Open Access

Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer

  • Authors:
    • Nobuya Daitoku
    • Yuji Miyamoto
    • Yukiharu Hiyoshi
    • Ryuma Tokunaga
    • Yuki Sakamoto
    • Hiroshi Sawayama
    • Takatsugu Ishimoto
    • Yoshifumi Baba
    • Naoya Yoshida
    • Hideo Baba
  • View Affiliations

  • Published online on: April 20, 2022     https://doi.org/10.3892/or.2022.8318
  • Article Number: 107
  • Copyright: © Daitoku et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Activin A is a member of the transforming growth factor‑β superfamily of cytokines and displays various pathophysiological activities, including regulation of muscle catabolism and atrophy. Activin A expression is upregulated in several human cancer types and in certain pathologies, its expression is associated with poor prognosis. In the present study, activin A expression was assessed in colorectal cancer (CRC) tissue specimens from 157 patients with primary CRC and the relationship between activin A levels and clinicopathological characteristics, including skeletal muscle mass, and prognosis, was determined. Furthermore, the effects of knockdown of endogenous or exposure to exogenous activin A on the malignant behavior of human CRC cell lines were investigated in vitro. The results indicated that activin A mRNA was significantly upregulated in CRC tumor tissues compared with normal intestinal epithelium. High activin A expression was significantly associated with shorter cancer‑specific survival (P=0.047) and overall survival (P=0.014). According to a multivariate analysis, tumor activin A levels were an independent prognostic factor for overall survival (P=0.001). However, activin A mRNA levels were not associated with the skeletal muscle index. The in vitro experiments demonstrated that exposure to exogenous activin A increased the proliferation, invasion and migration of CRC cell lines, whereas knockdown of endogenous activin A had the opposite effects. In conclusion, activin A is an autocrine and paracrine regulator of CRC cell proliferation and high tumor expression of activin A is associated with poor prognosis in patients with CRC.
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June-2022
Volume 47 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Daitoku N, Miyamoto Y, Hiyoshi Y, Tokunaga R, Sakamoto Y, Sawayama H, Ishimoto T, Baba Y, Yoshida N, Baba H, Baba H, et al: Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer. Oncol Rep 47: 107, 2022
APA
Daitoku, N., Miyamoto, Y., Hiyoshi, Y., Tokunaga, R., Sakamoto, Y., Sawayama, H. ... Baba, H. (2022). Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer. Oncology Reports, 47, 107. https://doi.org/10.3892/or.2022.8318
MLA
Daitoku, N., Miyamoto, Y., Hiyoshi, Y., Tokunaga, R., Sakamoto, Y., Sawayama, H., Ishimoto, T., Baba, Y., Yoshida, N., Baba, H."Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer". Oncology Reports 47.6 (2022): 107.
Chicago
Daitoku, N., Miyamoto, Y., Hiyoshi, Y., Tokunaga, R., Sakamoto, Y., Sawayama, H., Ishimoto, T., Baba, Y., Yoshida, N., Baba, H."Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer". Oncology Reports 47, no. 6 (2022): 107. https://doi.org/10.3892/or.2022.8318