SIRT1 suppresses pituitary tumor progression by downregulating PTTG1 expression

  • Authors:
    • Jinxiang Huang
    • Fenglin Zhang
    • Guohan Hu
    • Yuan Pan
    • Wei Sun
    • Lei Jiang
    • Peng Wang
    • Jiting Qiu
    • Xuehua Ding
  • View Affiliations

  • Published online on: June 21, 2022     https://doi.org/10.3892/or.2022.8354
  • Article Number: 143
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Abstract

Although pituitary tumors are among the most common types of brain tumor, the underlying molecular mechanism of this disease remains obscure. To this end, the role of sirtuin 1 (SIRT1) in pituitary tumors was reported. The results of reverse transcription‑quantitative PCR and immunohistochemistry revealed that sirtuin 1 (SIRT1) expression was downregulated in the tumor tissues of patients with pituitary tumors. In vitro experiments of the present study demonstrated that SIRT1 upregulation suppressed pituitary tumor cell line growth, while SIRT1 downregulation demonstrated the opposite effect. Additionally, it was determined that the enzymatic activity of SIRT1 was required for its cellular function. A mechanistic experiment determined that SIRT1 negatively regulated pituitary tumor‑transforming gene 1 (PTTG1) expression through the deacetylation of histone (H)3 lysine (K)9ac at the promoter region of PTTG1. Moreover, H3K9ac levels at the PTTG1 promoter were determined to be an essential regulatory element for PTTG1 expression. Thus, it was concluded that the SIRT1/H3K9ac/PTTG1 axis contributed to pituitary tumor formation and may represent a potential therapeutic strategy.
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August-2022
Volume 48 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Huang J, Zhang F, Hu G, Pan Y, Sun W, Jiang L, Wang P, Qiu J and Ding X: SIRT1 suppresses pituitary tumor progression by downregulating PTTG1 expression. Oncol Rep 48: 143, 2022
APA
Huang, J., Zhang, F., Hu, G., Pan, Y., Sun, W., Jiang, L. ... Ding, X. (2022). SIRT1 suppresses pituitary tumor progression by downregulating PTTG1 expression. Oncology Reports, 48, 143. https://doi.org/10.3892/or.2022.8354
MLA
Huang, J., Zhang, F., Hu, G., Pan, Y., Sun, W., Jiang, L., Wang, P., Qiu, J., Ding, X."SIRT1 suppresses pituitary tumor progression by downregulating PTTG1 expression". Oncology Reports 48.2 (2022): 143.
Chicago
Huang, J., Zhang, F., Hu, G., Pan, Y., Sun, W., Jiang, L., Wang, P., Qiu, J., Ding, X."SIRT1 suppresses pituitary tumor progression by downregulating PTTG1 expression". Oncology Reports 48, no. 2 (2022): 143. https://doi.org/10.3892/or.2022.8354