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Potential of VEGFR2 expression as a predictive marker of PD‑1 blockade in patients with advanced NSCLC

  • Authors:
    • Kyoichi Kaira
    • Hisao Imai
    • Tomonori Kawasaki
    • Kousuke Hashimoto
    • Yu Miura
    • Ayako Shiono
    • Ou Yamaguchi
    • Atsuto Mouri
    • Kunihiko Kobayashi
    • Masanori Yasuda
    • Hiroshi Kagamu
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, International Medical Center, Saitama Medical University, Hidaka, Saitama 350‑1298, Japan, Department of Pathology, International Medical Center, Saitama Medical University, Hidaka, Saitama 350‑1298, Japan
    Copyright: © Kaira et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 214
    |
    Published online on: October 20, 2022
       https://doi.org/10.3892/or.2022.8429
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Abstract

Angiogenesis serves a crucial role in cancer progression. Vascular endothelial growth factor (VEGF) exhibits an immunosuppressive function in patients with cancer. However, it remains unclear whether expression of VEGF in tumor tissue can predict the outcome of programmed death‑1 blockade in patients with advanced non‑small cell lung cancer (NSCLC). A training (n=32) and validation (n=76) cohort of patients with advanced NSCLC who received first‑line pembrolizumab were enrolled. Immunohistochemical staining for VEGF receptor 2 (VEGFR2) and tumor‑infiltrating lymphocytes (TILs; CD4, CD8 and FOXP3) was performed in tumor specimens of both cohorts and association with clinical outcomes was assessed. The percentages of high VEGFR2 expression were 34.3% (11/32) in training cohort and 25.0% (19/76) in validation cohort. No statistically significant difference in objective response between high and low VEGFR2 expression was observed for training (27.2 vs. 45.0%) and validation (31.2 vs. 35.7%) cohorts. The positive rate of intratumoral FOXP3 was significantly associated with high VEGFR2 expression for validation cohort, but not training cohort. In validation cohort, high VEGFR2 expression in patients with non‑adenocarcinoma (non‑AC) was significantly correlated with positive FOXP3 TILs in intratumoral and stromal sites, but not CD4 and CD8. High VEGFR2 expression in both cohorts indicated a significantly worse overall survival (OS) than low VEGFR2 expression. VEGFR2 was identified as an independent prognostic marker associated with worse OS. High VEGFR2 expression was a significant marker for predicting worse OS in patients treated with first‑line pembrolizumab, particularly in those with non‑AC.
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1 

Garon EB, Hellmann MD, Rizvi NA, Carcereny E, Leighl NB, Ahn MJ, Eder JP, Balmanoukian AS, Aggarwal C, Horn L, et al: Five-year overall survival for patients with advanced non-small-cell lung cancer treated with pembrolizumab: Results from the phase I KEYNOTE-001 study. J Clin Oncol. 37:2518–2527. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Ma K, Jin Q, Wang M, Li X and Zhang Y: Research progress and clinical application of predictive biomarker for immune checkpoint inhibitors. Expert Rev Mol Diagn. 19:517–529. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Song Y, Fu Y, Xie Q, Zhu B, Wang J and Zhang B: Antiangiogenic agents in combination with immune checkpoint inhibitors: A promising strategy for cancer treatment. Front Immunol. 11:19562020. View Article : Google Scholar : PubMed/NCBI

