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Article Open Access

METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS

  • Authors:
    • Jie-Xun Chen
    • Dong-Ming Chen
    • Dong Wang
    • Yi Xiao
    • Shuai Zhu
    • Xian-Lin Xu
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    Affiliations: Department of Urology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 94
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    Published online on: March 22, 2023
       https://doi.org/10.3892/or.2023.8531
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Abstract

The present study aimed to explore the potential roles of the methyltransferase‑like 3 (METTL3)‑mediated methylation of RAS related (RRAS) mRNA in the tumorigenesis and development of bladder cancer (BCa). For this purpose, the relative expression levels of METTL3 in BCa specimens and cell lines were measured using reverse transcription‑quantitative PCR (RT‑qPCR) and western blot analysis. The association between the METTL3 expression level and the clinical characteristics of patients with BCa was analyzed using The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis databases. Cellular experiments were performed to confirm the effects of METTL3 on the proliferative, migratory and invasive capacities of BCa cells. RT‑qPCR, western blot analysis, methylated RNA immunoprecipitation (MeRIP)‑qPCR and dual‑luciferase report assays were utilized to verify the METTL3/RRAS/YTH N6‑methyladenosine (m6A) RNA binding protein 2 (YTHDF2) regulatory axis in BCa. The results revealed that METTL3 expression was markedly increased in BCa specimens and cell lines, and was associated with poor clinical characteristics of patients with BCa. In vitro and in vivo assays demonstrated that the silencing of METTL3 markedly suppressed the proliferative, migratory and invasive capacities of BCa cells. MeRIP‑PCR and dual‑luciferase report assays indicated that METTL3 could bind to the m6A sites of RRAS mRNA and suppress the transcriptional activity of RRAS. YTHDF2 could recognize the m6A sites of RRAS and mediate RRAS degradation. On the whole, the findings of the present study reveal the pivotal role of METTL3‑catalyzed m6A modification in BCa tumorigenesis and development. The change could facilitate BCa tumor growth and metastasis by suppressing RRAS expression in an m6A YTHDF2‑dependent manner. Targeting the METTL3/RRAS/YTHDF2 regulatory axis may thus prove to be a promising strategy for the diagnosis and therapy of BCa.
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View References

1 

Tran L, Xiao JF, Agarwal N, Duex JE and Theodorescu D: Advances in bladder cancer biology and therapy. Nat Rev Cancer. 21:104–121. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Lenis AT, Lec PM, Chamie K and Mshs MD: Bladder cancer: A review. JAMA. 324:1980–1991. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Patel VG, Oh WK and Galsky MD: Treatment of muscle-invasive and advanced bladder cancer in 2020. CA Cancer J Clin. 70:404–423. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Joensen UN, Maibom SL and Poulsen AM: Surgical management of muscle invasive bladder cancer: A review of current recommendations. Semin Oncol Nurs. 37:1511042021. View Article : Google Scholar : PubMed/NCBI

5 

Witjes JA, Bruins HM, Cathomas R, Compérat EM, Cowan NC, Gakis G, Hernández V, Linares Espinós E, Lorch A, Neuzillet Y, et al: European association of urology guidelines on muscle-invasive and metastatic bladder cancer: Summary of the 2020 guidelines. Eur Urol. 79:82–104. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Nason GJ, Ajib K, Tan GH and Kulkarni GS: Bladder-sparing treatment options in localized muscle-invasive bladder cancer. Expert Rev Anticancer Ther. 20:179–188. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Nadal R and Bellmunt J: Management of metastatic bladder cancer. Cancer Treat Rev. 76:10–21. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Alifrangis C, McGovern U, Freeman A, Powles T and Linch M: Molecular and histopathology directed therapy for advanced bladder cancer. Nat Rev Urol. 16:465–483. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Jordan B and Meeks JJ: T1 bladder cancer: Current considerations for diagnosis and management. Nat Rev Urol. 16:23–34. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Jia J, Wu S, Jia Z, Wang C, Ju C, Sheng J, He F, Zhou M and He J: Novel insights into m6A modification of coding and non-coding RNAs in tumor biology: From molecular mechanisms to therapeutic significance. Int J Biol Sci. 18:4432–4451. 2022. View Article : Google Scholar : PubMed/NCBI

