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HOXA‑AS3 induces tumor progression through the epithelial‑mesenchymal transition pathway in epithelial ovarian cancer

  • Authors:
    • Kyung Jin Eoh
    • Dae Woo Lee
    • Eun Ji Nam
    • Jae In Kim
    • Hanna Moon
    • Sang Wun Kim
    • Young Tae Kim
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Center for Digital Health, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Gyeonggi‑do 16995, Republic of Korea, Department of Obstetrics and Gynecology, Bucheon St. Mary's Hospital, College of Medicine, Catholic University of Korea, Bucheon, Gyeonggi‑do 14647, Republic of Korea, Department of Obstetrics and Gynecology, Institute of Women's Medical Life Science, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea
    Copyright: © Eoh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 64
    |
    Published online on: February 14, 2023
       https://doi.org/10.3892/or.2023.8501
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Abstract

HOXA cluster antisense RNA 3 (HOXA‑AS3) is considered to be involved in several malignancies, however, its biological function in the progression of epithelial ovarian cancer (EOC) remains unclear. The present study compared the expression of HOXA‑AS3 in ovarian cancer and normal ovarian tissues and analyzed the association between the expression of HOXA‑AS3 and the survival outcomes of patients with ovarian cancer. RNA interference was used to suppress HOXA‑AS3 expression in ovarian cancer cell lines in order to demonstrate the function of HOXA‑AS3 in ovarian cancer progression. The associations between HOXA‑AS3 and epithelial‑mesenchymal transition (EMT) markers were explored to verify the mechanism of action of HOXA‑AS3 in ovarian cancer. The results of the present study revealed that ovarian cancer tissues exhibited higher HOXA‑AS3 expression than normal ovarian tissues. Clinical data indicated that HOXA‑AS3 was a significant predictor of progression‑free survival and overall survival. Patients with high HOXA‑AS3 expression had a poorer prognosis than patients with low HOXA‑AS3 expression. In vitro experiments using HOXA‑AS3‑knockdown ovarian cancer cell lines demonstrated that HOXA‑AS3 knockdown inhibited cell proliferation and migration. HOXA‑AS3 was a potent inducer and modulator of the expression of EMT pathway‑related markers and interacted with both the mRNA and protein forms of HOXA3. Collectively, the findings of the present study demonstrated that HOXA‑AS3 expression is associated with ovarian cancer progression and thus, may be employed as a prognostic marker and therapeutic target in EOC.
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1 

Shin W, Won YJ, Yoo CW, Lim J and Lim MC: Incidence trends for epithelial peritoneal, ovarian, and fallopian tube cancer during 1999–2016: A retrospective study based on the Korean National Cancer Incidence Database. J Gynecol Oncol. 31:e562020. View Article : Google Scholar : PubMed/NCBI

2 

Guttman M, Donaghey J, Carey BW, Garber M, Grenier JK, Munson G, Young G, Lucas AB, Ach R, Bruhn L, et al: lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature. 477:295–300. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Kim HJ, Eoh KJ, Kim LK, Nam EJ, Yoon SO, Kim KH, Lee JK, Kim SW and Kim YT: The long noncoding RNA HOXA11 antisense induces tumor progression and stemness maintenance in cervical cancer. Oncotarget. 7:83001–83016. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Eoh KJ, Paek J, Kim SW, Kim HJ, Lee HY, Lee SK and Kim YT: Long non-coding RNA, steroid receptor RNA activator (SRA), induces tumor proliferation and invasion through the NOTCH pathway in cervical cancer cell lines. Oncol Rep. 38:3481–3488. 2017.PubMed/NCBI

5 

Arumugam T, Ramachandran V, Fournier KF, Wang H, Marquis L, Abbruzzese JL, Gallick GE, Logsdon CD, McConkey DJ and Choi W: Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res. 69:5820–5828. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Fischer KR, Durrans A, Lee S, Sheng J, Li F, Wong ST, Choi H, El Rayes T, Ryu S, Troeger J, et al: Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature. 527:472–476. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Wu F, Zhang C, Cai J, Yang F, Liang T, Yan X, Wang H, Wang W, Chen J and Jiang T: Upregulation of long noncoding RNA HOXA-AS3 promotes tumor progression and predicts poor prognosis in glioma. Oncotarget. 8:53110–53123. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Zhang H, Liu Y, Yan L, Zhang M, Yu X, Du W, Wang S, Li Q, Chen H, Zhang Y, et al: Increased levels of the long noncoding RNA, HOXA-AS3, promote proliferation of A549 cells. Cell Death Dis. 9:7072018. View Article : Google Scholar : PubMed/NCBI

