Role of ubiquitin regulatory X domain‑containing protein 3B in the development of hepatocellular carcinoma (Review)
- Authors:
- Ziwei Guo
- Jun Liang
-
Affiliations: Department of Medical Oncology, Peking University International Hospital, Beijing 102206, P.R. China - Published online on: February 9, 2023 https://doi.org/10.3892/or.2023.8494
- Article Number: 57
-
Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
|
Rawla P, Sunkara T, Muralidharan P and Raj JP: Update in global trends and aetiology of hepatocellular carcinoma. Contemp Oncol (Pozn). 22:141–150. 2018.PubMed/NCBI | |
|
World Health Organization, . GLOBOCAN 2020 Graph production. http://gco.iarc.fr/todaySeptember. 2021 | |
|
Blanchette-Mackie EJ, Dwyer NK, Barber T, Coxey RA, Takeda T, Rondinone CM, Theodorakis JL, Greenberg AS and Londos C: Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes. J Lipid Res. 36:1211–1226. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, et al: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 551:340–345. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Muir K, Hazim A, He Y, Peyressatre M, Kim DY, Song X and Beretta L: Proteomic and lipidomic signatures of lipid metabolism in NASH-associated hepatocellular carcinoma. Cancer Res. 73:4722–4731. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou HL, Geng C, Luo G and Lou H: The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP. Genes Dev. 27:1046–1058. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Kloppsteck P, Ewens CA, Förster A, Zhang X and Freemont PS: Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family. Biochim Biophys Acta. 1823:125–129. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Rezvani K: UBXD proteins: A family of proteins with diverse functions in cancer. Int J Mol Sci. 17:17242016. View Article : Google Scholar : PubMed/NCBI | |
|
Liao Z, Luo R, Li G, Song Y, Zhan S, Zhao K, Hua W, Zhang Y, Wu X and Yang C: Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo. Theranostics. 9:4084–4100. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Nakatsukasa K, Huyer G, Michaelis S and Brodsky JL: Dissecting the ER-associated degradation of a misfolded polytopic membrane protein. Cell. 132:101–112. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Mukkavalli S, Klickstein JA, Ortiz B, Juo P and Raman M: The p97-UBXN1 complex regulates aggresome formation. J Cell Sci. 134:jcs2542012021. View Article : Google Scholar : PubMed/NCBI | |
|
Uchiyama K, Totsukawa G, Puhka M, Kaneko Y, Jokitalo E, Dreveny I, Beuron F, Zhang X, Freemont P and Kondo H: p37 is a p97 adaptssswor required for Golgi and ER biogenesis in interphase and at the end of mitosis. Dev Cell. 11:803–816. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Her NG, Toth JI, Ma CT, Wei Y, Motamedchaboki K, Sergienko E and Petroski MD: p97 composition changes caused by allosteric inhibition are suppressed by an on-target mechanism that increases the enzyme's ATPase activity. Cell Chem Biol. 23:517–528. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ye Y, Meyer HH and Rapoport TA: The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature. 414:652–656. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Olzmann JA, Richter CM and Kopito RR: Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover. Proc Natl Acad Sci USA. 110:1345–1350. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Liang J, Yin C, Doong H, Fang S, Peterhoff C, Nixon RA and Monteiro MJ: Characterization of erasin (UBXD2): A new ER protein that promotes ER-associated protein degradation. J Cell Sci. 119:4011–4024. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Nagahama M, Ohnishi M, Kawate Y, Matsui T, Miyake H, Yuasa K, Tani K, Tagaya M and Tsuji A: UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation. Biochem Biophys Res Commun. 382:303–308. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Raman M, Sergeev M, Garnaas M, Lydeard JR, Huttlin EL, Goessling W, Shah JV and Harper JW: Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. Nat Cell Biol. 17:1356–1369. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Schrul B and Kopito RR: Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains. Nat Cell Biol. 18:740–751. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Pawar A, Botolin D, Mangelsdorf DJ and Jump DB: The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression. J Biol Chem. 278:40736–40743. