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November-2022 Volume 48 Issue 5

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Review

Clinical implications of the oral‑gut microbiome axis and its association with colorectal cancer (Review)

  • Authors:
    • Fang Liu
    • Dan Su
    • Heng Zhang
    • Hong-Cheng Lin
    • Qian Zhou
    • Bo Cao
    • Dong-Lin Ren
  • View Affiliations / Copyright

    Affiliations: Department of Coloproctology, The Sixth Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510655, P.R. China, Department of Coloproctology, The First Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang, Guizhou 550001, P.R. China
  • Article Number: 192
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    Published online on: September 14, 2022
       https://doi.org/10.3892/or.2022.8407
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Abstract

Colorectal cancer (CRC) is a common form of carcinoma with an increasing global incidence and fatality rates. The current strategies for reducing the incidence and mortality rates of CRC include early screening, prevention, diagnosis and treatment. Additionally, modern high‑throughput sequencing technologies in combination with the continuous in‑depth study of the microbiome have highlighted the roles of microorganisms in the development of CRC. In particular, studies have demonstrated that oral‑gut and gut‑oral microbial transmission can regulate the pathogenesis of various diseases, suggesting the existence of an oral‑gut microbiome axis. However, to the best of our knowledge, only a few studies to date have assessed the oral‑gut microbiome axis in the context of CRC. Therefore, the present review article aimed to discuss the current literature investigating the oral‑gut axis in order to further explore the association between the oral‑gut microbiome axis and CRC. These data may provide a novel strategy for the early screening, prevention and treatment of CRC.
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1 

Siegel RL, Miller KD, Goding Sauer A, Fedewa SA, Butterly LF, Anderson JC, Cercek A, Smith RA and Jemal A: Colorectal cancer statistics, 2020. CA Cancer J Clin. 70:145–164. 2020. View Article : Google Scholar : PubMed/NCBI

2 

NIH HMP Working Group, . Peterson J, Garges S, Giovanni M, McInnes P, Wang L, Schloss JA, Bonazzi V, McEwen JE, Wetterstrand KA, et al: The NIH human microbiome project. Genome Res. 19:2317–2323. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Park SY, Hwang BO, Lim M, Ok SH, Lee SK, Chun KS, Park KK, Hu Y, Chung WY and Song NY: Oral-gut microbiome axis in gastrointestinal disease and cancer. Cancers (Basel). 13:21242021. View Article : Google Scholar : PubMed/NCBI

4 

Shi C, Lin L, Xie T, et al: Based on the ‘lung-gut’ axis to explore the influence of lung and gut microecology on lung diseases. J Nanjing Univ Tradit Chin Med. 02:168–173. 2020.https://t.cnki.net/kcms/detail?v=3uoqIhG8C44YLTlOAiTRKgchrJ08w1e7mYRGNWDareZlYKpvhaXcgDMecYtweZkXRiOLhIZAUMCDDjKrapSPMVkJLBTMn0eV&uniplatform=NZKPT&uid=WEEvREdxOWJmbC9oM1NjYkcyTjdROWp3THN6dy9lNCtTTG4zd1MwcFFNeDg=$R1yZ0H6jyaa0en3RxVUd8df-oHi7XMMDo7mtKT6mSmEvTuk11l2gFA!!

5 

Cerdó T, Ruíz A, Suárez A and Campoy C: Probiotic, prebiotic, and brain development. Nutrients. 9:12472017. View Article : Google Scholar

6 

Muller PA, Schneeberger M, Matheis F, Wang P, Kerner Z, Ilanges A, Pellegrino K, Del Mármol J, Castro TBR, Furuichi M, et al: Microbiota modulate sympathetic neurons via a gut-brain circuit. Nature. 583:441–446. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Schmidt TS, Hayward MR, Coelho LP, Li SS, Costea PI, Voigt AY, Wirbel J, Maistrenko OM, Alves RJ, Bergsten E, et al: Extensive transmission of microbes along the gastrointestinal tract. Elife. 8:e426932019. View Article : Google Scholar : PubMed/NCBI

8 

Lamont RJ, Koo H and Hajishengallis G: The oral microbiota: Dynamic communities and host interactions. Nat Rev Microbiol. 16:745–759. 2018. View Article : Google Scholar

