|
1
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Hessmann E, Buchholz SM, Demir IE, Singh
SK, Gress TM, Ellenrieder V and Neesse A: Microenvironmental
determinants of pancreatic cancer. Physiol Rev. 100:1707–1751.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Orth M, Metzger P, Gerum S, Mayerle J,
Schneider G, Belka C, Schnurr M and Lauber K: Pancreatic ductal
adenocarcinoma: Biological hallmarks, current status, and future
perspectives of combined modality treatment approaches. Radiat
Oncol. 14:1412019. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Yuen A and Díaz B: The impact of hypoxia
in pancreatic cancer invasion and metastasis. Hypoxia (Auckl).
2:91–106. 2014.PubMed/NCBI
|
|
5
|
Buttgereit F and Brand MD: A hierarchy of
ATP-consuming processes in mammalian cells. Biochem J. 312:163–167.
1995. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Fähling M: Surviving hypoxia by modulation
of mRNA translation rate. J Cell Mol Med. 13:2770–2779. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Wortel IMN, van der Meer LT, Kilberg MS
and van Leeuwen FN: Surviving stress: Modulation of ATF4-mediated
stress responses in normal and malignant cells. Trends Endocrinol
Metab. 28:794–806. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
B'chir W, Maurin AC, Carraro V, Averous J,
Jousse C, Muranishi Y, Parry L, Stepien G, Fafournoux P and Bruhat
A: The eIF2α/ATF4 pathway is essential for stress-induced autophagy
gene expression. Nucleic Acids Res. 41:7683–7699. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Guo X, Aviles G, Liu Y, Tian R, Unger BA,
Lin YT, Wiita AP, Xu K, Correia MA and Kampmann M: Mitochondrial
stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.
Nature. 579:427–432. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Pathria G, Scott DA, Feng Y, Sang Lee J,
Fujita Y, Zhang G, Sahu AD, Ruppin E, Herlyn M, Osterman AL and
Ronai ZA: Targeting the Warburg effect via LDHA inhibition engages
ATF4 signaling for cancer cell survival. EMBO J. 37:e997352018.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Fernandez MR and Cleveland JL: ATF4-amino
acid circuits: A recipe for resistance in melanoma. EMBO J.
37:e1006002018. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Chiou SH, Risca VI, Wang GX, Yang D,
Grüner BM, Kathiria AS, Ma RK, Vaka D, Chu P, Kozak M, et al:
BLIMP1 induces transient metastatic heterogeneity in pancreatic
cancer. Cancer Discov. 7:1184–1199. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Mesclon F, Lambert-Langlais S, Carraro V,
Parry L, Hainault I, Jousse C, Maurin AC, Bruhat A, Fafournoux P
and Averous J: Decreased ATF4 expression as a mechanism of acquired
resistance to long-term amino acid limitation in cancer cells.
Oncotarget. 8:27440–27453. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Palam LR, Gore J, Craven KE, Wilson JL and
Korc M: Integrated stress response is critical for gemcitabine
resistance in pancreatic ductal adenocarcinoma. Cell Death Dis.
6:e19132015. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Ait Ghezala H, Jolles B, Salhi S,
Castrillo K, Carpentier W, Cagnard N, Bruhat A, Fafournoux P and
Jean-Jean O: Translation termination efficiency modulates ATF4
response by regulating ATF4 mRNA translation at 5′ short ORFs.
Nucleic Acids Res. 40:9557–9570. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Blais JD, Filipenko V, Bi M, Harding HP,
Ron D, Koumenis C, Wouters BG and Bell JC: Activating transcription
factor 4 is translationally regulated by hypoxic stress. Mol Cell
Biol. 24:7469–7482. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Chee NT, Lohse I and Brothers SP:
mRNA-to-protein translation in hypoxia. Mol Cancer. 18:492019.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Logsdon DP, Shah F, Carta F, Supuran CT,
Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR and Fishel ML:
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1
dramatically affects pancreatic cancer cell survival. Sci Rep.
