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HOXA11 plays critical roles in disease progression and response to cytarabine in AML

  • Authors:
    • Jen-Fen Fu
    • Lee-Yung Shih
    • Tzung-Hai Yen
  • View Affiliations / Copyright

    Affiliations: Department of Medical Research, Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan 333, Taiwan, R.O.C., Department of Internal Medicine, Division of Hematology‑Oncology, Chang Gung Memorial Hospital, Taipei 105, Taiwan, R.O.C., Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan, R.O.C.
    Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 150
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    Published online on: June 1, 2021
       https://doi.org/10.3892/or.2021.8101
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Abstract

Lysine methyltransferase 2A (KMT2A, also known as MLL) translocations (MLL‑t) are frequently associated with mutations in RAS pathway genes in acute myeloid leukemia (AML). Previous findings with a mouse model showed that cooperation of MLL/AF10 with tyrosine‑protein phosphatase non‑receptor type 11 (PTPN11)G503A accelerated leukemia development, but increased cytarabine (Ara‑C) sensitivity of leukemia cells. To identify the genes responsible for reduced survival and Ara‑C resistance, transcriptomic profiling between six pairs of mouse MLL/AF10(OM‑LZ) leukemia cells harboring activating and wild‑type KRAS or PTPN11 was compared. A total of 23 differentially expressed genes (DEGs) with >1.5‑fold‑change between the paired cell lines were identified. The Gene Ontology (GO) terms overrepresented in these 23 DEGs included ‘immune system process’, ‘actin filament binding’, ‘cellular response to interferon‑alpha’ and ‘sequence‑specific DNA’. Among the four genes (Hoxa11, PR domain zinc finger protein 5, Iroquois‑class homeodomain protein IRX‑5 and homeobox protein PKNOX2) mapped to the GO term ‘sequence‑specific DNA’, HOXA11 upregulation was associated with AML harboring MLL‑t and RAS signaling mutations based on a meta‑analysis using data deposited in Oncomine™ and analysis of the clinical samples in the present study. Microarray data revealed that only Hoxa11 was upregulated in those cells harboring activating PTPN11. Functional studies of Hoxa11 knockdown or overexpression in MLL/AF10(OM‑LZ) cells revealed that Hoxa11 expression levels were associated with survival in vivo and Ara‑C sensitivity/apoptosis in vitro. In addition, Hoxa11 regulated the expression of the apoptosis‑related genes, NF‑κB inhibitor α, transcription factor p65 and transformation‑related protein p53. Furthermore, the results of a meta‑analysis using Heuser's AML dataset supported the finding that chemotherapy responders have higher expression levels of HOXA11. These results indicated that the expression of HOXA11 increased cell apoptosis and predicted an improved response to Ara‑C in AML.
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1 

Meyer C, Hofmann J, Burmeister T, Gröger D, Park TS, Emerenciano M, Pombo de Oliveira M, Renneville A, Villarese P, Macintyre E, et al: The MLL recombinome of acute leukemias in 2013. Leukemia. 27:2165–2176. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Meyer C, Burmeister T, Gröger D, Tsaur G, Fechina L, Renneville A, Sutton R, Venn NC, Emerenciano M, Pombo-de-Oliveira MS, et al: The MLL recombinome of acute leukemias in 2017. Leukemia. 32:273–284. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Balgobind BV, Raimondi SC, Harbott J, Zimmermann M, Alonzo TA, Auvrignon A, Beverloo HB, Chang M, Creutzig U, Dworzak MN, et al: Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: Results of an international retrospective study. Blood. 114:2489–2496. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ and Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group, : Refinement of cytogenetic classification in acute myeloid leukemia: Determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. Blood. 116:354–365. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Yu BD, Hess JL, Horning SE, Brown GA and Korsmeyer SJ: Altered Hox expression and segmental identity in Mll-mutant mice. Nature. 378:505–508. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Mohi MG, Williams IR, Dearolf CR, Chan G, Kutok JL, Cohen S, Morgan K, Boulton C, Shigematsu H, Keilhack H, et al: Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. Cancer Cell. 7:179–191. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Horton SJ, Grier DG, McGonigle GJ, Thompson A, Morrow M, De Silva I, Moulding DA, Kioussis D, Lappin TR, Brady HJ and Williams O: Continuous MLL-ENL expression is necessary to establish a ‘Hox Code’ and maintain immortalization of hematopoietic progenitor cells. Cancer Res. 65:9245–9252. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Suzuki A, Ito Y, Sashida G, Honda S, Katagiri T, Fujino T, Nakamura T and Ohyashiki K: t(7;11)(p15;p15) Chronic myeloid leukaemia developed into blastic transformation showing a novel NUP98/HOXA11 fusion. British J Haematol. 116:170–172. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Mizoguchi Y, Fujita N, Taki T, Hayashi Y and Hamamoto K: Juvenile myelomonocytic leukemia with t(7;11)(p15;p15) and NUP98-HOXA11 fusion. Am J Hematol. 84:295–297. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Martino V, Bianchera A, Reia L, Bussolati O, Fazzina R, Marino F, Montemurro L, Tonelli R, Pession A, Gazzola GC and Sala R: Down-regulation of HOXA4, HOXA7, HOXA10, HOXA11 and MEIS1 during monocyte-macrophage differentiation in THP-1 cells. Mol Med Rep. 2:241–244. 2009.PubMed/NCBI

