Open Access

Circular RNAs in endometrial carcinoma (Review)

  • Authors:
    • Shan Gao
    • Tianjun Zhao
    • Fangchi Meng
    • Yinzhou Luo
    • Yan Li
    • Yong Wang
  • View Affiliations

  • Published online on: October 19, 2022     https://doi.org/10.3892/or.2022.8427
  • Article Number: 212
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As one of the leading causes of death in women in Western developed countries, endometrial carcinoma (EC) is a common gynecological malignant tumor that seriously threatens women's health. In recent years, a trend has emerged of EC being manifested in younger women, and its overall incidence is gradually rising. Circular RNAs (circRNAs) are novel endogenous transcripts that have limited ability to encode proteins due to their covalent closed‑loop structure, which differs from that of other types of RNA. A growing body of evidence has demonstrated that circRNAs fulfill an important role in lung cancer, gastric cancer, breast cancer, EC and other malignant tumor types, and they can affect the occurrence and development of these malignancies through a variety of pathways, further demonstrating the potential of circRNAs as molecular biomarkers for the diagnosis, treatment and prognosis of malignant tumors. The purpose of the present review is to summarize the current understanding of the biogenesis and effects of circRNAs, and to discuss the expression, function and underlying mechanism of circRNAs in EC in order to identify potential novel biomarkers.
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December-2022
Volume 48 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Gao S, Zhao T, Meng F, Luo Y, Li Y and Wang Y: Circular RNAs in endometrial carcinoma (Review). Oncol Rep 48: 212, 2022
APA
Gao, S., Zhao, T., Meng, F., Luo, Y., Li, Y., & Wang, Y. (2022). Circular RNAs in endometrial carcinoma (Review). Oncology Reports, 48, 212. https://doi.org/10.3892/or.2022.8427
MLA
Gao, S., Zhao, T., Meng, F., Luo, Y., Li, Y., Wang, Y."Circular RNAs in endometrial carcinoma (Review)". Oncology Reports 48.6 (2022): 212.
Chicago
Gao, S., Zhao, T., Meng, F., Luo, Y., Li, Y., Wang, Y."Circular RNAs in endometrial carcinoma (Review)". Oncology Reports 48, no. 6 (2022): 212. https://doi.org/10.3892/or.2022.8427