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Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway

  • Authors:
    • Xiao-Hong Guo
    • Shui-Shan Jiang
    • Li-Li Zhang
    • Jun Hu
    • Dilda Edelbek
    • Yu-Qi Feng
    • Zi-Xian Yang
    • Peng-Chao Hu
    • Hua Zhong
    • Guo-Hua Yang
    • Fang Yang
  • View Affiliations / Copyright

    Affiliations: Department of Medical Biology, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China, Medical Security Office, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan University, Wuhan, Hubei 430071, P.R. China, Nursing Department, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Medical Genetics, School of Basic Medical Science, Demonstration Center for Experimental Basic Medicine Education, Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Oncology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Plant Sciences, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 253
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    Published online on: October 13, 2021
       https://doi.org/10.3892/or.2021.8204
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Abstract

Glucose transporter 1 (GLUT1) plays a primary role in the glucose metabolism of cancer cells. However, to the best of our knowledge, there are currently no anticancer drugs that inhibit GLUT1 function. The present study aimed to investigate the antineoplastic activity of berberine (BBR), the main active ingredient in numerous Traditional Chinese medicinal herbs, on HepG2 and MCF7 cells. The results of Cell Counting Kit‑8 assay, colony formation assay and flow cytometry revealed that BBR effectively inhibited the proliferation of tumor cells, and induced G2/M cell cycle arrest and apoptosis. Notably, the results of luminescence ATP detection assay and glucose uptake assay showed that BBR also significantly inhibited ATP synthesis and markedly decreased the glucose uptake ability, which suggested that the antitumor effect of BBR may occur via reversal of the Warburg effect. In addition, the results of reverse transcription‑quantitative PCR, western blotting and immunofluorescence staining indicated that BBR downregulated the protein expression levels of GLUT1, maintained the cytoplasmic internalization of GLUT1 and suppressed the Akt/mTOR signaling pathway in both HepG2 and MCF7 cell lines. Augmentation of Akt phosphorylation levels by the Akt activator, SC79, abolished the BBR‑induced decrease in ATP synthesis, glucose uptake, GLUT1 expression and cell proliferation, and reversed the proapoptotic effect of BBR. These findings indicated that the antineoplastic effect of BBR may involve the reversal of the Warburg effect by downregulating the Akt/mTOR/GLUT1 signaling pathway. Furthermore, the results of the co‑immunoprecipitation assay demonstrated that BBR increased the interaction between ubiquitin conjugating enzyme E2 I (Ubc9) and GLUT1, which suggested that Ubc9 may mediate the proteasomal degradation of GLUT1. On the other hand, BBR decreased the interaction between Gα‑interacting protein‑interacting protein at the C‑terminus (GIPC) and GLUT1, which suggested that the retention of GLUT1 in the cytoplasm may be achieved by inhibiting the interaction between GLUT1 and GIPC, thereby suppressing the glucose transporter function of GLUT1. The results of the present study provided a theoretical basis for the application of the Traditional Chinese medicine component, BBR, for cancer treatment.
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View References

1 

Efferth T, Xu AL and Lee DYW: Combining the wisdoms of traditional medicine with cutting-edge science and technology at the forefront of medical sciences. Phytomedicine. 64:1530782019. View Article : Google Scholar : PubMed/NCBI

2 

Wang Y, Yi X, Ghanam K, Zhang S, Zhao T and Zhu X: Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption. Metabolism. 63:1167–1177. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Kong W, Wei J, Abidi P, Lin M, Inaba S, Li C, Wang Y, Wang Z, Si S, Pan H, et al: Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med. 10:1344–1351. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Hou Q, He WJ, Wu YS, Hao HJ, Xie XY and Fu XB: Berberine: A Traditional Natural Product With Novel Biological Activities. Altern Ther Health Med. 26S:20–27. 2020.PubMed/NCBI

5 

Chen QQ, Shi JM, Ding Z, Xia Q, Zheng TS, Ren YB, Li M and Fan LH: Berberine induces apoptosis in non-small-cell lung cancer cells by upregulating miR-19a targeting tissue factor. Cancer Manag Res. 11:9005–9015. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Sun Y, Wang W and Tong Y: Berberine Inhibits Proliferative Ability of Breast Cancer Cells by Reducing Metadherin. Med Sci Monit. 25:9058–9066. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Refaat A, Abdelhamed S, Yagita H, Inoue H, Yokoyama S, Hayakawa Y and Saiki I: Berberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer. Oncol Lett. 6:840–844. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Kim JS, Oh D, Yim MJ, Park JJ, Kang KR, Cho IA, Moon SM, Oh JS, You JS, Kim CS, et al: Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells. Oncol Rep. 33:1775–1782. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Jiang SX, Qi B, Yao WJ, Gu CW, Wei XF, Zhao Y, Liu YZ and Zhao BS: Berberine displays antitumor activity in esophageal cancer cells in vitro. World J Gastroenterol. 23:2511–2518. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Luo Y, Tian G, Zhuang Z, Chen J, You N, Zhuo L, Liang B, Song Y, Zang S, Liu J, et al: Berberine prevents non-alcoholic steatohepatitis-derived hepatocellular carcinoma by inhibiting inflammation and angiogenesis in mice. Am J Transl Res. 11:2668–2682. 2019.PubMed/NCBI