11 

Zhao Y and Potter SS: Functional comparison of the Hoxa 4, Hoxa 10, and Hoxa 11 homeoboxes. Dev Biol. 244:21–36. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Liang DC, Shih LY, Fu JF, Li HY, Wang HI, Hung IJ, Yang CP, Jaing TH, Chen SH and Liu HC: K-Ras mutations and N-Ras mutations in childhood acute leukemias with or without mixed-lineage leukemia gene rearrangements. Cancer. 106:950–956. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Grossmann V, Schnittger S, Poetzinger F, Kohlmann A, Stiel A, Eder C, Fasan A, Kern W, Haferlach T and Haferlach C: High incidence of RAS signalling pathway mutations in MLL-rearranged acute myeloid leukemia. Leukemia. 27:1933–1936. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Driessen EM, van Roon EH, Spijkers-Hagelstein JA, Schneider P, de Lorenzo P, Valsecchi MG, Pieters R and Stam RW: Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants. Haematologica. 98:937–944. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Andersson AK, Ma J, Wang J, Chen X, Gedman AL, Dang J, Nakitandwe J, Holmfeldt L, Parker M, Easton J, et al: The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias. Nat Genet. 47:330–337. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Balgobind BV, Zwaan CM, Pieters R and Van den Heuvel-Eibrink MM: The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia. Leukemia. 25:1239–1248. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Barbosa TC, Andrade FG, Lopes BA, de Andrade CF, Mansur MB, Emerenciano M and Pombo-de-Oliveira MS: Impact of mutations in FLT3, PTPN11 and RAS genes on the overall survival of pediatric B cell precursor acute lymphoblastic leukemia in Brazil. Leuk Lymphoma. 55:1501–1509. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Tamai H, Miyake K, Takatori M, Miyake N, Yamaguchi H, Dan K, Shimada T and Inokuchi K: Activated K-Ras protein accelerates human MLL/AF4-induced leukemo-lymphomogenicity in a transgenic mouse model. Leukemia. 25:888–891. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Kim WI, Matise I, Diers MD and Largaespada DA: RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia. Blood. 113:1086–1096. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Ono R, Kumagai H, Nakajima H, Hishiya A, Taki T, Horikawa K, Takatsu K, Satoh T, Hayashi Y, Kitamura T and Nosaka T: Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation. Leukemia. 23:2197–2209. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Fu JF, Yen TH, Chen Y, Huang YJ, Hsu CL, Liang DC and Shih LY: Involvement of Gpr125 in the myeloid sarcoma formation induced by cooperating MLL/AF10(OM-LZ) and oncogenic KRAS in a mouse bone marrow transplantation model. Int J Cancer. 133:1792–1802. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Fu JF, Liang ST, Huang YJ, Liang KH, Yen TH, Liang DC and Shih LY: Cooperation of MLL/AF10(OM-LZ) with PTPN11 activating mutation induced monocytic leukemia with a shorter latency in a mouse bone marrow transplantation model. Int J Cancer. 140:1159–1172. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Rojas JM and Santos E: Ras genes and human cancer: Different implications and different roles. Curr Genomics. 3:2002. View Article : Google Scholar

24 

Schubbert S, Lieuw K, Rowe SL, Lee CM, Li X, Loh ML, Clapp DW and Shannon KM: Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells. Blood. 106:311–317. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Yang Z, Li Y, Yin F and Chan RJ: Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival. Exp Hematol. 36:1285–1296. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Fu JF, Hsu CL and Shih LY: MLL/AF10(OM-LZ)-immortalized cells expressed cytokines and induced host cell proliferation in a mouse bone marrow transplantation model. Int J Cancer. 126:1621–1629. 2010.PubMed/NCBI

27 

Valk PJ, Verhaak RG, Beijen MA, Erpelinck CA, Barjesteh van Waalwijk van Doorn-Khosrovani S, Boer JM, Beverloo HB, Moorhouse MJ, van der Spek PJ, Löwenberg B and Delwel R: Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Medicine. 350:1617–1628. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Wouters BJ, Löwenberg B, Erpelinck-Verschueren CA, van Putten WL, Valk PJ and Delwel R: Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood. 113:3088–3091. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Haferlach T, Kohlmann A, Wieczorek L, Basso G, Kronnie GT, Béné MC, De Vos J, Hernández JM, Hofmann WK, Mills KI, et al: Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: Report from the international microarray innovations in leukemia study group. J Clin Oncol. 28:2529–2537. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Balgobind BV, Hollink IH, Arentsen-Peters ST, Zimmermann M, Harbott J, Beverloo HB, von Bergh AR, Cloos J, Kaspers GJ, de Haas V, et al: Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia. Haematologica. 96:1478–1487. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Leonetti A, Baroli G, Fratini E, Pietropaoli S, Marcoli M, Mariottini P and Cervelli M: Epileptic seizures and oxidative stress in a mouse model over-expressing spermine oxidase. Amino Acids. 52:129–139. 2020. View Article : Google Scholar : PubMed/NCBI