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS and Goldstein JL: Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci USA. 100:12027–12032. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Gong Yi, Lee JN, Lee PC, Goldstein JL, Brown MS and Ye J: Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. Cell Metab. 3:15–24. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Lee JN, Zhang X, Feramisco JD, Gong Y and Ye J: Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step. J Biol Chem. 283:33772–33783. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Nohturfft A, Yabe D, Goldstein JL, Brown MS and Espenshade PJ: Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Cell. 102:315–323. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Ohsaki Y, Cheng J, Suzuki M, Fujita A and Fujimoto T: Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100. J Cell Sci. 121:2415–2422. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Sasako T, Ohsugi M, Kubota N, Itoh S, Okazaki Y, Terai A, Kubota T, Yamashita S, Nakatsukasa K, Kamura T, et al: Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism. Nat Commun. 10:9472019. View Article : Google Scholar : PubMed/NCBI | |
|
Yen CL, Monetti M, Burri BJ and Farese RV Jr: The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters. J Lipid Res. 46:1502–1511. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Loregger A, Raaben M, Tan J, Scheij S, Moeton M, van den Berg M, Gelberg-Etel H, Stickel E, Roitelman J, Brummelkamp T and Zelcer N: Haploid mammalian genetic screen identifies UBXD8 as a key determinant of HMGCR degradation and cholesterol biosynthesis. Arterioscler Thromb Vasc Biol. 37:2064–2074. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ishikawa H, Ma Z and Barber GN: STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature. 461:788–792. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, Geng T, Mordue DG, Fujimoto T, Cheng G, et al: UBXN3B positively regulates STING-mediated antiviral immune responses. Nat Commun. 9:23292018. View Article : Google Scholar : PubMed/NCBI | |
|
Preuss C, Jelenik T, Bódis K, Müssig K, Burkart V, Szendroedi J, Roden M and Markgraf DF: A new targeted lipidomics approach reveals lipid droplets in liver, muscle and heart as a repository for diacylglycerol and ceramide species in non-alcoholic fatty liver. Cells. 8:2772019. View Article : Google Scholar : PubMed/NCBI | |
|
Tian Y, Yang B, Qiu W, Hao Y, Zhang Z, Yang B, Li N, Cheng S, Lin Z, Rui YC, et al: ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy. Nat Commun. 10:33912019. View Article : Google Scholar : PubMed/NCBI | |
|
Trefts E, Gannon M and Wasserman DH: The liver. Curr Biol. 27:R1147–R1151. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Lonardo A, Ballestri S, Marchesini G, Angulo P and Loria P: Nonalcoholic fatty liver disease: A precursor of the metabolic syndrome. Dig Liver Dis. 47:181–190. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Guri Y, Colombi M, Dazert E, Hindupur SK, Roszik J, Moes S, Jenoe P, Heim MH, Riezman I, Riezman H and Hall MN: mTORC2 promotes tumorigenesis via lipid synthesis. Cancer Cell. 32:807–823.e12. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Huang X, Fan M and Huang W: Pleiotropic roles of FXR in liver and colorectal cancers. Mol Cell Endocrinol. 543:1115432022. View Article : Google Scholar : PubMed/NCBI | |
|
Yang S, Koteish A, Lin H, Huang J, Roskams T, Dawson V and Diehl AM: Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. Hepatology. 39:403–411. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang T, Zhang Y, Liu J, Ma Y, Ye Q, Yan X and Ding L: MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation. Cancer Metab. 10:22022. View Article : Google Scholar : PubMed/NCBI | |
|
Bauer DE, Hatzivassiliou G, Zhao F, Andreadis C and Thompson CB: ATP citrate lyase is an important component of cell growth and transformation. Oncogene. 24:6314–6322. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Litwack G: Chapter 9-lipids. Litwack G: Human biochemistry Boston: Academic Press; pp. 199–255. 2018 | |
|
Medes G, Thomas A and Wernhouse S: Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res. 13:27–29. 1953.PubMed/NCBI | |
|
Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen ZP, O'Neill HM, Ford RJ, Palanivel R, O'Brien M, et al: Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat Med. 19:1649–1654. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Lake AD, Novak P, Hardwick RN, Flores-Keown B, Zhao F, Klimecki WT and Cherrington NJ: The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease. Toxicol Sci. 137:26–35. 2014.Oyadomari S, Harding HP, Zhang Y, Oyadomari M and Ron D: Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab. 7:520–532. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Pinto Lde F, Compri CM, Fornari JV, Bartchewsky W, Cintra DE, Trevisan M, Carvalho Pde O, Ribeiro ML, Velloso LA, Saad MJ, et al: The immunosuppressant drug, thalidomide, improves hepatic alterations induced by a high-fat diet in mice. Liver Int. 30:603–610. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Crespo J, Cayón A, Fernández-Gil P, Hernández-Guerra M, Mayorga M, Domínguez-Díez A, Fernández-Escalante JC and Pons-Romero F: Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology. 34:1158–1163. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou YJ, Li YY, Nie YQ, Yang H, Zhan Q, Huang J, Shi SL, Lai XB and Huang HL: Influence of polygenetic polymorphisms on the susceptibility to non-alcoholic fatty liver disease of Chinese people. J Gastroenterol Hepatol. 25:772–777. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Kramer F, Torzewski J, Kamenz J, Veit K, Hombach V, Dedio J and Ivashchenko Y: Interleukin-1beta stimulates acute phase response and C-reactive protein synthesis by inducing an NFkappaB- and C/EBPbeta-dependent autocrine interleukin-6 loop. Mol Immunol. 45:2678–2689. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Banroques J, Doère M, Dreyfus M, Linder P and Tanner NK: Motif III in superfamily 2 ‘helicases’ helps convert the binding energy of ATP into a high-affinity RNA binding site in the yeast DEAD-box protein Ded1. J Mol Biol. 396:949–966. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Catalá M, Antón A and Portolés MT: Characterization of the simultaneous binding of Escherichia coli endotoxin to Kupffer and endothelial liver cells by flow cytometry. Cytometry. 36:123–130. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Luo W, Xu Q, Wang Q, Wu H and Hua J: Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease. Sci Rep. 7:446122017. View Article : Google Scholar : PubMed/NCBI | |
|
Liu PS, Wang H, Li X, Chao T, Teav T, Christen S, Di Conza G, Cheng WC, Chou CH, Vavakova M, et al: α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nat Immunol. 18:985–994. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Bertola A, Bonnafous S, Anty R, Patouraux S, Saint-Paul MC, Iannelli A, Gugenheim J, Barr J, Mato JM, Le Marchand-Brustel Y, et al: Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients. PLoS One. 5:e135772010. View Article : Google Scholar : PubMed/NCBI | |
|
Maina V, Sutti S, Locatelli I, Vidali M, Mombello C, Bozzola C and Albano E: Bias in macrophage activation pattern influences non-alcoholic steatohepatitis (NASH) in mice. Clin Sci (Lond). 122:545–553. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Herber DL, Cao W, Nefedova Y, Novitskiy SV, Nagaraj S, Tyurin VA, Corzo A, Cho HI, Celis E, Lennox B, et al: Lipid accumulation and dendritic cell dysfunction in cancer. Nat Med. 16:880–886. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Henning JR, Graffeo CS, Rehman A, Fallon NC, Zambirinis CP, Ochi A, Barilla R, Jamal M, Deutsch M, Greco S, et al: Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice. Hepatology. 58:589–602. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Tosello-Trampont AC, Krueger P, Narayanan S, Landes SG, Leitinger N and Hahn YS: NKp46(+) natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice. Hepatology. 63:799–812. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ambade A, Satishchandran A, Saha B, Gyongyosi B, Lowe P, Kodys K, Catalano D and Szabo G: Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10. Oncoimmunology. 5:e12215572016. View Article : Google Scholar : PubMed/NCBI | |
|
Wang W, Furneaux H, Cheng H, Caldwell MC, Hutter D, Liu Y, Holbrook N and Gorospe M: HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol. 20:760–769. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Gerber AP, Herschlag D and Brown PO: Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS Biol. 2:E792004. View Article : Google Scholar : PubMed/NCBI | |
|
