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Article

Conjoint analysis of OPRPN and SMR3A protein expression as potential predictive biomarkers for head and neck squamous cell carcinoma after radiotherapy

  • Authors:
    • Chao Rong
    • Jennifer Grünow
    • Julia Thierauf
    • Carlota Lucena-Porcel
    • Gerald Major
    • Dana Holzinger
    • Gerhard Dyckhoff
    • Johann Kern
    • Anne Lammert
    • Claudia Scherl
    • Nicole Rotter
    • Peter K. Plinkert
    • Annette Affolter
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Biology and Basic Medical Sciences, Suzhou Medical College of Soochow University, Suzhou 215123, P.R. China, Department of Otorhinolaryngology, Head and Neck Surgery, Experimental Head and Neck Oncology, Heidelberg University Hospital, D‑69120 Heidelberg, Germany, Institute of Pathology, Heidelberg University Hospital, D‑69120 Heidelberg, Germany, Department of Radiation Oncology, Heidelberg University Hospital, D‑69120 Heidelberg, Germany, Molecular Diagnostics of Oncogenic Infections, German Cancer Research Center (DKFZ), D‑69120 Heidelberg, Germany, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim of Heidelberg University, D‑68167 Mannheim, Germany
  • Article Number: 159
    |
    Published online on: July 20, 2022
       https://doi.org/10.3892/or.2022.8374
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Abstract

Increased submaxillary gland androgen‑regulated protein 3A (SMR3A) expression was previously shown to serve as an independent risk factor for oropharyngeal squamous cell carcinoma (OPSCC) and as a surrogate biomarker for active estrogen receptor 2 signaling in radioresistant tumor cells. In the present study, it was aimed to unravel the expression and clinical significance of another member of the opiorphin family, opiorphin prepropeptide (OPRPN), in the radiotherapy for head and neck squamous cell carcinoma (HNSCC). Expression of SMR3A and OPRPN were analyzed for the prior and post fractionated irradiation (4x2 Gy) by double immunofluorescence staining in established HNSCC cell lines as well as by immunohistochemical (IHC) staining in ex vivo tumor tissues. Next, in a retrospective experimental cohort study, primary tumor samples from OPSCC patients (n=96), who received definitive surgery and adjuvant radiotherapy were reviewed, and expression levels of OPRPN protein were detected by IHC. Immunoreactivity scores (IRS) were associated with pathological and clinical risk factors by Chi‑square analysis. Survival analysis was performed by using the Kaplan‑Meier plot, log‑rank test and Cox regression analysis. The expression levels of OPRPN and SMR3A protein were both induced by fractionated irradiation in vitro and ex vivo. In primary tumor samples, IRS of OPRPN was significantly higher than scores of SMR3A expression and positively correlated with expression patterns of SMR3A. SMR3A was confirmed to serve as an unfavorable factor, while OPRPN protein had no significant association with the clinical outcome of patients with OPSCC. A combinational analysis revealed that the subgroup with SMR3AhighOPRPNlow staining pattern had the worst clinical outcome among the various subgroups. Multivariate Cox regression analyses indicated that high expression of SMR3A serves as an independent unfavorable biomarker, while increased expression of OPRPN appears to exert protective function. In summary, the present study indicated that SMR3A and OPRPN serve as potential prognostic markers for HNSCC after radiotherapy.
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View References

1 

Tong Y, Tar M, Melman A and Davies K: The opiorphin gene (ProL1) and its homologues function in erectile physiology. BJU Int. 102:736–740. 2008. View Article : Google Scholar

2 

Wisner A, Dufour E, Messaoudi M, Nejdi A, Marcel A, Ungeheuer MN and Rougeot C: Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. Proc Natl Acad Sci USA. 103:17979–17984. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Mizerska-Dudka M and Kandefer-Szerszeń M: Opioids, neutral endopeptidase, its inhibitors and cancer: Is there a relationship among them? Arch Immunol Ther Exp (Warsz). 63:197–205. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Maguer-Satta V, Besançon R and Bachelard-Cascales E: Concise review: Neutral endopeptidase (CD10): A multifaceted environment actor in stem cells, physiological mechanisms, and cancer. Stem Cells. 29:389–396. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Chen L, Lin YL, Peng G and Li F: Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc Natl Acad Sci USA. 109:17966–17971. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Sørensen KD, Abildgaard MO, Haldrup C, Ulhøi BP, Kristensen H, Strand S, Parker C, Høyer S, Borre M and Ørntoft TF: Prognostic significance of aberrantly silenced ANPEP expression in prostate cancer. Br J Cancer. 108:420–428. 2013. View Article : Google Scholar