11 

Chen J, Fang Y, Xu Y and Sun H: Role of m6A modification in female infertility and reproductive system diseases. Int J Biol Sci. 18:3592–3604. 2022. View Article : Google Scholar : PubMed/NCBI

12 

Qu X, Zhang Y, Sang X, Ren D, Zhao H and Wong STC: Methyladenosine modification in RNAs: From regulatory roles to therapeutic implications in cancer. Cancers (Basel). 14:31952022. View Article : Google Scholar : PubMed/NCBI

13 

Zhang F, Liu H, Duan M, Wang G, Zhang Z, Wang Y, Qian Y, Yang Z and Jiang X: Crosstalk among m6A RNA methylation, hypoxia and metabolic reprogramming in TME: From immunosuppressive microenvironment to clinical application. J Hematol Oncol. 15:842022. View Article : Google Scholar : PubMed/NCBI

14 

Murakami S and Jaffrey SR: Hidden codes in mRNA: Control of gene expression by m6A. Mol Cell. 82:2236–2251. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Shi B, Liu WW, Yang K, Jiang GM and Wang H: The role, mechanism, and application of RNA methyltransferase METTL14 in gastrointestinal cancer. Mol Cancer. 21:1632022. View Article : Google Scholar : PubMed/NCBI

16 

Shen D, Wang B, Gao Y, Zhao L, Bi Y, Zhang J, Wang N, Kang H, Pang J, Liu Y, et al: Detailed resume of RNA m6A demethylases. Acta Pharm Sin B. 12:2193–2205. 2022. View Article : Google Scholar : PubMed/NCBI

17 

Chen D, Cheung H, Lau HC, Yu J and Wong CC: N6-methyladenosine RNA-binding protein YTHDF1 in gastrointestinal cancers: Function, molecular mechanism and clinical implication. Cancers (Basel). 14:34892022. View Article : Google Scholar : PubMed/NCBI

18 

Wu X, Ye W and Gong Y: The role of RNA methyltransferase METTL3 in normal and malignant hematopoiesis. Front Oncol. 12:8739032022. View Article : Google Scholar : PubMed/NCBI

19 

Li E, Xia M, Du Y, Long K, Ji F, Pan F, He L, Hu Z and Guo Z: METTL3 promotes homologous recombination repair and modulates chemotherapeutic response in breast cancer by regulating the EGF/RAD51 axis. Elife. 11:e752312022. View Article : Google Scholar : PubMed/NCBI

20 

Zhu Y, Peng X, Zhou Q, Tan L, Zhang C, Lin S and Long M: METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition. Cell Death Dis. 13:3582022. View Article : Google Scholar : PubMed/NCBI

21 

Li H, Wang C, Lan L, Yan L, Li W, Evans I, Ruiz EJ, Su Q, Zhao G, Wu W, et al: METTL3 promotes oxaliplatin resistance of gastric cancer CD133+ stem cells by promoting PARP1 mRNA stability. Cell Mol Life Sci. 79:1352022. View Article : Google Scholar : PubMed/NCBI

22 

Han J, Wang JZ, Yang X, Yu H, Zhou R, Lu HC, Yuan WB, Lu JC, Zhou ZJ, Lu Q, et al: METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner. Mol Cancer. 18:1102019. View Article : Google Scholar : PubMed/NCBI

23 

Cheng M, Sheng L, Gao Q, Xiong Q, Zhang H, Wu M, Liang Y, Zhu F, Zhang Y, Zhang X, et al: The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network. Oncogene. 38:3667–3680. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Wei Y, Zhang F, Zhang T, Zhang Y, Chen H, Wang F and Li Y: LDLRAD2 overexpression predicts poor prognosis and promotes metastasis by activating Wnt/β-catenin/EMT signaling cascade in gastric cancer. Aging (Albany NY). 11:8951–8968. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Li J, Huang W, Han Q, Xiong J and Song Z: LDLRAD2 promotes pancreatic cancer progression through Akt/mTOR signaling pathway. Med Oncol. 38:22021. View Article : Google Scholar : PubMed/NCBI

27 

Wan W, Ao X, Chen Q, Yu Y, Ao L, Xing W, Guo W, Wu X, Pu C, Hu X, et al: MEMETTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer. Mol Cancer. 21:602022. View Article : Google Scholar : PubMed/NCBI

