Open Access

Modulating epigenetic modifications for cancer therapy (Review)

  • Authors:
    • Leonardo Josué Castro-Muñoz
    • Elenaé Vázquez Ulloa
    • Cecilia Sahlgren
    • Marcela Lizano
    • Erick De La Cruz-Hernández
    • Adriana Contreras-Paredes
  • View Affiliations

  • Published online on: February 10, 2023     https://doi.org/10.3892/or.2023.8496
  • Article Number: 59
  • Copyright: © Castro-Muñoz et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer is a global public health concern. Alterations in epigenetic processes are among the earliest genomic aberrations occurring during cancer development and are closely related to progression. Unlike genetic mutations, aberrations in epigenetic processes are reversible, which opens the possibility for novel pharmacological treatments. Non‑coding RNAs (ncRNAs) represent an essential epigenetic mechanism, and emerging evidence links ncRNAs to carcinogenesis. Epigenetic drugs (epidrugs) are a group of promising target therapies for cancer treatment acting as coadjuvants to reverse drug resistance in cancer. The present review describes central epigenetic aberrations during malignant transformation and explains how epidrugs target DNA methylation, histone modifications and ncRNAs. Furthermore, clinical trials focused on evaluating the effect of these epidrugs alone or in combination with other anticancer therapies and other ncRNA‑based therapies are discussed. The use of epidrugs promises to be an effective tool for reversing drug resistance in some patients with cancer.
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March-2023
Volume 49 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Castro-Muñoz LJ, Ulloa EV, Sahlgren C, Lizano M, De La Cruz-Hernández E and Contreras-Paredes A: Modulating epigenetic modifications for cancer therapy (Review). Oncol Rep 49: 59, 2023
APA
Castro-Muñoz, L.J., Ulloa, E.V., Sahlgren, C., Lizano, M., De La Cruz-Hernández, E., & Contreras-Paredes, A. (2023). Modulating epigenetic modifications for cancer therapy (Review). Oncology Reports, 49, 59. https://doi.org/10.3892/or.2023.8496
MLA
Castro-Muñoz, L. J., Ulloa, E. V., Sahlgren, C., Lizano, M., De La Cruz-Hernández, E., Contreras-Paredes, A."Modulating epigenetic modifications for cancer therapy (Review)". Oncology Reports 49.3 (2023): 59.
Chicago
Castro-Muñoz, L. J., Ulloa, E. V., Sahlgren, C., Lizano, M., De La Cruz-Hernández, E., Contreras-Paredes, A."Modulating epigenetic modifications for cancer therapy (Review)". Oncology Reports 49, no. 3 (2023): 59. https://doi.org/10.3892/or.2023.8496