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Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer

  • Authors:
    • Nobuya Daitoku
    • Yuji Miyamoto
    • Yukiharu Hiyoshi
    • Ryuma Tokunaga
    • Yuki Sakamoto
    • Hiroshi Sawayama
    • Takatsugu Ishimoto
    • Yoshifumi Baba
    • Naoya Yoshida
    • Hideo Baba
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860‑8556, Japan
    Copyright: © Daitoku et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 107
    |
    Published online on: April 20, 2022
       https://doi.org/10.3892/or.2022.8318
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Abstract

Activin A is a member of the transforming growth factor‑β superfamily of cytokines and displays various pathophysiological activities, including regulation of muscle catabolism and atrophy. Activin A expression is upregulated in several human cancer types and in certain pathologies, its expression is associated with poor prognosis. In the present study, activin A expression was assessed in colorectal cancer (CRC) tissue specimens from 157 patients with primary CRC and the relationship between activin A levels and clinicopathological characteristics, including skeletal muscle mass, and prognosis, was determined. Furthermore, the effects of knockdown of endogenous or exposure to exogenous activin A on the malignant behavior of human CRC cell lines were investigated in vitro. The results indicated that activin A mRNA was significantly upregulated in CRC tumor tissues compared with normal intestinal epithelium. High activin A expression was significantly associated with shorter cancer‑specific survival (P=0.047) and overall survival (P=0.014). According to a multivariate analysis, tumor activin A levels were an independent prognostic factor for overall survival (P=0.001). However, activin A mRNA levels were not associated with the skeletal muscle index. The in vitro experiments demonstrated that exposure to exogenous activin A increased the proliferation, invasion and migration of CRC cell lines, whereas knockdown of endogenous activin A had the opposite effects. In conclusion, activin A is an autocrine and paracrine regulator of CRC cell proliferation and high tumor expression of activin A is associated with poor prognosis in patients with CRC.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

van der Stok EP, Spaander MCW, Grunhagen DJ, Verhoef C and Kuipers EJ: Surveillance after curative treatment for colorectal cancer. Nat Rev Clin Oncol. 14:297–315. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Tokunaga R, Imamura Y, Nakamura K, Uchihara T, Ishimoto T, Nakagawa S, Iwatsuki M, Baba Y, Sakamoto Y, Miyamoto Y, et al: Carbohydrate antigen 19-9 is a useful prognostic marker in esophagogastric junction adenocarcinoma. Cancer Med. 4:1659–1666. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Daitoku N, Miyamoto Y, Tokunaga R, Sakamoto Y, Hiyoshi Y, Iwatsuki M, Baba Y, Iwagami S, Yoshida N and Baba H: Controlling nutritional status (CONUT) score is a prognostic marker in metastatic colorectal cancer patients receiving first-line chemotherapy. Anticancer Res. 38:4883–4888. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Daitoku N, Miyamoto Y, Sakamoto Y, Tokunaga R, Hiyoshi Y, Nagai Y, Iwatsuki M, Iwagami S, Yoshida N and Baba H: Prognostic significance of serum p53 antibody according to KRAS status in metastatic colorectal cancer patients. Int J Clin Oncol. 25:651–659. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Taniguchi H, Yamazaki K, Yoshino T, Muro K, Yatabe Y, Watanabe T, Ebi H, Ochiai A, Baba E and Tsuchihara K; Japanese Society of Medical Oncology, : Japanese society of medical oncology clinical guidelines: RAS (KRAS/NRAS) mutation testing in colorectal cancer patients. Cancer Sci. 106:324–327. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Yoshino T, Arnold D, Taniguchi H, Pentheroudakis G, Yamazaki K, Xu RH, Kim TW, Ismail F, Tan IB, Yeh KH, et al: Pan-Asian adapted ESMO consensus guidelines for the management of patients with metastatic colorectal cancer: A JSMO-ESMO initiative endorsed by CSCO, KACO, MOS, SSO and TOS. Ann Oncol. 29:44–70. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Forones NM and Tanaka M: CEA and CA 19-9 as prognostic indexes in colorectal cancer. Hepatogastroenterology. 46:905–908. 1999.PubMed/NCBI

