Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
May-2023 Volume 49 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2023 Volume 49 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Estrogen receptors regulate galectin‑3 in androgen‑independent DU‑145 prostate cancer cells

  • Authors:
    • Deborah S. Souza
    • Carla Macheroni
    • Carolina M. Vicente
    • Renan P. Cavalheiro
    • Vanessa L. Campo
    • Catarina S. Porto
  • View Affiliations / Copyright

    Affiliations: Laboratory of Experimental Endocrinology, Department of Pharmacology, Paulista School of Medicine (EPM), Federal University of São Paulo (UNIFESP), São Paulo, SP 04039‑032, Brazil, Department of Biochemistry, Paulista School of Medicine (EPM), Federal University of São Paulo (UNIFESP), São Paulo, SP 04039‑032, Brazil, Barão de Mauá University Center (CBM), Ribeirão Preto, SP 14090‑180, Brazil
    Copyright: © Souza et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 93
    |
    Published online on: March 20, 2023
       https://doi.org/10.3892/or.2023.8530
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the role of estrogen receptor (ER)α and ERβ, and galectin‑3 (GAL‑3) in migration and invasion of androgen‑independent DU‑145 prostate cancer cells, and to examine the regulation of the expression of GAL‑3 by the activation of these receptors. Wound healing and cell invasion assays were performed using the control (basal level of cellular function) and treated DU‑145 cells. At 24 h of treatment, 17β‑estradiol (E2), the ERα‑selective agonist, 4,4',4"‑(4‑propyl‑(1H)‑pyrazole‑1,3,5‑triyl)trisphenol (PPT), or the ERβ‑selective agonist, 2,3‑bis(4‑hydroxyphenyl)‑propionitrile (diarylprepionitrile; DPN), increased the migration and invasion of the DU‑145 cells. Pre‑treatment with the ERα‑ and ERβ‑selective antagonists blocked these effects, indicating that ERα and ERβ are upstream receptors regulating these processes. Western blot analysis and immunofluorescence staining for the detection of the GAL‑3 were performed using the control and treated DU‑145 cells. Treatment of the DU‑145 cells with E2, PPT or DPN for 24 h increased the expression of the GAL‑3 compared to the control. Furthermore, a specific inhibitor of GAL‑3 (VA03) inhibited the migration and invasion of DU‑145 cells, indicating the involvement of the complex ERα/GAL‑3 and ERβ/GAL‑3 in the regulation of these processes. On the whole, the present study demonstrates that the activation of both ERs increases the expression and signaling of GAL‑3, and promotes the migration and invasion of DU‑145 cells. The findings of the present study provide novel insight into the signatures and molecular mechanisms of ERα and ERβ in DU‑145 cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Sathianathen NJ, Konety BR, Crook J, Saad F and Lawrentschuk N: Landmarks in prostate cancer. Nat Rev Urol. 15:627–642. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Baciarello G, Gizzi M and Fizazi K: Advancing therapies in metastatic castration-resistant prostate cancer. Expert Opin Pharmacother. 19:1797–1804. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Liu FT and Rabinovich GA: Galectins as modulators of tumour progression. Nat Rev Cancer. 5:29–41. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Thijssen VL, Heusschen R, Caers J and Griffioen AW: Galectin expression in cancer diagnosis and prognosis: A systematic review. Biochim Biophys Acta. 1855:235–247. 2015.PubMed/NCBI

5 

Laderach DJ, Gentilini LD, Giribaldi L, Delgado VC, Nugnes L, Croci DO, Al Nakouzi N, Sacca P, Casas G, Mazza O, et al: A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease. Cancer Res. 73:86–96. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Compagno D, Gentilini LD, Jaworski FM, Pérez IG, Contrufo G and Laderach DJ: Glycans and galectins in prostate cancer biology, angiogenesis, and metastasis. Glycobiology. 24:899–906. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Martínez-Bosch N, Rodriguez-Vida A, Juanpere N, Lloreta J, Rovira A, Albanell J, Bellmunt J and Navarro P: Galectins in prostate and bladder cancer: Tumorigenic roles and clinical opportunities. Nat Rev Urol. 16:433–445. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Ahmed H, Cappello F, Rodolico V and Vasta GR: Evidence of heavy methylation in the galectin 3 promoter in early stages of prostate adenocarcinoma: Development and validation of a methylated marker for early diagnosis of prostate cancer. Transl Oncol. 2:146–156. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Ellerhorst J, Troncoso P, Xu XC, Lee J and Lotan R: Galectin-1 and galectin-3 expression in human prostate tissue and prostate cancer. Urol Res. 27:362–367. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Pacis RA, Pilat MJ, Pienta KJ, Wojno K, Raz A, Hogan V and Cooper CR: Decreased galectin-3 expression in prostate cancer. Prostate. 44:118–123. 2000. View Article : Google Scholar : PubMed/NCBI

