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Article Open Access

Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer

  • Authors:
    • Nami Sato
    • Nozomu Sakai
    • Katsunori Furukawa
    • Tsukasa Takayashiki
    • Satoshi Kuboki
    • Shigetsugu Takano
    • Gaku Ohira
    • Hisahiro Matsubara
    • Masayuki Ohtsuka
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Graduate School of Medicine, Chiba University, Chuo‑ku, Chiba 260‑8670, Japan, Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chuo‑ku, Chiba 260‑8670, Japan
    Copyright: © Sato et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 87
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    Published online on: March 9, 2022
       https://doi.org/10.3892/or.2022.8298
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Abstract

Yin Yang 1 (YY1) is a multifunctional transcription factor with critical roles in carcinogenesis and metastasis. However, its biological role and clinical impact in colorectal cancer (CRC) remain unclear. In the present study, the function and underlying molecular mechanisms of YY1 in CRC progression were investigated. The immunohistochemistry (IHC) of 143 CRC tissues revealed a significant correlation of low YY1 expression with aggressive clinicopathological features, increased metastasis and recurrence and poor patient survival. Multivariate analysis identified low YY1 expression as an independent poor prognostic factor. Subsequently, the IHC of 66 paired CRC primary tumor and liver metastasis tissues revealed that low YY1 expression in the primary CRC was significantly associated with multiple liver metastases, major hepatectomy, extrahepatic metastasis and poor prognosis. In vitro experiments revealed that YY1 knockdown promoted the migration and invasion of CRC cells. To examine the downstream genes of YY1, a cDNA microarray assay was conducted and the differentially expressed genes between the YY1‑knockdown and control cells were compared. Integrin alpha V (ITGAV) and integrin beta 1 (ITGB1) were identified as upregulated hub genes using gene enrichment analysis and protein‑protein interaction analyses. Western blotting and IHC confirmed YY1 expression to be negatively correlated with ITGAV and ITGB1 expression. In summary, it was revealed that YY1, as a tumor‑suppressor in CRC, contributes to the survival of patients with CRC. Low YY1 expression was associated with the poor prognosis of the patients with primary CRC and liver metastases. YY1 suppressed the expression of ITGAV and ITGB1, and this transcriptional regulation may lead to the suppression of CRC cell migration and invasion.
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1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Zacharakis M, Xynos ID, Lazaris A, Smaro T, Kosmas C, Dokou A, Felekouras E, Antoniou E, Polyzos A, Sarantonis J, et al: Predictors of survival in stage IV metastatic colorectal cancer. Anticancer Res. 30:653–660. 2010.PubMed/NCBI

3 

Field K and Lipton L: Metastatic colorectal cancer-past, progress and future. World J Gastroenterol. 13:3806–3815. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Shi Y, Lee JS and Galvin KM: Everything you have ever wanted to know about Yin Yang 1. Biochim Biophys Acta. 1332:F49–F66. 1997.PubMed/NCBI

5 

Khachigian LM: The Yin and Yang of YY1 in tumor growth and suppression. Int J Cancer. 143:460–465. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Zhang Q, Wan M, Shi J, Horita DA, Miller LD, Kute TE, Kridel SJ, Kulik G and Sui G: Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation. J Mol Cell Biol. 8:232–243. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Liu D, Zhang J, Wu Y, Shi G, Yuan H, Lu Z, Zhu Q, Wu P, Lu C, Guo F, et al: YY1 suppresses proliferation and migration of pancreatic ductal adenocarcinoma by regulating the CDKN3/MdM2/P53/P21 signaling pathway. Int J Cancer. 142:1392–1404. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Wu S, Wang H, Li Y, Xie Y, Huang C, Zhao H, Miyagishi M and Kasim V: Transcription factor YY1 promotes cell proliferation by directly activating the pentose phosphate pathway. Cancer Res. 78:4549–4562. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Lee MH, Lahusen T, Wang RH, Xiao C, Xu X, Hwang YS, He WW, Shi Y and Deng CX: Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation. Oncogene. 31:116–127. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Zhang JJ, Zhu Y, Yang C, Liu X, Peng YP, Jiang KR, Miao Y and Xu ZK: Yin Yang-1 increases apoptosis through bax activation in pancreatic cancer cells. Oncotarget. 7:28498–28509. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Zhang JJ, Zhu Y, Xie KL, Peng YP, Tao JQ, Tang J, Li Z, Xu ZK, Dai CC, Qian ZY, et al: Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism. Mol Cancer. 13:1302014. View Article : Google Scholar : PubMed/NCBI

