Open Access

Diverse roles of UBE2T in cancer (Review)

  • Authors:
    • Nengqian Ma
    • Zhangzhan Li
    • Jingting Yan
    • Xianrong Liu
    • Liyan He
    • Ruijie Xie
    • Xianzhou Lu
  • View Affiliations

  • Published online on: February 22, 2023     https://doi.org/10.3892/or.2023.8506
  • Article Number: 69
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As a leading cause of mortalities worldwide, cancer results from accumulation of both genetic and epigenetic alterations. Disruption of epigenetic regulation in cancer, particularly aberrant ubiquitination, has drawn increasing interest in recent years. The present study aimed to review the roles of ubiquitin‑conjugating enzyme E2 T (UBE2T) and its associated pathways in the pathogenesis of pan‑cancer, and the development of small‑molecule modulators to regulate ubiquitination for treatment strategies. The current study comprehensively investigated the expression landscape and functional significance of UBE2T, as well as its correlation with cancer cell sensitivity to chemotherapy/radiotherapy. Multiple levels of evidence suggested that aberrant UBE2T played important roles in pan‑cancer. Information was collected from 16 clinical trials on ubiquitin enzymes, and it was found that these molecules had an important role in the ubiquitin‑proteasome system. Further studies are necessary to explore their feasibility and effectiveness as diagnostic and prognostic biomarkers, or as up/down‑stream and therapeutic targets for cancer treatment.
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April-2023
Volume 49 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Ma N, Li Z, Yan J, Liu X, He L, Xie R and Lu X: Diverse roles of UBE2T in cancer (Review). Oncol Rep 49: 69, 2023.
APA
Ma, N., Li, Z., Yan, J., Liu, X., He, L., Xie, R., & Lu, X. (2023). Diverse roles of UBE2T in cancer (Review). Oncology Reports, 49, 69. https://doi.org/10.3892/or.2023.8506
MLA
Ma, N., Li, Z., Yan, J., Liu, X., He, L., Xie, R., Lu, X."Diverse roles of UBE2T in cancer (Review)". Oncology Reports 49.4 (2023): 69.
Chicago
Ma, N., Li, Z., Yan, J., Liu, X., He, L., Xie, R., Lu, X."Diverse roles of UBE2T in cancer (Review)". Oncology Reports 49, no. 4 (2023): 69. https://doi.org/10.3892/or.2023.8506