9 

Mark Welch JL, Ramírez-Puebla ST and Borisy GG: Oral microbiome geography: Micron-scale habitat and niche. Cell Host Microbe. 28:160–168. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Li Y: Comparison and analysis of oral flora structure in patients with gingival cancer and periodontitis: Commonalities and differences. China Med Univ. 2020.https://t.cnki.net/kcms/detail?v=3uoqIhG8C475KOm_zrgu4lQARvep2SAkJrOyyi_z7N8gBvuHP4X-Bqg6NwePhrlvgbwoWSsn9prYQqxr4×Vg8WYkOENyNYHk&uniplatform=NZKPT&uid=WEEvREdxOWJmbC9oM1NjYkcyTjdROWp3THN6dy9lNCtTTG4zd1MwcFFNeDg=$R1yZ0H6jyaa0en3RxVUd8df-oHi7XMMDo7mtKT6mSmEvTuk11l2gFA!!

11 

Chukkapalli SS, Easwaran M, Rivera-Kweh MF, Velsko IM, Ambadapadi S, Dai J, Larjava H, Lucas AR and Kesavalu L: Sequential colonization of periodontal pathogens in induction of periodontal disease and atherosclerosis in LDLRnull mice. Pathog Dis. 75:ftx0032017. View Article : Google Scholar

12 

Segata N, Haake SK, Mannon P, Lemon KP, Waldron L, Gevers D, Huttenhower C and Izard J: Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples. Genome Biol. 13:R422012. View Article : Google Scholar

13 

Ridlon JM, Kang DJ, Hylemon PB and Bajaj JS: Bile acids and the gut microbiome. Curr Opin Gastroenterol. 30:332–338. 2014. View Article : Google Scholar

14 

Huh JW and Roh TY: Opportunistic detection of Fusobacterium nucleatum as a marker for the early gut microbial dysbiosis. BMC Microbiol. 20:2082020. View Article : Google Scholar

15 

Del Castillo E, Meier R, Chung M, Koestler DC, Chen T, Paster BJ, Charpentier KP, Kelsey KT, Izard J and Michaud DS: The microbiomes of pancreatic and duodenum tissue overlap and are highly subject specific but differ between pancreatic cancer and noncancer subjects. Cancer Epidemiol Biomarkers Prev. 28:370–383. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Gevers D, Kugathasan S, Denson LA, Vázquez-Baeza Y, Van Treuren W, Ren B, Schwager E, Knights D, Song SJ, Yassour M, et al: The treatment-naive microbiome in new-onset Crohn's disease. Cell Host Microbe. 15:382–392. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Atarashi K, Suda W, Luo C, Kawaguchi T, Motoo I, Narushima S, Kiguchi Y, Yasuma K, Watanabe E, Tanoue T, et al: Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. Science. 358:359–365. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Kong X, Liu J, Cetinbas M, Sadreyev R, Koh M, Huang H, Adeseye A, He P, Zhu J, Russell H, et al: New and preliminary evidence on altered oral and gut microbiota in individuals with autism spectrum disorder (ASD): Implications for ASD diagnosis and subtyping based on microbial biomarkers. Nutrients. 11:21282019. View Article : Google Scholar

19 

Ding HT, Taur Y and Walkup JT: Gut microbiota and autism: Key concepts and findings. J Autism Dev Disord. 47:480–489. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Luna RA, Oezguen N, Balderas M, Venkatachalam A, Runge JK, Versalovic J, Veenstra-VanderWeele J, Anderson GM, Savidge T and Williams KC: Distinct microbiome-neuroimmune signatures correlate with functional abdominal pain in children with autism spectrum disorder. Cell Mol Gastroenterol Hepatol. 3:218–230. 2016. View Article : Google Scholar

21 

Gargari G, Taverniti V, Gardana C, Cremon C, Canducci F, Pagano I, Barbaro MR, Bellacosa L, Castellazzi AM, Valsecchi C, et al: Fecal clostridiales distribution and short-chain fatty acids reflect bowel habits in irritable bowel syndrome. Environ Microbiol. 20:3201–3213. 2018. View Article : Google Scholar