12 

Wang CC, Tsai MF, Hong TM, Chang GC, Chen CY, Yang WM, Chen JJ and Yang PC: The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion. Oncogene. 24:4081–4093. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Chen Q, Zhang JJ, Ge WL, Chen L, Yuan H, Meng LD, Huang XM, Shen P, Miao Y and Jiang KR: YY1 inhibits the migration and invasion of pancreatic ductal adenocarcinoma by downregulating the FER/STAT3/MMP2 signaling pathway. Cancer Lett. 463:37–49. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Antonio-Andrés G, Rangel-Santiago J, Tirado-Rodríguez B, Martinez-Ruiz GU, Klunder-Klunder M, Vega MI, Lopez-Martinez B, Jiménez-Hernández E, Torres Nava J, Medina-Sanson A and Huerta-Yepez S: Role of Yin Yang-1 (YY1) in the transcription regulation of the multi-drug resistance (MDR1) gene. Leuk Lymphoma. 59:2628–2638. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Wottrich S, Kaufhold S, Chrysos E, Zoras O, Baritaki S and Bonavida B: Inverse correlation between the metastasis suppressor RKIP and the metastasis inducer YY1: Contrasting roles in the regulation of chemo/immuno-resistance in cancer. Drug Resist Updat. 30:28–38. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Vega MI, Valencia-Hipolito A, Hernandez-Atenogenes M, Vega GG, Mayani H, Mendez-Tenorio A, Martinez-Maza O, Huerta-Yepez S and Bonavida B: High expression of Kruppel-Like Factor 4 (KLF4) and its regulation by Yin Yang 1 (YY1) in non-Hodgkin's B-cell lymphomas: Clinical implication. Cancer Res. 73 (Suppl 8):S54502013.

17 

Cho AA and Bonavida B: Targeting the overexpressed YY1 in cancer inhibits EMT and metastasis. Crit Rev Oncog. 22:49–61. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Palmer MB, Majumder P, Cooper JC, Yoon H, Wade PA and Boss JM: Yin yang 1 regulates the expression of snail through a distal enhancer. Mol Cancer Res. 7:221–229. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Matsumura N, Huang Z, Baba T, Lee PS, Barnett JC, Mori S, Chang JT, Kuo WL, Gusberg AH, Whitaker RS, et al: Yin yang 1 modulates taxane response in epithelial ovarian cancer. Mol Cancer Res. 7:210–220. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Naidoo K, Clay V, Hoyland JA, Swindell R, Linton K, Illidge T, Radford JA and Byers RJ: YY1 expression predicts favourable outcome in follicular lymphoma. J Clin Pathol. 64:125–129. 2011. View Article : Google Scholar : PubMed/NCBI

21 

de Nigris F, Botti C, de Chiara A, Rossiello R, Apice G, Fazioli F, Fiorito C, Sica V and Napoli C: Expression of transcription factor Yin Yang 1 in human osteosarcomas. Eur J Cancer. 42:2420–2424. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Wang W, Yue Z, Tian Z, Xie Y, Zhang J, She Y, Yang B, Ye Y and Yang Y: Expression of Yin Yang 1 in cervical cancer and its correlation with E-cadherin expression and HPV16 E6. PLoS One. 13:e01933402018. View Article : Google Scholar : PubMed/NCBI

23 

Xu W, Banerji S, Davie JR, Kassie F, Yee D and Kratzke R: Yin Yang gene expression ratio signature for lung cancer prognosis. PLoS One. 8:e687422013. View Article : Google Scholar : PubMed/NCBI

