Open Access

miR‑151a‑5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT

  • Authors:
    • Yaya Xie
    • Yue Zhang
    • Xianju Liu
    • Lijun Cao
    • Mengting Han
    • Chunmei Wang
    • Jinlian Chen
    • Xingxing Zhang
  • View Affiliations

  • Published online on: January 20, 2023     https://doi.org/10.3892/or.2023.8487
  • Article Number: 50
  • Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal carcinoma (CRC) is one of the most common types of digestive cancer. It has been reported that the ectopic expression of microRNAs (miRs) plays a critical role in the occurrence and progression of CRC. In addition, it has also been suggested that miR‑151a‑5p may serve as a useful biomarker for the early detection and treatment of different types of cancer and particularly CRC. However, the specific effects and underlying mechanisms of miR‑151a‑5p in CRC remain elusive. The results of the current study demonstrated that miR‑151a‑5p was upregulated in CRC cell lines and clinical tissues derived from patients with CRC. Functionally, the results showed that miR‑151a‑5p significantly promoted CRC cell proliferation, migration and invasion. Additionally, dual luciferase reporter assays verified that agmatinase (AGMAT) was a direct target of miR‑151a‑5p and it was positively associated with miR‑151a‑5p expression. Mechanistically, miR‑151a‑5p could enhance the epithelial‑mesenchymal transition of CRC cells. Taken together, the results of the current study revealed a novel molecular mechanism indicating that the miR‑151a‑5p/AGMAT axis could serve a crucial role in the regulation of CRC and could therefore be considered as a potential therapeutic strategy for CRC.

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March-2023
Volume 49 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Xie Y, Zhang Y, Liu X, Cao L, Han M, Wang C, Chen J and Zhang X: miR‑151a‑5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT. Oncol Rep 49: 50, 2023
APA
Xie, Y., Zhang, Y., Liu, X., Cao, L., Han, M., Wang, C. ... Zhang, X. (2023). miR‑151a‑5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT. Oncology Reports, 49, 50. https://doi.org/10.3892/or.2023.8487
MLA
Xie, Y., Zhang, Y., Liu, X., Cao, L., Han, M., Wang, C., Chen, J., Zhang, X."miR‑151a‑5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT". Oncology Reports 49.3 (2023): 50.
Chicago
Xie, Y., Zhang, Y., Liu, X., Cao, L., Han, M., Wang, C., Chen, J., Zhang, X."miR‑151a‑5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT". Oncology Reports 49, no. 3 (2023): 50. https://doi.org/10.3892/or.2023.8487