Clement SL, Scheckel C, Stoecklin G and Lykke-Andersen J: Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment. Mol Cell Biol. 31:256–266. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Lafarga V, Cuadrado A, Lopez de Silanes I, Bengoechea R, Fernandez-Capetillo O and Nebreda AR: p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint. Mol Cell Biol. 9:4341–4351. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Meerang M, Ritz D, Paliwal S, Garajova Z, Bosshard M, Mailand N, Janscak P, Hübscher U, Meyer H and Ramadan K: The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nat Cell Biol. 13:1376–1382. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Kim HH, Abdelmohsen K, Lal A, Pullmann R Jr, Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J, Shokat KM and Gorospe M: Nuclear HuR accumulation through phosphorylation by Cdk1. Genes Dev. 22:1804–1815. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Park ES, Yoo YJ and Elangovan M: The opposite role of two UBA-UBX containing proteins, p47 and SAKS1 in the degradation of a single ERAD substrate, α-TCR. Mol Cell Biochem. 425:37–45. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Sepulveda D, Rojas-Rivera D, Rodríguez DA, Groenendyk J, Köhler A, Lebeaupin C, Ito S, Urra H, Carreras-Sureda A, Hazari Y, et al: Interactome screening identifies the ER luminal chaperone Hsp47 as a regulator of the unfolded protein response transducer IRE1α. Mol Cell. 69:238–252.e7. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Karagöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F and Walter P: An unfolded protein-induced conformational switch activates mammalian IRE1. Elife. 6:e307002017. View Article : Google Scholar : PubMed/NCBI | |
|
Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP and Ron D: Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science. 287:664–666. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Bertolotti A, Zhang Y, Hendershot LM, Harding HP and Ron D: Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol. 2:326–332. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Carrara M, Prischi F, Nowak PR and Ali MM: Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling. EMBO J. 34:1589–1600. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, et al: An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 11:619–633. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Blais JD, Filipenko V, Bi M, Harding HP, Ron D, Koumenis C, Wouters BG and Bell JC: Activating transcription factor 4 is translationally regulated by hypoxic stress. Mol Cell Biol. 24:7469–7482. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Adachi Y, Yamamoto K, Okada T, Yoshida H, Harada A and Mori K: ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. Cell Struct Funct. 33:75–89. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Schindler AJ and Schekman R: In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles. Proc Natl Acad Sci USA. 106:17775–17780. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Lally JSV, Ghoshal S, DePeralta DK, Moaven O, Wei L, Masia R, Erstad DJ, Fujiwara N, Leong V, Houde VP, et al: Inhibition of acetyl-CoA carboxylase by phosphorylation or the inhibitor ND-654 suppresses lipogenesis and hepatocellular carcinoma. Cell Metab. 29:174–182.e5. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu H, Zhang Q and Chen G: CXCR6 deficiency ameliorates ischemia-reperfusion injury by reducing the recruitment and cytokine production of hepatic NKT cells in a mouse model of non-alcoholic fatty liver disease. Int Immunopharmacol. 72:224–234. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou ZJ, Xin HY, Li J, Hu ZQ, Luo CB and Zhou SL: Intratumoral plasmacytoid dendritic cells as a poor prognostic factor for hepatocellular carcinoma following curative resection. Cancer Immunol Immunother. 68:1223–1233. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Tang T, Sui Y, Lian M, Li Z and Hua J: Pro-inflammatory activated Kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death. PLoS One. 8:e819492013. View Article : Google Scholar : PubMed/NCBI | |
|
Wu L, Parekh VV, Gabriel CL, Bracy DP, Marks-Shulman PA, Tamboli RA, Kim S, Mendez-Fernandez YV, Besra GS, Lomenick JP, et al: Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc Natl Acad Sci USA. 109:E1143–E1152. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Ben Haij N, Planès R, Leghmari K, Serrero M, Delobel P, Izopet J, BenMohamed L and Bahraoui E: HIV-1 Tat protein induces production of proinflammatory cytokines by human dendritic cells and monocytes/macrophages through engagement of TLR4-MD2-CD14 complex and activation of NF-κB pathway. PLoS One. 10:e01294252015. View Article : Google Scholar : PubMed/NCBI |