9 

Lin S, Zhang R, An X, Li Z, Fang C, Pan B, Chen W, Xu G and Han W: LncRNA HOXA-AS3 confers cisplatin resistance by interacting with HOXA3 in non-small-cell lung carcinoma cells. Oncogenesis. 8:602019. View Article : Google Scholar : PubMed/NCBI

10 

Yim GW, Lee DW, Kim JI and Kim YT: Long Non-coding RNA LOC285194 promotes epithelial ovarian cancer progression via the apoptosis signaling pathway. In Vivo. 36:121–131. 2022. View Article : Google Scholar : PubMed/NCBI

11 

Eoh KJ, Kim HJ, Lee JW, Kim LK, Park SA, Kim HS, Kim YT and Koo PJ: E2F8 induces cell proliferation and invasion through the Epithelial-mesenchymal transition and notch signaling pathways in ovarian cancer. Int J Mol Sci. 21:58132020. View Article : Google Scholar : PubMed/NCBI

12 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 464:1071–1076. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Kim HJ, Lee DW, Yim GW, Nam EJ, Kim S, Kim SW and Kim YT: Long non-coding RNA HOTAIR is associated with human cervical cancer progression. Int J Oncol. 46:521–530. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Sun H, Chen J, Qian W, Kang J, Wang J, Jiang L, Qiao L, Chen W and Zhang J: Integrated long non-coding RNA analyses identify novel regulators of epithelial-mesenchymal transition in the mouse model of pulmonary fibrosis. J Cell Mol Med. 20:1234–1246. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Sun Z, Yang S, Zhou Q, Wang G, Song J, Li Z, Zhang Z, Xu J, Xia K and Chang Y: Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment. Mol Cancer. 17:822018. View Article : Google Scholar : PubMed/NCBI

17 

Marcucci F, Stassi G and De Maria R: Epithelial-mesenchymal transition: A new target in anticancer drug discovery. Nat Rev Drug Discov. 15:311–325. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Tang Y, Cheung BB, Atmadibrata B, Marshall GM, Dinger ME, Liu PY and Liu T: The regulatory role of long noncoding RNAs in cancer. Cancer Lett. 391:12–19. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Ohana P, Bibi O, Matouk I, Levy C, Birman T, Ariel I, Schneider T, Ayesh S, Giladi H, Laster M, et al: Use of H19 regulatory sequences for targeted gene therapy in cancer. Int J Cancer. 98:645–650. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Mizrahi A, Czerniak A, Levy T, Amiur S, Gallula J, Matouk I, Abu-Lail R, Sorin V, Birman T, de Groot N, et al: Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences. J Transl Med. 7:692009. View Article : Google Scholar : PubMed/NCBI

21 

Gofrit ON, Benjamin S, Halachmi S, Leibovitch I, Dotan Z, Lamm DL, Ehrlich N, Yutkin V, Ben-Am M and Hochberg A: DNA based therapy with diphtheria toxin-A BC-819: A phase 2b marker lesion trial in patients with intermediate risk nonmuscle invasive bladder cancer. J Urol. 191:1697–1702. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Hanna N, Ohana P, Konikoff FM, Leichtmann G, Hubert A, Appelbaum L, Kopelman Y, Czerniak A and Hochberg A: Phase 1/2a, dose-escalation, safety, pharmacokinetic and preliminary efficacy study of intratumoral administration of BC-819 in patients with unresectable pancreatic cancer. Cancer Gene Ther. 19:374–381. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Hasenpusch G, Pfeifer C, Aneja MK, Wagner K, Reinhardt D, Gilon M, Ohana P, Hochberg A and Rudolph C: Aerosolized BC-819 inhibits primary but not secondary lung cancer growth. PLoS One. 6:e207602011. View Article : Google Scholar : PubMed/NCBI