4 

Padda SK and Reckamp LK: Combination of immunotherapy and antiangiogenic therapy in cancer-a rational approach. J Thorac Oncol. 16:178–182. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Finn RS, Qin S, Ikeda M, Galle PR, Ducreux M, Kim YY, Kudo M, Breder V, Merle P, Kaseb AO, et al: Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. N Engl J Med. 382:1894–1905. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Rini BI, Plimack ER, Stus V, Gafanov R, Hawkins R, Nosov D, Pouliot F, Alekseev B, Soulières D, Melichar B, et al: Pembrolizumab plus axitinib versus sunitinib for advanced renal-cell carcinoma. N Engl J Med. 380:1116–1127. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Socinski MA, Jotte RM, Cappuzzo F, Orlandi F, Stroyakovskiy D, Nogami N, Rodríguez-Abreu D, Moro-Sibilot D, Thomas CA, Barlesi F, et al: Atezolizumab for first-line treatment of metastatic nonsquamous NSCLC. N Engl J Med. 378:2288–2301. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Motzer RJ, Penkov K, Haanen J, Rini B, Albiges L, Campbell MT, Venugopal B, Kollmannsberger C, Negrier S, Uemura M, et al: Avelumab plus axitinib versus sunitinib for advanced renal-cell carcinoma. N Engl J Med. 380:1103–1115. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Herbst RS, Arkenau HT, Bendell J, Arrowsmith E, Wermke M, Soriano A, Penel N, Santana-Davila R, Bischoff H, Chau I, et al: Phase 1 expansion cohort of ramucirumab plus pembrolizumab in advanced treatment-naïve NSCLC. J Thorac Oncol. 16:289–298. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Mok TSK, Wu YL, Kudaba I, Kowalski DM, Cho BC, Turna HZ, Castro G Jr, Srimuninnimit V, Laktionov KK, Bondarenko I, et al: Pembrolizumab versus chemotherapy for previously untreated, PD-L1 expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): A randomized, open-label, controlled, phase 3 Trial. Lancet. 393:1819–1830. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Garon EB, Ciuleanu TE, Arrieta O, Prabhash K, Syrigos KN, Goksel T, Park K, Gorbunova V, Kowalyszyn RD, Pikiel J, et al: Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): A multicenter, double-blind, randomised phase 3 Trial. Lancet. 384:665–673. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Bilguun EO, Kaira K, Kawabata-Iwakawa R, Rokudai S, Shimizu K, Yokobori T, Oyama T, Shirabe K and Nishiyama M: Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: A theranostic study for the precision medicine. BMC Cancer. 20:9352020. View Article : Google Scholar : PubMed/NCBI

13 

Gandhi L, Rodríguez-Abreu D, Gadgeel S, Esteban E, Felip E, De Angelis F, Domine M, Clingan P, Hochmair MJ, Powell SF, et al: Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N Engl J Med. 378:2078–2092. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Paz-Ares L, Luft A, Vicente D, Tafreshi A, Gümüş M, Mazières J, Hermes B, Çay Şenler F, Csőszi T, Fülöp A, et al: Pembrolizumab plus chemotherapy for squamous non-small-cell lung cancer. N Engl J Med. 379:2040–2051. 2018. View Article : Google Scholar : PubMed/NCBI

15 

CTCAEv 4.0, URL. http://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm#ctc_40

16 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumour: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Imai H, Kaira K, Hashimoto K, Nitanda H, Taguchi R, Yanagihara A, Umesaki T, Yamaguchi O, Mouri A, Kawasaki T, et al: Tumor immunity is related to 18F-FDG uptake in thymic epithelial tumor. Cancer Med. 10:6317–6326. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Halse H, Colebatch AJ, Petrone P, Henderson MA, Mills JK, Snow H, Westwood JA, Sandhu S, Raleigh JM, Behren A, et al: Multiplex immunohistochemistry accurately defines the immune context of metastatic melanoma. Sci Rep. 8:111582018. View Article : Google Scholar : PubMed/NCBI

19 

Zhu P, Hu C, Hui K and Jiang X: The role and significance of VEGFR2 regulatory T cells in tumor immunity. Onco Targets Ther. 10:4315–4319. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Suzuki H, Onishi H, Wada J, Yamasaki A, Tanaka H, Nakano K, Morisaki T and Katano M: VEGFR2 is selectively expressed by FOXP3high CD4+ Treg. Eur J Immunol. 40:197–203. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Zhang Z, Huang H, Coleman M, Ziemys A, Gopal P, Kazumi S and Brekken R: VEGFR2 activity on myeloid cells mediates immune-suppression in the tumor environment. JCI Insight. 6:e1507352021. View Article : Google Scholar : PubMed/NCBI

