Open Access

Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer (Review)

  • Authors:
    • Ling Yang
    • Hong-Jian Xie
    • Ying-Ying Li
    • Xia Wang
    • Xing-Xin Liu
    • Jia Mai
  • View Affiliations

  • Published online on: February 25, 2022     https://doi.org/10.3892/or.2022.8293
  • Article Number: 82
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cisplatin is one of the most effective chemotherapy drugs for ovarian cancer, but resistance is common. The initial response to platinum‑based chemotherapy is as high as 80%, but in most advanced patients, final relapse and death are caused by acquired drug resistance. The development of resistance to therapy in ovarian cancer is a significant hindrance to therapeutic efficacy. The resistance of ovarian cancer cells to chemotherapeutic mechanisms is rather complex and includes multidrug resistance, DNA damage repair, cell metabolism, oxidative stress, cell cycle regulation, cancer stem cells, immunity, apoptotic pathways, autophagy and abnormal signaling pathways. The present review provided an update of recent developments in our understanding of the mechanisms of ovarian cancer platinum‑based chemotherapy resistance, discussed current and emerging approaches for targeting these patients and presented challenges associated with these approaches, with a focus on development and overcoming resistance.
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April-2022
Volume 47 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Yang L, Xie H, Li Y, Wang X, Liu X and Mai J: Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer (Review). Oncol Rep 47: 82, 2022
APA
Yang, L., Xie, H., Li, Y., Wang, X., Liu, X., & Mai, J. (2022). Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer (Review). Oncology Reports, 47, 82. https://doi.org/10.3892/or.2022.8293
MLA
Yang, L., Xie, H., Li, Y., Wang, X., Liu, X., Mai, J."Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer (Review)". Oncology Reports 47.4 (2022): 82.
Chicago
Yang, L., Xie, H., Li, Y., Wang, X., Liu, X., Mai, J."Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer (Review)". Oncology Reports 47, no. 4 (2022): 82. https://doi.org/10.3892/or.2022.8293