28 

Xia H, Wu Y, Zhao J, Cheng C, Lin J, Yang Y, Lu L, Xiang Q, Bian T and Liu Q: N6-methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2. Cell Death Differ. Feb 24–2023.(Epub ahead of print). View Article : Google Scholar

29 

Timcheva K, Dufour S, Touat-Todeschini L, Burnard C, Carpentier MC, Chuffart F, Merret R, Helsmoortel M, Ferré S, Grézy A, et al: Chromatin-associated YTHDC1 coordinates heat-induced reprogramming of gene expression. Cell Rep. 41:1117842022. View Article : Google Scholar : PubMed/NCBI

30 

Hu L, Yu Y, Shen Y, Huang H, Lin D, Wang K, Yu Y, Li K, Cao Y, Wang Q, et al: Ythdf2 promotes pulmonary hypertension by suppressing Hmox1-dependent anti-inflammatory and antioxidant function in alveolar macrophages. Redox Biol. 61:1026382023. View Article : Google Scholar : PubMed/NCBI

31 

Yang Y, Yan Y, Yin J, Tang N, Wang K, Huang L, Hu J, Feng Z, Gao Q and Huang A: O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N6-methyladenosine-dependent manner. Signal Transduct Target Ther. 8:632023. View Article : Google Scholar : PubMed/NCBI

32 

Zhuang M, Geng X, Han P, Che P, Liang F, Liu C, Yang L, Yu J, Zhang Z, Dong W and Ji SJ: YTHDF2 in dentate gyrus is the m6A reader mediating m6A modification in hippocampus-dependent learning and memory. Mol Psychiatry. Jan 20–2023.(Epub ahead of print). View Article : Google Scholar

33 

Martin A, Woolbright BL, Umar S, Ingersoll MA and Taylor JA III: Bladder cancer, inflammageing and microbiomes. Nat Rev Urol. 19:495–509. 2022. View Article : Google Scholar : PubMed/NCBI

34 

Lee YC, Lam HM, Rosser C, Theodorescu D, Parks WC and Chan KS: The dynamic roles of the bladder tumour microenvironment. Nat Rev Urol. 19:515–533. 2022. View Article : Google Scholar : PubMed/NCBI

35 

Liu S, Chen X and Lin T: Emerging strategies for the improvement of chemotherapy in bladder cancer: Current knowledge and future perspectives. J Adv Res. 39:187–202. 2022. View Article : Google Scholar : PubMed/NCBI

36 

Ranti D, Bieber C, Wang YS, Sfakianos JP and Horowitz A: Natural killer cells: Unlocking new treatments for bladder cancer. Trends Cancer. 8:698–710. 2022. View Article : Google Scholar : PubMed/NCBI

37 

Li Y, Meng L and Zhao B: The roles of N6-methyladenosine methylation in the regulation of bone development, bone remodeling and osteoporosis. Pharmacol Ther. 238:1081742022. View Article : Google Scholar : PubMed/NCBI

38 

Zhuo R, Xu M, Wang X, Zhou B, Wu X, Leone V, Chang EB and Zhong X: The regulatory role of N6-methyladenosine modification in the interaction between host and microbes. Wiley Interdiscip Rev RNA. 13:e17252022. View Article : Google Scholar : PubMed/NCBI

39 

Zhou H, Mao L, Xu H, Wang S and Tian J: The functional roles of m6A modification in T lymphocyte responses and autoimmune diseases. Cytokine Growth Factor Rev. 65:51–60. 2022. View Article : Google Scholar : PubMed/NCBI

40 

Li X, Ma S, Deng Y, Yi P and Yu J: Targeting the RNA m6A modification for cancer immunotherapy. Mol Cancer. 21:762022. View Article : Google Scholar : PubMed/NCBI

41 

Liu H, Gu J, Huang Z, Han Z, Xin J, Yuan L, Du M, Chu H, Wang M and Zhang Z: Fine particulate matter induces METTL3-mediated m6A modification of BIRC5 mRNA in bladder cancer. J Hazard Mater. 437:1293102022. View Article : Google Scholar : PubMed/NCBI