22 

Sasaki M, Shimoyama Y, Ishikawa T, Kodama Y, Tajika S and Kimura S: Contribution of different adherent properties of Granulicatella adiacens and Abiotrophia defectiva to their associations with oral colonization and the risk of infective endocarditis. J Oral Sci. 62:36–39. 2020. View Article : Google Scholar

23 

Nakatsu G, Li X, Zhou H, Sheng J, Wong SH, Wu WK, Ng SC, Tsoi H, Dong Y, Zhang N, et al: Gut mucosal microbiome across stages of colorectal carcinogenesis. Nat Commun. 6:87272015. View Article : Google Scholar : PubMed/NCBI

24 

Xia M, Jin Z, Zheng C, et al: Intervention of traditional Chinese medicine on colitis-cancer transformation based on oral micro-ecology. China J Tradit Chin Med Pharm. 06:2566–2570. 2019.https://t.cnki.net/kcms/detail?v=3uoqIhG8C44YLTlOAiTRKgchrJ08w1e7CoKB_BvAJUQwzoapsKG3EAOyzzGLBX35huQLjuJ1cPcmeJlWp_hGquH37rR5bVDu&uniplatform=NZKPT&uid=WEEvREdxOWJmbC9oM1NjYkcyTjdROWp3THN6dy9lNCtTTG4zd1MwcFFNeDg=$R1yZ0H6jyaa0en3RxVUd8df-oHi7XMMDo7mtKT6mSmEvTuk11l2gFA!!

25 

Toda K, Hisata K, Satoh T, Katsumata N, Odamaki T, Mitsuyama E, Katayama T, Kuhara T, Aisaka K, Shimizu T and Xiao JZ: Neonatal oral fluid as a transmission route for bifidobacteria to the infant gut immediately after birth. Sci Rep. 9:86922019. View Article : Google Scholar : PubMed/NCBI

26 

Iwauchi M, Horigome A, Ishikawa K, Mikuni A, Nakano M, Xiao JZ, Odamaki T and Hironaka S: Relationship between oral and gut microbiota in elderly people. Immun Inflamm Dis. 7:229–236. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Odamaki T, Kato K, Sugahara H, Hashikura N, Takahashi S, Xiao JZ, Abe F and Osawa R: Age-related changes in gut microbiota composition from newborn to centenarian: A cross-sectional study. BMC Microbiol. 16:902016. View Article : Google Scholar

28 

Shaffer M and Lozupone C: Prevalence and source of fecal and oral bacteria on infant, child, and adult hands. mSystems. 3:e00192–17. 2018. View Article : Google Scholar : PubMed/NCBI

29 

De Graaf M, Beck R, Caccio SM, Duim B, Fraaij P, Le Guyader FS, Lecuit M, Le Pendu J, de Wit E and Schultsz C: Sustained fecal-oral human-to-human transmission following a zoonotic event. Curr Opin Virol. 22:1–6. 2017. View Article : Google Scholar

30 

Bui D, Brown HE, Harris RB and Oren E: Serologic evidence for fecal-oral transmission of Helicobacter pylori. Am J Trop Med Hyg. 94:82–88. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Bertolini M and Dongari-Bagtzoglou A: The relationship of Candida albicans with the oral bacterial microbiome in health and disease. Adv Exp Med Biol. 1197:69–78. 2019. View Article : Google Scholar

32 

Acharya C, Sahingur SE and Bajaj JS: Microbiota, cirrhosis, and the emerging oral-gut-liver axis. JCI Insight. 2:e944162017. View Article : Google Scholar

33 

Oikonomou T, Papatheodoridis GV, Samarkos M, Goulis I and Cholongitas E: Clinical impact of microbiome in patients with decompensated cirrhosis. World J Gastroenterol. 24:3813–3820. 2018. View Article : Google Scholar

34 

Bajaj JS, Matin P, White MB, Fagan A, Deeb JG, Acharya C, Dalmet SS, Sikaroodi M, Gillevet PM and Sahingur SE: Periodontal therapy favorably modulates the oral-gut-hepatic axis in cirrhosis. Am J Physiol Gastrointest Liver Physiol. 315:G824–G837. 2018. View Article : Google Scholar

35 

Acharya C and Bajaj JS: Is it time to spit? More evidence for the oral-gut-liver axis in liver disease. Hepatol Int. 15:4–5. 2021. View Article : Google Scholar