8:137592018. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Zhang S, Zhao L, Wang J, Chen N, Yan J and
Pan X: HIF-2α and Oct4 have synergistic effects on survival and
myocardial repair of very small embryonic-like mesenchymal stem
cells in infarcted hearts. Cell Death Dis. 8:e25482017. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Uniacke J, Holterman CE, Lachance G,
Franovic A, Jacob MD, Fabian MR, Payette J, Holcik M, Pause A and
Lee S: An oxygen-regulated switch in the protein synthesis
machinery. Nature. 486:126–129. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Ho JJD, Wang M, Audas TE, Kwon D, Carlsson
SK, Timpano S, Evagelou SL, Brothers S, Gonzalgo ML, Krieger JR, et
al: Systemic reprogramming of translation efficiencies on oxygen
stimulus. Cell Rep. 14:1293–1300. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Uniacke J, Perera JK, Lachance G,
Francisco CB and Lee S: Cancer cells exploit eIF4E2-directed
synthesis of hypoxia response proteins to drive tumor progression.
Cancer Res. 74:1379–1389. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Rzymski T, Milani M, Pike L, Buffa F,
Mellor HR, Winchester L, Pires I, Hammond E, Ragoussis I and Harris
AL: Regulation of autophagy by ATF4 in response to severe hypoxia.
Oncogene. 29:4424–4435. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Koumenis C and Wouters BG: ‘Translating’
tumor hypoxia: Unfolded protein response (UPR)-dependent and
UPR-independent pathways. Mol Cancer Res. 4:423–436. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Suarez-Arnedo A, Torres Figueroa F,
Clavijo C, Arbeláez P, Cruz JC and Muñoz-Camargo C: An image J
plugin for the high throughput image analysis of in vitro scratch
wound healing assays. PLoS One. 15:e02325652020. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Wei L, Lin Q, Lu Y, Li G, Huang L, Fu Z,
Chen R and Zhou Q: Cancer-associated fibroblasts-mediated ATF4
expression promotes malignancy and gemcitabine resistance in
pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1
transactivation. Cell Death Dis. 12:3342021. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Koong AC, Mehta VK, Le QT, Fisher GA,
Terris DJ, Brown JM, Bastidas AJ and Vierra M: Pancreatic tumors
show high levels of hypoxia. Int J Radiat Oncol Biol Phys.
48:919–922. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Graffman S, Björk P, Ederoth P and Ihse I:
Polarographic pO2 measurements of intra-abdominal adenocarcinoma in
connection with intraoperative radiotherapy before and after change
of oxygen concentration of anaesthetic gases. Acta Oncol.
40:105–107. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
McKeown SR: Defining normoxia, physoxia
and hypoxia in tumours-implications for treatment response. Br J
Radiol. 87:201306762014. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Saxena K and Jolly MK: Acute vs chronic vs
cyclic hypoxia: Their differential dynamics, molecular mechanisms,
and effects on tumor progression. Biomolecules. 9:3392019.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Koh MY, Lemos R Jr, Liu X and Powis G: The
hypoxia-associated factor switches cells from HIF-1α- to
HIF-2α-dependent signaling promoting stem cell characteristics,
aggressive tumor growth and invasion. Cancer Res. 71:4015–4027.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Koh MY and Powis G: Passing the baton: The
HIF switch. Trends Biochem Sci. 37:364–372. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Onnis B, Rapisarda A and Melillo G:
Development of HIF-1 inhibitors for cancer therapy. J Cell Mol Med.
