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Article

High expression of LY6E is an independent prognostic factor of colorectal cancer patients

  • Authors:
    • Han Jo Kim
    • Inpyo Hong
    • Sanghyun Roh
    • Sooyoun Kim
    • Hyeongjoo Kim
    • Seunghyun Oh
    • Tae Sung Ahn
    • Dong Hyun Kang
    • Moo-Jun Baek
    • Dongjun Jeong
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, College of Medicine, Soonchunhyang University, Dongnam, Cheonan, Chungcheongnam 31151, Republic of Korea, Department of Pathology, College of Medicine, Soonchunhyang University, Dongnam, Cheonan, Chungcheongnam 31151, Republic of Korea, R&D Center Pharmaceutical Laboratory, Korean Drug Co., Ltd., Gangnam, Seoul 06300, Republic of Korea, Soonchunhyang Medical Science Research Institute, College of Medicine, Soonchunhyang University, Dongnam, Cheonan, Chungcheongnam 31151, Republic of Korea, Department of Surgery, College of Medicine, Soonchunhyang University, Dongnam, Cheonan, Chungcheongnam 31151, Republic of Korea
  • Article Number: 80
    |
    Published online on: March 3, 2023
       https://doi.org/10.3892/or.2023.8517
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Abstract

Colorectal cancer (CRC) is common cancer worldwide, and the 5‑year relative survival rate of CRC patients with distant metastasis is as low as 14%. Therefore, identifying markers of CRC is important for the early detection of CRC and applying appropriate treatment strategies. The lymphocyte antigen 6 family (LY6 family) is closely related to the behavior of various cancer types. Among the LY6 family, the lymphocyte antigen 6 complex, locus E (LY6E), which is specifically highly expressed in CRC. Hence, the effects of LY6E on cell function in CRC and its role in CRC recurrence and metastasis were investigated. Reverse transcription‑quantitative PCR, western blotting and in vitro functional studies were carried out using four CRC cell lines. Immunohistochemical analysis of 110 CRC tissues was performed to explore the biological functions and expression patterns of LY6E in CRC. LY6E was overexpressed CRC tissues compared with that in adjacent normal tissues. High expression of LY6E in CRC tissues was an independent prognostic factor of worse overall survival (P=0.048). Knockdown of LY6E using small interfering RNA inhibited CRC cell proliferation, migration, invasion, and soft agar colony formation, indicating some of its effects on CRC carcinogenic functions. High expression of LY6E may have oncogenic functions in CRC and be useful as a valuable prognostic marker and potential therapeutic target for CRC.
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1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Ryuk JP, Choi GS, Park JS, Kim HJ, Park SY, Yoon GS, Jun SH and Kwon YC: Predictive factors and the prognosis of recurrence of colorectal cancer within 2 years after curative resection. Ann Surg Treat Res. 86:143–151. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Siegel RL, Miller KD, Goding Sauer A, Fedewa SA, Butterly LF, Anderson JC, Cercek A, Smith RA and Jemal A: Colorectal cancer statistics, 2020. CA Cancer J Clin. 70:145–164. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Luo L, McGarvey P, Madhavan S, Kumar R, Gusev Y and Upadhyay G: Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome. Oncotarget. 7:11165–11193. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Loughner CL, Bruford EA, McAndrews MS, Delp EE, Swamynathan S and Swamynathan SK: Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Human Genomics. 10:102016. View Article : Google Scholar : PubMed/NCBI

6 

Upadhyay G: Emerging role of lymphocyte antigen-6 family of genes in cancer and immune cells. Front Immunol. 10:8192019. View Article : Google Scholar : PubMed/NCBI

7 

Davies A, Simmons DL, Hale G, Harrison RA, Tighe H, Lachmann PJ and Waldmann H: CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. J Exp Med. 170:637–654. 1989. View Article : Google Scholar : PubMed/NCBI

8 

Eisen A, Schulzer M, MacNeil M, Pant B and Mak E: Duration of amyotrophic lateral sclerosis is age dependent. Muscle Nerve. 16:27–32. 1993. View Article : Google Scholar : PubMed/NCBI

9 

Malek TR, Fleming TJ and Codias EK: Regulation of T lymphocyte function by glycosylphosphatidylinositol (GPI)-anchored proteins. Semin Immunol. 6:105–113. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Naylor TL, Greshock J, Wang Y, Colligon T, Yu QC, Clemmer V, Zaks TZ and Weber BL: High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization. Breast Cancer Res. 7:R1186–R1198. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Grisanzio C and Freedman ML: Chromosome 8q24-associated cancers and MYC. Genes Cancer. 1:555–559. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Russ E, Bhuvaneshwar K, Wang G, Jin B, Gage MM, Madhavan S, Gusev Y and Upadhyay G: High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma. Oncotarget. 12:145–159. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Yeom CJ, Zeng L, Goto Y, Morinibu A, Zhu Y, Shinomiya K, Kobayashi M, Itasaka S, Yoshimura M, Hur CG, et al: LY6E: A conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis. Oncotarget. 7:65837–65848. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Classon BJ and Coverdale L: Mouse stem cell antigen Sca-2 is a member of the Ly-6 family of cell surface proteins. Proc Natl Acad Sci USA. 91:5296–5300. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Antica M, Wu L and Scollay R: Stem cell antigen 2 expression in adult and developing mice. Immunol Lett. 55:47–51. 1997. View Article : Google Scholar : PubMed/NCBI