11 

van den Brûle FA, Waltregny D, Liu FT and Castronovo V: Alteration of the cytoplasmic/nuclear expression pattern of galectin-3 correlates with prostate carcinoma progression. Int J Cancer. 89:361–367. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Merseburger AS, Kramer MW, Hennenlotter J, Simon P, Knapp J, Hartmann JT, Stenzl A, Serth J and Kuczyk MA: Involvement of decreased Galectin-3 expression in the pathogenesis and progression of prostate cancer. Prostate. 68:72–77. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Wang Y, Nangia-Makker P, Tait L, Balan V, Hogan V, Pienta KJ and Raz A: Regulation of prostate cancer progression by galectin-3. Am J Pathol. 174:1515–1523. 2009. View Article : Google Scholar : PubMed/NCBI

14 

de Melo-Júnior MR, Araújo-Filho JL, Lins CA, de Pontes-Filho NT and de Carvalho LB Jr: Immobilization of anti-galectin-3 onto polysiloxane-polyvinyl alcohol disks for tumor prostatic diseases diagnosis. Appl Biochem Biotechnol. 160:2198–2207. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Knapp JS, Lokeshwar SD, Vogel U, Hennenlotter J, Schwentner C, Kramer MW, Stenzl A and Merseburger AS: Galectin-3 expression in prostate cancer and benign prostate tissues: Correlation with biochemical recurrence. World J Urol. 31:351–358. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Geisler C, Gaisa NT, Pfister D, Fuessel S, Kristiansen G, Braunschweig T, Gostek S, Beine B, Diehl HC, Jackson AM, et al: Identification and validation of potential new biomarkers for prostate cancer diagnosis and prognosis using 2D-DIGE and MS. Biomed Res Int. 2015:4542562015. View Article : Google Scholar : PubMed/NCBI

17 

Ahmed H, Banerjee PP and Vasta GR: Differential expression of galectins in normal, benign, and malignant prostate epithelial cells: Silencing of galectin-3 expression in prostate cancer by its promoter methylation. Biochem Biophys Res Commun. 358:241–246. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Califice S, Castronovo V, Bracke M and van den Brûle F: Dual activities of galectin-3 in human prostate cancer: Tumor suppression of nuclear galectin-3 vs tumor promotion of cytoplasmic galectin-3. Oncogene. 23:7527–7536. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Fukumori T, Oka N, Takenaka Y, Nangia-Makker P, Elsamman E, Kasai T, Shono M, Kanayama HO, Ellerhorst J, Lotan R and Raz A: Galectin-3 regulates mitochondrial stability and antiapoptotic function in response to anticancer drug in prostate cancer. Cancer Res. 66:3114–3119. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Wang Y, Nangia-Makker P, Balan V, Hogan V and Raz A: Calpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatment. Cell Death Dis. 1:e1012010. View Article : Google Scholar : PubMed/NCBI

21 

Wang Y, Balan V, Gao X, Reddy PG, Kho D, Tait L and Raz A: The significance of galectin-3 as a new basal cell marker in prostate cancer. Cell Death Dis. 4:e7532013. View Article : Google Scholar : PubMed/NCBI

22 

Guha P, Kaptan E, Bandyopadhyaya G, Kaczanowska S, Davila E, Thompson K, Martin SS, Kalvakolanu DV, Vasta GR and Ahmed H: Cod glycopeptide with picomolar affinity to galectin-3 suppresses T-cell apoptosis and prostate cancer metastasis. Proc Natl Acad Sci USA. 110:5052–5057. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Glinsky VV, Glinsky GV, Rittenhouse-Olson K, Huflejt ME, Glinskii OV, Deutscher SL and Quinn TP: The role of Thomsen-Friedenreich antigen in adhesion of human breast and prostate cancer cells to the endothelium. Cancer Res. 61:4851–4857. 2001.PubMed/NCBI