7 

Piattelli A, Fioroni M, Iezzi G, Perrotti V, Stellini E, Piattelli M and Rubini C: CD10 expression in stromal cells of oral cavity squamous cell carcinoma: A clinic and pathologic correlation. Oral Dis. 12:301–304. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Erhuma M, Köbel M, Mustafa T, Wulfänger J, Dralle H, Hoang-Vu C, Langner J, Seliger B and Kehlen A: Expression of neutral endopeptidase (NEP/CD10) on pancreatic tumor cell lines, pancreatitis and pancreatic tumor tissues. Int J Cancer. 120:2393–2400. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Kawamura J, Shimada Y, Kitaichi H, Komoto I, Hashimoto Y, Kaganoi J, Miyake M, Yamasaki S, Kondo K and Imamura M: Clinicopathological significance of aminopeptidase N/CD13 expression in human gastric carcinoma. Hepatogastroenterology. 54:36–40. 2007.PubMed/NCBI

10 

Leemans CR, Snijders PJF and Brakenhoff RH: The molecular landscape of head and neck cancer. Nat Rev Cancer. 18:269–282. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Higgins GS, O'Cathail SM, Muschel RJ and McKenna WG: Drug radiotherapy combinations: Review of previous failures and reasons for future optimism. Cancer Treat Rev. 41:105–113. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Castilho RM, Squarize CH and Almeida LO: Epigenetic modifications and head and neck cancer: Implications for tumor progression and resistance to therapy. Int J Mol Sci. 18:15062017. View Article : Google Scholar

13 

Caudell JJ, Torres-Roca JF, Gillies RJ, Enderling H, Kim S, Rishi A, Moros EG and Harrison LB: The future of personalised radiotherapy for head and neck cancer. Lancet Oncol. 18:e266–e273. 2017. View Article : Google Scholar

14 

Koffler J, Holzinger D, Sanhueza GA, Flechtenmacher C, Zaoui K, Lahrmann B, Grabe N, Plinkert PK and Hess J: Submaxillary gland androgen-regulated protein 3A expression is an unfavorable risk factor for the survival of oropharyngeal squamous cell carcinoma patients after surgery. Eur Arch Otorhinolaryngol. 270:1493–1500. 2013. View Article : Google Scholar

15 

Grünow J, Rong C, Hischmann J, Zaoui K, Flechtenmacher C, Weber KJ, Plinkert P and Hess J: Regulation of submaxillary gland androgen-regulated protein 3A via estrogen receptor 2 in radioresistant head and neck squamous cell carcinoma cells. J Exp Clin Cancer Res. 36:252017. View Article : Google Scholar

16 

Lang Z, Wu Y, Pan X, Qu G and Zhang T: Study of differential gene expression between invasive multifocal/multicentric and unifocal breast cancer. J BUON. 23:134–142. 2018.PubMed/NCBI

17 

Jiang L, Ji N, Zhou Y, Li J, Liu X, Wang Z, Chen Q and Zeng X: CAL 27 is an oral adenosquamous carcinoma cell line. Oral Oncol. 45:e204–e207. 2009. View Article : Google Scholar

18 

Sravya T, Rao GV, Kumar MP and Sudheerkanth K: Oral adenosquamous carcinoma: Report of a rare entity with a special insight on its histochemistry. J Oral Maxillofac Pathol. 20:5482016. View Article : Google Scholar

19 

Holzinger D, Schmitt M, Dyckhoff G, Benner A, Pawlita M and Bosch FX: Viral RNA patterns and high viral load reliably define oropharynx carcinomas with active HPV16 involvement. Cancer Res. 72:4993–5003. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Karsai S, Abel U, Roesch-Ely M, Affolter A, Hofele C, Joos S, Plinkert PK and Bosch FX: Comparison of p16(INK4a) expression with p53 alterations in head and neck cancer by tissue microarray analysis. J Pathol. 211:314–322. 2007. View Article : Google Scholar