42 

Ni Z, Sun P, Zheng J, Wu M, Yang C, Cheng M, Yin M, Cui C, Wang G, Yuan L, et al: JNK signaling promotes bladder cancer immune escape by regulating METTL3-mediated m6A modification of PD-L1 mRNA. Cancer Res. 82:1789–1802. 2022. View Article : Google Scholar : PubMed/NCBI

43 

Yu H, Yang X, Tang J, Si S, Zhou Z, Lu J, Han J, Yuan B, Wu Q, Lu Q and Yang H: ALKBH5 inhibited cell proliferation and sensitized bladder cancer cells to cisplatin by m6A-CK2α-mediated glycolysis. Mol Ther Nucleic Acids. 23:27–41. 2020. View Article : Google Scholar : PubMed/NCBI

44 

Li H, Prever L, Hsu MY, Lo WT, Margaria JP, De Santis MC, Zanini C, Forni M, Novelli F, Pece S, et al: Phosphoinositide conversion inactivates R-RAS and drives metastases in breast cancer. Adv Sci (Weinh). 9:e21032492022. View Article : Google Scholar : PubMed/NCBI

45 

Hu Q, Masuda T, Koike K, Sato K, Tobo T, Kuramitsu S, Kitagawa A, Fujii A, Noda M, Tsuruda Y, et al: Oxysterol binding protein-like 3 (OSBPL3) is a novel driver gene that promotes tumor growth in part through R-Ras/Akt signaling in gastric cancer. Sci Rep. 11:191782021. View Article : Google Scholar : PubMed/NCBI

46 

Raza A, Pandey MS, Jin Q and Mulder KM: km23-1/DYNLRB1 regulation of MEK/ERK signaling and R-Ras in invasive human colorectal cancer cells. Cell Biol Int. 44:155–165. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Sung H, Kanchi KL, Wang X, Hill KS, Messina JL, Lee JH, Kim Y, Dees ND, Ding L, Teer JK, et al: Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation. Oncotarget. 7:23885–23896. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Liu R, Jia Y, Kong G and He A: Novel insights into roles of N6-methyladenosine reader YTHDF2 in cancer progression. J Cancer Res Clin Oncol. 148:2215–2230. 2022. View Article : Google Scholar : PubMed/NCBI

49 

Lee Y, Choe J, Park OH and Kim YK: Molecular mechanisms driving mRNA degradation by m6A modification. Trends Genet. 36:177–188. 2020. View Article : Google Scholar : PubMed/NCBI

50 

Chen X, Zhou X and Wang X: m6A binding protein YTHDF2 in cancer. Exp Hematol Oncol. 11:212022. View Article : Google Scholar : PubMed/NCBI

51 

Wang JY and Lu AQ: The biological function of m6A reader YTHDF2 and its role in human disease. Cancer Cell Int. 21:1092021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Chen D, Wang D, Xiao Y, Zhu S and Xu X: METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS. Oncol Rep 49: 94, 2023.
APA
Chen, J., Chen, D., Wang, D., Xiao, Y., Zhu, S., & Xu, X. (2023). METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS. Oncology Reports, 49, 94. https://doi.org/10.3892/or.2023.8531
MLA
Chen, J., Chen, D., Wang, D., Xiao, Y., Zhu, S., Xu, X."METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS". Oncology Reports 49.5 (2023): 94.
Chicago
Chen, J., Chen, D., Wang, D., Xiao, Y., Zhu, S., Xu, X."METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS". Oncology Reports 49, no. 5 (2023): 94. https://doi.org/10.3892/or.2023.8531
Copy and paste a formatted citation
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Spandidos Publications style
Chen J, Chen D, Wang D, Xiao Y, Zhu S and Xu X: METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS. Oncol Rep 49: 94, 2023.
APA
Chen, J., Chen, D., Wang, D., Xiao, Y., Zhu, S., & Xu, X. (2023). METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS. Oncology Reports, 49, 94. https://doi.org/10.3892/or.2023.8531
MLA
Chen, J., Chen, D., Wang, D., Xiao, Y., Zhu, S., Xu, X."METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS". Oncology Reports 49.5 (2023): 94.
Chicago
Chen, J., Chen, D., Wang, D., Xiao, Y., Zhu, S., Xu, X."METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS". Oncology Reports 49, no. 5 (2023): 94. https://doi.org/10.3892/or.2023.8531
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