36 

Imai J, Kitamoto S and Kamada N: The pathogenic oral-gut-liver axis: New understandings and clinical implications. Expert Rev Clin Immunol. 17:727–736. 2021. View Article : Google Scholar

37 

Du Teil Espina M, Gabarrini G, Harmsen HJM, Westra J, van Winkelhoff AJ and van Dijl JM: Talk to your gut: The oral-gut microbiome axis and its immunomodulatory role in the etiology of rheumatoid arthritis. FEMS Microbiol Rev. 43:1–18. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Lorenzo D, GianVincenzo Z, Carlo Luca R, Karan G, Jorge V, Roberto M and Javad P: Oral-gut microbiota and arthritis: Is there an evidence-based axis? J Clin Med. 8:2019.

39 

Bellando-Randone S, Russo E, Venerito V, Matucci-Cerinic M, Iannone F, Tangaro S and Amedei A: Exploring the oral microbiome in rheumatic diseases, state of art and future prospective in personalized medicine with an AI approach. J Pers Med. 11:6252021. View Article : Google Scholar : PubMed/NCBI

40 

Li BZ, Zhou HY, Guo B, Chen WJ, Tao JH, Cao NW, Chu XJ and Meng X: Dysbiosis of oral microbiota is associated with systemic lupus erythematosus. Arch Oral Biol. 113:1047082020. View Article : Google Scholar

41 

Ray K: The oral-gut axis in IBD. Nat Rev Gastroenterol Hepatol. 17:5322020. View Article : Google Scholar

42 

Xiang Z, Koo H, Chen Q, Zhou X, Liu Y and Simon-Soro A: Potential implications of SARS-CoV-2 oral infection in the host microbiota. J Oral Microbiol. 13:18534512020. View Article : Google Scholar

43 

De Oliveira AM, Lourenço TGB and Colombo APV: Impact of systemic probiotics as adjuncts to subgingival instrumentation on the oral-gut microbiota associated with periodontitis: A randomized controlled clinical trial. J Periodontol. 93:31–44. 2022. View Article : Google Scholar

44 

Byrd KM and Gulati AS: The ‘Gum-Gut’ axis in inflammatory bowel diseases: A hypothesis-driven review of associations and advances. Front Immunol. 12:6201242021. View Article : Google Scholar

45 

Narengaowa, Kong W, Lan F, Awan UF, Qing H and Ni J: The oral-gut-brain axis: The influence of microbes in Alzheimer's disease. Front Cell Neurosci. 15:6337352021. View Article : Google Scholar

46 

Yamashita Y and Takeshita T: The oral microbiome and human health. J Oral Sci. 59:201–206. 2017. View Article : Google Scholar

47 

Kilian M, Chapple IL, Hannig M, Marsh PD, Meuric V, Pedersen AM, Tonetti MS, Wade WG and Zaura E: The oral microbiome-an update for oral healthcare professionals. Br Dent J. 221:657–666. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Zarco MF, Vess TJ and Ginsburg GS: The oral microbiome in health and disease and the potential impact on personalized dental medicine. Oral Dis. 18:109–120. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Gao L, Xu T, Huang G, Jiang S, Gu Y and Chen F: Oral microbiomes: More and more importance in oral cavity and whole body. Protein Cell. 9:488–500. 2018. View Article : Google Scholar

50 

Wade WG: The oral microbiome in health and disease. Pharmacol Res. 69:137–143. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Flemer B, Warren RD, Barrett MP, Cisek K, Das A, Jeffery IB, Hurley E, O'Riordain M, Shanahan F and O'Toole PW: The oral microbiota in colorectal cancer is distinctive and predictive. Gut. 67:1454–1463. 2018. View Article : Google Scholar

52 

Gaiser RA, Halimi A, Alkharaan H, Lu L, Davanian H, Healy K, Hugerth LW, Ateeb Z, Valente R, Fernández Moro C, et al: Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer. Gut. 68:2186–2194. 2019. View Article : Google Scholar

53 

Kitamoto S, Nagao-Kitamoto H, Jiao Y, Gillilland MG III, Hayashi A, Imai J, Sugihara K, Miyoshi M, Brazil JC, Kuffa P, et al: The intermucosal connection between the mouth and gut in commensal pathobiont-driven colitis. Cell. 182:447–462.e14. 2020. View Article : Google Scholar