21 

Nasser W, Flechtenmacher C, Holzinger D, Hofele C and Bosch FX: Aberrant expression of p53, p16INK4a and Ki-67 as basic biomarker for malignant progression of oral leukoplakias. J Oral Pathol Med. 40:629–635. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Horn D, Freudlsperger C, Holzinger D, Kunzmann K, Plinkert P, Dyckhoff G, Hoffmann J, Freier K and Hess J: Upregulation of pAKT(Ser473) expression in progression of HPV-positive oropharyngeal squamous cell carcinoma. Head Neck. 39:2397–2405. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Freudlsperger C, Horn D, Weißfuß S, Weichert W, Weber KJ, Saure D, Sharma S, Dyckhoff G, Grabe N, Plinkert P, et al: Phosphorylation of AKT(Ser473) serves as an independent prognostic marker for radiosensitivity in advanced head and neck squamous cell carcinoma. Int J Cancer. 136:2775–2785. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Grégoire V, Langendijk JA and Nuyts S: Advances in radiotherapy for head and neck cancer. J Clin Oncol. 33:3277–3284. 2015. View Article : Google Scholar

25 

Barton MB, Jacob S, Shafiq J, Wong K, Thompson SR, Hanna TP and Delaney GP: Estimating the demand for radiotherapy from the evidence: A review of changes from 2003 to 2012. Radiother Oncol. 112:140–144. 2014. View Article : Google Scholar

26 

Acuña Sanhueza GA, Faller L, George B, Koffler J, Misetic V, Flechtenmacher C, Dyckhoff G, Plinkert PP, Angel P, Simon C and Hess J: Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells. BMC Cancer. 12:722012. View Article : Google Scholar

27 

Fu S, Tar MT, Melman A and Davies KP: Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells. FASEB J. 28:3633–3644. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Javelot H, Messaoudi M, Garnier S and Rougeot C: Human opiorphin is a naturally occurring antidepressant acting selectively on enkephalin-dependent delta-opioid pathways. J Physiol Pharmacol. 61:355–362. 2010.

29 

Tian XZ, Chen J, Xiong W, He T and Chen Q: Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice. Peptides. 30:1348–1354. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Mukherjee A, Park A, Wang L and Davies KP: Role of opiorphin genes in prostate cancer growth and progression. Future Oncol. 17:2209–2223. 2021. View Article : Google Scholar

31 

Carl-McGrath S, Lendeckel U, Ebert M and Röcken C: Ectopeptidases in tumour biology: A review. Histol Histopathol. 21:1339–1353. 2006.

32 

Fujita S, Yamamoto S, Akasu T, Moriya Y, Taniguchi H and Shimoda T: Quantification of CD10 mRNA in colorectal cancer and relationship between mRNA expression and liver metastasis. Anticancer Res. 27:3307–3311. 2007.PubMed/NCBI

33 

Luo Y, Fujii K, Ohmori H, Sasahira T, Moriwaka Y, Isobe M and Kuniyasu H: Antisense phosphorothioate oligodeoxynucleic acid for CD10 suppresses liver metastasis of colorectal cancer. Pathobiology. 76:267–273. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Kuniyasu H, Luo Y, Fujii K, Sasahira T, Moriwaka Y, Tatsumoto N, Sasaki T, Yamashita Y and Ohmori H: CD10 enhances metastasis of colorectal cancer by abrogating the anti-tumoural effect of methionine-enkephalin in the liver. Gut. 59:348–356. 2010. View Article : Google Scholar

35 

Chua RG, Calenda G, Zhang X, Siragusa J, Tong Y, Tar M, Aydin M, DiSanto ME, Melman A and Davies KP: Testosterone regulates erectile function and Vcsa1 expression in the corpora of rats. Mol Cell Endocrinol. 303:67–73. 2009. View Article : Google Scholar

36 

Señorale-Pose M, Jacqueson A, Rougeon F and Rosinski-Chupin I: Acinar cells are target cells for androgens in mouse submandibular glands. J Histochem Cytochem. 46:669–678. 1998. View Article : Google Scholar

37 

Derer A, Spiljar M, Bäumler M, Hecht M, Fietkau R, Frey B and Gaipl US: Chemoradiation increases PD-L1 expression in certain melanoma and glioblastoma cells. Front Immunol. 7:6102016. View Article : Google Scholar

38 

Guglas K, Kolenda T, Teresiak A, Kopczyńska M, Łasińska I, Mackiewicz J, Mackiewicz A and Lamperska K: lncRNA expression after irradiation and chemoexposure of HNSCC cell lines. Noncoding RNA. 4:332018.