33 

Fu JF, Yen TH, Huang YJ and Shih LY: Ets1 plays a critical role in MLL/EB1-mediated leukemic transformation in a mouse bone marrow transplantation model. Neoplasia. 21:469–481. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Heuser M, Wingen LU, Steinemann D, Cario G, von Neuhoff N, Tauscher M, Bullinger L, Krauter J, Heil G, Döhner H, et al: Gene-expression profiles and their association with drug resistance in adult acute myeloid leukemia. Haematologica. 90:1484–1492. 2005.PubMed/NCBI

35 

Sun Y, Zeng C, Gan S, Li H, Cheng Y, Chen D, Li R and Zhu W: LncRNA HOTTIP-Mediated HOXA11 expression promotes cell growth, migration and inhibits cell apoptosis in breast cancer. Int J Mol Sci. 19:4722018. View Article : Google Scholar : PubMed/NCBI

36 

Guo X, Yan B and Qiu Y: HOXA11 regulates chemoresistance by modulating p53 gene expression in acute myeloid leukemia. Blood. 134:5182. 2019. View Article : Google Scholar

37 

Fiegl H, Windbichler G, Mueller-Holzner E, Goebel G, Lechner M, Jacobs IJ and Widschwendter M: HOXA11 DNA methylation--a novel prognostic biomarker in ovarian cancer. Int J Cancer. 123:725–729. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Hwang JA, Lee BB, Kim Y, Park SE, Heo K, Hong SH, Kim YH, Han J, Shim YM, Lee YS and Kim DH: HOXA11 hypermethylation is associated with progression of non-small cell lung cancer. Oncotarget. 4:2317–2325. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Cui Y, Gao D, Linghu E, Zhan Q, Chen R, Brock MV, Herman JG and Guo M: Epigenetic changes and functional study of HOXA11 in human gastric cancer. Epigenomics. 7:201–213. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Li Q, Chen C, Ren X and Sun W: DNA methylation profiling identifies the HOXA11 gene as an early diagnostic and prognostic molecular marker in human lung adenocarcinoma. Oncotarget. 8:33100–33109. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Se YB, Kim SH, Kim JY, Kim JE, Dho YS, Kim JW, Kim YH, Woo HG, Kim SH, Kang SH, et al: Underexpression of HOXA11 is associated with treatment resistance and poor prognosis in glioblastoma. Cancer Res Treat. 49:387–398. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Wang L, Cui Y, Sheng J, Yang Y, Kuang G, Fan Y, Jin J and Zhang Q: Epigenetic inactivation of HOXA11, a novel functional tumor suppressor for renal cell carcinoma, is associated with RCC TNM classification. Oncotarget. 8:21861–21870. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Xia B, Shan M, Wang J, Zhong Z, Geng J, He X, Vu T, Zhang D and Pang D: Homeobox A11 hypermethylation indicates unfavorable prognosis in breast cancer. Oncotarget. 8:9794–9805. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fu J, Shih L and Yen T: <em>HOXA11</em> plays critical roles in disease progression and response to cytarabine in AML. Oncol Rep 46: 150, 2021.
APA
Fu, J., Shih, L., & Yen, T. (2021). <em>HOXA11</em> plays critical roles in disease progression and response to cytarabine in AML. Oncology Reports, 46, 150. https://doi.org/10.3892/or.2021.8101
MLA
Fu, J., Shih, L., Yen, T."<em>HOXA11</em> plays critical roles in disease progression and response to cytarabine in AML". Oncology Reports 46.1 (2021): 150.
Chicago
Fu, J., Shih, L., Yen, T."<em>HOXA11</em> plays critical roles in disease progression and response to cytarabine in AML". Oncology Reports 46, no. 1 (2021): 150. https://doi.org/10.3892/or.2021.8101
Copy and paste a formatted citation
x
Spandidos Publications style
Fu J, Shih L and Yen T: <em>HOXA11</em> plays critical roles in disease progression and response to cytarabine in AML. Oncol Rep 46: 150, 2021.
APA
Fu, J., Shih, L., & Yen, T. (2021). <em>HOXA11</em> plays critical roles in disease progression and response to cytarabine in AML. Oncology Reports, 46, 150. https://doi.org/10.3892/or.2021.8101
MLA
Fu, J., Shih, L., Yen, T."<em>HOXA11</em> plays critical roles in disease progression and response to cytarabine in AML". Oncology Reports 46.1 (2021): 150.
Chicago
Fu, J., Shih, L., Yen, T."<em>HOXA11</em> plays critical roles in disease progression and response to cytarabine in AML". Oncology Reports 46, no. 1 (2021): 150. https://doi.org/10.3892/or.2021.8101
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