24 

Seligson D, Horvath S, Huerta-Yepez S, Hanna S, Garban H, Roberts A, Shi T, Liu X, Chia D, Goodglick L and Bonavida B: Expression of transcription factor Yin Yang 1 in prostate cancer. Int J Oncol. 27:131–141. 2005.PubMed/NCBI

25 

Kang W, Tong JH, Chan AW, Zhao J, Dong Y, Wang S, Yang W, Sin FM, Ng SS, Yu J, et al: Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma. J Transl Med. 12:802014. View Article : Google Scholar : PubMed/NCBI

26 

Sanchez-Carbayo M, Socci ND, Lozano J, Saint F and Cordon-Cardo C: Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. J Clin Oncol. 24:778–789. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Ogata H, Goto S, Sato K, Fujibuchi W, Bono H and Kanehisa M: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 27:29–34. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Berrier AL and Yamada KM: Cell-matrix adhesion. J Cell Physiol. 213:565–573. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Caswell PT and Norman JC: Integrin trafficking and the control of cell migration. Traffic. 7:14–21. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Missan DS and DiPersio M: Integrin control of tumor invasion. Crit Rev Eukaryot Gene Expr. 22:309–324. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Chinnappan D, Xiao D, Ratnasari A, Andry C, King TC and Weber HC: Transcription factor YY1 expression in human gastrointestinal cancer cells. Int J Oncol. 34:1417–1423. 2009.PubMed/NCBI

33 

Zhang N, Li X, Wu CW, Dong Y, Cai M, Mok MT, Wang H, Chen J, Ng SS, Chen M, et al: microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis. Oncogene. 32:5078–5088. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Liu J, Zhan Y, Wang J, Wang J, Guo J and Kong D: Long noncoding RNA LINC01578 drives colon cancer metastasis through a positive feedback loop with the NF-κB/YY1 axis. Mol Oncol. 14:3211–3233. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Yokoyama NN, Pate KT, Sprowl S and Waterman ML: A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer. Nucleic Acids Res. 38:6375–6388. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Chen Z, Han S, Huang W, Wu J, Liu Y, Cai S, He Y, Wu S and Song W: MicroRNA-215 suppresses cell proliferation, migration and invasion of colon cancer by repressing Yin-Yang 1. Biochem Biophys Res Commun. 479:482–488. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Tauriello DV, Calon A, Lonardo E and Batlle E: Determinants of metastatic competency in colorectal cancer. Mol Oncol. 11:97–119. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Dmello RS, To SQ and Chand AL: Therapeutic targeting of the tumour microenvironment in metastatic colorectal cancer. Int J Mol Sci. 22:20672021. View Article : Google Scholar : PubMed/NCBI

39 

Chen Q, Yang C, Chen L, Zhang JJ, Ge WL, Yuan H, Meng LD, Huang XM, Shen P, Miao Y and Jiang KR: YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways. Br J Cancer. 121:912–921. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Zheng L, Chen Y, Ye L, Jiao W, Song H, Mei H, Li D, Yang F, Li H, Huang K and Tong Q: miRNA-584-3p inhibits gastric cancer progression by repressing Yin Yang 1-facilitated MMP-14 expression. Sci Rep. 7:89672017. View Article : Google Scholar : PubMed/NCBI

41 

Hynes RO: Integrins: Bidirectional, allosteric signaling machines. Cell. 110:673–687. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Hamidi H and Ivaska J: Every step of the way: Integrins in cancer progression and metastasis. Nat Rev Cancer. 18:533–548. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Seguin L, Desgrosellier JS, Weis SM and Cheresh DA: Integrins and cancer: Regulators of cancer stemness, metastasis, and drug resistance. Trends Cell Biol. 25:234–240. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Lepsenyi M, Algethami N, Al-Haidari AA, Algaber A, Syk I, Rahman M and Thorlacius H: CXCL2-CXCR2 axis mediates αV integrin-dependent peritoneal metastasis of colon cancer cells. Clin Exp Metastasis. 38:401–410. 2021. View Article : Google Scholar : PubMed/NCBI