24 

Glinsky VV, Glinsky GV, Glinskii OV, Huxley VH, Turk JR, Mossine VV, Deutscher SL, Pienta KJ and Quinn TP: Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium. Cancer Res. 63:3805–3811. 2003.PubMed/NCBI

25 

Dondoo TO, Fukumori T, Daizumoto K, Fukawa T, Kohzuki M, Kowada M, Kusuhara Y, Mori H, Nakatsuji H, Takahashi M and Kanayama HO: Galectin-3 is implicated in tumor progression and resistance to anti-androgen drug through regulation of androgen receptor signaling in prostate cancer. Anticancer Res. 37:125–134. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Farhad M, Rolig AS and Redmond WL: The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment. Oncoimmunology. 7:e14344672018. View Article : Google Scholar : PubMed/NCBI

27 

Dumic J, Dabelic S and Flögel M: Galectin-3: An open-ended story. Biochim Biophys Acta. 1760:616–635. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Wang L and Guo XL: Molecular regulation of galectin-3 expression and therapeutic implication in cancer progression. Biomed Pharmacother. 78:165–171. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Ruebel KH, Jin L, Qian X, Scheithauer BW, Kovacs K, Nakamura N, Zhang H, Raz A and Lloyd RV: Effects of DNA methylation on galectin-3 expression in pituitary tumors. Cancer Res. 65:1136–1140. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Heldring N, Pike A, Andersson S, Matthews J, Cheng G, Hartman J, Tujague M, Ström A, Treuter E, Warner M and Gustafsson JA: Estrogen receptors: How do they signal and what are their targets. Physiol Rev. 87:905–931. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Thiebaut C, Vlaeminck-Guillem V, Trédan O, Poulard C and Le Romancer M: Non genomic signaling of steroid receptors in cancer. Mol Cell Endocrinol. 538:1114532021. View Article : Google Scholar : PubMed/NCBI

32 

Pisolato R, Lombardi AP, Vicente CM, Lucas TF, Lazari MF and Porto CS: Expression and regulation of the estrogen receptors in PC-3 human prostate cancer cells. Steroids. 107:74–86. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Souza DS, Lombardi A, Vicente CM, Lucas T, Erustes AG, Pereira G and Porto CS: Estrogen receptors localization and signaling pathways in DU-145 human prostate cancer cells. Mol Cell Endocrinol. 483:11–23. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Lombardi AP, Pisolato R, Vicente CM, Lazari MF, Lucas TF and Porto CS: Estrogen receptor beta (ERβ) mediates expression of β-catenin and proliferation in prostate cancer cell line PC-3. Mol Cell Endocrinol. 430:12–24. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Lombardi A, Cavalheiro RP, Porto CS and Vicente CM: Estrogen receptor signaling pathways involved in invasion and colony formation of androgen-independent prostate cancer cells PC-3. Int J Mol Sci. 22:11532021. View Article : Google Scholar : PubMed/NCBI

36 

Silva RS, Lombardi A, Souza DS, Vicente CM and Porto CS: Activation of estrogen receptor beta (ERβ) regulates the expression of N-cadherin, E-cadherin and β-catenin in androgen-independent prostate cancer cells. Int J Biochem Cell Biol. 96:40–50. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Stauffer SR, Coletta CJ, Tedesco R, Nishiguchi G, Carlson K, Sun J, Katzenellenbogen BS and Katzenellenbogen JA: Pyrazole ligands: Structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem. 43:4934–4947. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Meyers MJ, Sun J, CarlsonK E, Marriner GA, Katzenellenbogen BS and Katzenellenbogen JA: Estrogen receptor-beta potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem. 44:4230–4251. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Bustos SO, da Silva Pereira GJ, de Freitas Saito R, Gil CD, Zanatta DB, Smaili SS and Chammas R: Galectin-3 sensitized melanoma cell lines to vemurafenib (PLX4032) induced cell death through prevention of autophagy. Oncotarget. 9:14567–14579. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Lombardi A, Vicente CM and Porto CS: Estrogen receptors promote migration, invasion and colony formation of the androgen-independent prostate cancer cells PC-3 through β-catenin pathway. Front Endocrinol. 11:1842020. View Article : Google Scholar : PubMed/NCBI