11 

Kou Y, Li L, Li H, Tan Y, Li B, Wang K and Du B: Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells. Biochem Biophys Res Commun. 479:290–296. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Maiti P, Plemmons A and Dunbar GL: Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments. PLoS One. 14:e02256602019. View Article : Google Scholar : PubMed/NCBI

13 

Abrams SL, Follo MY, Steelman LS, Lertpiriyapong K, Cocco L, Ratti S, Martelli AM, Candido S, Libra M, Murata RM, et al: Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells. Adv Biol Regul. 71:172–182. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Warburg O: On the origin of cancer cells. Science. 123:309–314. 1956. View Article : Google Scholar : PubMed/NCBI

15 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Massari F, Ciccarese C, Santoni M, Iacovelli R, Mazzucchelli R, Piva F, Scarpelli M, Berardi R, Tortora G, Lopez-Beltran A, et al: Metabolic phenotype of bladder cancer. Cancer Treat Rev. 45:46–57. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Xiao H, Wang J, Yan W, Cui Y, Chen Z, Gao X, Wen X and Chen J: GLUT1 regulates cell glycolysis and proliferation in prostate cancer. Prostate. 78:86–94. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Powles T, Murray I, Brock C, Oliver T and Avril N: Molecular positron emission tomography and PET/CT imaging in urological malignancies. Eur Urol. 51:1511–1520; discussion 1520–1521. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Deng D, Xu C, Sun P, Wu J, Yan C, Hu M and Yan N: Crystal structure of the human glucose transporter GLUT1. Nature. 510:121–125. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Reinicke K, Sotomayor P, Cisterna P, Delgado C, Nualart F and Godoy A: Cellular distribution of Glut-1 and Glut-5 in benign and malignant human prostate tissue. J Cell Biochem. 113:553–562. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Yu M, Yongzhi H, Chen S, Luo X, Lin Y, Zhou Y, Jin H, Hou B, Deng Y, Tu L, et al: The prognostic value of GLUT1 in cancers: A systematic review and meta-analysis. Oncotarget. 8:43356–43367. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Amann T, Maegdefrau U, Hartmann A, Agaimy A, Marienhagen J, Weiss TS, Stoeltzing O, Warnecke C, Schölmerich J, Oefner PJ, et al: GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis. Am J Pathol. 174:1544–1552. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Oh S, Kim H, Nam K and Shin I: Glut1 promotes cell proliferation, migration and invasion by regulating epidermal growth factor receptor and integrin signaling in triple-negative breast cancer cells. BMB Rep. 50:132–137. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, Reynolds GE, Chi JT, Wu J, Solow-Cordero DE, et al: Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med. 3:94ra702011. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Δ Δ C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Fearnhead HO, Vandenabeele P and Vanden Berghe T: How do we fit ferroptosis in the family of regulated cell death? Cell Death Differ. 24:1991–1998. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Boado RJ: Post-transcription modulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived factors. J Neural Transm Suppl. 59:255–261. 2000.PubMed/NCBI

28 

Giorgino F, de Robertis O, Laviola L, Montrone C, Perrini S, McCowen KC and Smith RJ: The sentrin-conjugating enzyme mUbc9 interacts with GLUT4 and GLUT1 glucose transporters and regulates transporter levels in skeletal muscle cells. Proc Natl Acad Sci USA. 97:1125–1130. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Wieman HL, Horn SR, Jacobs SR, Altman BJ, Kornbluth S and Rathmell JC: An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. Biochem J. 418:345–367. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Balakrishna A and Kumar MH: Evaluation of Synergetic Anticancer Activity of Berberine and Curcumin on Different Models of A549, Hep-G2, MCF-7, Jurkat, and K562 Cell Lines. BioMed Res Int. 2015:3546142015. View Article : Google Scholar : PubMed/NCBI

31 

Yu R, Zhang ZQ, Wang B, Jiang HX, Cheng L and Shen LM: Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation. Cancer Cell Int. 14:492014. View Article : Google Scholar : PubMed/NCBI

