Open Access

Anticancer effects of natural phytochemicals in anaplastic thyroid cancer (Review)

  • Authors:
    • Yitian Li
    • Jing Zhang
    • Huihui Zhou
    • Zhen Du
  • View Affiliations

  • Published online on: July 15, 2022     https://doi.org/10.3892/or.2022.8368
  • Article Number: 156
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Anaplastic thyroid cancer (ATC) is an aggressive and lethal malignancy having a dismal prognosis. Phytochemicals are bioactive components obtained from plants that have been proven useful to treat numerous diseases. Phytochemicals are also an important source of novel anticancer drugs and an important area of research due to the numerous available candidates that can potentially treat cancers. This review discusses naturally occurring phytochemicals and their derivatives that show promising anticancer effects in anaplastic thyroid cancer. Anticancer effects include cell growth inhibition, induction of apoptosis, promoting cell cycle arrest, suppressing angiogenesis, modulating autophagy, and increasing the production of reactive oxygen species. Phytochemicals are not only prospective candidates in the therapy of anaplastic thyroid cancer but also exhibit potential as adjuvants to improve the anticancer effects of other drugs. Although some phytochemicals have excellent anticancer properties, drug resistance observed during the use of resveratrol and artemisinin in different anaplastic thyroid cancer cell lines is still a problem. Anaplastic thyroid cancer cells have several biological, clinical, and drug‑resistance features that differ from differentiated thyroid cancer cells. Phytochemicals such as resveratrol and quercetin exhibit different biological effects in anaplastic thyroid cancer and differentiated thyroid cancer. Tumor cells depend on increased aerobic glycolysis by mitochondrial oxidative phosphorylation to provide energy for their rapid growth, invasiveness, and drug resistance. Phytochemicals can alter signaling cascades, modulate the metabolic properties of cancer cells, and influence the mitochondrial membrane potential of anaplastic thyroid cancer cells. These findings enrich our knowledge of the anticancer effects of phytochemicals and highlight alternative therapies to prevent drug resistance in anaplastic thyroid cancer.
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September-2022
Volume 48 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Li Y, Zhang J, Zhou H and Du Z: Anticancer effects of natural phytochemicals in anaplastic thyroid cancer (Review). Oncol Rep 48: 156, 2022
APA
Li, Y., Zhang, J., Zhou, H., & Du, Z. (2022). Anticancer effects of natural phytochemicals in anaplastic thyroid cancer (Review). Oncology Reports, 48, 156. https://doi.org/10.3892/or.2022.8368
MLA
Li, Y., Zhang, J., Zhou, H., Du, Z."Anticancer effects of natural phytochemicals in anaplastic thyroid cancer (Review)". Oncology Reports 48.3 (2022): 156.
Chicago
Li, Y., Zhang, J., Zhou, H., Du, Z."Anticancer effects of natural phytochemicals in anaplastic thyroid cancer (Review)". Oncology Reports 48, no. 3 (2022): 156. https://doi.org/10.3892/or.2022.8368