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Article Open Access

CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway

  • Authors:
    • Xiao Liu
    • Yonghua Tong
    • Qiu Huang
    • Yu He
    • Haojie Shang
    • Zhiqiang Chen
    • Kun Tang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 103
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    Published online on: March 31, 2023
       https://doi.org/10.3892/or.2023.8540
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Abstract

Bladder cancer (BCa) is a common malignant disease with high recurrence and variable prognosis. Circular RNAs (circRNAs) are implicated in the development of multiple diseases. However, the biological activities of circRNAs in BCa remain largely elusive. In the present study, it was found that circRPPH1 was upregulated in BCa cell lines compared with normal urothelial cells. CircRPPH1 downregulation could inhibit the proliferation, migration and invasion of BCa cells in vitro and in vivo. Mechanistically, it was demonstrated that circRPPH1 can act as a sponge of miR‑296‑5P to upregulate STAT3, and interact with FUS to promote phosphorylated (p)‑STAT3 nuclear transport. Overall, circRPPH1 could promote BCa progression through sponging miR‑296‑5p to upregulate the expression of STAT3 and interacting with FUS to promote p‑STAT3 nuclear transport. CircRPPH1 was first identified to play a tumorigenic role in BCa, which could be an underlying therapeutic target.
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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Tong Y, Huang Q, He Y, Shang H, Chen Z and Tang K: CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway. Oncol Rep 49: 103, 2023.
APA
Liu, X., Tong, Y., Huang, Q., He, Y., Shang, H., Chen, Z., & Tang, K. (2023). CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway. Oncology Reports, 49, 103. https://doi.org/10.3892/or.2023.8540
MLA
Liu, X., Tong, Y., Huang, Q., He, Y., Shang, H., Chen, Z., Tang, K."CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway". Oncology Reports 49.5 (2023): 103.
Chicago
Liu, X., Tong, Y., Huang, Q., He, Y., Shang, H., Chen, Z., Tang, K."CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway". Oncology Reports 49, no. 5 (2023): 103. https://doi.org/10.3892/or.2023.8540
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Tong Y, Huang Q, He Y, Shang H, Chen Z and Tang K: CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway. Oncol Rep 49: 103, 2023.
APA
Liu, X., Tong, Y., Huang, Q., He, Y., Shang, H., Chen, Z., & Tang, K. (2023). CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway. Oncology Reports, 49, 103. https://doi.org/10.3892/or.2023.8540
MLA
Liu, X., Tong, Y., Huang, Q., He, Y., Shang, H., Chen, Z., Tang, K."CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway". Oncology Reports 49.5 (2023): 103.
Chicago
Liu, X., Tong, Y., Huang, Q., He, Y., Shang, H., Chen, Z., Tang, K."CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway". Oncology Reports 49, no. 5 (2023): 103. https://doi.org/10.3892/or.2023.8540
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