41 

Vicente CM, Lima MA, Yates EA, Nader HB and Toma L: Enhanced tumorigenic potential of colorectal cancer cells by extracellular sulfatases. Mol Cancer Res. 13:510–523. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Marchiori MF, Riul TB, Oliveira Bortot L, Andrade P, Junqueira GG, Foca G, Doti N, Ruvo M, Dias-Baruffi M, Carvalho I and Campo VL: Binding of triazole-linked galactosyl arylsulfonamides to galectin-3 affects Trypanosoma cruzi cell invasion. Bioorg Med Chem. 25:6049–6059. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Wang Y, Jing Y, Ding L, Zhang X, Song Y, Chen S, Zhao X, Huang X, Pu Y, Wang Z, et al: Epiregulin reprograms cancer-associated fibroblasts and facilitates oral squamous cell carcinoma invasion via JAK2-STAT3 pathway. J Exp Clin Cancer Res. 38:2742019. View Article : Google Scholar : PubMed/NCBI

44 

Macheroni C, Gameiro Lucas TF, Souza DS, Vicente CM, Pereira GJDS, Junior IDSV, Juliano MA and Porto CS: Activation of estrogen receptor ESR1 and ESR2 induces proliferation of the human testicular embryonal carcinoma NT2/D1 cells. Mol Cell Endocrinol. 554:1117082022. View Article : Google Scholar : PubMed/NCBI

45 

Nelson AW, Tilley WD, Neal DE and Carroll JS: Estrogen receptor beta in prostate cancer: Friend or foe? Endocr Relat Cancer. 21:T219–T234. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Lau KM and To KF: Importance of estrogenic signaling and its mediated receptors in prostate cancer. Int J Mol Sci. 17:14342016. View Article : Google Scholar : PubMed/NCBI

47 

Kowalska K and Piastowska-Ciesielska AW: Oestrogens and oestrogen receptors in prostate cancer. Springer Plus. 5:5222016. View Article : Google Scholar : PubMed/NCBI

48 

Warner M, Fan X, Strom A, Wu W and Gustafsson JÅ: 25 years of ERβ: A personal journey. J Mol Endocrinol. 68:R1–R9. 2021. View Article : Google Scholar : PubMed/NCBI

49 

Nelson AW, Groen AJ, Miller JL, Warren AY, Holmes KA, Tarulli GA, Tilley WD, Katzenellenbogen BS, Hawse JR, Gnanapragasam VJ and Carroll JS: Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity. Mol Cell Endocrinol. 440:138–150. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Semenas J, Wang T, Sajid Syed Khaja A, Firoj Mahmud A, Simoulis A, Grundström T, Fällman M and Persson JL: Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration-resistant prostate cancer. Mol Oncol. 15:968–986. 2021. View Article : Google Scholar : PubMed/NCBI

51 

Rossi V, Di Zazzo E, Galasso G, De Rosa C, Abbondanza C, Sinisi AA, Altucci L, Migliaccio A and Castoria G: Estrogens modulate somatostatin receptors expression and synergize with the somatostatin analog pasireotide in prostate cells. Front Pharmacol. 10:282019. View Article : Google Scholar : PubMed/NCBI

52 

Leung YK, Lam HM, Wu S, Song D, Levin L, Cheng L, Wu CL and Ho SM: Estrogen receptor beta2 and beta5 are associated with poor prognosis in prostate cancer and promote cancer cell migration and invasion. Endocr Relat Cancer. 17:675–689. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Gustafsson JA, Strom A and Warner M: Update on ERbeta. J Steroid Biochem Mol Biol. 191:1053122019. View Article : Google Scholar : PubMed/NCBI

54 

Kadrofske MM, Openo KP and Wang JL: The human LGALS3 (galectin 3) gene: Determination of the gene structure and functional characterization of the promoter. Arch Biochem Biophys. 349:7–20. 1998. View Article : Google Scholar : PubMed/NCBI

55 

Yang H, Lei C, Cheng C, Feng Y, Zhang W, Petracco RG and Sak S: The Antiapoptotic effect of Galectin-3 in human endometrial cells under the regulation of estrogen and progesterone. Biol Reprod. 87:392012. View Article : Google Scholar : PubMed/NCBI

56 

Bima C, Chiloiro S, Giampietro A, Gessi M, Mattogno PP, Lauretti L, Anile C, Rindi G, Pontecorvi A, De Marinis L and Bianchi A: Galectin-3 and estrogen receptor alpha as prognostic markers in prolactinoma: Preliminary results from a pilot study. Front Endocrinol (Lausanne). 12:6840552021. View Article : Google Scholar : PubMed/NCBI