9 

Miyamoto Y, Baba Y, Sakamoto Y, Ohuchi M, Tokunaga R, Kurashige J, Hiyoshi Y, Iwagami S, Yoshida N, Yoshida M, et al: Sarcopenia is a negative prognostic factor after curative resection of colorectal cancer. Ann Surg Oncol. 22:2663–2668. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Miyamoto Y, Baba Y, Sakamoto Y, Ohuchi M, Tokunaga R, Kurashige J, Hiyoshi Y, Iwagami S, Yoshida N, Watanabe M and Baba H: Negative impact of skeletal muscle loss after systemic chemotherapy in patients with unresectable colorectal cancer. PLoS One. 10:e01297422015. View Article : Google Scholar : PubMed/NCBI

11 

Evans WJ: Skeletal muscle loss: Cachexia, sarcopenia, and inactivity. Am J Clin Nutr. 91:1123S–1127S. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Kitano Y, Yamashita YI, Saito Y, Nakagawa S, Okabe H, Imai K, Komohara Y, Miyamoto Y, Chikamoto A, Ishiko T and Baba H: Sarcopenia affects systemic and local immune system and impacts postoperative outcome in patients with extrahepatic cholangiocarcinoma. World J Surg. 43:2271–2280. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Harada K, Ida S, Baba Y, Ishimoto T, Kosumi K, Tokunaga R, Izumi D, Ohuchi M, Nakamura K, Kiyozumi Y, et al: Prognostic and clinical impact of sarcopenia in esophageal squamous cell carcinoma. Dis Esophagus. 29:627–633. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Levolger S, van Vugt JL, de Bruin RW and JN IJ: Systematic review of sarcopenia in patients operated on for gastrointestinal and hepatopancreatobiliary malignancies. Br J Surg. 102:1448–1458. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Gaddykurten D, Tsuchida K and Vale W: Activins and the receptor serine kinase superfamily. Recent Prog Horm Res. 50:109–129. 1995.PubMed/NCBI

16 

Miyamoto Y, Hanna DL, Zhang W, Baba H and Lenz HJ: Molecular pathways: Cachexia signaling-a targeted approach to cancer treatment. Clin Cancer Res. 22:3999–4004. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Lokireddy S, Wijesoma IW, Bonala S, Wei M, Sze SK, McFarlane C, Kambadur R and Sharma M: Myostatin is a novel tumoral factor that induces cancer cachexia. Biochem J. 446:23–36. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Lyu S, Jiang C, Xu R, Huang Y and Yan S: INHBA upregulation correlates with poorer prognosis in patients with esophageal squamous cell carcinoma. Cancer Manag Res. 10:1585–1596. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Oshima T, Yoshihara K, Aoyama T, Hasegawa S, Sato T, Yamamoto N, Akito N, Shiozawa M, Yoshikawa T, Numata K, et al: Relation of INHBA gene expression to outcomes in gastric cancer after curative surgery. Anticancer Res. 34:2303–2309. 2014.PubMed/NCBI

