Open Access

CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway

  • Authors:
    • Xiao Liu
    • Yonghua Tong
    • Qiu Huang
    • Yu He
    • Haojie Shang
    • Zhiqiang Chen
    • Kun Tang
  • View Affiliations

  • Published online on: March 31, 2023     https://doi.org/10.3892/or.2023.8540
  • Article Number: 103
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bladder cancer (BCa) is a common malignant disease with high recurrence and variable prognosis. Circular RNAs (circRNAs) are implicated in the development of multiple diseases. However, the biological activities of circRNAs in BCa remain largely elusive. In the present study, it was found that circRPPH1 was upregulated in BCa cell lines compared with normal urothelial cells. CircRPPH1 downregulation could inhibit the proliferation, migration and invasion of BCa cells in vitro and in vivo. Mechanistically, it was demonstrated that circRPPH1 can act as a sponge of miR‑296‑5P to upregulate STAT3, and interact with FUS to promote phosphorylated (p)‑STAT3 nuclear transport. Overall, circRPPH1 could promote BCa progression through sponging miR‑296‑5p to upregulate the expression of STAT3 and interacting with FUS to promote p‑STAT3 nuclear transport. CircRPPH1 was first identified to play a tumorigenic role in BCa, which could be an underlying therapeutic target.
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May-2023
Volume 49 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Liu X, Tong Y, Huang Q, He Y, Shang H, Chen Z and Tang K: CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway. Oncol Rep 49: 103, 2023
APA
Liu, X., Tong, Y., Huang, Q., He, Y., Shang, H., Chen, Z., & Tang, K. (2023). CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway. Oncology Reports, 49, 103. https://doi.org/10.3892/or.2023.8540
MLA
Liu, X., Tong, Y., Huang, Q., He, Y., Shang, H., Chen, Z., Tang, K."CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway". Oncology Reports 49.5 (2023): 103.
Chicago
Liu, X., Tong, Y., Huang, Q., He, Y., Shang, H., Chen, Z., Tang, K."CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway". Oncology Reports 49, no. 5 (2023): 103. https://doi.org/10.3892/or.2023.8540