57 

Mourad-Zeidan AA, Melnikova VO, Wang H, Raz A and Bar-Eli M: Expression profiling of Galectin-3-depleted melanoma cells reveals its major role in melanoma cell plasticity and vasculogenic mimicry. Am J Pathol. 173:1839–1852. 2008. View Article : Google Scholar : PubMed/NCBI

58 

Wang YG, Kim SJ, Baek JH, Lee HW, Jeong SY and Chun KH: Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression. Exp Mol Med. 44:387–393. 2012. View Article : Google Scholar : PubMed/NCBI

59 

Shimura T, Takenaka Y, Tsutsumi S, Hogan V, Kikuchi A and Raz A: Galectin-3, a novel binding partner of beta-catenin. Cancer Res. 64:6363–6367. 2004. View Article : Google Scholar : PubMed/NCBI

60 

Yang Y, Zhou Z, He S, Fan T, Jin Y, Zhu X, Chen C, Zhang ZR and Huang Y: Treatment of prostate carcinoma with (galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates. Biomaterials. 33:2260–2271. 2012. View Article : Google Scholar : PubMed/NCBI

61 

Glinsky VV and Raz A: Modified citrus pectin anti-metastatic properties: One bullet, multiple targets. Carbohydr Res. 344:1788–1791. 2009. View Article : Google Scholar : PubMed/NCBI

62 

Conti S, Vexler A, Hagoel L, Kalich-Philosoph L, Corn BW, Honig N, Shtraus N, Meir Y, Ron I, Eliaz I and Lev-Ari S: Modified citrus pectin as a potential sensitizer for radiotherapy in prostate cancer. Integr Cancer Ther. 17:1225–1234. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Souza DS, Macheroni C, Vicente CM, Cavalheiro RP, Campo VL and Porto CS: Estrogen receptors regulate galectin‑3 in androgen‑independent DU‑145 prostate cancer cells. Oncol Rep 49: 93, 2023.
APA
Souza, D.S., Macheroni, C., Vicente, C.M., Cavalheiro, R.P., Campo, V.L., & Porto, C.S. (2023). Estrogen receptors regulate galectin‑3 in androgen‑independent DU‑145 prostate cancer cells. Oncology Reports, 49, 93. https://doi.org/10.3892/or.2023.8530
MLA
Souza, D. S., Macheroni, C., Vicente, C. M., Cavalheiro, R. P., Campo, V. L., Porto, C. S."Estrogen receptors regulate galectin‑3 in androgen‑independent DU‑145 prostate cancer cells". Oncology Reports 49.5 (2023): 93.
Chicago
Souza, D. S., Macheroni, C., Vicente, C. M., Cavalheiro, R. P., Campo, V. L., Porto, C. S."Estrogen receptors regulate galectin‑3 in androgen‑independent DU‑145 prostate cancer cells". Oncology Reports 49, no. 5 (2023): 93. https://doi.org/10.3892/or.2023.8530
Copy and paste a formatted citation
x
Spandidos Publications style
Souza DS, Macheroni C, Vicente CM, Cavalheiro RP, Campo VL and Porto CS: Estrogen receptors regulate galectin‑3 in androgen‑independent DU‑145 prostate cancer cells. Oncol Rep 49: 93, 2023.
APA
Souza, D.S., Macheroni, C., Vicente, C.M., Cavalheiro, R.P., Campo, V.L., & Porto, C.S. (2023). Estrogen receptors regulate galectin‑3 in androgen‑independent DU‑145 prostate cancer cells. Oncology Reports, 49, 93. https://doi.org/10.3892/or.2023.8530
MLA
Souza, D. S., Macheroni, C., Vicente, C. M., Cavalheiro, R. P., Campo, V. L., Porto, C. S."Estrogen receptors regulate galectin‑3 in androgen‑independent DU‑145 prostate cancer cells". Oncology Reports 49.5 (2023): 93.
Chicago
Souza, D. S., Macheroni, C., Vicente, C. M., Cavalheiro, R. P., Campo, V. L., Porto, C. S."Estrogen receptors regulate galectin‑3 in androgen‑independent DU‑145 prostate cancer cells". Oncology Reports 49, no. 5 (2023): 93. https://doi.org/10.3892/or.2023.8530
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team