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Review Open Access

Role of ubiquitin regulatory X domain‑containing protein 3B in the development of hepatocellular carcinoma (Review)

  • Authors:
    • Ziwei Guo
    • Jun Liang
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Peking University International Hospital, Beijing 102206, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 57
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    Published online on: February 9, 2023
       https://doi.org/10.3892/or.2023.8494
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Abstract

The majority of new cases and fatalities from hepatocellular carcinoma (HCC) occur in China; however, the overall morbidity and mortality rates are decreasing. A major risk factor due to the evolving epidemiology is improper lipid metabolism. Although investigations on aberrant lipid metabolism are numerous, there are only a limited number of studies available on proteasomal degradation processes. The degradation process is mainly involved in endoplasmic reticulum stabilization, the balance of lipid metabolism, and physiological functions of Golgi apparatus, endoplasmic reticulum, lysosomes and other organelles, however, this process has been little studied in the development of tumorigenesis. In order to provide some theoretical support for future research on ubiquitin regulatory X domain‑containing protein 3B (UBXN3B), the present review focuses on the role of UBXN3B, which is involved in the stabilization of the endoplasmic reticulum and the maintenance of lipid homeostasis, as well as in the promotion and development of non‑alcoholic fatty liver disease and HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Guo Z and Liang J: Role of ubiquitin regulatory X domain‑containing protein 3B in the development of hepatocellular carcinoma (Review). Oncol Rep 49: 57, 2023.
APA
Guo, Z., & Liang, J. (2023). Role of ubiquitin regulatory X domain‑containing protein 3B in the development of hepatocellular carcinoma (Review). Oncology Reports, 49, 57. https://doi.org/10.3892/or.2023.8494
MLA
Guo, Z., Liang, J."Role of ubiquitin regulatory X domain‑containing protein 3B in the development of hepatocellular carcinoma (Review)". Oncology Reports 49.3 (2023): 57.
Chicago
Guo, Z., Liang, J."Role of ubiquitin regulatory X domain‑containing protein 3B in the development of hepatocellular carcinoma (Review)". Oncology Reports 49, no. 3 (2023): 57. https://doi.org/10.3892/or.2023.8494
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Z and Liang J: Role of ubiquitin regulatory X domain‑containing protein 3B in the development of hepatocellular carcinoma (Review). Oncol Rep 49: 57, 2023.
APA
Guo, Z., & Liang, J. (2023). Role of ubiquitin regulatory X domain‑containing protein 3B in the development of hepatocellular carcinoma (Review). Oncology Reports, 49, 57. https://doi.org/10.3892/or.2023.8494
MLA
Guo, Z., Liang, J."Role of ubiquitin regulatory X domain‑containing protein 3B in the development of hepatocellular carcinoma (Review)". Oncology Reports 49.3 (2023): 57.
Chicago
Guo, Z., Liang, J."Role of ubiquitin regulatory X domain‑containing protein 3B in the development of hepatocellular carcinoma (Review)". Oncology Reports 49, no. 3 (2023): 57. https://doi.org/10.3892/or.2023.8494
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