20 

Katayama Y, Oshima T, Sakamaki K, Aoyama T, Sato T, Masudo K, Shiozawa M, Yoshikawa T, Rino Y, Imada T and Masuda M: Clinical significance of INHBA gene expression in patients with gastric cancer who receive curative resection followed by adjuvant S-1 chemotherapy. In Vivo. 31:565–571. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Okano M, Yamamoto H, Ohkuma H, Kano Y, Kim H, Nishikawa S, Konno M, Kawamoto K, Haraguchi N, Takemasa I, et al: Significance of INHBA expression in human colorectal cancer. Oncol Rep. 30:2903–2908. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Hoda MA, Rozsas A, Lang E, Klikovits T, Lohinai Z, Torok S, Berta J, Bendek M, Berger W, Hegedus B, et al: High circulating activin a level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma. Oncotarget. 7:13388–13399. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Sauerbrei W, Taube SE, McShane LM, Cavenagh MM and Altman DG: Reporting recommendations for tumor marker prognostic studies (REMARK): An abridged explanation and elaboration. J Natl Cancer Inst. 110:803–811. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Hoda MA, Munzker J, Ghanim B, Schelch K, Klikovits T, Laszlo V, Sahin E, Bedeir A, Lackner A, Dome B, et al: Suppression of activin a signals inhibits growth of malignant pleural mesothelioma cells. Br J Cancer. 107:1978–1986. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Zhou X, Wang JL, Lu J, Song Y, Kwak KS, Jiao Q, Rosenfeld R, Chen Q, Boone T, Simonet WS, et al: Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell. 142:531–543. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Janssen I, Heymsfield SB and Ross R: Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc. 50:889–896. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Loumaye A, de Barsy M, Nachit M, Lause P, van Maanen A, Trefois P, Gruson D and Thissen JP: Circulating activin A predicts survival in cancer patients. J Cachexia Sarcopenia Muscle. 8:768–777. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Zhong XL, Pons M, Poirier C, Jiang Y, Liu J, Sandusky GE, Shahda S, Nakeeb A, Schmidt CM, House MG, et al: The systemic activin response to pancreatic cancer: Implications for effective cancer cachexia therapy. J Cachexia Sarcopenia Muscle. 10:1083–1101. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Matsuzaki K: Smad phosphoisoform signaling specificity: The right place at the right time. Carcinogenesis. 32:1578–1588. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Albano D, Messina C, Vitale J and Sconfienza LM: Imaging of sarcopenia: Old evidence and new insights. Eur Radiol. 30:2199–2208. 2020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Daitoku N, Miyamoto Y, Hiyoshi Y, Tokunaga R, Sakamoto Y, Sawayama H, Ishimoto T, Baba Y, Yoshida N, Baba H, Baba H, et al: Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer. Oncol Rep 47: 107, 2022.
APA
Daitoku, N., Miyamoto, Y., Hiyoshi, Y., Tokunaga, R., Sakamoto, Y., Sawayama, H. ... Baba, H. (2022). Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer. Oncology Reports, 47, 107. https://doi.org/10.3892/or.2022.8318
MLA
Daitoku, N., Miyamoto, Y., Hiyoshi, Y., Tokunaga, R., Sakamoto, Y., Sawayama, H., Ishimoto, T., Baba, Y., Yoshida, N., Baba, H."Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer". Oncology Reports 47.6 (2022): 107.
Chicago
Daitoku, N., Miyamoto, Y., Hiyoshi, Y., Tokunaga, R., Sakamoto, Y., Sawayama, H., Ishimoto, T., Baba, Y., Yoshida, N., Baba, H."Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer". Oncology Reports 47, no. 6 (2022): 107. https://doi.org/10.3892/or.2022.8318
Copy and paste a formatted citation
x
Spandidos Publications style
Daitoku N, Miyamoto Y, Hiyoshi Y, Tokunaga R, Sakamoto Y, Sawayama H, Ishimoto T, Baba Y, Yoshida N, Baba H, Baba H, et al: Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer. Oncol Rep 47: 107, 2022.
APA
Daitoku, N., Miyamoto, Y., Hiyoshi, Y., Tokunaga, R., Sakamoto, Y., Sawayama, H. ... Baba, H. (2022). Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer. Oncology Reports, 47, 107. https://doi.org/10.3892/or.2022.8318
MLA
Daitoku, N., Miyamoto, Y., Hiyoshi, Y., Tokunaga, R., Sakamoto, Y., Sawayama, H., Ishimoto, T., Baba, Y., Yoshida, N., Baba, H."Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer". Oncology Reports 47.6 (2022): 107.
Chicago
Daitoku, N., Miyamoto, Y., Hiyoshi, Y., Tokunaga, R., Sakamoto, Y., Sawayama, H., Ishimoto, T., Baba, Y., Yoshida, N., Baba, H."Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer". Oncology Reports 47, no. 6 (2022): 107. https://doi.org/10.3892/or.2022.8318
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