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Diverse roles of UBE2T in cancer (Review)

  • Authors:
    • Nengqian Ma
    • Zhangzhan Li
    • Jingting Yan
    • Xianrong Liu
    • Liyan He
    • Ruijie Xie
    • Xianzhou Lu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Zhuhui, Hengyang, Hunan 421002, P.R. China, Radiotherapy Center, Department of Oncology, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Zhuhui, Hengyang, Hunan 421002, P.R. China, Department of Ultrasound Medicine, Hengyang Central Hospital, Zhuhui, Hengyang, Hunan 421002, P.R. China, Department of Pain Rehabilitation, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Zhuhui, Hengyang, Hunan 421002, P.R. China, Department of Hand and Microsurgery, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Zhuhui, Hengyang, Hunan 421002, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 69
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    Published online on: February 22, 2023
       https://doi.org/10.3892/or.2023.8506
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Abstract

As a leading cause of mortalities worldwide, cancer results from accumulation of both genetic and epigenetic alterations. Disruption of epigenetic regulation in cancer, particularly aberrant ubiquitination, has drawn increasing interest in recent years. The present study aimed to review the roles of ubiquitin‑conjugating enzyme E2 T (UBE2T) and its associated pathways in the pathogenesis of pan‑cancer, and the development of small‑molecule modulators to regulate ubiquitination for treatment strategies. The current study comprehensively investigated the expression landscape and functional significance of UBE2T, as well as its correlation with cancer cell sensitivity to chemotherapy/radiotherapy. Multiple levels of evidence suggested that aberrant UBE2T played important roles in pan‑cancer. Information was collected from 16 clinical trials on ubiquitin enzymes, and it was found that these molecules had an important role in the ubiquitin‑proteasome system. Further studies are necessary to explore their feasibility and effectiveness as diagnostic and prognostic biomarkers, or as up/down‑stream and therapeutic targets for cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Ma N, Li Z, Yan J, Liu X, He L, Xie R and Lu X: Diverse roles of UBE2T in cancer (Review). Oncol Rep 49: 69, 2023.
APA
Ma, N., Li, Z., Yan, J., Liu, X., He, L., Xie, R., & Lu, X. (2023). Diverse roles of UBE2T in cancer (Review). Oncology Reports, 49, 69. https://doi.org/10.3892/or.2023.8506
MLA
Ma, N., Li, Z., Yan, J., Liu, X., He, L., Xie, R., Lu, X."Diverse roles of UBE2T in cancer (Review)". Oncology Reports 49.4 (2023): 69.
Chicago
Ma, N., Li, Z., Yan, J., Liu, X., He, L., Xie, R., Lu, X."Diverse roles of UBE2T in cancer (Review)". Oncology Reports 49, no. 4 (2023): 69. https://doi.org/10.3892/or.2023.8506
Copy and paste a formatted citation
x
Spandidos Publications style
Ma N, Li Z, Yan J, Liu X, He L, Xie R and Lu X: Diverse roles of UBE2T in cancer (Review). Oncol Rep 49: 69, 2023.
APA
Ma, N., Li, Z., Yan, J., Liu, X., He, L., Xie, R., & Lu, X. (2023). Diverse roles of UBE2T in cancer (Review). Oncology Reports, 49, 69. https://doi.org/10.3892/or.2023.8506
MLA
Ma, N., Li, Z., Yan, J., Liu, X., He, L., Xie, R., Lu, X."Diverse roles of UBE2T in cancer (Review)". Oncology Reports 49.4 (2023): 69.
Chicago
Ma, N., Li, Z., Yan, J., Liu, X., He, L., Xie, R., Lu, X."Diverse roles of UBE2T in cancer (Review)". Oncology Reports 49, no. 4 (2023): 69. https://doi.org/10.3892/or.2023.8506
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