Open Access

circNSUN2 promotes the malignant biological behavior of colorectal cancer cells via the miR‑181a‑5p/ROCK2 axis

Retraction in: /10.3892/or.2023.8672

  • Authors:
    • Junlin Chi
    • Shuang Liu
    • Zhizhong Wu
    • Yanqiang Shi
    • Chengmin Shi
    • Tong Zhang
    • Binghong Xiong
    • Yujian Zeng
    • Xiangqian Dong
  • View Affiliations

  • Published online on: May 27, 2021     https://doi.org/10.3892/or.2021.8093
  • Article Number: 142
  • Copyright: © Chi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Aberrant expression of circular RNAs (circRNAs) has been demonstrated to be related to the development of colorectal cancer (CRC), the third most common cancer worldwide. However, the mechanism of the effect of circRNA NOP2/Sun domain family, member 2 (circNSUN2) on the malignant biological behavior of CRC remains unclear. In the present study, the expression of circNSUN2 and microRNA (miR)‑181a‑5p was detected by RT‑qPCR. The expression of Rho‑associated coiled‑coil‑containing protein kinase 2 (ROCK2) was measured by western blotting. Cell proliferation was detected by CCK‑8 assay. The cell apoptosis rate was measured by flow cytometry. Cell migration ability was evaluated by Transwell assay. The interactions between circNSUN2, miR‑181a‑5p and ROCK2 were verified by dual‑luciferase reporter assay. The results revealed that circNSUN2 was highly expressed in CRC tissues and cell lines. Knockdown of circNSUN2 inhibited the malignant biological behavior of CRC in vivo and in vitro. Moreover, miR‑181a‑5p was revealed to be a target gene of circNSUN2, and the expression of ROCK2 was negatively regulated by miR‑181a‑5p. Knockdown of circNSUN2 inhibited proliferation and migration, and induced apoptosis of CRC cells and suppressed tumor growth by targeting miR‑181a‑5p to decrease ROCK2 expression. In conclusion, circNSUN2 promoted the progression of CRC by sponging miR‑181a‑5p to increase the expression of ROCK2.
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July-2021
Volume 46 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Chi J, Liu S, Wu Z, Shi Y, Shi C, Zhang T, Xiong B, Zeng Y and Dong X: circNSUN2 promotes the malignant biological behavior of colorectal cancer cells via the miR‑181a‑5p/ROCK2 axis Retraction in /10.3892/or.2023.8672. Oncol Rep 46: 142, 2021
APA
Chi, J., Liu, S., Wu, Z., Shi, Y., Shi, C., Zhang, T. ... Dong, X. (2021). circNSUN2 promotes the malignant biological behavior of colorectal cancer cells via the miR‑181a‑5p/ROCK2 axis Retraction in /10.3892/or.2023.8672. Oncology Reports, 46, 142. https://doi.org/10.3892/or.2021.8093
MLA
Chi, J., Liu, S., Wu, Z., Shi, Y., Shi, C., Zhang, T., Xiong, B., Zeng, Y., Dong, X."circNSUN2 promotes the malignant biological behavior of colorectal cancer cells via the miR‑181a‑5p/ROCK2 axis Retraction in /10.3892/or.2023.8672". Oncology Reports 46.1 (2021): 142.
Chicago
Chi, J., Liu, S., Wu, Z., Shi, Y., Shi, C., Zhang, T., Xiong, B., Zeng, Y., Dong, X."circNSUN2 promotes the malignant biological behavior of colorectal cancer cells via the miR‑181a‑5p/ROCK2 axis Retraction in /10.3892/or.2023.8672". Oncology Reports 46, no. 1 (2021): 142. https://doi.org/10.3892/or.2021.8093