32 

Lebelo MT, Joubert AM and Visagie MH: Warburg effect and its role in tumourigenesis. Arch Pharm Res. 42:833–847. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Kennedy KM and Dewhirst MW: Tumor metabolism of lactate: The influence and therapeutic potential for MCT and CD147 regulation. Future Oncol. 6:127–148. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Semenza GL: Tumor metabolism: Cancer cells give and take lactate. J Clin Invest. 118:3835–3837. 2008.PubMed/NCBI

35 

Mao L, Chen Q, Gong K, Xu X, Xie Y, Zhang W, Cao H, Hu T, Hong X and Zhan YY: Berberine decelerates glucose metabolism via suppression of mTOR dependent HIF 1α protein synthesis in colon cancer cells. Oncol Rep. 39:2436–2442. 2018.PubMed/NCBI

36 

Ruan H, Zhan YY, Hou J, Xu B, Chen B, Tian Y, Wu D, Zhao Y, Zhang Y, Chen X, et al: Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells. Oncogene. 36:6906–6918. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Wang Y and Zhang S: Berberine suppresses growth and metastasis of endometrial cancer cells via miR-101/COX-2. Biomed Pharmacother. 103:1287–1293. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Pan Y, Shao D, Zhao Y, Zhang F, Zheng X, Tan Y, He K, Li J and Chen L: Berberine Reverses Hypoxia-induced Chemoresistance in Breast Cancer through the Inhibition of AMPK- HIF-1α. Int J Biol Sci. 13:794–803. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Liu L, Fan J, Ai G, Liu J, Luo N, Li C and Cheng Z: Berberine in combination with cisplatin induces necroptosis and apoptosis in ovarian cancer cells. Biol Res. 52:372019. View Article : Google Scholar : PubMed/NCBI

40 

Tong X and Pelling JC: Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention. Anticancer Agents Med Chem. 13:971–978. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Gismondi A, Nanni V, Monteleone V, Colao C, Di Marco G and Canini A: Plant miR171 modulates mTOR pathway in HEK293 cells by targeting GNA12. Mol Biol Rep. 48:435–449. 2021. View Article : Google Scholar : PubMed/NCBI

42 

Alolga RN, Fan Y, Chen Z, Liu LW, Zhao YJ, Li J, Chen Y, Lai MD, Li P and Qi LW: Significant pharmacokinetic differences of berberine are attributable to variations in gut microbiota between Africans and Chinese. Sci Rep. 6:276712016. View Article : Google Scholar : PubMed/NCBI

43 

Farooqi AA, Qureshi MZ, Khalid S, Attar R, Martinelli C, Sabitaliyevich UY, Nurmurzayevich SB, Taverna S, Poltronieri P and Xu B: Regulation of cell signaling pathways by berberine in different cancers: Searching for missing pieces of an incomplete jig-saw puzzle for an effective cancer therapy. Cancers (Basel). 11:4782019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo X, Jiang S, Zhang L, Hu J, Edelbek D, Feng Y, Yang Z, Hu P, Zhong H, Yang G, Yang G, et al: Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway. Oncol Rep 46: 253, 2021.
APA
Guo, X., Jiang, S., Zhang, L., Hu, J., Edelbek, D., Feng, Y. ... Yang, F. (2021). Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway. Oncology Reports, 46, 253. https://doi.org/10.3892/or.2021.8204
MLA
Guo, X., Jiang, S., Zhang, L., Hu, J., Edelbek, D., Feng, Y., Yang, Z., Hu, P., Zhong, H., Yang, G., Yang, F."Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway". Oncology Reports 46.6 (2021): 253.
Chicago
Guo, X., Jiang, S., Zhang, L., Hu, J., Edelbek, D., Feng, Y., Yang, Z., Hu, P., Zhong, H., Yang, G., Yang, F."Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway". Oncology Reports 46, no. 6 (2021): 253. https://doi.org/10.3892/or.2021.8204
Copy and paste a formatted citation
x
Spandidos Publications style
Guo X, Jiang S, Zhang L, Hu J, Edelbek D, Feng Y, Yang Z, Hu P, Zhong H, Yang G, Yang G, et al: Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway. Oncol Rep 46: 253, 2021.
APA
Guo, X., Jiang, S., Zhang, L., Hu, J., Edelbek, D., Feng, Y. ... Yang, F. (2021). Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway. Oncology Reports, 46, 253. https://doi.org/10.3892/or.2021.8204
MLA
Guo, X., Jiang, S., Zhang, L., Hu, J., Edelbek, D., Feng, Y., Yang, Z., Hu, P., Zhong, H., Yang, G., Yang, F."Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway". Oncology Reports 46.6 (2021): 253.
Chicago
Guo, X., Jiang, S., Zhang, L., Hu, J., Edelbek, D., Feng, Y., Yang, Z., Hu, P., Zhong, H., Yang, G., Yang, F."Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway". Oncology Reports 46, no. 6 (2021): 253. https://doi.org/10.3892/or.2021.8204
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