45 

Brakebusch C and Fässler R: Beta 1 integrin function in vivo: Adhesion, migration and more. Cancer Metastasis Rev. 24:403–411. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Attieh Y, Clark AG, Grass C, Richon S, Pocard M, Mariani P, Elkhatib N, Betz T, Gurchenkov B and Vignjevic DM: Cancer-associated fibroblasts lead tumor invasion through integrin-β3-dependent fibronectin assembly. J Cell Biol. 216:3509–3520. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Kato H, Liao Z, Mitsios JV, Wang H-Y, Deryugina EI, Varner JA, Quigley JP and Shattil SJ: The primacy of β1 integrin activation in the metastatic cascade. PLoS One. 7:e465762012. View Article : Google Scholar : PubMed/NCBI

48 

Mook OR, van Marle J, Jonges R, Vreeling-Sindelárová H, Frederiks WM and Van Noorden CJ: Interactions between colon cancer cells and hepatocytes in rats in relation to metastasis. J Cell Mol Med. 12:2052–2061. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Waisberg J, De Souza Viana L, Affonso Junior RJ, Silva SR, Denadai MV, Margeotto FB, De Souza CS and Matos D: Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer. Anticancer Res. 34:5599–5607. 2014.PubMed/NCBI

50 

Liu QZ, Gao XH, Chang WJ, Gong HF, Fu CG, Zhang W and Cao GW: Expression of ITGB1 predicts prognosis in colorectal cancer: A large prospective study based on tissue microarray. Int J Clin Exp Pathol. 8:12802–12810. 2015.PubMed/NCBI

51 

Zhang J, Liu K, Peng P, Li S, Ye Z, Su Y, Liu S, Qin M and Huang J: Upregulation of nectin-4 is associated with ITGB1 and vasculogenic mimicry and may serve as a predictor of poor prognosis in colorectal cancer. Oncol Lett. 18:1163–1170. 2019.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sato N, Sakai N, Furukawa K, Takayashiki T, Kuboki S, Takano S, Ohira G, Matsubara H and Ohtsuka M: Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer. Oncol Rep 47: 87, 2022.
APA
Sato, N., Sakai, N., Furukawa, K., Takayashiki, T., Kuboki, S., Takano, S. ... Ohtsuka, M. (2022). Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer. Oncology Reports, 47, 87. https://doi.org/10.3892/or.2022.8298
MLA
Sato, N., Sakai, N., Furukawa, K., Takayashiki, T., Kuboki, S., Takano, S., Ohira, G., Matsubara, H., Ohtsuka, M."Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer". Oncology Reports 47.5 (2022): 87.
Chicago
Sato, N., Sakai, N., Furukawa, K., Takayashiki, T., Kuboki, S., Takano, S., Ohira, G., Matsubara, H., Ohtsuka, M."Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer". Oncology Reports 47, no. 5 (2022): 87. https://doi.org/10.3892/or.2022.8298
Copy and paste a formatted citation
x
Spandidos Publications style
Sato N, Sakai N, Furukawa K, Takayashiki T, Kuboki S, Takano S, Ohira G, Matsubara H and Ohtsuka M: Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer. Oncol Rep 47: 87, 2022.
APA
Sato, N., Sakai, N., Furukawa, K., Takayashiki, T., Kuboki, S., Takano, S. ... Ohtsuka, M. (2022). Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer. Oncology Reports, 47, 87. https://doi.org/10.3892/or.2022.8298
MLA
Sato, N., Sakai, N., Furukawa, K., Takayashiki, T., Kuboki, S., Takano, S., Ohira, G., Matsubara, H., Ohtsuka, M."Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer". Oncology Reports 47.5 (2022): 87.
Chicago
Sato, N., Sakai, N., Furukawa, K., Takayashiki, T., Kuboki, S., Takano, S., Ohira, G., Matsubara, H., Ohtsuka, M."Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer". Oncology Reports 47, no. 5 (2022): 87. https://doi.org/10.3892/or.2022.8298
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