13:2780–2786. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Downes NL, Laham-Karam N, Kaikkonen MU and
Ylä-Herttuala S: Differential but complementary HIF1α and HIF2α
transcriptional regulation. Mol Ther. 26:1735–1745. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Holmquist-Mengelbier L, Fredlund E,
Löfstedt T, Noguera R, Navarro S, Nilsson H, Pietras A,
Vallon-Christersson J, Borg A, Gradin K, et al: Recruitment of
HIF-1alpha and HIF-2alpha to common target genes is differentially
regulated in neuroblastoma: HIF-2alpha promotes an aggressive
phenotype. Cancer Cell. 10:413–423. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Koh MY, Darnay BG and Powis G:
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and
ubiquitinates hypoxia-inducible factor 1alpha, leading to its
oxygen-independent degradation. Mol Cell Biol. 28:7081–7095. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Serocki M, Bartoszewska S,
Janaszak-Jasiecka A, Ochocka RJ, Collawn JF and Bartoszewski R:
miRNAs regulate the HIF switch during hypoxia: A novel therapeutic
target. Angiogenesis. 21:183–202. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Lu ZJ, Lu LG, Tao KZ, Chen DF, Xia Q, Weng
JJ, Zhu F, Wang XP and Zheng P: MicroRNA-185 suppresses growth and
invasion of colon cancer cells through inhibition of the
hypoxia-inducible factor-2α pathway in vitro and in
vivo. Mol Med Rep. 10:2401–2408. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Uchida T, Rossignol F, Matthay MA, Mounier
R, Couette S, Clottes E and Clerici C: Prolonged hypoxia
differentially regulates hypoxia-inducible factor (HIF)-1alpha and
HIF-2alpha expression in lung epithelial cells: Implication of
natural antisense HIF-1alpha. J Biol Chem. 279:14871–14878. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Nagelkerke A, Bussink J, Mujcic H, Wouters
BG, Lehmann S, Sweep FC and Span PN: Hypoxia stimulates migration
of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded
protein response. Breast Cancer Res. 15:R22013. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Du J, Liu H, Mao X, Qin Y and Fan C: ATF4
promotes lung cancer cell proliferation and invasion partially
through regulating Wnt/β-catenin signaling. Int J Med Sci.
18:1442–1448. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Dadey DYA, Kapoor V, Khudanyan A, Thotala
D and Hallahan DE: PERK regulates glioblastoma sensitivity to ER
stress although promoting radiation resistance. Mol Cancer Res.
16:1447–1453. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Zeng P, Sun S, Li R, Xiao ZX and Chen H:
HER2 upregulates ATF4 to promote cell migration via activation of
ZEB1 and downregulation of E-cadherin. Int J Mol Sci. 20:22232019.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
González-González A, Muñoz-Muela E,
Marchal JA, Cara FE, Molina MP, Cruz-Lozano M, Jiménez G, Verma A,
Ramírez A, Qian W, et al: Activating transcription factor 4
modulates TGFβ-induced aggressiveness in triple-negative breast
cancer via SMAD2/3/4 and mTORC2 signaling. Clin Cancer Res.
24:5697–5709. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Rundqvist H and Johnson RS: Tumour
oxygenation: Implications for breast cancer prognosis. J Intern
Med. 274:105–112. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Vaupel P, Schlenger K, Knoop C and Höckel
M: Oxygenation of human tumors: Evaluation of tissue oxygen
distribution in breast cancers by computerized O2 tension
measurements. Cancer Res. 51:3316–3322. 1991.PubMed/NCBI
|
|
47
|
Lando D, Peet DJ, Whelan DA, Gorman JJ and
Whitelaw ML: Asparagine hydroxylation of the HIF transactivation
domain a hypoxic switch. Science. 295:858–861. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Gradiz R, Silva HC, Carvalho L, Botelho MF
and Mota-Pinto A: MIA PaCa-2 and PANC-1-pancreas ductal
adenocarcinoma cell lines with neuroendocrine differentiation and
somatostatin receptors. Sci Rep. 6:216482016. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Yoshida T, Ri M, Kinoshita S, Narita T,
Totani H, Ashour R, Ito A, Kusumoto S, Ishida T, Komatsu H and Iida
S: Low expression of neural cell adhesion molecule, CD56, is
associated with low efficacy of bortezomib plus dexamethasone
therapy in multiple myeloma. PLoS One. 13:e01967802018. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Garcia-Carbonero N, Li W, Cabeza-Morales
M, Martinez-Useros J and Garcia-Foncillas J: New hope for
pancreatic ductal adenocarcinoma treatment targeting endoplasmic
reticulum stress response: A systematic review. Int J Mol Sci.
19:24682018. View Article : Google Scholar : PubMed/NCBI
|