22 

Shibaki R, Murakami S, Shinno Y, Matsumoto Y, Yoshida T, Goto Y, Kanda S, Horinouchi H, Fujiwara T, Yamamoto N, et al: Predictive value of serum VEGF levels for elderly patients or for patients with poor performance status receiving anti-PD-1 antibody therapy for advanced non-small cell lung cancer. Cancer Immunol Immunother. 69:1229–1236. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Makker V, Rasco D, Vogelzang NJ, Brose MS, Cohn AL, Mier J, Simone CD, Hyman DM, Stepan DE, Dutcus CE, et al: Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer: An interim analysis of a multicenter, open-label, single-arm, phase 2 trial. Lancet Oncol. 20:711–718. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Herbest RS, Arkenau HT, Santana-Davila R, Calvo E, Paz-Ares L, Cassier PA, Bendell J, Penel N, Krebs MG, Martin-Leberal J, et al: Ramucirumab plus pembrolizumab in patients with previously treated advanced non-small-cell lung cancer, gastro-oesophageal cancer, or urothelial carcinomas (JVDE): A multicohort, non-randomised, open-label, phase 1a/b trial. Lancet Oncol. 20:1109–1123. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Arkenau HT, Martin-Liberal J, Calvo E, Penel N, Krebs MG, Herbst RS, Walgren RA, Widau RC, Mi G, Jin J, et al: Ramucirumab plus pembrolizumab in patients with previously treated advanced or metastatic biliary tract cancer: Nonrandomized, open-label, phase I trial (JVDF). Oncologist. 23:1407–e136. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Reckamp KL, Radman MW, Dragnew KH, Minichiello K, Villaruz LC, Faller B, Baghdadi TA, Hines S, Everhart L, Highleyman L, et al: Phase II randomized study of ramucirumab and pembrolozumab versus standard of care in advanced non-small-cell lung cancer previously treated with immunotherapy-Lung-MAP S1800A. J Clin Oncol. 40:2295–2306. 2022. View Article : Google Scholar : PubMed/NCBI

27 

Paz-Ares L, Ciuleanu TE, Cobo M, Schenker M, Zurawski B, Menezes J, Richardet E, Bennouna J, Felip E, Juan-Vidal O, et al: First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): An international, randomised, open-label, phase 3 trial. Lancet Oncol. 22:198–211. 2021. View Article : Google Scholar : PubMed/NCBI

28 

Paz-Ares LG, Ramalingam SS, Ciuleanu TE, Lee JS, Urban L, Caro RB, Park K, Sakai H, Ohe Y, Nishio M, et al: First-line Nivolumab plus Ipilimumab in advanced NSCLC: 4-year outcomes from the randomized, open-label, phase 3 CheckMate 227 Part 1 Trial. J Thorac Oncol. 17:289–308. 2022. View Article : Google Scholar : PubMed/NCBI

29 

Ma X, Riaz N, Samstein RM, Lee M, Makarov V, Valero C, Chowell D, Kuo F, Hoen D, Fitzgerald CWR, et al: Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity. Nat Genet. 54:996–1012. 2022. View Article : Google Scholar : PubMed/NCBI

30 

Sun H, Liu SY, Zhou JY, Xu JT, Zhang HK, Yan HH, Huan JJ, Dai PP, Xu CR, Su J, et al: Specific TP53 subtype as biomarker for immune checkpoint inhibitors in lung adenocarcinoma. EBioMedicine. 60:1029902020. View Article : Google Scholar : PubMed/NCBI

31 

West HJ, McCleland M, Cappuzzo F, Reck M, Mok TS, Jotte RM, Nishio M, Kim E, Morris S, Zou W, et al: Clinical efficacy of atezolizumab plus bevacizumab and chemotherapy in KRAS-mutated non-small cell lung cancer with STK11, KEAP1, or TP53 comutations: Subgroup results from the phase III IMpower150 trial. J Immunother Cancer. 10:e0030272022. View Article : Google Scholar : PubMed/NCBI