16 

AlHossiny M, Luo L, Frazier WR, Steiner N, Gusev Y, Kallakury B, Glasgow E, Creswell K, Madhavan S, Kumar R and Upadhyay G: Ly6E/K signaling to TGFβ promotes breast cancer progression, immune escape, and drug resistance. Cancer Res. 76:3376–3386. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Lv Y, Song Y, Ni C, Wang S, Chen Z, Shi X, Jiang Q, Cao C and Zuo Y: Overexpression of lymphocyte antigen 6 complex, locus E in gastric cancer promotes cancer cell growth and metastasis. Cell Physiol Biochem. 45:1219–1229. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Yin Y, Chen X and Shu Y: Gene expression of the invasive phenotype of TNF-alpha-treated MCF-7 cells. Biomed Pharmacother. 63:421–428. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Derynck R, Muthusamy BP and Saeteurn KY: Signaling pathway cooperation in TGF-β-induced epithelial-mesenchymal transition. Curr Opin Cell Biol. 31:56–66. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Asundi J, Crocker L, Tremayne J, Chang P, Sakanaka C, Tanguay J, Spencer S, Chalasani S, Luis E, Gascoigne K, et al: An antibody-drug conjugate directed against lymphocyte antigen 6 complex, locus E (LY6E) provides robust tumor killing in a wide range of solid tumor malignancies. Clin Cancer Res. 21:3252–3262. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Derynck R, Akhurst RJ and Balmain A: TGF-beta signaling in tumor suppression and cancer progression. Nat Genet. 29:117–129. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Lamouille S, Xu J and Derynck R: Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Massagué J: TGFβ signalling in context. Nat Rev Mol Cell Biol. 13:616–630. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Brunen D, Willems SM, Kellner U, Midgley R, Simon I and Bernards R: TGF-β: An emerging player in drug resistance. Cell Cycle. 12:2960–2968. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Yoo YA, Kim YH, Kim JS and Seo JH: The functional implications of Akt activity and TGF-beta signaling in tamoxifen-resistant breast cancer. Biochim Biophys Acta. 1783:438–447. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Gupta GP and Massagué J: Cancer metastasis: Building a framework. Cell. 127:679–695. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim HJ, Hong I, Roh S, Kim S, Kim H, Oh S, Ahn TS, Kang DH, Baek M, Jeong D, Jeong D, et al: High expression of LY6E is an independent prognostic factor of colorectal cancer patients. Oncol Rep 49: 80, 2023.
APA
Kim, H.J., Hong, I., Roh, S., Kim, S., Kim, H., Oh, S. ... Jeong, D. (2023). High expression of LY6E is an independent prognostic factor of colorectal cancer patients. Oncology Reports, 49, 80. https://doi.org/10.3892/or.2023.8517
MLA
Kim, H. J., Hong, I., Roh, S., Kim, S., Kim, H., Oh, S., Ahn, T. S., Kang, D. H., Baek, M., Jeong, D."High expression of LY6E is an independent prognostic factor of colorectal cancer patients". Oncology Reports 49.4 (2023): 80.
Chicago
Kim, H. J., Hong, I., Roh, S., Kim, S., Kim, H., Oh, S., Ahn, T. S., Kang, D. H., Baek, M., Jeong, D."High expression of LY6E is an independent prognostic factor of colorectal cancer patients". Oncology Reports 49, no. 4 (2023): 80. https://doi.org/10.3892/or.2023.8517
Copy and paste a formatted citation
x
Spandidos Publications style
Kim HJ, Hong I, Roh S, Kim S, Kim H, Oh S, Ahn TS, Kang DH, Baek M, Jeong D, Jeong D, et al: High expression of LY6E is an independent prognostic factor of colorectal cancer patients. Oncol Rep 49: 80, 2023.
APA
Kim, H.J., Hong, I., Roh, S., Kim, S., Kim, H., Oh, S. ... Jeong, D. (2023). High expression of LY6E is an independent prognostic factor of colorectal cancer patients. Oncology Reports, 49, 80. https://doi.org/10.3892/or.2023.8517
MLA
Kim, H. J., Hong, I., Roh, S., Kim, S., Kim, H., Oh, S., Ahn, T. S., Kang, D. H., Baek, M., Jeong, D."High expression of LY6E is an independent prognostic factor of colorectal cancer patients". Oncology Reports 49.4 (2023): 80.
Chicago
Kim, H. J., Hong, I., Roh, S., Kim, S., Kim, H., Oh, S., Ahn, T. S., Kang, D. H., Baek, M., Jeong, D."High expression of LY6E is an independent prognostic factor of colorectal cancer patients". Oncology Reports 49, no. 4 (2023): 80. https://doi.org/10.3892/or.2023.8517
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