Targeting USP22 with miR‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells

  • Authors:
    • Xiaoyang Hua
    • Heng Chu
    • Chuanxiao Wang
    • Xuexin Shi
    • Ailin Wang
    • Zhe Zhang
  • View Affiliations

  • Published online on: August 9, 2021     https://doi.org/10.3892/or.2021.8166
  • Article Number: 215
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Abstract

Lung cancer is one of the most common forms of cancer and accounts for a significant proportion of all cancer‑related deaths. Lung adenocarcinoma (LUAD) accounts for approximately 40% of all cases of lung cancer. In recent years, new developments in both the diagnosis and treatment of LUAD have been achieved. Unfortunately, the prognosis remains poor for patients with malignant LUAD. Hypoxia is a common characteristic of solid tumors and induce the immune evasion by increasing the expression of programmed cell death‑ligand‑1 (PD‑L1) in the tumor. In this study, it was predicted that ubiquitin‑specific peptidase 22 (USP22) is the direct target of the microRNA (miR)‑30‑5p family, including miR‑30a‑5p, miR‑30b‑5p, miR‑30c‑5p, miR‑30d‑5p and miR‑30e‑5p. Furthermore, the binding of USP22 with the miR‑30‑5p family was confirmed by luciferase assay. In addition, it was demonstrated that targeting USP22 via the miR‑30‑5p family inhibited the induction of PD‑L1 expression in hypoxic conditions, thus preventing activated T cells from killing LUAD cells. Our results indicated that miR‑30a‑5p, miR‑30b‑5p, miR‑30c‑5p, miR‑30d‑5p and miR‑30e‑5p represent new targets for the treatment of LUAD.
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October-2021
Volume 46 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hua X, Chu H, Wang C, Shi X, Wang A and Zhang Z: Targeting USP22 with miR‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells. Oncol Rep 46: 215, 2021
APA
Hua, X., Chu, H., Wang, C., Shi, X., Wang, A., & Zhang, Z. (2021). Targeting USP22 with miR‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells. Oncology Reports, 46, 215. https://doi.org/10.3892/or.2021.8166
MLA
Hua, X., Chu, H., Wang, C., Shi, X., Wang, A., Zhang, Z."Targeting USP22 with miR‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells". Oncology Reports 46.4 (2021): 215.
Chicago
Hua, X., Chu, H., Wang, C., Shi, X., Wang, A., Zhang, Z."Targeting USP22 with miR‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells". Oncology Reports 46, no. 4 (2021): 215. https://doi.org/10.3892/or.2021.8166