32 

Skoulidis F, Li BT, Dy GK, Price TJ, Falchook GS, Wolf J, Italiano A, Schuler M, Borghaei H, Barlesi F, et al: Sotorasib for Lung Cancers with KRAS p.G12C Mutation. N Engl J Med. 384:2371–2381. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Frost N, Kollmeier J, Vollbrecht C, Grah C, Matthes B, Pultermann D, von Laffert M, Lüders H, Olive E, Raspe M, et al: KRASG12C/TP53 co-mutations identify long-term responders to first line palliative treatment with pembrolizumab monotherapy in PD-L1 high (≥50%) lung adenocarcinoma. Transl Lung Cancer Res. 10:737–752. 2021. View Article : Google Scholar : PubMed/NCBI

34 

Ohtaki Y, Kaira K, Yajima T, Erkhem-Ochir B, Kawashima O, Kamiyoshihara M, Igai H, Onozato R, Ibe T, Kosaka T, et al: Comprehensive expression analysis of chemosensitivity-related markers in large cell neuroendocrine carcinoma of the lung. Thorac Cancer. 12:2666–2679. 2021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kaira K, Imai H, Kawasaki T, Hashimoto K, Miura Y, Shiono A, Yamaguchi O, Mouri A, Kobayashi K, Yasuda M, Yasuda M, et al: Potential of VEGFR2 expression as a predictive marker of PD‑1 blockade in patients with advanced NSCLC. Oncol Rep 48: 214, 2022.
APA
Kaira, K., Imai, H., Kawasaki, T., Hashimoto, K., Miura, Y., Shiono, A. ... Kagamu, H. (2022). Potential of VEGFR2 expression as a predictive marker of PD‑1 blockade in patients with advanced NSCLC. Oncology Reports, 48, 214. https://doi.org/10.3892/or.2022.8429
MLA
Kaira, K., Imai, H., Kawasaki, T., Hashimoto, K., Miura, Y., Shiono, A., Yamaguchi, O., Mouri, A., Kobayashi, K., Yasuda, M., Kagamu, H."Potential of VEGFR2 expression as a predictive marker of PD‑1 blockade in patients with advanced NSCLC". Oncology Reports 48.6 (2022): 214.
Chicago
Kaira, K., Imai, H., Kawasaki, T., Hashimoto, K., Miura, Y., Shiono, A., Yamaguchi, O., Mouri, A., Kobayashi, K., Yasuda, M., Kagamu, H."Potential of VEGFR2 expression as a predictive marker of PD‑1 blockade in patients with advanced NSCLC". Oncology Reports 48, no. 6 (2022): 214. https://doi.org/10.3892/or.2022.8429
Copy and paste a formatted citation
x
Spandidos Publications style
Kaira K, Imai H, Kawasaki T, Hashimoto K, Miura Y, Shiono A, Yamaguchi O, Mouri A, Kobayashi K, Yasuda M, Yasuda M, et al: Potential of VEGFR2 expression as a predictive marker of PD‑1 blockade in patients with advanced NSCLC. Oncol Rep 48: 214, 2022.
APA
Kaira, K., Imai, H., Kawasaki, T., Hashimoto, K., Miura, Y., Shiono, A. ... Kagamu, H. (2022). Potential of VEGFR2 expression as a predictive marker of PD‑1 blockade in patients with advanced NSCLC. Oncology Reports, 48, 214. https://doi.org/10.3892/or.2022.8429
MLA
Kaira, K., Imai, H., Kawasaki, T., Hashimoto, K., Miura, Y., Shiono, A., Yamaguchi, O., Mouri, A., Kobayashi, K., Yasuda, M., Kagamu, H."Potential of VEGFR2 expression as a predictive marker of PD‑1 blockade in patients with advanced NSCLC". Oncology Reports 48.6 (2022): 214.
Chicago
Kaira, K., Imai, H., Kawasaki, T., Hashimoto, K., Miura, Y., Shiono, A., Yamaguchi, O., Mouri, A., Kobayashi, K., Yasuda, M., Kagamu, H."Potential of VEGFR2 expression as a predictive marker of PD‑1 blockade in patients with advanced NSCLC". Oncology Reports 48, no. 6 (2022): 214. https://doi.org/10.3892/or.2022.8429
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