54 

Bullman S, Pedamallu CS, Sicinska E, Clancy TE, Zhang X, Cai D, Neuberg D, Huang K, Guevara F, Nelson T, et al: Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science. 358:1443–1448. 2017. View Article : Google Scholar : PubMed/NCBI

55 

Casasanta MA, Yoo CC, Udayasuryan B, Sanders BE, Umaña A, Zhang Y, Peng H, Duncan AJ, Wang Y, Li L, et al: Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration. Sci Signal. 13:eaba91572020. View Article : Google Scholar

56 

Brennan CA and Garrett WS: Fusobacterium nucleatum-symbiont, opportunist and oncobacterium. Nat Rev Microbiol. 17:156–166. 2019. View Article : Google Scholar

57 

Gopalakrishnan V, Helmink BA, Spencer CN, Reuben A and Wargo JA: The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy. Cancer Cell. 33:570–580. 2018. View Article : Google Scholar

58 

Wei Z, Cao S, Liu S, Yao Z, Sun T, Li Y, Li J, Zhang D and Zhou Y: Could gut microbiota serve as prognostic biomarker associated with colorectal cancer patients' survival? A pilot study on relevant mechanism. Oncotarget. 7:46158–46172. 2016. View Article : Google Scholar

59 

Rubinstein MR, Wang X, Liu W, Hao Y, Cai G and Han YW: Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. Cell Host Microbe. 14:195–206. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, Clancy TE, Chung DC, Lochhead P, Hold GL, et al: Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe. 14:207–215. 2013. View Article : Google Scholar : PubMed/NCBI

61 

Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, et al: Enterotypes of the human gut microbiome. Nature. 473:174–180. 2011. View Article : Google Scholar : PubMed/NCBI

62 

Chong ES: A potential role of probiotics in colorectal cancer prevention: Review of possible mechanisms of action. World J Microbiol Biotechnol. 30:351–374. 2014. View Article : Google Scholar

63 

Biedermann L and Rogler G: The intestinal microbiota: Its role in health and disease. Eur J Pediatr. 174:151–167. 2015. View Article : Google Scholar : PubMed/NCBI

64 

Arthur JC, Perez-Chanona E, Mühlbauer M, Tomkovich S, Uronis JM, Fan TJ, Campbell BJ, Abujamel T, Dogan B, Rogers AB, et al: Intestinal inflammation targets cancer-inducing activity of the microbiota. Science. 338:120–123. 2012. View Article : Google Scholar : PubMed/NCBI

65 

Ray K: IBD. Gut microbiota in IBD goes viral. Nat Rev Gastroenterol Hepatol. 12:1222015. View Article : Google Scholar

66 

Raisch J, Rolhion N, Dubois A, Darfeuille-Michaud A and Bringer MA: Intracellular colon cancer-associated Escherichia coli promote protumoral activities of human macrophages by inducing sustained COX-2 expression. Lab Invest. 95:296–307. 2015. View Article : Google Scholar

67 

Gagnière J, Raisch J, Veziant J, Barnich N, Bonnet R, Buc E, Bringer MA, Pezet D and Bonnet M: Gut microbiota imbalance and colorectal cancer. World J Gastroenterol. 22:501–518. 2016. View Article : Google Scholar

68 

Rossi M, Mirbagheri SEYEDS, Keshavarzian A and Bishehsari F: Nutraceuticals in colorectal cancer: A mechanistic approach. Eur J Pharmacol. 833:396–402. 2018. View Article : Google Scholar

69 

Li Q, Ding C, Meng T, Lu W, Liu W, Hao H and Cao L: Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner. J Pharmacol Sci. 135:148–155. 2017. View Article : Google Scholar

70 

de Martel C, Ferlay J, Franceschi S, Vignat J, Bray F, Forman D and Plummer M: Global burden of cancers attributable to infections in 2008: A review and synthetic analysis. Lancet Oncol. 13:607–615. 2012. View Article : Google Scholar

71 

Yu L, Ge S, Feng X, et al: Research progress of Porphyromonas gingivalis. J Prev Treat Stomatol Dis. 05:314–317. 2016.https://t.cnki.net/kcms/detail?v=3uoqIhG8C44YLTlOAiTRKgchrJ08w1e7bFPagIuZu8mSNNqTzqA10SmLmWs9SCrXF-1zbj6qv97WC8n64gYCrTahio_5NDeO&uniplatform=NZKPT&uid=WEEvREdxOWJmbC9oM1NjYkcyTjdROWp3THN6dy9lNCtTTG4zd1MwcFFNeDg=$R1yZ0H6jyaa0en3RxVUd8df-oHi7XMMDo7mtKT6mSmEvTuk11l2gFA!!