24 

Lavie O, Edelman D, Levy T, Fishman A, Hubert A, Segev Y, Raveh E, Gilon M and Hochberg A: A phase 1/2a, dose-escalation, safety, pharmacokinetic, and preliminary efficacy study of intraperitoneal administration of BC-819 (H19-DTA) in subjects with recurrent ovarian/peritoneal cancer. Arch Gynecol Obstet. 295:751–761. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Sidi AA, Ohana P, Benjamin S, Shalev M, Ransom JH, Lamm D, Hochberg A and Leibovitch I: Phase I/II marker lesion study of intravesical BC-819 DNA plasmid in H19 over expressing superficial bladder cancer refractory to bacillus Calmette-Guerin. J Urol. 180:2379–2383. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Smaldone MC and Davies BJ: BC-819, a plasmid comprising the H19 gene regulatory sequences and diphtheria toxin A, for the potential targeted therapy of cancers. Curr Opin Mol Ther. 12:607–616. 2010.PubMed/NCBI

27 

Zhu XX, Yan YW, Chen D, Ai CZ, Lu X, Xu SS, Jiang S, Zhong GS, Chen DB and Jiang YZ: Long non-coding RNA HoxA-AS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells. Oncotarget. 7:63561–63570. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Chen YG, Satpathy AT and Chang HY: Gene regulation in the immune system by long noncoding RNAs. Nat Immunol. 18:962–972. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Jiang C, Li X, Zhao H and Liu H: Long non-coding RNAs: Potential new biomarkers for predicting tumor invasion and metastasis. Mol Cancer. 15:622016. View Article : Google Scholar : PubMed/NCBI

30 

Peng WX, Koirala P and Mo YY: LncRNA-mediated regulation of cell signaling in cancer. Oncogene. 36:5661–5667. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Kyba M: Modulating the malignancy of Hox proteins. Blood. 129:269–270. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Monterisi S, Lo Riso P, Russo K, Bertalot G, Vecchi M, Testa G, Di Fiore PP and Bianchi F: HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype. Oncogene. 37:3575–3588. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Eoh KJ, Lee DW, Nam EJ, Kim JI, Moon H, Kim SW and Kim YT: HOXA‑AS3 induces tumor progression through the epithelial‑mesenchymal transition pathway in epithelial ovarian cancer. Oncol Rep 49: 64, 2023.
APA
Eoh, K.J., Lee, D.W., Nam, E.J., Kim, J.I., Moon, H., Kim, S.W., & Kim, Y.T. (2023). HOXA‑AS3 induces tumor progression through the epithelial‑mesenchymal transition pathway in epithelial ovarian cancer. Oncology Reports, 49, 64. https://doi.org/10.3892/or.2023.8501
MLA
Eoh, K. J., Lee, D. W., Nam, E. J., Kim, J. I., Moon, H., Kim, S. W., Kim, Y. T."HOXA‑AS3 induces tumor progression through the epithelial‑mesenchymal transition pathway in epithelial ovarian cancer". Oncology Reports 49.3 (2023): 64.
Chicago
Eoh, K. J., Lee, D. W., Nam, E. J., Kim, J. I., Moon, H., Kim, S. W., Kim, Y. T."HOXA‑AS3 induces tumor progression through the epithelial‑mesenchymal transition pathway in epithelial ovarian cancer". Oncology Reports 49, no. 3 (2023): 64. https://doi.org/10.3892/or.2023.8501
Copy and paste a formatted citation
x
Spandidos Publications style
Eoh KJ, Lee DW, Nam EJ, Kim JI, Moon H, Kim SW and Kim YT: HOXA‑AS3 induces tumor progression through the epithelial‑mesenchymal transition pathway in epithelial ovarian cancer. Oncol Rep 49: 64, 2023.
APA
Eoh, K.J., Lee, D.W., Nam, E.J., Kim, J.I., Moon, H., Kim, S.W., & Kim, Y.T. (2023). HOXA‑AS3 induces tumor progression through the epithelial‑mesenchymal transition pathway in epithelial ovarian cancer. Oncology Reports, 49, 64. https://doi.org/10.3892/or.2023.8501
MLA
Eoh, K. J., Lee, D. W., Nam, E. J., Kim, J. I., Moon, H., Kim, S. W., Kim, Y. T."HOXA‑AS3 induces tumor progression through the epithelial‑mesenchymal transition pathway in epithelial ovarian cancer". Oncology Reports 49.3 (2023): 64.
Chicago
Eoh, K. J., Lee, D. W., Nam, E. J., Kim, J. I., Moon, H., Kim, S. W., Kim, Y. T."HOXA‑AS3 induces tumor progression through the epithelial‑mesenchymal transition pathway in epithelial ovarian cancer". Oncology Reports 49, no. 3 (2023): 64. https://doi.org/10.3892/or.2023.8501
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