39 

Ricco N, Flor A, Wolfgeher D, Efimova EV, Ramamurthy A, Appelbe OK, Brinkman J, Truman AW, Spiotto MT and Kron SJ: Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer. Mol Oncol. 13:1927–1943. 2019. View Article : Google Scholar

40 

Todorovic V, Prevc A, Zakelj MN, Savarin M, Brozic A, Groselj B, Strojan P, Cemazar M and Sersa G: Mechanisms of different response to ionizing irradiation in isogenic head and neck cancer cell lines. Radiat Oncol. 14:2142019. View Article : Google Scholar

41 

Wu Q, Cao R, Chen J and Xie X: Screening and identification of biomarkers associated with clinicopathological parameters and prognosis in oral squamous cell carcinoma. Exp Ther Med. 18:3579–3587. 2019.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Rong C, Grünow J, Thierauf J, Lucena-Porcel C, Major G, Holzinger D, Dyckhoff G, Kern J, Lammert A, Scherl C, Scherl C, et al: Conjoint analysis of OPRPN and SMR3A protein expression as potential predictive biomarkers for head and neck squamous cell carcinoma after radiotherapy. Oncol Rep 48: 159, 2022.
APA
Rong, C., Grünow, J., Thierauf, J., Lucena-Porcel, C., Major, G., Holzinger, D. ... Affolter, A. (2022). Conjoint analysis of OPRPN and SMR3A protein expression as potential predictive biomarkers for head and neck squamous cell carcinoma after radiotherapy. Oncology Reports, 48, 159. https://doi.org/10.3892/or.2022.8374
MLA
Rong, C., Grünow, J., Thierauf, J., Lucena-Porcel, C., Major, G., Holzinger, D., Dyckhoff, G., Kern, J., Lammert, A., Scherl, C., Rotter, N., Plinkert, P. K., Affolter, A."Conjoint analysis of OPRPN and SMR3A protein expression as potential predictive biomarkers for head and neck squamous cell carcinoma after radiotherapy". Oncology Reports 48.3 (2022): 159.
Chicago
Rong, C., Grünow, J., Thierauf, J., Lucena-Porcel, C., Major, G., Holzinger, D., Dyckhoff, G., Kern, J., Lammert, A., Scherl, C., Rotter, N., Plinkert, P. K., Affolter, A."Conjoint analysis of OPRPN and SMR3A protein expression as potential predictive biomarkers for head and neck squamous cell carcinoma after radiotherapy". Oncology Reports 48, no. 3 (2022): 159. https://doi.org/10.3892/or.2022.8374
Copy and paste a formatted citation
x
Spandidos Publications style
Rong C, Grünow J, Thierauf J, Lucena-Porcel C, Major G, Holzinger D, Dyckhoff G, Kern J, Lammert A, Scherl C, Scherl C, et al: Conjoint analysis of OPRPN and SMR3A protein expression as potential predictive biomarkers for head and neck squamous cell carcinoma after radiotherapy. Oncol Rep 48: 159, 2022.
APA
Rong, C., Grünow, J., Thierauf, J., Lucena-Porcel, C., Major, G., Holzinger, D. ... Affolter, A. (2022). Conjoint analysis of OPRPN and SMR3A protein expression as potential predictive biomarkers for head and neck squamous cell carcinoma after radiotherapy. Oncology Reports, 48, 159. https://doi.org/10.3892/or.2022.8374
MLA
Rong, C., Grünow, J., Thierauf, J., Lucena-Porcel, C., Major, G., Holzinger, D., Dyckhoff, G., Kern, J., Lammert, A., Scherl, C., Rotter, N., Plinkert, P. K., Affolter, A."Conjoint analysis of OPRPN and SMR3A protein expression as potential predictive biomarkers for head and neck squamous cell carcinoma after radiotherapy". Oncology Reports 48.3 (2022): 159.
Chicago
Rong, C., Grünow, J., Thierauf, J., Lucena-Porcel, C., Major, G., Holzinger, D., Dyckhoff, G., Kern, J., Lammert, A., Scherl, C., Rotter, N., Plinkert, P. K., Affolter, A."Conjoint analysis of OPRPN and SMR3A protein expression as potential predictive biomarkers for head and neck squamous cell carcinoma after radiotherapy". Oncology Reports 48, no. 3 (2022): 159. https://doi.org/10.3892/or.2022.8374
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