72 

Zhao L: Discussion on the treatment of extraintestinal symptoms and complications in patients with inflammatory bowel disease. Clin Res Pract. 2:142–143. 2017.

73 

Barton MK: Evidence accumulates indicating periodontal disease as a risk factor for colorectal cancer or lymphoma. CA Cancer J Clin. 67:173–174. 2017. View Article : Google Scholar : PubMed/NCBI

74 

Yang Y, Weng W, Peng J, Hong L, Yang L, Toiyama Y, Gao R, Liu M, Yin M, Pan C, et al: Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating Toll-like receptor 4 signaling to nuclear factor-κB, and up-regulating expression of MicroRNA-21. Gastroenterology. 152:851–866.e24. 2017. View Article : Google Scholar : PubMed/NCBI

75 

Yamaoka Y, Suehiro Y, Hashimoto S, Hoshida T, Fujimoto M, Watanabe M, Imanaga D, Sakai K, Matsumoto T, Nishioka M, et al: Fusobacterium nucleatum as a prognostic marker of colorectal cancer in a Japanese population. J Gastroenterol. 53:517–524. 2018. View Article : Google Scholar

76 

Yang CY, Yeh YM, Yu HY, Chin CY, Hsu CW, Liu H, Huang PJ, Hu SN, Liao CT, Chang KP and Chang YL: Oral microbiota community dynamics associated with oral squamous cell carcinoma staging. Front Microbiol. 9:8622018. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Liu F, Su D, Zhang H, Lin H, Zhou Q, Cao B and Ren D: Clinical implications of the oral‑gut microbiome axis and its association with colorectal cancer (Review). Oncol Rep 48: 192, 2022.
APA
Liu, F., Su, D., Zhang, H., Lin, H., Zhou, Q., Cao, B., & Ren, D. (2022). Clinical implications of the oral‑gut microbiome axis and its association with colorectal cancer (Review). Oncology Reports, 48, 192. https://doi.org/10.3892/or.2022.8407
MLA
Liu, F., Su, D., Zhang, H., Lin, H., Zhou, Q., Cao, B., Ren, D."Clinical implications of the oral‑gut microbiome axis and its association with colorectal cancer (Review)". Oncology Reports 48.5 (2022): 192.
Chicago
Liu, F., Su, D., Zhang, H., Lin, H., Zhou, Q., Cao, B., Ren, D."Clinical implications of the oral‑gut microbiome axis and its association with colorectal cancer (Review)". Oncology Reports 48, no. 5 (2022): 192. https://doi.org/10.3892/or.2022.8407
Copy and paste a formatted citation
x
Spandidos Publications style
Liu F, Su D, Zhang H, Lin H, Zhou Q, Cao B and Ren D: Clinical implications of the oral‑gut microbiome axis and its association with colorectal cancer (Review). Oncol Rep 48: 192, 2022.
APA
Liu, F., Su, D., Zhang, H., Lin, H., Zhou, Q., Cao, B., & Ren, D. (2022). Clinical implications of the oral‑gut microbiome axis and its association with colorectal cancer (Review). Oncology Reports, 48, 192. https://doi.org/10.3892/or.2022.8407
MLA
Liu, F., Su, D., Zhang, H., Lin, H., Zhou, Q., Cao, B., Ren, D."Clinical implications of the oral‑gut microbiome axis and its association with colorectal cancer (Review)". Oncology Reports 48.5 (2022): 192.
Chicago
Liu, F., Su, D., Zhang, H., Lin, H., Zhou, Q., Cao, B., Ren, D."Clinical implications of the oral‑gut microbiome axis and its association with colorectal cancer (Review)". Oncology Reports 48, no. 5 (2022): 192. https://doi.org/10.3892/or.2022.8407
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