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Inhibition of GP130/STAT3 and EMT by combined bazedoxifene and paclitaxel treatment in ovarian cancer

  • Authors:
    • Sun-Ae Park
    • Lee Kyung Kim
    • Hye Min Park
    • Hee Jung Kim
    • Tae-Hwe Heo
  • View Affiliations / Copyright

    Affiliations: Laboratory of Pharmacoimmunology, Integrated Research Institute of Pharmaceutical Sciences and BK21 FOUR Team for Advanced Program for Smart Pharma Leaders, College of Pharmacy, The Catholic University of Korea, Bucheon‑si, Gyeonggi‑do 14662, Republic of Korea
    Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 52
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    Published online on: January 13, 2022
       https://doi.org/10.3892/or.2022.8263
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Abstract

The interleukin 6 (IL‑6)/glycoprotein 130 (GP130)/signal transducer and activator of transcription 3 (STAT3) signalling pathway, with GP130 as an intermediate membrane receptor, is involved in the survival, metastasis, and resistance of ovarian cancer. Bazedoxifene, an FDA‑approved drug, is an inhibitor of GP130 and a selective estrogen modulator (SERM). We studied the mechanism of the combination therapy of bazedoxifene and paclitaxel in inhibiting the IL‑6‑mediated GP130/STAT3 signaling pathway in ovarian cancer. Surface plasmon resonance (SPR) was used to assess the binding of bazedoxifene to GP130. Migration, invasion, and apoptosis of ovarian cancer cells were assessed using bazedoxifene and paclitaxel. In addition, we determined the effects of bazedoxifene and paclitaxel alone or in combination on the GP130/STAT3 pathway and epithelial‑mesenchymal transition (EMT). The results revealed that the combination of bazedoxifene and paclitaxel suppressed cell viability, migration, and invasion in the ovarian cancer cells. In addition, the combination treatment increased apoptosis. Furthermore, bazedoxifene combined with paclitaxel inhibited the growth of ovarian cancer cells in a xenograft tumour model. This combination reduced STAT3 phosphorylation and suppressed gene expression and EMT. In conclusion, inhibition of GP130/STAT3 signalling and EMT via a combination of bazedoxifene and paclitaxel could be used as a therapeutic strategy by which to overcome ovarian cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Park S, Kim LK, Park HM, Kim HJ and Heo T: Inhibition of GP130/STAT3 and EMT by combined bazedoxifene and paclitaxel treatment in ovarian cancer. Oncol Rep 47: 52, 2022.
APA
Park, S., Kim, L.K., Park, H.M., Kim, H.J., & Heo, T. (2022). Inhibition of GP130/STAT3 and EMT by combined bazedoxifene and paclitaxel treatment in ovarian cancer. Oncology Reports, 47, 52. https://doi.org/10.3892/or.2022.8263
MLA
Park, S., Kim, L. K., Park, H. M., Kim, H. J., Heo, T."Inhibition of GP130/STAT3 and EMT by combined bazedoxifene and paclitaxel treatment in ovarian cancer". Oncology Reports 47.3 (2022): 52.
Chicago
Park, S., Kim, L. K., Park, H. M., Kim, H. J., Heo, T."Inhibition of GP130/STAT3 and EMT by combined bazedoxifene and paclitaxel treatment in ovarian cancer". Oncology Reports 47, no. 3 (2022): 52. https://doi.org/10.3892/or.2022.8263
Copy and paste a formatted citation
x
Spandidos Publications style
Park S, Kim LK, Park HM, Kim HJ and Heo T: Inhibition of GP130/STAT3 and EMT by combined bazedoxifene and paclitaxel treatment in ovarian cancer. Oncol Rep 47: 52, 2022.
APA
Park, S., Kim, L.K., Park, H.M., Kim, H.J., & Heo, T. (2022). Inhibition of GP130/STAT3 and EMT by combined bazedoxifene and paclitaxel treatment in ovarian cancer. Oncology Reports, 47, 52. https://doi.org/10.3892/or.2022.8263
MLA
Park, S., Kim, L. K., Park, H. M., Kim, H. J., Heo, T."Inhibition of GP130/STAT3 and EMT by combined bazedoxifene and paclitaxel treatment in ovarian cancer". Oncology Reports 47.3 (2022): 52.
Chicago
Park, S., Kim, L. K., Park, H. M., Kim, H. J., Heo, T."Inhibition of GP130/STAT3 and EMT by combined bazedoxifene and paclitaxel treatment in ovarian cancer". Oncology Reports 47, no. 3 (2022): 52. https://doi.org/10.3892/or.2022.8263
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