., Papaconstantinou, D., Antonopoulou, I., Pikoulis, A., Panagiotides, I., Pikoulis, E., Syrigos, K."The clinical significance of PD‑L1 in colorectal cancer (Review)". Oncology Reports 45.6 (2021): 92.
Chicago
Ntomi, V., Foukas, P., Papaconstantinou, D., Antonopoulou, I., Pikoulis, A., Panagiotides, I., Pikoulis, E., Syrigos, K."The clinical significance of PD‑L1 in colorectal cancer (Review)". Oncology Reports 45, no. 6 (2021): 92. https://doi.org/10.3892/or.2021.8043
Copy and paste a formatted citation
x
Spandidos Publications style
Ntomi V, Foukas P, Papaconstantinou D, Antonopoulou I, Pikoulis A, Panagiotides I, Pikoulis E and Syrigos K: The clinical significance of PD‑L1 in colorectal cancer (Review). Oncol Rep 45: 92, 2021.
APA
Ntomi, V., Foukas, P., Papaconstantinou, D., Antonopoulou, I., Pikoulis, A., Panagiotides, I. ... Syrigos, K. (2021). The clinical significance of PD‑L1 in colorectal cancer (Review). Oncology Reports, 45, 92. https://doi.org/10.3892/or.2021.8043
MLA
Ntomi, V., Foukas, P., Papaconstantinou, D., Antonopoulou, I., Pikoulis, A., Panagiotides, I., Pikoulis, E., Syrigos, K."The clinical significance of PD‑L1 in colorectal cancer (Review)". Oncology Reports 45.6 (2021): 92.
Chicago
Ntomi, V., Foukas, P., Papaconstantinou, D., Antonopoulou, I., Pikoulis, A., Panagiotides, I., Pikoulis, E., Syrigos, K."The clinical significance of PD‑L1 in colorectal cancer (Review)". Oncology Reports 45, no. 6 (2021): 92. https://doi.org/10.3892/or.2021.8043
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